1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine has been researched along with Pheochromocytoma, Extra-Adrenal in 8 studies
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine : A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Polymer-encapsulated PC12 cells, a dopaminergic cell line derived from a rat pheochromocytoma, were transplanted in five Macaca fascicularis monkeys which had been previously rendered hemiparkinsonian by a unilateral carotid injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine." | 3.69 | Functional recovery in hemiparkinsonian primates transplanted with polymer-encapsulated PC12 cells. ( Aebischer, P; Goddard, M; Signore, AP; Timpson, RL, 1994) |
| "The toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine (2'Et-MPTP), and their corresponding pyridinium species was studied in the rat pheochromocytoma PC12 cell line." | 3.68 | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine- and 1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine-induced toxicity in PC12 cells: role of monoamine oxidase A. ( Basma, AN; Geller, HM; Giovanni, A; Heikkila, RE; Nicklas, WJ, 1990) |
| "5 mM MPTP for 72 h resulted in a 50% cell loss with respect to the control cells, and clorgyline, a MAO-A inhibitor, antagonized this toxic effect." | 1.27 | Evaluation of the toxicity of the dopaminergic neurotoxins MPTP and MPP+ in PC12 pheochromocytoma cells: binding and biological studies. ( Bernardi, F; Corsini, GU; Del Zompo, M; Marongiu, ME; Piccardi, MP, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Denton, T | 2 |
| Howard, BD | 4 |
| Aebischer, P | 1 |
| Goddard, M | 1 |
| Signore, AP | 1 |
| Timpson, RL | 1 |
| Andersen, JK | 1 |
| Zhang, MB | 2 |
| Zhong, XH | 1 |
| Rozenberg, YY | 1 |
| Basma, AN | 1 |
| Heikkila, RE | 1 |
| Nicklas, WJ | 1 |
| Giovanni, A | 1 |
| Geller, HM | 1 |
| Naoi, M | 1 |
| Takahashi, T | 1 |
| Nagatsu, T | 1 |
| Marongiu, ME | 1 |
| Piccardi, MP | 1 |
| Bernardi, F | 1 |
| Corsini, GU | 1 |
| Del Zompo, M | 1 |
| Bitler, CM | 1 |
8 other studies available for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and Pheochromocytoma, Extra-Adrenal
| Article | Year |
|---|---|
Inhibition of dopamine uptake by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a cause of parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenal Gland Neoplasms; Animals; Biological Transport | 1984 |
Functional recovery in hemiparkinsonian primates transplanted with polymer-encapsulated PC12 cells.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenal Gland Neoplasms; Adrenal Medulla; Animals; Cap | 1994 |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-resistant, flat-cell PC12 variants having a partial loss of transformed phenotype.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenal Gland Neoplasms; Animals; Cell Transformation, | 1990 |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine- and 1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine-induced toxicity in PC12 cells: role of monoamine oxidase A.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenal Gland Neoplasms; Animals; Cell Survival; Clorg | 1990 |
Metabolism of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in a rat pheochromocytoma cell line, PC12h.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Chromatography, | 1987 |
Evaluation of the toxicity of the dopaminergic neurotoxins MPTP and MPP+ in PC12 pheochromocytoma cells: binding and biological studies.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Adrenal Gland Neoplasms; | 1988 |
PC12 variants deficient in catecholamine transport.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenal Gland Neoplasms; Animals; Biological Transport | 1986 |
A dopaminergic cell line variant resistant to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenosine Triphosphate; Adrenal Gland Neoplasms; Anima | 1987 |