1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine has been researched along with Nervous System Disorders in 26 studies
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine : A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study was to investigate the effect of chronic cerebral hypoperfusion (CCH) on cognitive dysfunction, structural abnormalities of the hippocampus and white matter (WM), and levels of inflammatory cytokines in control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse models." | 3.91 | Hippocampal damage and white matter lesions contribute to cognitive impairment in MPTP-lesioned mice with chronic cerebral hypoperfusion. ( Feng, S; Gao, L; Gao, Y; Huang, Z; Nie, K; Tang, H; Wang, L; Zhang, Y; Zhao, J; Zhu, R, 2019) |
| " After 4 days of treatment, and as the dosage was gradually increased, the animals exhibited mild motor deficits." | 1.28 | 1-Methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine (2'-methyl-MPTP) is less neurotoxic than MPTP in the common marmoset. ( Gibb, WR; Jackson, EA; Jenner, P; Marsden, CD; Nomoto, M; Rose, S, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (34.62) | 18.7374 |
| 1990's | 14 (53.85) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (7.69) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Berridge, MS | 1 |
| Sayre, LM | 1 |
| Arora, PK | 1 |
| Terris, AH | 1 |
| Riachi, NJ | 2 |
| Harik, SI | 2 |
| Ma, J | 1 |
| Dong, L | 1 |
| Chang, Q | 1 |
| Chen, S | 1 |
| Zheng, J | 1 |
| Li, D | 1 |
| Wu, S | 1 |
| Yang, H | 1 |
| Li, X | 1 |
| Gao, Y | 1 |
| Tang, H | 1 |
| Nie, K | 1 |
| Zhu, R | 1 |
| Gao, L | 1 |
| Feng, S | 1 |
| Wang, L | 2 |
| Zhao, J | 1 |
| Huang, Z | 1 |
| Zhang, Y | 1 |
| Shah, A | 1 |
| Garzon-Muvdi, T | 1 |
| Mahajan, R | 1 |
| Duenas, VJ | 1 |
| Quiñones-Hinojosa, A | 1 |
| Matsumoto, J | 1 |
| Takahashi, T | 1 |
| Agata, M | 1 |
| Toyofuku, H | 1 |
| Sasada, N | 1 |
| Del Zompo, M | 1 |
| Piccardi, MP | 1 |
| Ruiu, S | 1 |
| Quartu, M | 1 |
| Gessa, GL | 1 |
| Vaccari, A | 1 |
| Oishi, T | 1 |
| Hasegawa, E | 1 |
| Murai, Y | 1 |
| Dluzen, DE | 1 |
| Steiner, JP | 1 |
| Hamilton, GS | 1 |
| Ross, DT | 1 |
| Valentine, HL | 1 |
| Guo, H | 1 |
| Connolly, MA | 1 |
| Liang, S | 1 |
| Ramsey, C | 1 |
| Li, JH | 1 |
| Huang, W | 1 |
| Howorth, P | 1 |
| Soni, R | 1 |
| Fuller, M | 1 |
| Sauer, H | 1 |
| Nowotnik, AC | 1 |
| Suzdak, PD | 1 |
| Lee, EH | 1 |
| Liu, SP | 1 |
| Lu, KT | 1 |
| Lin, WR | 1 |
| Sonsalla, PK | 2 |
| Zeevalk, GD | 1 |
| Manzino, L | 1 |
| Giovanni, A | 1 |
| Nicklas, WJ | 1 |
| Behmand, RA | 1 |
| Hadjiconstantinou, M | 1 |
| Neff, NH | 1 |
| Rose, S | 1 |
| Nomoto, M | 1 |
| Jackson, EA | 1 |
| Gibb, WR | 1 |
| Jenner, P | 1 |
| Marsden, CD | 1 |
| Lange, KW | 1 |
| Carr, LA | 1 |
| Rowell, PP | 1 |
| Lai, M | 1 |
| Griffiths, HR | 1 |
| Sandyk, R | 1 |
| Iacono, RP | 1 |
| Fuller, RW | 2 |
| Hemrick-Luecke, SK | 2 |
| Ueki, A | 1 |
| Willoughby, J | 1 |
| Glover, V | 1 |
| Sandler, M | 1 |
| Stibbe, K | 1 |
| Stern, GM | 1 |
| Corsini, GU | 1 |
| Pintus, S | 1 |
| Chiueh, CC | 1 |
| Weiss, JF | 1 |
| Kopin, IJ | 1 |
| Melamed, E | 1 |
| Martinovits, G | 1 |
| Pikarsky, E | 1 |
| Rosenthal, J | 1 |
| Uzzan, A | 1 |
| Youngster, SK | 1 |
| Heikkila, RE | 2 |
| Pileblad, E | 1 |
| Carlsson, A | 1 |
2 reviews available for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and Nervous System Disorders
| Article | Year |
|---|---|
Animal models of neurological disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenergic Agents; Amyloid beta-Protein Precursor; Ani | 2010 |
The neurotoxicity of MPTP and its relationship to the pathophysiology of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Humans; MPTP Poisoning; Nervous System; Nervous System | 1989 |
24 other studies available for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and Nervous System Disorders
| Article | Year |
|---|---|
Design and synthesis of 18F-labeled neurotoxic analogs of MPTP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Fluorine Radioisotopes; Hydrolysis; Isotope L | 1993 |
CXCR4 knockout induces neuropathological changes in the MPTP-lesioned model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Mice; Mice, Inbred C57BL; Nervous System Dise | 2023 |
Hippocampal damage and white matter lesions contribute to cognitive impairment in MPTP-lesioned mice with chronic cerebral hypoperfusion.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apoptosis; Brain; Brain Ischemia; Carotid Ste | 2019 |
A study of the biological pharmacology of IFO, a new selective and reversible monoamine oxidase-B inhibitor.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biogenic Monoamines; Brain; Dopamine; In Vitr | 1994 |
Selective MPP+ uptake into synaptic dopamine vesicles: possible involvement in MPTP neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amphetamine; Animals; Biomarkers; Brain; Corpus Striat | 1993 |
Sulfhydryl drugs reduce neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striat | 1993 |
Effects of testosterone upon MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system of C57/B1 mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Catecholamine | 1996 |
Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Carrier Proteins; Cells, Cultured; Chickens; | 1997 |
Comparative studies of the neurotoxicity of MPTP in rats of different ages.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aging; Animals; Behavior, Animal; Brain; Brain Chemist | 1992 |
MK-801 fails to protect against the dopaminergic neuropathology produced by systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice or intranigral 1-methyl-4-phenylpyridinium in rats.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Dizocilpine Male | 1992 |
Correlation of MPTP neurotoxicity in vivo with oxidation of MPTP by the brain and blood-brain barrier in vitro in five rat strains.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Biogenic Amines; Blood-Brai | 1991 |
Differential recovery of dopamine synthetic enzymes following MPTP and the consequences of GM1 ganglioside treatment.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; | 1990 |
1-Methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine (2'-methyl-MPTP) is less neurotoxic than MPTP in the common marmoset.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Biogenic Amines; Brain Chem | 1990 |
Behavioural effects and supersensitivity in the rat following intranigral MPTP and MPP+ administration.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aging; Animals; Behavior, Animal; Injections; Male; MP | 1990 |
Attenuation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity by tobacco smoke.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striat | 1990 |
Role of reactive oxygen species in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cell Line; Cell Survival; Disease Models, Ani | 1990 |
A high dose of MPTP overcomes the protective effect of selegiline against dopaminergic neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striat | 1989 |
Endogenous urinary monoamine oxidase inhibitor excretion in Parkinson's disease and other neurological disorders.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adult; Aged; Aged, 80 and over; Female; Humans; Isatin | 1989 |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in mice is enhanced by pretreatment with diethyldithiocarbamate.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Amin | 1985 |
Diphenylhydantoin and phenobarbital suppress the dopaminergic neurotoxicity of MPTP in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anticonvulsants; Male; Mice; Mice, Inbred C57 | 1986 |
Evaluation of the biological activity of several analogs of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Corpus | 1987 |
Catecholamine-uptake inhibitors prevent the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mouse brain.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Catecholamines; Male; Maprotiline; Maz | 1985 |
Differential neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in Swiss-Webster mice from different sources.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemist | 1985 |
Mechanisms of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity to striatal dopamine neurons in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Dopamine; Male; Mice; Nervou | 1985 |