1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine has been researched along with Cognitive Decline in 5 studies
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine : A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study was to investigate the effect of chronic cerebral hypoperfusion (CCH) on cognitive dysfunction, structural abnormalities of the hippocampus and white matter (WM), and levels of inflammatory cytokines in control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse models." | 3.91 | Hippocampal damage and white matter lesions contribute to cognitive impairment in MPTP-lesioned mice with chronic cerebral hypoperfusion. ( Feng, S; Gao, L; Gao, Y; Huang, Z; Nie, K; Tang, H; Wang, L; Zhang, Y; Zhao, J; Zhu, R, 2019) |
| "In addition to motor dysfunction, cognitive impairments have been reported to occur in patients with early-stage Parkinson's disease (PD)." | 1.72 | Asparagine endopeptidase deletion ameliorates cognitive impairments by inhibiting proinflammatory microglial activation in MPTP mouse model of Parkinson disease. ( Chai, X; Gao, J; Tan, X; Yang, Z; Zhang, W, 2022) |
| "Silibinin administration restored these mitochondrial disorders, as expected for the protection against MPTP injury." | 1.62 | Oral Administration of Silibinin Ameliorates Cognitive Deficits of Parkinson's Disease Mouse Model by Restoring Mitochondrial Disorders in Hippocampus. ( Fu, J; Fujisaki, H; Hattori, S; Hayashi, T; Ikejima, T; Liu, W; Liu, X; Mizuno, K; Song, S; Wang, C, 2021) |
| "The main symptom of Parkinson's disease (PD) is motor dysfunction and remarkably approximately 30-40% of PD patients exhibit cognitive impairments." | 1.56 | Novel fatty acid-binding protein 3 ligand inhibits dopaminergic neuronal death and improves motor and cognitive impairments in Parkinson's disease model mice. ( Fukunaga, K; Haga, H; Izumi, H; Kawahata, I; Miyachi, H; Shinoda, Y; Yamada, R, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 4 (80.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, J | 1 |
| Zhang, W | 1 |
| Chai, X | 1 |
| Tan, X | 1 |
| Yang, Z | 1 |
| Haga, H | 1 |
| Yamada, R | 1 |
| Izumi, H | 1 |
| Shinoda, Y | 1 |
| Kawahata, I | 1 |
| Miyachi, H | 1 |
| Fukunaga, K | 1 |
| Liu, X | 1 |
| Wang, C | 1 |
| Liu, W | 1 |
| Song, S | 1 |
| Fu, J | 1 |
| Hayashi, T | 1 |
| Mizuno, K | 1 |
| Hattori, S | 1 |
| Fujisaki, H | 1 |
| Ikejima, T | 1 |
| Chang, E | 1 |
| Wang, J | 1 |
| Gao, Y | 1 |
| Tang, H | 1 |
| Nie, K | 1 |
| Zhu, R | 1 |
| Gao, L | 1 |
| Feng, S | 1 |
| Wang, L | 2 |
| Zhao, J | 1 |
| Huang, Z | 1 |
| Zhang, Y | 1 |
5 other studies available for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and Cognitive Decline
| Article | Year |
|---|---|
Asparagine endopeptidase deletion ameliorates cognitive impairments by inhibiting proinflammatory microglial activation in MPTP mouse model of Parkinson disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Cognitive Dysfunction; Cyst | 2022 |
Novel fatty acid-binding protein 3 ligand inhibits dopaminergic neuronal death and improves motor and cognitive impairments in Parkinson's disease model mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; Antiparkinson Agents; Blood- | 2020 |
Oral Administration of Silibinin Ameliorates Cognitive Deficits of Parkinson's Disease Mouse Model by Restoring Mitochondrial Disorders in Hippocampus.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Administration, Oral; alpha-Synuclein; Animals; Apopto | 2021 |
Brain-derived neurotrophic factor attenuates cognitive impairment and motor deficits in a mouse model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain-Derived Neurotrophic Factor; Cognitive | 2021 |
Hippocampal damage and white matter lesions contribute to cognitive impairment in MPTP-lesioned mice with chronic cerebral hypoperfusion.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apoptosis; Brain; Brain Ischemia; Carotid Ste | 2019 |