1-methyl-3-isobutylxanthine has been researched along with Sepsis in 4 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sepsis was induced by cecal ligation and puncture and resulted in lactate acidosis, hypotension, and reduction in MBF (-30%; P < 0." | 1.34 | Cyclic adenosine monophosphate-phosphodiesterase inhibitors reduce skeletal muscle protein catabolism in septic rats. ( Baviera, AM; Goncalves, DA; Graca, FA; Kettelhut, IC; Lira, EC; Lönnroth, P; Migliorini, RH; Navegantes, LC; Strindberg, L; Zanon, NM, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Neviere, R | 1 |
| Delguste, F | 1 |
| Durand, A | 1 |
| Inamo, J | 1 |
| Boulanger, E | 1 |
| Preau, S | 1 |
| Lira, EC | 1 |
| Graca, FA | 1 |
| Goncalves, DA | 1 |
| Zanon, NM | 1 |
| Baviera, AM | 1 |
| Strindberg, L | 1 |
| Lönnroth, P | 1 |
| Migliorini, RH | 1 |
| Kettelhut, IC | 1 |
| Navegantes, LC | 1 |
| Abi-Gerges, N | 1 |
| Tavernier, B | 1 |
| Mebazaa, A | 1 |
| Faivre, V | 1 |
| Paqueron, X | 1 |
| Payen, D | 1 |
| Fischmeister, R | 1 |
| Méry, PF | 1 |
| Barker, LA | 1 |
| Winbery, SL | 1 |
| Smith, LW | 1 |
| McDonough, KH | 1 |
4 other studies available for 1-methyl-3-isobutylxanthine and Sepsis
| Article | Year |
|---|---|
Abnormal Mitochondrial cAMP/PKA Signaling Is Involved in Sepsis-Induced Mitochondrial and Myocardial Dysfunction.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Western; Cell Respiration; Cyclic AMP; Cyclic AMP-De | 2016 |
Cyclic adenosine monophosphate-phosphodiesterase inhibitors reduce skeletal muscle protein catabolism in septic rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carotid Arteries; Cyclic AMP; Male; Muscle, Skeletal; Muscles; | 2007 |
Sequential changes in autonomic regulation of cardiac myocytes after in vivo endotoxin injection in rat.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifl | 1999 |
Supersensitivity and changes in the active population of beta adrenoceptors in rat right atria in early sepsis.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Atrial Function; Colforsin; Dose-Res | 1990 |