1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine has been researched along with Glioma in 5 studies
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine : A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The toxic effect of the Parkinsonism-producing neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) was investigated using a neuronal cell culture system, namely, neuroblastoma X glioma hybrid NG 108-15." | 7.68 | MPTP-induced ATP depletion and cell death in neuroblastoma X glioma hybrid NG 108-15 cells: protection by glucose and sensitization by tetraphenylborate. ( Horng, J; Krishna, G; Kutty, RK; Santostasi, G, 1991) |
| "The toxic effect of the Parkinsonism-producing neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) was investigated using a neuronal cell culture system, namely, neuroblastoma X glioma hybrid NG 108-15." | 3.68 | MPTP-induced ATP depletion and cell death in neuroblastoma X glioma hybrid NG 108-15 cells: protection by glucose and sensitization by tetraphenylborate. ( Horng, J; Krishna, G; Kutty, RK; Santostasi, G, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sharpe, MA | 1 |
| Han, J | 1 |
| Baskin, AM | 1 |
| Baskin, DS | 1 |
| Saulino, MF | 1 |
| Schengrund, CL | 1 |
| Kutty, RK | 1 |
| Santostasi, G | 1 |
| Horng, J | 1 |
| Krishna, G | 1 |
| Lin, ZX | 1 |
| Chang, CC | 1 |
| Trosko, JE | 1 |
| Notter, MF | 1 |
| Irwin, I | 1 |
| Langston, JW | 1 |
| Gash, DM | 1 |
5 other studies available for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and Glioma
| Article | Year |
|---|---|
Design and synthesis of a MAO-B-selectively activated prodrug based on MPTP: a mitochondria-targeting chemotherapeutic agent for treatment of human malignant gliomas.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Antineoplastic Agents; Drug Delivery Systems; Drug Des | 2015 |
Effects of specific gangliosides on the in vitro proliferation of MPTP-susceptible cells.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cell Division; Culture Media; Drug Resistance | 1993 |
MPTP-induced ATP depletion and cell death in neuroblastoma X glioma hybrid NG 108-15 cells: protection by glucose and sensitization by tetraphenylborate.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Adenine Nucleotides; Aden | 1991 |
Gap junctional intercellular communication (GJIC) in rat glioma cells--characterizations to detect inhibitors of metabolic cooperation.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Brain Neoplasms; Cell Commun | 1990 |
Neurotoxicity of MPTP and MPP+ in vitro: characterization using specific cell lines.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Cell Differentia | 1988 |