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1-methyl-3-isobutylxanthine and Osteosarcoma

1-methyl-3-isobutylxanthine has been researched along with Osteosarcoma in 20 studies

1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.

Osteosarcoma: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)

Research Excerpts

ExcerptRelevanceReference
"We studied the binding and degradation of 125I-labeled epidermal growth factor (EGF) by UMR-106 osteosarcoma cells and the regulation of EGF receptor affinity for EGF by the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and by treatments that raise intracellular levels of cyclic AMP."3.67Regulation of osteosarcoma EGF receptor affinity by phorbol ester and cyclic AMP. ( Borst, SE; Catherwood, BD, 1989)
" Pretreatment of ROS cells for 2 days with the glucocorticoid triamcinolone acetonide (TRM), shifted the dose-response curve for PKA activation by PTH upward compared to the control value."1.27Glucocorticoids and 1,25-dihydroxyvitamin D3 regulate parathyroid hormone stimulation of adenosine 3',5'-monophosphate-dependent protein kinase in rat osteosarcoma cells. ( Catherwood, BD; Lorang, MT; Rubin, JE; Titus, L, 1988)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-199010 (50.00)18.7374
1990's8 (40.00)18.2507
2000's2 (10.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chen, X1
Dai, JC1
Greenfield, EM1
Findlay, DM1
Houssami, S1
Christopoulos, G1
Sexton, PM1
Yu, XP1
Chandrasekhar, S1
Belinsky, GS1
Tashjian, AH1
Frick, KK1
Scher, CD1
Green, J1
Kleeman, CR1
Schotland, S1
Chaimovitz, C1
Whisenant, N1
Zhang, BX2
Khademazad, M2
Loessberg, P2
Muallem, S2
Abou-Samra, AB2
Zajac, JD1
Schiffer-Alberts, D1
Skurat, R1
Kearns, A1
Segre, GV2
Bringhurst, FR1
Mohan, S1
Baylink, DJ1
Pines, M1
Santora, A1
Spiegel, A1
Titus, L1
Rubin, JE1
Lorang, MT1
Catherwood, BD3
Rodan, SB1
Wesolowski, G1
Rodan, GA3
Gutierrez, GE1
Mundy, GR1
Katz, MS1
Noda, M2
Yoon, K1
Theofan, G1
Price, PA1
Borst, SE1
Jueppner, H1
Potts, JT1

Other Studies

20 other studies available for 1-methyl-3-isobutylxanthine and Osteosarcoma

ArticleYear
Termination of immediate-early gene expression after stimulation by parathyroid hormone or isoproterenol.
    American journal of physiology. Cell physiology, 2002, Volume: 283, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; beta-Adrenergic Receptor Kinases; Colforsin; Cyclic

2002
Homologous regulation of the rat C1a calcitonin receptor (CTR) in nonosteoclastic cells is independent of CTR messenger ribonucleic acid changes and cyclic adenosine 3',5'-monophosphate-dependent protein kinase activation.
    Endocrinology, 1996, Volume: 137, Issue:11

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Cal

1996
Parathyroid hormone (PTH 1-34) regulation of rat osteocalcin gene transcription.
    Endocrinology, 1997, Volume: 138, Issue:8

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Bone Neoplasms; Cyclic AMP; Dose-Response Relat

1997
Direct measurement of hormone-induced acidification in intact bone.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2000, Volume: 15, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Animals, Newborn; Bone and Bones; Bone Neop

2000
Platelet-derived growth factor-stimulated c-myc RNA accumulation in MG-63 human osteosarcoma cells is independent of both protein kinase A and protein kinase C.
    Molecular and cellular biology, 1990, Volume: 10, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Calcium; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug

1990
Acute phosphate depletion dissociates hormonal stimulated second messengers in osteoblast-like cells.
    Endocrinology, 1991, Volume: 129, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Calcium; Cyclic AMP; Dinoprostone; Endothelins; Osteoblasts; Osteosarco

1991
Regulation of Na-K-2Cl cotransport in osteoblasts.
    The American journal of physiology, 1991, Volume: 261, Issue:3 Pt 1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Carrier Proteins; Cell Line; Chlorides; Colforsin; Cyclic AMP;

1991
Regulation of cell volume by the osteosarcoma cell line UMR-106-01.
    The American journal of physiology, 1991, Volume: 261, Issue:3 Pt 1

    Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Animals; Calcium; Cell Line; Cell Membrane Permeability; Cyt

1991
Cyclic adenosine 3',5'-monophosphate (cAMP)-dependent and cAMP-independent regulation of parathyroid hormone receptors on UMR 106-01 osteoblastic osteosarcoma cells.
    Endocrinology, 1991, Volume: 129, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Chlorides; Cyclic AMP;

1991
Evidence that the inhibition of TE85 human bone cell proliferation by agents which stimulate cAMP production may in part be mediated by changes in the IGF-II regulatory system.
    Growth regulation, 1991, Volume: 1, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Bone and Bones; Bucladesine; Carrier Proteins; Cel

1991
Effects of phorbol esters and pertussis toxin on agonist-stimulated cyclic AMP production in rat osteosarcoma cells.
    Biochemical pharmacology, 1986, Oct-15, Volume: 35, Issue:20

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cyclic AMP; Drug Synergism; Interphase; Osteosarcom

1986
Glucocorticoids and 1,25-dihydroxyvitamin D3 regulate parathyroid hormone stimulation of adenosine 3',5'-monophosphate-dependent protein kinase in rat osteosarcoma cells.
    Endocrinology, 1988, Volume: 123, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcitriol; Cell Line; Cyclic AMP; Cytosol; Enzyme Activation;

1988
Clonal differences in prostaglandin synthesis among osteosarcoma cell lines.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1986, Volume: 1, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Chromatograph

1986
Alterations in hormone-sensitive adenylate cyclase of cloned rat osteosarcoma cells during long-term culture.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1986, Volume: 1, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Bone Neoplasms; Calcitonin; Dinoprostone; F

1986
Cyclic AMP-mediated stabilization of osteocalcin mRNA in rat osteoblast-like cells treated with parathyroid hormone.
    The Journal of biological chemistry, 1988, Dec-05, Volume: 263, Issue:34

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium-Binding Protei

1988
Bone Gla protein messenger ribonucleic acid is regulated by both 1,25-dihydroxyvitamin D3 and 3',5'-cyclic adenosine monophosphate in rat osteosarcoma cells.
    Molecular endocrinology (Baltimore, Md.), 1989, Volume: 3, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcitriol; Calcium-Binding Proteins; Cell Count;

1989
Transcriptional regulation of osteopontin production in rat osteoblast-like cells by parathyroid hormone.
    The Journal of cell biology, 1989, Volume: 108, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blotting, Western; Cal

1989
Regulation of osteosarcoma EGF receptor affinity by phorbol ester and cyclic AMP.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1989, Volume: 4, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Colforsin; Cyclic AMP; Epidermal Growth Factor; ErbB Receptors; Humans;

1989
Inactivation of pertussis toxin-sensitive guanyl nucleotide-binding proteins increase parathyroid hormone receptors and reverse agonist-induced receptor down-regulation in ROS 17/2.8 cells.
    Endocrinology, 1989, Volume: 125, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylate Cyclase Toxin; Animal

1989
1,25-Dihydroxycholecalciferol and glucocorticosteroid regulation of adenylate cyclase in an osteoblast-like cell line.
    The Journal of biological chemistry, 1985, Jan-25, Volume: 260, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Calcitriol; Cell Line; Cholera Toxin; Colfo

1985