1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine has been researched along with Amyotrophic Lateral Sclerosis in 8 studies
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine : A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, JD | 1 |
| Woodruff, TM | 1 |
| Chen, X | 1 |
| Wales, P | 1 |
| Quinti, L | 1 |
| Zuo, F | 1 |
| Moniot, S | 1 |
| Herisson, F | 1 |
| Rauf, NA | 1 |
| Wang, H | 1 |
| Silverman, RB | 1 |
| Ayata, C | 1 |
| Maxwell, MM | 1 |
| Steegborn, C | 1 |
| Schwarzschild, MA | 1 |
| Outeiro, TF | 1 |
| Kazantsev, AG | 1 |
| Vila, M | 2 |
| Przedborski, S | 2 |
| Choi, DK | 1 |
| Pennathur, S | 1 |
| Perier, C | 1 |
| Tieu, K | 1 |
| Teismann, P | 1 |
| Wu, DC | 1 |
| Jackson-Lewis, V | 1 |
| Vonsattel, JP | 1 |
| Heinecke, JW | 1 |
| Edwards, RH | 1 |
| Andreassen, OA | 1 |
| Ferrante, RJ | 1 |
| Klivenyi, P | 1 |
| Klein, AM | 1 |
| Dedeoglu, A | 1 |
| Albers, DS | 1 |
| Kowall, NW | 1 |
| Beal, MF | 1 |
| Tanner, CM | 1 |
| Langston, JW | 1 |
| Uhl, GR | 1 |
| Javitch, JA | 1 |
| Snyder, SH | 1 |
3 reviews available for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Targeting programmed cell death in neurodegenerative diseases.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Anim | 2003 |
Neural degeneration and the transport of neurotransmitters.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amyotrophic Lateral Sclerosis; Animals; Biological Tra | 1993 |
Do environmental toxins cause Parkinson's disease? A critical review.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Age Factors; Amyotrophic Lateral Sclerosis; Environmen | 1990 |
5 other studies available for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
TDP-43 Puts the STING in ALS.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amyotrophic Lateral Sclerosis; Bites and Stings; DNA-B | 2021 |
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Amyotrophic Lateral Sclerosis; Animal | 2015 |
Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amyotrophic Lateral Sclerosis; Animals; Brain; Corpus | 2005 |
Transgenic ALS mice show increased vulnerability to the mitochondrial toxins MPTP and 3-nitropropionic acid.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Amyotrophic Lateral Sc | 2001 |
Normal MPTP binding in parkinsonian substantial nigra: evidence for extraneuronal toxin conversion in human brain.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aged; Amyotrophic Lateral Sclerosis; Autoradiography; | 1985 |