1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine has been researched along with Brain Injuries in 7 studies
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine : A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In study 1, the authors examined the effect of V-10,367 (50 mg/kg x 2 per day, by mouth) on neurofilament M (NFM) protein levels and on alpha-spectrin breakdown products (SBDPs) when dosed for 2 days, starting 24 hours after TBI and killed on day 3." | 1.31 | Neuroimmunophilin ligand V-10,367 is neuroprotective after 24-hour delayed administration in a mouse model of diffuse traumatic brain injury. ( Detloff, MR; Dutta, S; Hall, ED; Kupina, NC, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amini, M | 1 |
| Ma, CL | 1 |
| Farazifard, R | 1 |
| Zhu, G | 1 |
| Zhang, Y | 1 |
| Vanderluit, J | 1 |
| Zoltewicz, JS | 1 |
| Hage, F | 1 |
| Savitt, JM | 1 |
| Lagace, DC | 1 |
| Slack, RS | 1 |
| Beique, JC | 1 |
| Baudry, M | 1 |
| Greer, PA | 1 |
| Bergeron, R | 1 |
| Park, DS | 1 |
| Neirinckx, V | 1 |
| Marquet, A | 1 |
| Coste, C | 1 |
| Rogister, B | 1 |
| Wislet-Gendebien, S | 1 |
| Visanji, NP | 1 |
| Fox, SH | 1 |
| Johnston, TH | 1 |
| Millan, MJ | 1 |
| Brotchie, JM | 1 |
| Sawada, H | 1 |
| Suzuki, H | 1 |
| Nagatsu, T | 1 |
| Sawada, M | 1 |
| Kupina, NC | 1 |
| Detloff, MR | 1 |
| Dutta, S | 1 |
| Hall, ED | 1 |
| Andersen, F | 1 |
| Watanabe, H | 1 |
| Bjarkam, C | 1 |
| Danielsen, EH | 1 |
| Cumming, P | 1 |
| Sapirstein, A | 1 |
| Bonventre, JV | 1 |
1 review available for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and Brain Injuries
| Article | Year |
|---|---|
Specific physiological roles of cytosolic phospholipase A(2) as defined by gene knockouts.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Airway Resistance; Anaphylaxis; Animals; Brain Injurie | 2000 |
6 other studies available for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and Brain Injuries
| Article | Year |
|---|---|
Conditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazol | 2013 |
Adult bone marrow neural crest stem cells and mesenchymal stem cells are not able to replace lost neurons in acute MPTP-lesioned mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Bone Marrow Cells; Brain Injuries; Cell Death | 2013 |
Alpha1-adrenoceptors mediate dihydroxyphenylalanine-induced activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaques.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenergic alpha-Antagonists; Animals; Benserazide; Br | 2009 |
Neuroprotective and neurotoxic phenotypes of activated microglia in neonatal mice with respective MPTP- and ethanol-induced brain injury.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Animals, Newborn; Brain Injuries; Corpus Stri | 2010 |
Neuroimmunophilin ligand V-10,367 is neuroprotective after 24-hour delayed administration in a mouse model of diffuse traumatic brain injury.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Administration, Oral; Animals; Body Weight; Brain Inju | 2002 |
Pig brain stereotaxic standard space: mapping of cerebral blood flow normative values and effect of MPTP-lesioning.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Brain Injuries; Brain Mapping; Cerebro | 2005 |