1-methyl-3-isobutylxanthine has been researched along with Osteosarcoma in 20 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Osteosarcoma: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We studied the binding and degradation of 125I-labeled epidermal growth factor (EGF) by UMR-106 osteosarcoma cells and the regulation of EGF receptor affinity for EGF by the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and by treatments that raise intracellular levels of cyclic AMP." | 3.67 | Regulation of osteosarcoma EGF receptor affinity by phorbol ester and cyclic AMP. ( Borst, SE; Catherwood, BD, 1989) |
| " Pretreatment of ROS cells for 2 days with the glucocorticoid triamcinolone acetonide (TRM), shifted the dose-response curve for PKA activation by PTH upward compared to the control value." | 1.27 | Glucocorticoids and 1,25-dihydroxyvitamin D3 regulate parathyroid hormone stimulation of adenosine 3',5'-monophosphate-dependent protein kinase in rat osteosarcoma cells. ( Catherwood, BD; Lorang, MT; Rubin, JE; Titus, L, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (50.00) | 18.7374 |
| 1990's | 8 (40.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, X | 1 |
| Dai, JC | 1 |
| Greenfield, EM | 1 |
| Findlay, DM | 1 |
| Houssami, S | 1 |
| Christopoulos, G | 1 |
| Sexton, PM | 1 |
| Yu, XP | 1 |
| Chandrasekhar, S | 1 |
| Belinsky, GS | 1 |
| Tashjian, AH | 1 |
| Frick, KK | 1 |
| Scher, CD | 1 |
| Green, J | 1 |
| Kleeman, CR | 1 |
| Schotland, S | 1 |
| Chaimovitz, C | 1 |
| Whisenant, N | 1 |
| Zhang, BX | 2 |
| Khademazad, M | 2 |
| Loessberg, P | 2 |
| Muallem, S | 2 |
| Abou-Samra, AB | 2 |
| Zajac, JD | 1 |
| Schiffer-Alberts, D | 1 |
| Skurat, R | 1 |
| Kearns, A | 1 |
| Segre, GV | 2 |
| Bringhurst, FR | 1 |
| Mohan, S | 1 |
| Baylink, DJ | 1 |
| Pines, M | 1 |
| Santora, A | 1 |
| Spiegel, A | 1 |
| Titus, L | 1 |
| Rubin, JE | 1 |
| Lorang, MT | 1 |
| Catherwood, BD | 3 |
| Rodan, SB | 1 |
| Wesolowski, G | 1 |
| Rodan, GA | 3 |
| Gutierrez, GE | 1 |
| Mundy, GR | 1 |
| Katz, MS | 1 |
| Noda, M | 2 |
| Yoon, K | 1 |
| Theofan, G | 1 |
| Price, PA | 1 |
| Borst, SE | 1 |
| Jueppner, H | 1 |
| Potts, JT | 1 |
20 other studies available for 1-methyl-3-isobutylxanthine and Osteosarcoma
| Article | Year |
|---|---|
Termination of immediate-early gene expression after stimulation by parathyroid hormone or isoproterenol.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; beta-Adrenergic Receptor Kinases; Colforsin; Cyclic | 2002 |
Homologous regulation of the rat C1a calcitonin receptor (CTR) in nonosteoclastic cells is independent of CTR messenger ribonucleic acid changes and cyclic adenosine 3',5'-monophosphate-dependent protein kinase activation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Cal | 1996 |
Parathyroid hormone (PTH 1-34) regulation of rat osteocalcin gene transcription.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Bone Neoplasms; Cyclic AMP; Dose-Response Relat | 1997 |
Direct measurement of hormone-induced acidification in intact bone.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Animals, Newborn; Bone and Bones; Bone Neop | 2000 |
Platelet-derived growth factor-stimulated c-myc RNA accumulation in MG-63 human osteosarcoma cells is independent of both protein kinase A and protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; Calcium; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug | 1990 |
Acute phosphate depletion dissociates hormonal stimulated second messengers in osteoblast-like cells.
Topics: 1-Methyl-3-isobutylxanthine; Calcium; Cyclic AMP; Dinoprostone; Endothelins; Osteoblasts; Osteosarco | 1991 |
Regulation of Na-K-2Cl cotransport in osteoblasts.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carrier Proteins; Cell Line; Chlorides; Colforsin; Cyclic AMP; | 1991 |
Regulation of cell volume by the osteosarcoma cell line UMR-106-01.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Animals; Calcium; Cell Line; Cell Membrane Permeability; Cyt | 1991 |
Cyclic adenosine 3',5'-monophosphate (cAMP)-dependent and cAMP-independent regulation of parathyroid hormone receptors on UMR 106-01 osteoblastic osteosarcoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Chlorides; Cyclic AMP; | 1991 |
Evidence that the inhibition of TE85 human bone cell proliferation by agents which stimulate cAMP production may in part be mediated by changes in the IGF-II regulatory system.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Bone and Bones; Bucladesine; Carrier Proteins; Cel | 1991 |
Effects of phorbol esters and pertussis toxin on agonist-stimulated cyclic AMP production in rat osteosarcoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cyclic AMP; Drug Synergism; Interphase; Osteosarcom | 1986 |
Glucocorticoids and 1,25-dihydroxyvitamin D3 regulate parathyroid hormone stimulation of adenosine 3',5'-monophosphate-dependent protein kinase in rat osteosarcoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcitriol; Cell Line; Cyclic AMP; Cytosol; Enzyme Activation; | 1988 |
Clonal differences in prostaglandin synthesis among osteosarcoma cell lines.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Chromatograph | 1986 |
Alterations in hormone-sensitive adenylate cyclase of cloned rat osteosarcoma cells during long-term culture.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Bone Neoplasms; Calcitonin; Dinoprostone; F | 1986 |
Cyclic AMP-mediated stabilization of osteocalcin mRNA in rat osteoblast-like cells treated with parathyroid hormone.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium-Binding Protei | 1988 |
Bone Gla protein messenger ribonucleic acid is regulated by both 1,25-dihydroxyvitamin D3 and 3',5'-cyclic adenosine monophosphate in rat osteosarcoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcitriol; Calcium-Binding Proteins; Cell Count; | 1989 |
Transcriptional regulation of osteopontin production in rat osteoblast-like cells by parathyroid hormone.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blotting, Western; Cal | 1989 |
Regulation of osteosarcoma EGF receptor affinity by phorbol ester and cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Colforsin; Cyclic AMP; Epidermal Growth Factor; ErbB Receptors; Humans; | 1989 |
Inactivation of pertussis toxin-sensitive guanyl nucleotide-binding proteins increase parathyroid hormone receptors and reverse agonist-induced receptor down-regulation in ROS 17/2.8 cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylate Cyclase Toxin; Animal | 1989 |
1,25-Dihydroxycholecalciferol and glucocorticosteroid regulation of adenylate cyclase in an osteoblast-like cell line.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Calcitriol; Cell Line; Cholera Toxin; Colfo | 1985 |