1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine has been researched along with Pregnancy in 23 studies
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine : A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Idiopathic Parkinson's disease (PD) is a neurodegenerative disorder of mature and older individuals." | 1.36 | Modeling a sensitization stage and a precipitation stage for Parkinson's disease using prenatal and postnatal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration. ( Charlton, CG; King, J; Mackey, V; Muthian, G, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (26.09) | 18.7374 |
| 1990's | 5 (21.74) | 18.2507 |
| 2000's | 8 (34.78) | 29.6817 |
| 2010's | 4 (17.39) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sai, T | 1 |
| Uchida, K | 1 |
| Nakayama, H | 1 |
| Kim, HG | 1 |
| Park, G | 1 |
| Piao, Y | 1 |
| Kang, MS | 1 |
| Pak, YK | 1 |
| Hong, SP | 1 |
| Oh, MS | 1 |
| Cho, Y | 1 |
| Son, HJ | 1 |
| Kim, EM | 1 |
| Choi, JH | 1 |
| Kim, ST | 1 |
| Ji, IJ | 1 |
| Choi, DH | 1 |
| Joh, TH | 1 |
| Kim, YS | 1 |
| Hwang, O | 1 |
| Muthian, G | 1 |
| Mackey, V | 1 |
| King, J | 1 |
| Charlton, CG | 1 |
| Sun, X | 1 |
| Xiong, Z | 1 |
| Zhang, Y | 1 |
| Meng, Y | 1 |
| Xu, G | 1 |
| Xia, Z | 2 |
| Li, J | 1 |
| Zhang, R | 1 |
| Ke, Z | 1 |
| Hu, Y | 1 |
| Fredriksson, A | 1 |
| Schröder, N | 1 |
| Archer, T | 1 |
| Silva, RM | 1 |
| Ries, V | 1 |
| Oo, TF | 1 |
| Yarygina, O | 1 |
| Jackson-Lewis, V | 1 |
| Ryu, EJ | 1 |
| Lu, PD | 1 |
| Marciniak, SJ | 1 |
| Ron, D | 1 |
| Przedborski, S | 1 |
| Kholodilov, N | 1 |
| Greene, LA | 1 |
| Burke, RE | 1 |
| Lloyd, SA | 1 |
| Faherty, CJ | 1 |
| Smeyne, RJ | 1 |
| Richardson, JR | 1 |
| Caudle, WM | 1 |
| Wang, M | 1 |
| Dean, ED | 1 |
| Pennell, KD | 1 |
| Miller, GW | 1 |
| Bains, M | 1 |
| Cousins, JC | 1 |
| Roberts, JL | 1 |
| Imamura, K | 1 |
| Takeshima, T | 1 |
| Nakaso, K | 1 |
| Nakashima, K | 1 |
| Salach, JI | 1 |
| Singer, TP | 2 |
| Castagnoli, N | 1 |
| Trevor, A | 1 |
| Otto, D | 1 |
| Unsicker, K | 1 |
| Sapirstein, A | 1 |
| Bonventre, JV | 1 |
| Pérez-Otaño, I | 1 |
| Oset, C | 1 |
| Trinidad Herrero, M | 1 |
| Luquin, MR | 1 |
| Kupsch, A | 1 |
| Oertel, W | 1 |
| Obeso, JA | 1 |
| Del Río, J | 1 |
| Ochi, N | 3 |
| Naoi, M | 3 |
| Mogi, M | 1 |
| Ohya, Y | 3 |
| Mizutani, N | 3 |
| Watanabe, K | 3 |
| Harada, M | 1 |
| Nagatsu, T | 3 |
| Krueger, MJ | 1 |
| McKeown, K | 1 |
| Ramsay, RR | 1 |
| Youngster, SK | 1 |
| Weissman, EM | 1 |
| Norman, AB | 1 |
| Calderon, SF | 1 |
| Zubrycki, EM | 1 |
| el-Etri, MM | 1 |
| Shipley, MT | 1 |
| Sanberg, PR | 1 |
| Tipton, KF | 1 |
| McCrodden, JM | 1 |
| Youdim, MB | 1 |
| Buckman, TD | 1 |
| Eiduson, S | 1 |
| Cohen, G | 1 |
| Mytilineou, C | 1 |
1 review available for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and Pregnancy
| Article | Year |
|---|---|
Specific physiological roles of cytosolic phospholipase A(2) as defined by gene knockouts.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Airway Resistance; Anaphylaxis; Animals; Brain Injurie | 2000 |
22 other studies available for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and Pregnancy
| Article | Year |
|---|---|
Biochemical evaluation of the neurotoxicity of MPTP and MPP⁺ in embryonic and newborn mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic | 2013 |
Effects of the root bark of Paeonia suffruticosa on mitochondria-mediated neuroprotection in an MPTP-induced model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Chromatography, High Pressure Liquid; Disease | 2014 |
Doxycycline is neuroprotective against nigral dopaminergic degeneration by a dual mechanism involving MMP-3.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cell Death; Cells, Cultured; Dopamine; Dose-R | 2009 |
Modeling a sensitization stage and a precipitation stage for Parkinson's disease using prenatal and postnatal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Birth | 2010 |
Harpagoside attenuates MPTP/MPP⁺ induced dopaminergic neurodegeneration and movement disorder via elevating glial cell line-derived neurotrophic factor.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antibodies; Axons; Cells, Cultured; Corpus St | 2012 |
Neurobehavioural deficits following postnatal iron overload: I spontaneous motor activity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Animals, Newborn; Basal Ganglia; Brain; Brain | 2003 |
CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Animals, Newborn; Apoptosis; Axotomy; Behavio | 2005 |
Adult and in utero exposure to cocaine alters sensitivity to the Parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cell Count; Cocaine; DNA Primers; Dopamine Ag | 2006 |
Developmental exposure to the pesticide dieldrin alters the dopamine system and increases neurotoxicity in an animal model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Animals, Newborn; Dieldrin; Disease Models, A | 2006 |
Neuroprotection by estrogen against MPP+-induced dopamine neuron death is mediated by ERalpha in primary cultures of mouse mesencephalon.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Astrocytes; Cells, Cult | 2007 |
Homocysteine is toxic for dopaminergic neurons in primary mesencephalic culture.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antipsychotic Agents; Cells, Cultured; Dopami | 2007 |
Oxidation of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by monoamine oxidases A and B and suicide inactivation of the enzymes by MPTP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Female; Humans; Isoenzymes; Kinetics; Mitochondria; Mo | 1984 |
FGF-2-mediated protection of cultured mesencephalic dopaminergic neurons against MPTP and MPP+: specificity and impact of culture conditions, non-dopaminergic neurons, and astroglial cells.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Astrocytes; Cells, Cultured; Dopamine; Dopami | 1993 |
Neurotoxic effect of prenatal exposure to MPTP on the dopaminergic systems of the marmoset brain.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Adolescent; Animals; C | 1992 |
Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in prenatal stage on the dopamine system in the postnatal mouse brain.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Abortion, Veterinary; Animals; Brain; Dopamine; Dose-R | 1991 |
Transplacentally-transported 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) affects the catecholamine and indoleamine levels in the fetal mouse brain.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Brain | 1990 |
Mechanism-based inactivation of monoamine oxidases A and B by tetrahydropyridines and dihydropyridines.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Female; Humans; Hydrogen-Ion Concentration; Kinetics; | 1990 |
Uptake of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and the N-methyl-4-phenylpyridinium ion (MPP+) into fetal mouse brain through the placenta.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Chromatog | 1989 |
The effect of prenatal treatment with MPTP or MPP+ on the development of dopamine-mediated behaviors in rats.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Amphetamines; Animals; Ap | 1989 |
Oxidation and enzyme-activated irreversible inhibition of rat liver monoamine oxidase-B by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Clorgyline; Female; Half-Life; Isoenzymes; Ki | 1986 |
Photoinactivation of B-type monoamine oxidase by a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine metabolite.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Blood Platelets; Brain; Cattle; Cercopithecus | 1985 |
Studies on the mechanism of action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Culture Techniques; Female; Kinetics; Monoami | 1985 |