1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine has been researched along with Genetic Predisposition in 18 studies
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine : A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Genetic susceptibility is a strong risk factor for PD." | 1.56 | Functional validation of a human GLUD2 variant in a murine model of Parkinson's disease. ( Chen, X; Ding, L; Gao, F; Gong, J; Guo, W; Li, Y; Lin, Y; Pan, X; Peng, G; Sun, X; Wang, S; Xu, P; Xuan, A; Yang, X; Zhang, W; Zhang, X; Zhang, Y; Zhang, Z; Zhu, X, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (72.22) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, W | 1 |
| Gong, J | 1 |
| Ding, L | 1 |
| Zhang, Z | 1 |
| Pan, X | 1 |
| Chen, X | 1 |
| Guo, W | 1 |
| Zhang, X | 1 |
| Yang, X | 1 |
| Peng, G | 1 |
| Lin, Y | 1 |
| Gao, F | 1 |
| Li, Y | 1 |
| Zhu, X | 1 |
| Xuan, A | 1 |
| Wang, S | 1 |
| Sun, X | 1 |
| Zhang, Y | 1 |
| Xu, P | 1 |
| Müller-Nedebock, AC | 1 |
| Brennan, RR | 1 |
| Venter, M | 1 |
| Pienaar, IS | 1 |
| van der Westhuizen, FH | 1 |
| Elson, JL | 1 |
| Ross, OA | 1 |
| Bardien, S | 1 |
| Chou, VP | 1 |
| Ko, N | 1 |
| Holman, TR | 1 |
| Manning-Boğ, AB | 1 |
| Franke, SK | 1 |
| van Kesteren, RE | 1 |
| Hofman, S | 1 |
| Wubben, JA | 1 |
| Smit, AB | 1 |
| Philippens, IH | 1 |
| Yu, M | 1 |
| Suo, H | 1 |
| Liu, M | 1 |
| Cai, L | 1 |
| Liu, J | 1 |
| Huang, Y | 1 |
| Xu, J | 1 |
| Wang, Y | 1 |
| Zhu, C | 1 |
| Fei, J | 1 |
| Huang, F | 1 |
| Bolin, LM | 1 |
| Strycharska-Orczyk, I | 1 |
| Murray, R | 1 |
| Langston, JW | 1 |
| Di Monte, D | 1 |
| Tsang, F | 1 |
| Soong, TW | 1 |
| Sedelis, M | 1 |
| Hofele, K | 1 |
| Schwarting, RK | 1 |
| Huston, JP | 1 |
| Belknap, JK | 1 |
| Klivenyi, P | 2 |
| Starkov, AA | 1 |
| Calingasan, NY | 2 |
| Gardian, G | 1 |
| Browne, SE | 1 |
| Yang, L | 1 |
| Bubber, P | 1 |
| Gibson, GE | 1 |
| Patel, MS | 1 |
| Beal, MF | 2 |
| Marchetti, B | 1 |
| Serra, PA | 1 |
| L'Episcopo, F | 1 |
| Tirolo, C | 1 |
| Caniglia, S | 1 |
| Testa, N | 1 |
| Cioni, S | 1 |
| Gennuso, F | 1 |
| Rocchitta, G | 1 |
| Desole, MS | 1 |
| Mazzarino, MC | 1 |
| Miele, E | 1 |
| Morale, MC | 1 |
| Teng, X | 1 |
| Sakai, T | 1 |
| Liu, L | 1 |
| Sakai, R | 1 |
| Kaji, R | 1 |
| Fukui, K | 1 |
| Carvey, PM | 1 |
| Punati, A | 1 |
| Newman, MB | 1 |
| Kim, JM | 2 |
| Lee, KH | 1 |
| Jeon, YJ | 1 |
| Oh, JH | 1 |
| Jeong, SY | 1 |
| Song, IS | 1 |
| Lee, DS | 1 |
| Kim, NS | 1 |
| Pattarini, R | 1 |
| Smeyne, RJ | 1 |
| Morgan, JI | 1 |
| Thomas, B | 1 |
| von Coelln, R | 1 |
| Mandir, AS | 1 |
| Trinkaus, DB | 1 |
| Farah, MH | 1 |
| Leong Lim, K | 1 |
| Flint Beal, M | 1 |
| Dawson, VL | 1 |
| Dawson, TM | 1 |
| Imai, Y | 1 |
| Inoue, H | 1 |
| Kataoka, A | 1 |
| Hua-Qin, W | 1 |
| Masuda, M | 1 |
| Ikeda, T | 1 |
| Tsukita, K | 1 |
| Soda, M | 1 |
| Kodama, T | 1 |
| Fuwa, T | 1 |
| Honda, Y | 1 |
| Kaneko, S | 1 |
| Matsumoto, S | 1 |
| Wakamatsu, K | 1 |
| Ito, S | 1 |
| Miura, M | 1 |
| Aosaki, T | 1 |
| Itohara, S | 1 |
| Takahashi, R | 1 |
| Andreassen, OA | 1 |
| Ferrante, RJ | 1 |
| Dedeoglu, A | 1 |
| Albers, DW | 1 |
| Carlson, EJ | 1 |
| Epstein, CJ | 1 |
| Richfield, EK | 1 |
| Thiruchelvam, MJ | 1 |
| Cory-Slechta, DA | 1 |
| Wuertzer, C | 1 |
| Gainetdinov, RR | 1 |
| Caron, MG | 1 |
| Di Monte, DA | 1 |
| Federoff, HJ | 1 |
4 reviews available for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and Genetic Predisposition
| Article | Year |
|---|---|
The unresolved role of mitochondrial DNA in Parkinson's disease: An overview of published studies, their limitations, and future prospects.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Confounding Factors, Epidemiologic; DNA, Mitochondrial | 2019 |
Interactions between environmental and genetic factors in the pathophysiology of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Disease Progression; Dopamine; Environ | 2003 |
Hormones are key actors in gene x environment interactions programming the vulnerability to Parkinson's disease: glia as a common final pathway.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Dopamine; Environment; Estrogens; Gene | 2005 |
Progressive dopamine neuron loss in Parkinson's disease: the multiple hit hypothesis.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aging; Animals; Disease Models, Animal; Disease Progre | 2006 |
14 other studies available for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and Genetic Predisposition
| Article | Year |
|---|---|
Functional validation of a human GLUD2 variant in a murine model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amino Acid Transport System X-AG; Animals; Brain-Deriv | 2020 |
Gene-environment interaction models to unmask susceptibility mechanisms in Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Gene-Environment Interaction; Genetic Predisp | 2014 |
Individual and Familial Susceptibility to MPTP in a Common Marmoset Model for Parkinson's Disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Callithrix; Corpus Striatum; Disease Models, | 2016 |
NRSF/REST neuronal deficient mice are more vulnerable to the neurotoxin MPTP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Genetic Predisposition to Disease; Mice; Mice | 2013 |
Increased vulnerability of dopaminergic neurons in MPTP-lesioned interleukin-6 deficient mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Astrocytes; Corpus Striatum; Disease Models, | 2002 |
Chromosomal loci influencing the susceptibility to the parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Bayes Theorem; Chromosome Mapping; Chromosome | 2003 |
Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Caudate Nucleus; Cell Count; Cerebral Cortex; | 2004 |
Attenuation of MPTP-induced neurotoxicity and locomotor dysfunction in Nucling-deficient mice via suppression of the apoptosome pathway.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apoptosis; Apoptotic Protease-Activating Fact | 2006 |
Identification of genes related to Parkinson's disease using expressed sequence tags.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biomarkers; Cell Death; Chromogranins; Cytosk | 2006 |
Temporal mRNA profiles of inflammatory mediators in the murine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Cell Survival; Chemokines; Corpus Stri | 2007 |
MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Benzylamines; Catecholamines; Cell Survival; | 2007 |
Pael receptor is involved in dopamine metabolism in the nigrostriatal system.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striat | 2007 |
Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Carrier Prote | 2001 |
Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aging; alpha-Synuclein; Amphetamine; Animals; Behavior | 2002 |