Compounds > 1-methyl-3-isobutylxanthine
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1-methyl-3-isobutylxanthine and Pituitary Neoplasms

1-methyl-3-isobutylxanthine has been researched along with Pituitary Neoplasms in 31 studies

1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.

Pituitary Neoplasms: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.

Research Excerpts

ExcerptRelevanceReference
"The rat insulinoma RIN 5F and the mouse pituitary AtT-20 cell line, which are known to express several biologically active peptides, were found to express CCK mRNA, to correctly process, and to release immunoreactive cholecystokinin (CCK) peptides."3.68CCK mRNA expression, pro-CCK processing, and regulated secretion of immunoreactive CCK peptides by rat insulinoma (RIN 5F) and mouse pituitary tumor (AtT-20) cells in culture. ( Beinfeld, MC, 1992)
" Moreover, PDBu, which causes attenuation of the maximal response to vasoactive intestinal polypeptide (VIP), also induced a small right shift in the dose-response curve for VIP-induced cyclic AMP accumulation."1.28Regulation of GH3 pituitary tumour-cell adenylate cyclase activity by activators of protein kinase C. ( Brown, BL; Dobson, PR; Quilliam, LA, 1989)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199014 (45.16)18.7374
1990's16 (51.61)18.2507
2000's1 (3.23)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gershengorn, MC2
Rebecchi, MJ1
Geras, E1
Arevalo, CO1
Guild, S1
Drummond, AH1
Cronin, MJ1
Myers, GA1
MacLeod, RM1
Hewlett, EL1
Heisler, S1
Veilleux, R1
Labrie, F1
Wojcikiewicz, RJ1
Dobson, PR3
Brown, BL3
Antoni, FA1
Barnard, RJ1
Shipston, MJ1
Smith, SM1
Simpson, J1
Paterson, JM1
Irminger, JC1
Vollenweider, FM1
Neerman-Arbez, M1
Halban, PA1
Gilkes, AF2
Guild, SB2
Cramb, G2
Maia, AL1
Harney, JW2
Larsen, PR2
Abou-Samra, AB1
Jüppner, H1
Khalifa, A1
Karga, H1
Kong, XF1
Schiffer-Alberts, D1
Xie, LY1
Segre, GV1
Wang, X1
Chik, CL1
Ho, AK1
Sato, N1
Greer, MA1
Hinkle, PM1
Nelson, EJ1
Haymes, AA1
McArdle, CA1
Lania, A2
Persani, L2
Ballaré, E1
Mantovani, S1
Losa, M1
Spada, A2
Kim, SW1
Borgato, S1
Filopanti, M1
Mantovani, G1
Conti, M1
Gourdji, D1
Bataille, D1
Vauclin, N1
Grouselle, D1
Rosselin, G1
Tixier-Vidal, A1
MacKay, KB1
Mollard, P1
Zhang, Y1
Rodman, D1
Cooper, DM1
Beinfeld, MC1
Piroli, G1
Weisenberg, LS1
Grillo, C1
De Nicola, AF1
Jefferson, AB1
Schulman, H1
Ivins, KJ1
Luedtke, RR1
Artymyshyn, RP1
Molinoff, PB1
Quilliam, LA2
Litvin, Y1
Leiser, M1
Fleischer, N2
Erlichman, J1
Pasmantier, R1
Danoff, A1
Schubart, UK1
Sletholt, K1
Haug, E1
Gautvik, KM1
Mormède, P1
Baird, A1
Ishibashi, M1
Yamaji, T1

Reviews

1 review available for 1-methyl-3-isobutylxanthine and Pituitary Neoplasms

ArticleYear
Thyrotropin releasing hormone. A review of the mechanisms of acute stimulation of pituitary hormone release.
    Molecular and cellular biochemistry, 1982, Jun-25, Volume: 45, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cells, Cultured; Chlortetracycline; Cyclic AMP; Guany

1982

Other Studies

30 other studies available for 1-methyl-3-isobutylxanthine and Pituitary Neoplasms

ArticleYear
Thyrotropin-releasing hormone (TRH) action in mouse thyrotropic tumor cells in culture: evidence against a role for adenosine 3',5'-monophosphate as a mediator of TRH-stimulated thyrotropin release.
    Endocrinology, 1980, Volume: 107, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Bucladesine; Cell Line; Cholera Toxin; Cycl

1980
Adenosine 3',5'-cyclic monophosphate-dependent release of prolactin from GH3 pituitary tumour cells. A quantitative analysis.
    The Biochemical journal, 1983, Dec-15, Volume: 216, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Diterpe

1983
Pertussis toxin actions on the pituitary-derived 235-1 clone: effects of PGE1, cholera toxin, and forskolin on cyclic AMP metabolism and prolactin release.
    Journal of cyclic nucleotide and protein phosphorylation research, 1983, Volume: 9, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Bacterial Toxins; Cells, Cultured; Cholera Toxin;

1983
PHI stimulates ACTH release from pituitary tumor cell.
    Molecular and cellular endocrinology, 1984, Volume: 35, Issue:2-3

    Topics: 1-Methyl-3-isobutylxanthine; Adrenocorticotropic Hormone; Animals; Calcium; Cell Line; Corticotropin

1984
Muscarinic acetylcholine receptor activation causes inhibition of cyclic AMP accumulation, prolactin and growth hormone secretion in GH3 rat anterior pituitary tumour cells.
    Biochimica et biophysica acta, 1984, Sep-14, Volume: 805, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Carbachol; Cell Line; Cyclic AMP; Growth Hormon

1984
Calcineurin feedback inhibition of agonist-evoked cAMP formation.
    The Journal of biological chemistry, 1995, Nov-24, Volume: 270, Issue:47

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenergic beta-Agonists; Amino Acid Sequence; Anima

1995
Human proinsulin conversion in the regulated and the constitutive pathways of transfected AtT20 cells.
    The Journal of biological chemistry, 1994, Jan-21, Volume: 269, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Chromatography, High Pressure Liquid; Clone Cells;

1994
Phorbol ester activation of protein kinase C inhibits CNP-stimulated cyclic GMP production in the mouse AtT-20 pituitary tumour cell line.
    Biochemical and biophysical research communications, 1994, Nov-15, Volume: 204, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Cell Line; Colforsin; Cyclic GMP; D

1994
Pituitary cells respond to thyroid hormone by discrete, gene-specific pathways.
    Endocrinology, 1995, Volume: 136, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cyclic AMP; Cyclohexim

1995
Parathyroid hormone (PTH) stimulates adrenocorticotropin release in AtT-20 cells stably expressing a common receptor for PTH and PTH-related peptide.
    Endocrinology, 1993, Volume: 132, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adrenocorticotropic Hormone; Animals; Cell Line; Corticotropin-Releasin

1993
Cyclic adenosine monophosphate is not part of the transduction chain by which cell-swelling induces secretion in either normal or tumor-derived GH4C1 pituitary cells.
    Metabolism: clinical and experimental, 1993, Volume: 42, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cell Size; Colforsin; Cyclic AMP; Hypotonic Solutions

1993
Regulation of L-type voltage-gated calcium channels by epidermal growth factor.
    Endocrinology, 1993, Volume: 133, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifl

1993
Functional interaction between gonadotropin-releasing hormone and PACAP in gonadotropes and alpha T3-1 cells.
    Annals of the New York Academy of Sciences, 1996, Dec-26, Volume: 805

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Cell Line; Cyclic AMP; Follicle Stimulating

1996
Constitutively active Gs alpha is associated with an increased phosphodiesterase activity in human growth hormone-secreting adenomas.
    The Journal of clinical endocrinology and metabolism, 1998, Volume: 83, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; Adenoma; Adult; Aged; Enzyme Inhibitors; Female; Glycoproteins; GTP-Bin

1998
Studies of the hormonal regulation of type 2 5'-iodothyronine deiodinase messenger ribonucleic acid in pituitary tumor cells using semiquantitative reverse transcription-polymerase chain reaction.
    Endocrinology, 1998, Volume: 139, Issue:12

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blotting, Northern; De

1998
Relevant cAMP-specific phosphodiesterase isoforms in human pituitary: effect of Gs(alpha) mutations.
    The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:8

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenoma; Cyclic AMP Response Eleme

2001
Vasoactive intestinal peptide (VIP) stimulates prolactin (PRL) release and cAMP production in a rat pituitary cell line (GH3/B6). Additive effects of VIP and TRH on PRL release.
    FEBS letters, 1979, Aug-01, Volume: 104, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cyclic AMP; Dose-Response Relationship, Drug; Gastr

1979
Atrial natriuretic peptide effects in AtT-20 pituitary tumour cells.
    Molecular and cellular endocrinology, 1992, Volume: 89, Issue:1-2

    Topics: 1-Methyl-3-isobutylxanthine; Adrenocorticotropic Hormone; Animals; Atrial Natriuretic Factor; Calciu

1992
Limited accumulation of cyclic AMP underlies a modest vasoactive-intestinal-peptide-mediated increase in cytosolic [Ca2+] transients in GH3 pituitary cells.
    The Biochemical journal, 1992, Jun-15, Volume: 284 ( Pt 3)

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Calcium; Cell Line; Colforsin; Cyclic

1992
CCK mRNA expression, pro-CCK processing, and regulated secretion of immunoreactive CCK peptides by rat insulinoma (RIN 5F) and mouse pituitary tumor (AtT-20) cells in culture.
    Neuropeptides, 1992, Volume: 22, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Cholecystokinin; Chromatography, High Pres

1992
Subcellular distribution of cyclic adenosine 3',5'-monophosphate-binding protein and estrogen receptors in control pituitaries and estrogen-induced pituitary tumors.
    Journal of the National Cancer Institute, 1990, Apr-04, Volume: 82, Issue:7

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Carrier Proteins; Cell Nucleus; Chromatography, DEAE-Cellulose

1990
Phosphorylation of microtubule-associated protein-2 in GH3 cells. Regulation by cAMP and by calcium.
    The Journal of biological chemistry, 1991, Jan-05, Volume: 266, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Cell Line; Cholera Toxin; Colforsin; Cyc

1991
Regulation of dopamine D2 receptors in a novel cell line (SUP1).
    Molecular pharmacology, 1991, Volume: 39, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Dopamine; Dopamine Agents; Female; Iodine Radioiso

1991
Modulation of cyclic AMP accumulation in GH3 cells by a phorbol ester and thyroliberin.
    Biochemical and biophysical research communications, 1985, Jun-28, Volume: 129, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Animals; Bacteri

1985
Somatostatin inhibits corticotropin-releasing factor-stimulated adrenocorticotropin release, adenylate cyclase, and activation of adenosine 3',5'-monophosphate-dependent protein kinase isoenzymes in AtT20 cells.
    Endocrinology, 1986, Volume: 119, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenocorticotropic Hormone; Animals; Cell Line; Col

1986
P19, a hormonally regulated phosphoprotein of peptide hormone-producing cells: secretagogue-induced phosphorylation in AtT-20 mouse pituitary tumor cells and in rat and hamster insulinoma cells.
    Endocrinology, 1986, Volume: 119, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenoma, Islet Cell; Adrenocort

1986
On the involvement of cyclic AMP and extracellular Ca2+ in the regulation of hormone release from rat pituitary tumour (GH3) cells in culture.
    Bioscience reports, 1987, Volume: 7, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcimycin; Calcium; Cell Line; Cobalt; Cyclic AM

1987
Estrogens, cyclic adenosine 3',5'-monophosphate, and phorbol esters modulate the prolactin response of GH3 cells to basic fibroblast growth factor.
    Endocrinology, 1988, Volume: 122, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cyclic AMP; Drug Interactions; Estradiol; Fibroblas

1988
Regulation of GH3 pituitary tumour-cell adenylate cyclase activity by activators of protein kinase C.
    The Biochemical journal, 1989, Sep-15, Volume: 262, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Bombesin; Cholera Toxin; Colforsin; Cyclic AMP; Dose

1989
Mechanism of the inhibitory action of dopamine and somatostatin on prolactin secretion from human lactotrophs in culture.
    The Journal of clinical endocrinology and metabolism, 1985, Volume: 60, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Adenoma; Adolescent; Adult; Calcimycin; Calcium; Cells, Cultured; Cycli

1985