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1-methyl-3-isobutylxanthine and Neuroblastoma

1-methyl-3-isobutylxanthine has been researched along with Neuroblastoma in 43 studies

1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.

Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Research Excerpts

ExcerptRelevanceReference
"To clarify the functional significance of type IV phosphodiesterase (PDEIV) in neurons and glia cells [3H]rolipram binding and phosphodiesterase (PDE) activity were examined in cytosol and membrane fractions of neuroblastoma N18TG-2 and glioma C6Bu-1 cells."7.69[3H]Rolipram binding and phosphodiesterase activity in neuroblastoma N18TG-2 and glioma C6Bu-1. ( Hasegawa, H; Murayama, T; Nogiri, S; Nomura, Y; Tohda, M, 1994)
"Cell hybrids (BIM) were produced between human neuroblastoma cells (IMR-32) and thymidine auxotrophs (B3T) of rat nerve-like cells (B103) in order to obtain cell lines undergoing stable neuronal differentiation."7.68Spontaneous and cAMP-dependent induction of a resting phase and neurite formation in cell hybrids between human neuroblastoma cells and thymidine auxotrophs of rat nerve-like cells. ( Adachi, Y; Furuyama, J; Hatanaka, M; Ishii, K; Sakamoto, H, 1990)
"Regulation of cholecystokinin (CCK) and the proto-oncogene c-fos mRNA expression was studied in the human neuroblastoma cell line SK-N-MC."7.68Phorbol 12-myristate-13-acetate (PMA) stimulates a differential expression of cholecystokinin (CCK) and c-fos mRNA in a human neuroblastoma cell line. ( Folkesson, R; Monstein, HJ, 1991)
"Treatment with reserpine, which increases conversion of peptide B to the heptapeptide in bovine chromaffin cells in culture does not stimulate the accumulation of Met-enkephalyl-Arg6-Phe7 in the human neuroblastoma cells."5.27Met-enkephalyl-Arg6-Phe7 immunoreactivity in a human neuroblastoma cell line: effect of dibutyryl 3':5'-cyclic AMP and reserpine. ( Adams, M; Boarder, MR; Marriott, D, 1986)
"The prostacyclin mimetic cicaprost increased phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) in Chinese hamster ovary cells transiently expressing human (hIP-CHO) or mouse prostacyclin (mIP-CHO) receptors, but not in human neuroblastoma SK-N-SH cells or rat/mouse neuroblastoma-glioma NG108-15 cells which endogenously express IP receptors."3.72Prostacyclin receptor-mediated activation of extracellular signal-regulated kinases 1 and 2. ( Chow, KB; Chu, KM; Wise, H; Wong, YH, 2004)
"Acute incubation of NMDA with neuroblastoma x glioma hybrid (NG108-15) cells or neuroblastoma SK-N-SH cells produced significant attenuation of nociceptin/orphanin FQ (N/OFQ)-induced activation of G protein and inhibition of adenylyl cyclase."3.70Attenuation of nociceptin/orphanin FQ-induced signaling by N-methyl-D-aspartate in neuronal cells. ( Ma, L; Pei, G; Xin, SM; Zhang, Y; Zhao, J, 1998)
" We provide evidence in support of the existence of mu* in human neuroblastoma cells, SH-SY5Y, and mu* upregulation during morphine treatment."3.69Constitutive mu opioid receptor activation as a regulatory mechanism underlying narcotic tolerance and dependence. ( Bilsky, EJ; Porreca, F; Sadée, W; Wang, Z, 1994)
"To clarify the functional significance of type IV phosphodiesterase (PDEIV) in neurons and glia cells [3H]rolipram binding and phosphodiesterase (PDE) activity were examined in cytosol and membrane fractions of neuroblastoma N18TG-2 and glioma C6Bu-1 cells."3.69[3H]Rolipram binding and phosphodiesterase activity in neuroblastoma N18TG-2 and glioma C6Bu-1. ( Hasegawa, H; Murayama, T; Nogiri, S; Nomura, Y; Tohda, M, 1994)
"Pharmacological characteristics of native neuronal nicotinic acetylcholine receptor-mediated ion currents in mouse N1E-115 neuroblastoma cells have been investigated by superfusion of voltage clamped cells with known concentrations of the agonists acetylcholine, nicotine and cytisine, and the antagonists alpha-bungarotoxin and neuronal bungarotoxin."3.69alpha 4 beta 2 subunit combination specific pharmacology of neuronal nicotinic acetylcholine receptors in N1E-115 neuroblastoma cells. ( Abraham, D; Oortgiesen, M; Vijverberg, HP; Zwart, R, 1994)
"Cell hybrids (BIM) were produced between human neuroblastoma cells (IMR-32) and thymidine auxotrophs (B3T) of rat nerve-like cells (B103) in order to obtain cell lines undergoing stable neuronal differentiation."3.68Spontaneous and cAMP-dependent induction of a resting phase and neurite formation in cell hybrids between human neuroblastoma cells and thymidine auxotrophs of rat nerve-like cells. ( Adachi, Y; Furuyama, J; Hatanaka, M; Ishii, K; Sakamoto, H, 1990)
"Regulation of cholecystokinin (CCK) and the proto-oncogene c-fos mRNA expression was studied in the human neuroblastoma cell line SK-N-MC."3.68Phorbol 12-myristate-13-acetate (PMA) stimulates a differential expression of cholecystokinin (CCK) and c-fos mRNA in a human neuroblastoma cell line. ( Folkesson, R; Monstein, HJ, 1991)
"Chronic pertussis toxin treatment (5 days) of NG108-15 neuroblastoma X glioma hybrid cells had no significant effect on basal cyclic AMP levels whereas it effectively blocked the inhibitory action of acute (10 min) exposure of carbachol (10(-4)M) on intracellular cyclic AMP accumulation, stimulated by prostaglandin E1."3.67Chronic exposure to pertussis toxin alters muscarinic receptor-mediated regulation of cyclic AMP metabolism in neuroblastoma x glioma NG108-15 hybrid cells. ( Askelöf, P; Bartfai, T; Gillenius, P; Westlind-Danielsson, A, 1988)
" Upon pretreatment with morphine over greater than or equal to 12 h, a fourfold shift of the PGE1-morphine dose-response curve was observed, whether or not IBMX was added."1.28Regulation of cyclic AMP by the mu-opioid receptor in human neuroblastoma SH-SY5Y cells. ( Duan, DS; Eiger, S; Lameh, J; Sadée, W; Yu, VC, 1990)
" The VIP/PHM-27 gene dosage was unchanged by Bt2cAMP and phorbol esters."1.27Synergistic stimulation of VIP/PHM-27 gene expression by cyclic AMP and phorbol esters in human neuroblastoma cells. ( Hayakawa, Y; Nishizawa, M; Ohsawa, K; Okamoto, H; Yamagami, T; Yamamoto, H; Yanaihara, N, 1985)
" At peptide concentrations of 1 microM clear-cut plateaus of the dose-response curves are not yet reached."1.27Atrial natriuretic hormones raise the level of cyclic GMP in neural cell lines. ( Friedl, A; Hamprecht, B; Harmening, C, 1986)
"Carbachol treatment of cells resulted in down-regulation of muscarinic cholinergic receptors to 45."1.27Agonist-induced down-regulation of muscarinic cholinergic and alpha 2-adrenergic receptors after inactivation of Ni by pertussis toxin. ( Hoffman, BB; Thomas, JM, 1986)
"Treatment with reserpine, which increases conversion of peptide B to the heptapeptide in bovine chromaffin cells in culture does not stimulate the accumulation of Met-enkephalyl-Arg6-Phe7 in the human neuroblastoma cells."1.27Met-enkephalyl-Arg6-Phe7 immunoreactivity in a human neuroblastoma cell line: effect of dibutyryl 3':5'-cyclic AMP and reserpine. ( Adams, M; Boarder, MR; Marriott, D, 1986)

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-199016 (37.21)18.7374
1990's23 (53.49)18.2507
2000's3 (6.98)29.6817
2010's1 (2.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Leung, YM1
Huang, CF1
Chao, CC1
Lu, DY1
Kuo, CS1
Cheng, TH1
Chang, LY1
Chou, CH1
Chu, KM1
Chow, KB1
Wong, YH1
Wise, H1
Billups, D1
Billups, B1
Challiss, RA2
Nahorski, SR1
Hall, JM1
Strange, PG2
Freedman, SB1
Dawson, G5
Villereal, ML1
Miller, RJ1
Wang, Z1
Bilsky, EJ1
Porreca, F1
Sadée, W2
Tohda, M1
Murayama, T1
Hasegawa, H1
Nogiri, S1
Nomura, Y1
Zwart, R1
Abraham, D1
Oortgiesen, M1
Vijverberg, HP1
Inukai, T1
Chik, CL1
Ho, AK1
Bergsbaken, CL1
Sommers, SL1
Law, PY1
Morgan, AJ1
Murray, KJ1
Adler, EM1
Fink, JS1
Cai, Y1
Zhang, Y2
Wu, Y1
Pei, G2
Cibelli, G1
Jüngling, S1
Schoch, S1
Gerdes, HH1
Thiel, G1
Boddeke, HW1
Meigel, I1
Boeijinga, P1
Arbuckle, J1
Docherty, RJ1
Gylys, KH1
Tran, N1
Magendzo, K1
Zaki, P1
Evans, CJ1
Wojcikiewicz, RJ1
Luo, SG1
Zhao, J1
Xin, SM1
Ma, L1
Drake, WM1
Ajayi, A1
Lowe, SR1
Mirtella, A1
Bartlett, TJ1
Clark, AJ1
Sidhu, A1
Olde, B1
Humblot, N1
Kimura, K1
Gardner, N1
Roseboom, PH1
Urben, CM1
Kalin, NH1
Bennett, T1
Propst, F1
Moroder, L1
Wünsch, E1
Hamprecht, B2
Hall, AK1
Thomas, JM2
Vagelos, R1
Hoffman, BB2
Ajiro, K1
Shibata, K1
Nishikawa, Y1
McAtee, P2
Ishii, K1
Adachi, Y1
Hatanaka, M1
Sakamoto, H1
Furuyama, J1
Yu, VC1
Eiger, S1
Duan, DS1
Lameh, J1
Klann, E1
Shelton, KR1
Monstein, HJ1
Folkesson, R1
Ohsawa, K1
Hayakawa, Y1
Nishizawa, M1
Yamagami, T1
Yamamoto, H1
Yanaihara, N1
Okamoto, H1
Friedl, A1
Harmening, C1
Scheideler, MA1
Boarder, MR1
Marriott, D1
Adams, M1
Graeff, RM1
Walseth, TF1
Goldberg, ND1
Berry-Kravis, E1
Kazmierczak, BI1
Derechin, V1
Westlind-Danielsson, A1
Gillenius, P1
Askelöf, P1
Bartfai, T1
Baumgold, J1
Fishman, PH1
Akil, M1
Fisher, SK1
Ruusala, AI1
Mattsson, M1
Esscher, T1
Abrahamsson, L1
Jergil, B1
Påhlman, S1

Other Studies

43 other studies available for 1-methyl-3-isobutylxanthine and Neuroblastoma

ArticleYear
Voltage-gated K+ channels play a role in cAMP-stimulated neuritogenesis in mouse neuroblastoma N2A cells.
    Journal of cellular physiology, 2011, Volume: 226, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium Channels; Cell Differentiation; Cell Line, Tumor; Colf

2011
Prostacyclin receptor-mediated activation of extracellular signal-regulated kinases 1 and 2.
    Cellular signalling, 2004, Volume: 16, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain Neoplasms; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP

2004
Modulation of Gq-protein-coupled inositol trisphosphate and Ca2+ signaling by the membrane potential.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Sep-27, Volume: 26, Issue:39

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium Signaling; Cell Line; Cell Line, Tumor; Cells, Culture

2006
The use of a prostacyclin analogue, [3H]iloprost, for studying prostacyclin-binding sites on human platelets and neuronal hybrid cells.
    Bioscience reports, 1984, Volume: 4, Issue:11

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Binding, Competitive; Blood Platelets; Brain; Cell Line; Cell

1984
Identification and characterization of voltage-sensitive calcium channels in neuronal clonal cell lines.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1984, Volume: 4, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain Neoplasms; Calcium Channel Blockers; Cell Transformation

1984
Constitutive mu opioid receptor activation as a regulatory mechanism underlying narcotic tolerance and dependence.
    Life sciences, 1994, Volume: 54, Issue:20

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cerebral Ventricles; Cyclic AMP; Drug Tolerance; Ho

1994
[3H]Rolipram binding and phosphodiesterase activity in neuroblastoma N18TG-2 and glioma C6Bu-1.
    Neuroscience letters, 1994, Jul-04, Volume: 175, Issue:1-2

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imi

1994
alpha 4 beta 2 subunit combination specific pharmacology of neuronal nicotinic acetylcholine receptors in N1E-115 neuroblastoma cells.
    Brain research, 1994, Aug-22, Volume: 654, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Alkaloids; Animals; Azocines; Bucladesine; Bungarotoxins

1994
Vasoactive intestinal polypeptide stimulates cyclic AMP production in mouse N1E-115 neuroblastoma cells: modulation by a protein kinase C activator and ionomycin.
    Peptides, 1994, Volume: 15, Issue:8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Animals; Calcium; Carcin

1994
Effect of forskolin and isobutylmethylxanthine on delta-opioid receptor activity in neuroblastoma x glioma NG108-15 cells.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Differentiation; Colforsin; Cyclic AMP; Enkephalin, Leuci

1993
Comparison of the effect of isobutylmethylxanthine and phosphodiesterase-selective inhibitors on cAMP levels in SH-SY5Y neuroblastoma cells.
    Biochemical pharmacology, 1993, Jun-22, Volume: 45, Issue:12

    Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Adenylyl Cyclase Inhibitors; Cell Line; C

1993
Calcium regulation of vasoactive intestinal polypeptide mRNA abundance in SH-SY5Y human neuroblastoma cells.
    Journal of neurochemistry, 1993, Volume: 61, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Calcimycin; Calcium; Colforsin; Cyclic AMP; Gene Expression Regulation,

1993
delta Opioid receptor in neuronal cells undergoes acute and homologous desensitization.
    Biochemical and biophysical research communications, 1996, Feb-15, Volume: 219, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Analgesics; Animals; Cerebral Cortex; Cyclic AMP; Dose-Response Relatio

1996
Identification of a functional cAMP response element in the secretogranin II gene.
    European journal of biochemistry, 1996, Feb-15, Volume: 236, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Bucladesine; Cell Differentiation; Chromogranin

1996
Modulation by calcineurin of 5-HT3 receptor function in NG108-15 neuroblastoma x glioma cells.
    British journal of pharmacology, 1996, Volume: 118, Issue:7

    Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Brain Neoplasms; Calcineurin; Calmodulin-

1996
cAMP decreases steady-state levels of delta-opioid receptor mRNA in NG108-15 cells.
    Neuroreport, 1997, Jul-07, Volume: 8, Issue:9-10

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Dinoprostone; Neuroblastoma; Phosphodie

1997
Phosphorylation of inositol 1,4,5-trisphosphate receptors by cAMP-dependent protein kinase. Type I, II, and III receptors are differentially susceptible to phosphorylation and are phosphorylated in intact cells.
    The Journal of biological chemistry, 1998, Mar-06, Volume: 273, Issue:10

    Topics: 1-Methyl-3-isobutylxanthine; Calcium; Calcium Channels; Carbachol; Colforsin; Cyclic AMP; Cyclic AMP

1998
Attenuation of nociceptin/orphanin FQ-induced signaling by N-methyl-D-aspartate in neuronal cells.
    Neuroreport, 1998, Mar-09, Volume: 9, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Gliom

1998
Desensitization of CGRP and adrenomedullin receptors in SK-N-MC cells: implications for the RAMP hypothesis.
    Endocrinology, 1999, Volume: 140, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Humans; Intracellular

1999
Regulation of human D1 dopamine receptor function and gene expression in SK-N-MC neuroblastoma cells.
    Neuroscience, 1999, Volume: 91, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Benzazepine

1999
Persistent corticotropin-releasing factor(1) receptor desensitization and downregulation in the human neuroblastoma cell line IMR-32.
    Brain research. Molecular brain research, 2001, Aug-15, Volume: 92, Issue:1-2

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Amphibian Proteins; Bromodeoxyuridine; Carrier Prote

2001
Effect of a phosphodiesterase inhibitor on cyclic GMP changes induced by muscarinic agonists in mouse neuroblastoma cells [proceedings].
    British journal of pharmacology, 1978, Volume: 64, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Cyclic GMP; Mice; Neuroblastoma; Parasympatho

1978
The influence of secretin, glucagon and other peptides, of amino acids, prostaglandin endoperoxide analogues and diazepam on the level of adenosine 3',5'-cyclic monophosphate in neuroblastoma x glioma hybrid cells.
    Journal of neurochemistry, 1979, Volume: 32, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amino Acids; Cyclic AMP

1979
Influence of cyclic AMP and serum factors upon expression of a retinoid-responsive gene in neuroblastoma cells.
    Journal of molecular neuroscience : MN, 1992, Volume: 3, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Amino Acid Sequence; Animals; Blood Physiological Phenomena;

1992
Decreased cyclic AMP degradation in NG 108-15 neuroblastoma X glioma hybrid cells and S49 lymphoma cells chronically treated with drugs that inhibit adenylate cyclase.
    Journal of neurochemistry, 1990, Volume: 54, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Alprostadil; Animals; Cyclic AMP; Glioma;

1990
Subtype-specific cyclic AMP-dependent histone H1 phosphorylation at the differentiation of mouse neuroblastoma cells.
    The Journal of biological chemistry, 1990, Apr-15, Volume: 265, Issue:11

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Caffeine; Cell Differentiation; Cell Line; Colfor

1990
Phospholipase C activity in NCB-20 cells is inhibited by protein kinase A-mediated phosphorylation of low molecular mass GTP-binding proteins.
    The Journal of biological chemistry, 1990, Apr-25, Volume: 265, Issue:12

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Brain; Cell L

1990
Spontaneous and cAMP-dependent induction of a resting phase and neurite formation in cell hybrids between human neuroblastoma cells and thymidine auxotrophs of rat nerve-like cells.
    Journal of cellular physiology, 1990, Volume: 143, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Axons; Bucladesine; Calcimycin; Cell Cycle; Cell Transformatio

1990
Regulation of cyclic AMP by the mu-opioid receptor in human neuroblastoma SH-SY5Y cells.
    Journal of neurochemistry, 1990, Volume: 55, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe

1990
A lead-associated nuclear protein which increases in maturing brain and in differentiating neuroblastoma 2A cells exposed to cyclic AMP-elevating agents.
    Brain research. Developmental brain research, 1990, Dec-01, Volume: 57, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blotting, Western; Bra

1990
Phorbol 12-myristate-13-acetate (PMA) stimulates a differential expression of cholecystokinin (CCK) and c-fos mRNA in a human neuroblastoma cell line.
    FEBS letters, 1991, Nov-18, Volume: 293, Issue:1-2

    Topics: 1-Methyl-3-isobutylxanthine; Base Sequence; Cell Line; Cholecystokinin; Gene Expression Regulation,

1991
Synergistic stimulation of VIP/PHM-27 gene expression by cyclic AMP and phorbol esters in human neuroblastoma cells.
    Biochemical and biophysical research communications, 1985, Nov-15, Volume: 132, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Cells, Cultured; Cyclic AMP; Drug Synergism; Gene Expressi

1985
Atrial natriuretic hormones raise the level of cyclic GMP in neural cell lines.
    Journal of neurochemistry, 1986, Volume: 46, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Calcimycin; Calcium; Cell Line; Cyc

1986
Direct demonstration of the activation of UDP-N-acetylgalactosamine: [GM3]N-acetylgalactosaminyltransferase by cyclic AMP.
    Journal of neurochemistry, 1986, Volume: 46, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Cell Line; Cyclic AMP; Enkephalin, Leucine; Enkephalin,

1986
Agonist-induced down-regulation of muscarinic cholinergic and alpha 2-adrenergic receptors after inactivation of Ni by pertussis toxin.
    Endocrinology, 1986, Volume: 119, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase

1986
Met-enkephalyl-Arg6-Phe7 immunoreactivity in a human neuroblastoma cell line: effect of dibutyryl 3':5'-cyclic AMP and reserpine.
    Regulatory peptides, 1986, Dec-30, Volume: 16, Issue:3-4

    Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Bucladesine; Cell Line; Cyclic AMP; Enkephalin, Methionine

1986
The dynamics of cGMP metabolism in neuroblastoma N1E-115 cells determined by 18O labeling of guanine nucleotide alpha-phosphoryls.
    Neurochemical research, 1987, Volume: 12, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterase

1987
Neuromodulator-mediated phosphorylation of specific proteins in a neurotumor hybrid cell line (NCB-20).
    Journal of neurochemistry, 1988, Volume: 50, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Alprostadil; Animals; Brain; Calcimycin;

1988
Chronic exposure to pertussis toxin alters muscarinic receptor-mediated regulation of cyclic AMP metabolism in neuroblastoma x glioma NG108-15 hybrid cells.
    Journal of neurochemistry, 1988, Volume: 51, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Atropine; Carbachol; Cyclic AMP; Glioma; Hybrid Cells; Neu

1988
Muscarinic receptor-mediated increase in cAMP levels in SK-N-SH human neuroblastoma cells.
    Biochemical and biophysical research communications, 1988, Aug-15, Volume: 154, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Carbachol; Cell Line; Colforsin; Cyclic AMP; H

1988
Rapid dephosphorylation of protein kinase C substrates by protein kinase A activators results from inhibition of diacylglycerol release.
    The Journal of biological chemistry, 1989, Jul-05, Volume: 264, Issue:19

    Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Arachidonic Acid; Arachidonic Acids; Biological T

1989
Muscarinic receptor-stimulated phosphoinositide turnover in human SK-N-SH neuroblastoma cells: differential inhibition by agents that elevate cyclic AMP.
    Journal of neurochemistry, 1989, Volume: 53, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Alprostadil; Bucladesine; Carbacho

1989
12-O-tetradecanoyl-phorbol-13-acetate-induced differentiation of human neuroblastoma cells is not accompanied by an increase in the intracellular concentration of cyclic AMP.
    Brain research, 1985, Volume: 350, Issue:1-2

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Carrier Proteins; Clone Cells; Colchicine; Cyclic AMP; Mice; N

1985