1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine has been researched along with Brain Inflammation in 18 studies
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine : A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Chronic administration of vinpocetine (for 14 days) significantly and dose dependently attenuated movement disabilities and oxidative-nitrosative stress in MPTP-treated rats." | 1.42 | Vinpocetine attenuates MPTP-induced motor deficit and biochemical abnormalities in Wistar rats. ( Deshmukh, R; Sharma, S, 2015) |
| "Although the pathogenesis of Parkinson's disease (PD) remains unknown, it appears that microglial activation is associated with enhanced neurodegeneration in animal models of PD as well as in PD patients." | 1.33 | Proteomic analysis of microglial contribution to mouse strain-dependent dopaminergic neurotoxicity. ( Hong, JS; Kovacs, M; Liu, J; Ma, T; McLaughlin, P; Zhang, J; Zhang, W; Zhou, Y, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (44.44) | 29.6817 |
| 2010's | 9 (50.00) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Hammond, SL | 1 |
| Bantle, CM | 1 |
| Popichak, KA | 1 |
| Wright, KA | 1 |
| Thompson, D | 1 |
| Forero, C | 1 |
| Kirkley, KS | 1 |
| Damale, PU | 1 |
| Chong, EKP | 1 |
| Tjalkens, RB | 1 |
| Mani, S | 1 |
| Sekar, S | 1 |
| Barathidasan, R | 1 |
| Manivasagam, T | 2 |
| Thenmozhi, AJ | 1 |
| Sevanan, M | 1 |
| Chidambaram, SB | 1 |
| Essa, MM | 2 |
| Guillemin, GJ | 1 |
| Sakharkar, MK | 1 |
| Gil-Martínez, AL | 1 |
| Cuenca, L | 1 |
| Sánchez, C | 1 |
| Estrada, C | 1 |
| Fernández-Villalba, E | 2 |
| Herrero, MT | 2 |
| Carelli, S | 1 |
| Giallongo, T | 1 |
| Gombalova, Z | 1 |
| Rey, F | 1 |
| Gorio, MCF | 1 |
| Mazza, M | 1 |
| Di Giulio, AM | 1 |
| Sun, Q | 1 |
| Wang, S | 1 |
| Chen, J | 1 |
| Cai, H | 1 |
| Huang, W | 1 |
| Zhang, Y | 1 |
| Wang, L | 1 |
| Xing, Y | 1 |
| Sharma, S | 1 |
| Deshmukh, R | 1 |
| Lecca, D | 1 |
| Nevin, DK | 1 |
| Mulas, G | 1 |
| Casu, MA | 1 |
| Diana, A | 1 |
| Rossi, D | 1 |
| Sacchetti, G | 1 |
| Carta, AR | 1 |
| Boger, HA | 1 |
| Middaugh, LD | 1 |
| Zaman, V | 1 |
| Hoffer, B | 1 |
| Granholm, AC | 1 |
| Wang, WF | 2 |
| Wu, SL | 2 |
| Liou, YM | 2 |
| Wang, AL | 1 |
| Pawlak, CR | 2 |
| Ho, YJ | 2 |
| Sy, HN | 1 |
| Chen, CH | 1 |
| Huang, YT | 1 |
| Chiou, CS | 1 |
| Garrido-Gil, P | 1 |
| Joglar, B | 1 |
| Rodriguez-Perez, AI | 1 |
| Guerra, MJ | 1 |
| Labandeira-Garcia, JL | 1 |
| Anandhan, A | 1 |
| Barcia, C | 1 |
| Sánchez Bahillo, A | 1 |
| Bautista, V | 1 |
| Poza Y Poza, M | 1 |
| Fernández-Barreiro, A | 1 |
| Hirsch, EC | 1 |
| Shen, YQ | 1 |
| Hebert, G | 2 |
| Su, Y | 1 |
| Moze, E | 1 |
| Neveu, PJ | 1 |
| Li, KS | 1 |
| Mingam, R | 1 |
| Arsaut, J | 1 |
| Dantzer, R | 1 |
| Demotes-Mainard, J | 1 |
| McLaughlin, P | 1 |
| Zhou, Y | 1 |
| Ma, T | 1 |
| Liu, J | 1 |
| Zhang, W | 1 |
| Hong, JS | 1 |
| Kovacs, M | 1 |
| Zhang, J | 1 |
| Pattarini, R | 1 |
| Smeyne, RJ | 1 |
| Morgan, JI | 1 |
| Oizumi, H | 1 |
| Hayashita-Kinoh, H | 1 |
| Hayakawa, H | 1 |
| Arai, H | 1 |
| Furuya, T | 1 |
| Ren, YR | 1 |
| Yasuda, T | 1 |
| Seki, T | 1 |
| Mizuno, Y | 1 |
| Mochizuki, H | 1 |
18 other studies available for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and Brain Inflammation
| Article | Year |
|---|---|
NF-κB Signaling in Astrocytes Modulates Brain Inflammation and Neuronal Injury Following Sequential Exposure to Manganese and MPTP During Development and Aging.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Astrocytes; Encephalitis; Manganese; Mice; Mi | 2020 |
Naringenin Decreases α-Synuclein Expression and Neuroinflammation in MPTP-Induced Parkinson's Disease Model in Mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; Anti-Inflammatory Agents; Cy | 2018 |
Effect of NAC treatment and physical activity on neuroinflammation in subchronic Parkinsonism; is physical activity essential?
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acetylcysteine; Analysis of Variance; Animals; Calcium | 2018 |
Counteracting neuroinflammation in experimental Parkinson's disease favors recovery of function: effects of Er-NPCs administration.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Coculture Techniques; Corpus Striatum; Cytoki | 2018 |
MicroRNA-190 alleviates neuronal damage and inhibits neuroinflammation via Nlrp3 in MPTP-induced Parkinson's disease mouse model.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apoptosis; Brain; Cell Line, Tumor; Disease M | 2019 |
Vinpocetine attenuates MPTP-induced motor deficit and biochemical abnormalities in Wistar rats.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Cyclic AMP; Cyclic GMP; Ence | 2015 |
Neuroprotective and anti-inflammatory properties of a novel non-thiazolidinedione PPARγ agonist in vitro and in MPTP-treated mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Animals, Newborn; Cells, Cultured; Cerebral C | 2015 |
Differential effects of the dopamine neurotoxin MPTP in animals with a partial deletion of the GDNF receptor, GFR alpha1, gene.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Cell Count; Cell Survival; Disease Mod | 2008 |
MPTP lesion causes neuroinflammation and deficits in object recognition in Wistar rats.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Avoidance Learning; Bra | 2009 |
MPTP-induced dopaminergic degeneration and deficits in object recognition in rats are accompanied by neuroinflammation in the hippocampus.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Dopamine; Encephalitis; Hip | 2010 |
Involvement of PPAR-γ in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Angiotensin II Type 1 Receptor B | 2012 |
Therapeutic attenuation of neuroinflammation and apoptosis by black tea theaflavin in chronic MPTP/probenecid model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antioxidants; Apoptosis; bcl-2-Associated X P | 2013 |
Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Astrocytes; Biomarkers; Calbindins; Corpus St | 2004 |
In mice, production of plasma IL-1 and IL-6 in response to MPTP is related to behavioral lateralization.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Corpus | 2005 |
Cellular distribution of interleukin-1alpha-immunoreactivity after MPTP intoxication in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Astrocytes; Biomarkers; Corpus Striatum; Dise | 2005 |
Proteomic analysis of microglial contribution to mouse strain-dependent dopaminergic neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cells, Cultured; Coculture Techniques; Dinopr | 2006 |
Temporal mRNA profiles of inflammatory mediators in the murine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Cell Survival; Chemokines; Corpus Stri | 2007 |
Alteration in the differentiation-related molecular expression in the subventricular zone in a mouse model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acute Disease; Animals; Biomarkers; Caspases; Caspases | 2008 |