1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine has been researched along with Encephalopathy, Toxic in 23 studies
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine : A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Currently, obesity is considered a systemic inflammation; however, the effects of obesity on the vulnerability of dopaminergic neurons to oxidative stress are not fully defined." | 5.33 | Enhanced susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in high-fat diet-induced obesity. ( Choi, JY; Jang, EH; Kang, JH; Park, CS, 2005) |
| "Causes of dopaminergic neuronal loss in Parkinson's disease (PD) are subject of investigation and the common use of models of acute neurodegeneration induced by neurotoxins 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 6-hydroxydopamine, and rotenone contributed to advances in the study of PD." | 1.91 | Protective Effects of Flavonoid Rutin Against Aminochrome Neurotoxicity. ( Costa, ACS; Costa, SL; Cuenca-Bermejo, L; De Araújo, FM; de Fatima Dias Costa, M; de Jesus, LB; Farias, AA; Ferreira, KMS; Frota, AF; Herrero, MT; Menezes-Filho, JA; Munoz, P; Sanches, FS; Santos, CC; Segura-Aguilar, J; Silva, VDA; Soares, EN; Souza, JT, 2023) |
| "Morphine is an opioid pain killer and a strong analgesic that is used to treat chronic pain." | 1.72 | Morphine attenuates neurotoxic effects of MPTP in zebrafish embryos by regulating oxidant/antioxidant balance and acetylcholinesterase activity. ( Alturfan, AA; Cansız, D; Emekli-Alturfan, E; Unal, I; Ustundag, UV, 2022) |
| "Parkinson's disease is the second most common neurodegenerative disease." | 1.62 | The neuroprotective effects of isoquercitrin purified from apple pomace by high-speed countercurrent chromatography in the MPTP acute mouse model of Parkinson's disease. ( Cheng, Y; Hu, Y; Li, H; Liu, C; Liu, J; Qin, X; Wang, W; Wei, Y; Zhang, P, 2021) |
| "5Gy) TBI, C57BL/6 mice were administered with MPTP (15mg/kg, four times, 2h apart) intraperitoneally (i." | 1.35 | Potential mechanisms of neuroprotection induced by low dose total-body gamma-irradiation in C57 mice administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). ( Guo, Q; Li, S; Liang, Y; Su, B; Wen, C; Zhang, Y, 2009) |
| "Nicotine pre-treatment attenuated behavioral deficits and lessened lesion-induced losses of the striatal dopamine transporter, and alpha6beta2* and alpha4beta2* nicotinic receptors (nAChRs)." | 1.35 | Nicotine is neuroprotective when administered before but not after nigrostriatal damage in rats and monkeys. ( Bordia, T; Huang, LZ; Michael McIntosh, J; Parameswaran, N; Quik, M, 2009) |
| "Currently, obesity is considered a systemic inflammation; however, the effects of obesity on the vulnerability of dopaminergic neurons to oxidative stress are not fully defined." | 1.33 | Enhanced susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in high-fat diet-induced obesity. ( Choi, JY; Jang, EH; Kang, JH; Park, CS, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 14 (60.87) | 29.6817 |
| 2010's | 3 (13.04) | 24.3611 |
| 2020's | 6 (26.09) | 2.80 |
| Authors | Studies |
|---|---|
| Pretorius, A | 1 |
| Ogunrombi, MO | 1 |
| Fourie, H | 1 |
| Terre'blanche, G | 1 |
| Castagnoli, N | 1 |
| Bergh, JJ | 1 |
| Petzer, JP | 1 |
| Dong, H | 1 |
| Wu, H | 1 |
| Bai, C | 1 |
| Ye, K | 1 |
| Mao, L | 1 |
| Lei, Y | 1 |
| Liu, Y | 2 |
| Xu, H | 1 |
| Lin, J | 1 |
| Zhu, J | 1 |
| Dong, Q | 1 |
| Huang, M | 1 |
| Bargues-Carot, A | 1 |
| Riaz, Z | 1 |
| Wickham, H | 1 |
| Zenitsky, G | 1 |
| Jin, H | 1 |
| Anantharam, V | 1 |
| Kanthasamy, A | 1 |
| Kanthasamy, AG | 1 |
| De Araújo, FM | 1 |
| Frota, AF | 1 |
| de Jesus, LB | 1 |
| Cuenca-Bermejo, L | 1 |
| Ferreira, KMS | 1 |
| Santos, CC | 1 |
| Soares, EN | 1 |
| Souza, JT | 1 |
| Sanches, FS | 1 |
| Costa, ACS | 1 |
| Farias, AA | 1 |
| de Fatima Dias Costa, M | 1 |
| Munoz, P | 1 |
| Menezes-Filho, JA | 1 |
| Segura-Aguilar, J | 1 |
| Costa, SL | 1 |
| Herrero, MT | 1 |
| Silva, VDA | 1 |
| Mitsumoto, Y | 1 |
| Takamori, S | 1 |
| Kishida, K | 1 |
| Pu, Y | 1 |
| Chang, L | 1 |
| Qu, Y | 1 |
| Wang, S | 1 |
| Tan, Y | 1 |
| Wang, X | 1 |
| Zhang, J | 1 |
| Hashimoto, K | 1 |
| Liu, C | 1 |
| Wang, W | 1 |
| Li, H | 1 |
| Liu, J | 1 |
| Zhang, P | 1 |
| Cheng, Y | 1 |
| Qin, X | 1 |
| Hu, Y | 1 |
| Wei, Y | 1 |
| Cansız, D | 1 |
| Ustundag, UV | 1 |
| Unal, I | 1 |
| Alturfan, AA | 1 |
| Emekli-Alturfan, E | 1 |
| Garcia, E | 1 |
| Limon, D | 1 |
| Perez-De La Cruz, V | 1 |
| Giordano, M | 1 |
| Diaz-Muñoz, M | 1 |
| Maldonado, PD | 1 |
| Herrera-Mundo, MN | 1 |
| Pedraza-Chaverri, J | 1 |
| Santamaria, A | 1 |
| Zhang, Y | 1 |
| Li, S | 1 |
| Liang, Y | 1 |
| Wen, C | 1 |
| Guo, Q | 1 |
| Su, B | 1 |
| Huang, LZ | 1 |
| Parameswaran, N | 1 |
| Bordia, T | 1 |
| Michael McIntosh, J | 1 |
| Quik, M | 1 |
| Thomas, B | 1 |
| Mandir, AS | 1 |
| West, N | 1 |
| Andrabi, SA | 1 |
| Stirling, W | 1 |
| Dawson, VL | 1 |
| Dawson, TM | 1 |
| Lee, MK | 1 |
| Muramatsu, Y | 2 |
| Kurosaki, R | 2 |
| Mikami, T | 1 |
| Michimata, M | 2 |
| Matsubara, M | 2 |
| Imai, Y | 2 |
| Kato, H | 1 |
| Itoyama, Y | 1 |
| Araki, T | 2 |
| Watanabe, H | 1 |
| Boeckler, F | 1 |
| Leng, A | 1 |
| Mura, A | 1 |
| Bettinetti, L | 1 |
| Feldon, J | 1 |
| Gmeiner, P | 1 |
| Ferger, B | 1 |
| Maharaj, DS | 1 |
| Saravanan, KS | 1 |
| Maharaj, H | 1 |
| Mohanakumar, KP | 1 |
| Daya, S | 1 |
| Finch, CE | 1 |
| Choi, JY | 1 |
| Jang, EH | 1 |
| Park, CS | 1 |
| Kang, JH | 1 |
| Tripanichkul, W | 1 |
| Sripanichkulchai, K | 1 |
| Finkelstein, DI | 1 |
| Kou, J | 1 |
| Klorig, DC | 1 |
| Bloomquist, JR | 1 |
| Richardson, JR | 1 |
| Caudle, WM | 1 |
| Wang, M | 1 |
| Dean, ED | 1 |
| Pennell, KD | 1 |
| Miller, GW | 1 |
| Jiang, B | 1 |
| Zhang, H | 1 |
| Bi, J | 1 |
| Zhang, XL | 1 |
| Muralikrishnan, D | 1 |
| Ebadi, M | 1 |
1 review available for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and Encephalopathy, Toxic
| Article | Year |
|---|---|
Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson's Disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; DDT; Dieldrin; Herbicides; H | 2022 |
22 other studies available for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and Encephalopathy, Toxic
| Article | Year |
|---|---|
Interactions of 1-methyl-3-phenylpyrrolidine and 3-methyl-1-phenyl-3-azabicyclo[3.1.0]hexane with monoamine oxidase B.
Topics: Animals; Hexanes; Kinetics; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Monoamine Oxidase; Neurot | 2010 |
Transient MPTP exposure at a sensitive developmental window altered gut microbiome and led to male-biased motor and social behavioral deficits in adult zebrafish.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Dopamine; Gastrointestinal Microbiome; Larva; | 2022 |
Protective Effects of Flavonoid Rutin Against Aminochrome Neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Inflammatory Agents; Disease Models, Ani | 2023 |
Psychosocial stress enhances susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in C57BL/6N mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Mice; Neurotoxicity S | 2019 |
Glyphosate exposure exacerbates the dopaminergic neurotoxicity in the mouse brain after repeated administration of MPTP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Disease Models, Animal; Dopamine; Dopa | 2020 |
The neuroprotective effects of isoquercitrin purified from apple pomace by high-speed countercurrent chromatography in the MPTP acute mouse model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apoptosis; Countercurrent Distribution; Disea | 2021 |
Morphine attenuates neurotoxic effects of MPTP in zebrafish embryos by regulating oxidant/antioxidant balance and acetylcholinesterase activity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acetylcholinesterase; Analgesics, Opioid; Animals; Ant | 2022 |
Lipid peroxidation, mitochondrial dysfunction and neurochemical and behavioural deficits in different neurotoxic models: protective role of S-allylcysteine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antioxidants; Basal Ganglia; Behavior, Animal | 2008 |
Potential mechanisms of neuroprotection induced by low dose total-body gamma-irradiation in C57 mice administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Chroma | 2009 |
Nicotine is neuroprotective when administered before but not after nigrostriatal damage in rats and monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amphetamine; Analysis of Variance; Animals; Autoradiog | 2009 |
Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; beta-Synuclein; Cell Surviva | 2011 |
Therapeutic effect of neuronal nitric oxide synthase inhibitor (7-nitroindazole) against MPTP neurotoxicity in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Arginine; Bra | 2002 |
Role of dopamine transporter against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Dopamine Agents; Dopamine Plasma Membrane Tra | 2003 |
Attenuation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity by the novel selective dopamine D3-receptor partial agonist FAUC 329 predominantly in the nucleus accumbens of mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Dopamine; Dopamine Agonists; | 2003 |
Acetaminophen and aspirin inhibit superoxide anion generation and lipid peroxidation, and protect against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Acetaminophen; Analgesics | 2004 |
The neurotoxicology of hard foraging and fat-melts.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Disease Models, Animal; Fats; Hunger; | 2004 |
Enhanced susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in high-fat diet-induced obesity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animal Feed; Animals; Antioxidants; Astrocytes; Blotti | 2005 |
Estrogen down-regulates glial activation in male mice following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxication.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Basal Ganglia; Cell Cou | 2006 |
Potentiating effect of the ATP-sensitive potassium channel blocker glibenclamide on complex I inhibitor neurotoxicity in vitro and in vivo.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenosine Triphosphate; Animals; Blotting, Western; Ca | 2006 |
Developmental exposure to the pesticide dieldrin alters the dopamine system and increases neurotoxicity in an animal model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Animals, Newborn; Dieldrin; Disease Models, A | 2006 |
Neuroprotective activities of catalpol on MPP+/MPTP-induced neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; | 2008 |
SKF-38393, a dopamine receptor agonist, attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzaze | 2001 |