1-methyl-3-isobutylxanthine has been researched along with Retinal Degeneration in 4 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Retinal Degeneration: A retrogressive pathological change in the retina, focal or generalized, caused by genetic defects, inflammation, trauma, vascular disease, or aging. Degeneration affecting predominantly the macula lutea of the retina is MACULAR DEGENERATION. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p304)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tsang, SH | 1 |
| Woodruff, ML | 1 |
| Lin, CS | 1 |
| Jacobson, BD | 1 |
| Naumann, MC | 1 |
| Hsu, CW | 1 |
| Davis, RJ | 1 |
| Cilluffo, MC | 1 |
| Chen, J | 1 |
| Fain, GL | 1 |
| Sharma, AK | 1 |
| Rohrer, B | 1 |
| Sandberg, MA | 1 |
| Miller, S | 1 |
| Berson, EL | 1 |
| Williams, DS | 1 |
| Colley, NJ | 1 |
| Farber, DB | 1 |
4 other studies available for 1-methyl-3-isobutylxanthine and Retinal Degeneration
| Article | Year |
|---|---|
Effect of the ILE86TER mutation in the γ subunit of cGMP phosphodiesterase (PDE6) on rod photoreceptor signaling.
Topics: 1-Methyl-3-isobutylxanthine; Algorithms; Animals; Cyclic Nucleotide Phosphodiesterases, Type 6; Eye | 2012 |
Sustained elevation of intracellular cGMP causes oxidative stress triggering calpain-mediated apoptosis in photoreceptor degeneration.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Apoptosis; Calcium; Calpain; Caspase 3; Catalase; Cell Line; C | 2007 |
Rod electroretinograms in an elevated cyclic guanosine monophosphate-type human retinal degeneration. Comparison with retinitis pigmentosa.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Animals; Cats; Child; Cyclic GMP; Electroretinograph | 1990 |
Photoreceptor degeneration in a pure-cone retina. Effects of cyclic nucleotides, and inhibitors of phosphodiesterase and protein synthesis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Dibutyryl Cyclic GMP; Lizards; Nerve Degeneration | 1987 |