1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine has been researched along with Acidosis, Lactic in 1 studies
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine : A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.
Acidosis, Lactic: Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in association with diseases such as DIABETES MELLITUS; LEUKEMIA; or LIVER FAILURE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amiloride was found to protect substantia nigra (SNc) neurons from MPTP-induced degeneration, as determined by attenuated reductions in striatal tyrosine hydroxylase (TH) and dopamine transporter (DAT) immunohistochemistry, as well as smaller declines in striatal DAT radioligand binding and dopamine levels." | 1.35 | Amiloride is neuroprotective in an MPTP model of Parkinson's disease. ( Albinson, K; Arias, RL; Beyer, C; Bowlby, MR; Dunlop, J; Dwyer, JM; Kagan, N; Kubek, K; Lin, Q; Monaghan, M; Sung, ML; Vasylyev, D; Zaleska, MM; Zhang, MY, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arias, RL | 1 |
| Sung, ML | 1 |
| Vasylyev, D | 1 |
| Zhang, MY | 1 |
| Albinson, K | 1 |
| Kubek, K | 1 |
| Kagan, N | 1 |
| Beyer, C | 1 |
| Lin, Q | 1 |
| Dwyer, JM | 1 |
| Zaleska, MM | 1 |
| Bowlby, MR | 1 |
| Dunlop, J | 1 |
| Monaghan, M | 1 |
1 other study available for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and Acidosis, Lactic
| Article | Year |
|---|---|
Amiloride is neuroprotective in an MPTP model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acid Sensing Ion Channels; Acidosis, Lactic; Amiloride | 2008 |