1-methyl-3-isobutylxanthine has been researched along with Muscle Relaxation in 75 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The influence of aging on the relaxant response and the change in cyclic nucleotide content induced by vasoactive intestinal polypeptide (VIP), nitric oxide (NO), electrical field stimulation of the non-adrenergic non-cholinergic neurones and substances acting at different levels of the cyclic AMP and cyclic GMP transduction pathways was studied in longitudinal muscle strips of the rat gastric fundus." | 3.69 | Influence of age on the signal transduction pathway of non-adrenergic non-cholinergic neurotransmitters in the rat gastric fundus. ( Lefebvre, RA; Smits, GJ, 1995) |
| "Chlorogenic acid (CGA) is a polyphenol found in coffee and medicinal herbs such as Lonicera japonica." | 1.48 | Effects of chlorogenic acid on carbachol-induced contraction of mouse urinary bladder. ( Kaneda, T; Sasaki, N; Shimizu, K; Urakawa, N, 2018) |
| " The dose-response curve to norepinephrine was shifted to the left in intact vessels compared with strips of vessels in the muscle bath, which suggests that whole vessels were more sensitive to norepinephrine." | 1.31 | Vascular smooth muscle mechanics in isolated perfused segments of carotid arteries. ( Bagwell, CA; Beall, A; Brophy, C; Jerius, H; Karolyi, D, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (29.33) | 18.7374 |
| 1990's | 41 (54.67) | 18.2507 |
| 2000's | 9 (12.00) | 29.6817 |
| 2010's | 2 (2.67) | 24.3611 |
| 2020's | 1 (1.33) | 2.80 |
| Authors | Studies |
|---|---|
| Davey, DD | 1 |
| Erhardt, PW | 1 |
| Cantor, EH | 1 |
| Greenberg, SS | 1 |
| Ingebretsen, WR | 1 |
| Wiggins, J | 1 |
| Güven, C | 1 |
| Parlar, A | 1 |
| Kaneda, T | 1 |
| Sasaki, N | 1 |
| Urakawa, N | 1 |
| Shimizu, K | 1 |
| Xin, W | 1 |
| Soder, RP | 1 |
| Cheng, Q | 1 |
| Rovner, ES | 1 |
| Petkov, GV | 1 |
| Melarange, R | 1 |
| Elphick, MR | 1 |
| Oostendorp, J | 1 |
| Obels, PP | 1 |
| Terpstra, AR | 1 |
| Nelemans, SA | 1 |
| Zaagsma, J | 1 |
| Daenas, C | 1 |
| Hatziefthimiou, AA | 1 |
| Gourgoulianis, KI | 1 |
| Molyvdas, PA | 1 |
| Santos-Silva, AJ | 1 |
| Cairrão, E | 1 |
| Morgado, M | 1 |
| Alvarez, E | 1 |
| Verde, I | 1 |
| Napoli, SA | 1 |
| Gruetter, CA | 1 |
| Ignarro, LJ | 1 |
| Kadowitz, PJ | 1 |
| Bergstrand, H | 1 |
| Holzmann, S | 1 |
| Kukovetz, WR | 1 |
| Schmidt, K | 1 |
| Bitar, KN | 1 |
| Makhlouf, GM | 1 |
| Bowman, A | 1 |
| Gillespie, JS | 2 |
| Hayashi, K | 1 |
| Masuda, K | 1 |
| Metsä-Ketelä, T | 1 |
| Yen, YC | 1 |
| Yang, MC | 2 |
| Kenny, AD | 2 |
| Pang, PK | 2 |
| Ishikawa, Y | 1 |
| Takahashi, T | 1 |
| Yamamura, T | 1 |
| Matsuura, M | 1 |
| Trevethick, MA | 2 |
| Feniuk, W | 2 |
| Humphrey, PP | 2 |
| Yan, YJ | 1 |
| VanderWall, KJ | 1 |
| Bealer, JF | 1 |
| Adzick, NS | 1 |
| Harrison, MR | 1 |
| Fujita, H | 1 |
| Usui, H | 1 |
| Kurahashi, K | 1 |
| Yoshikawa, M | 1 |
| Fujitani, Y | 1 |
| Ueda, H | 1 |
| Okada, T | 1 |
| Urade, Y | 1 |
| Karaki, H | 1 |
| Yamagishi, T | 1 |
| Yanagisawa, T | 2 |
| Satoh, K | 1 |
| Taira, N | 2 |
| Rabe, KF | 2 |
| Tenor, H | 2 |
| Dent, G | 2 |
| Schudt, C | 2 |
| Nakashima, M | 1 |
| Magnussen, H | 2 |
| Bergh, CM | 1 |
| Brophy, CM | 1 |
| Dransfield, DT | 1 |
| Lincoln, T | 1 |
| Goldenring, JR | 1 |
| Rasmussen, H | 1 |
| Smits, GJ | 1 |
| Lefebvre, RA | 3 |
| Barbier, AJ | 2 |
| Sun, YD | 1 |
| Benishin, CG | 1 |
| Linde, C | 1 |
| Quast, U | 1 |
| Kageyama, M | 1 |
| Liebig, S | 1 |
| Williams, P | 1 |
| Datta, S | 1 |
| German, K | 1 |
| Stephenson, TP | 1 |
| Bedwani, JR | 1 |
| Haruno, I | 1 |
| Yoshitomi, T | 1 |
| Harada, Y | 1 |
| Katori, M | 1 |
| Ishikawa, S | 1 |
| Civelli, M | 1 |
| Giossi, M | 1 |
| Caruso, P | 1 |
| Razzetti, R | 1 |
| Bergamaschi, M | 1 |
| Bongrani, S | 1 |
| Gasco, A | 1 |
| McLean, PG | 1 |
| Coupar, IM | 1 |
| Simon, OR | 1 |
| Powell, N | 1 |
| Davis, P | 1 |
| Gossell, M | 1 |
| Kamata, K | 1 |
| Kondoh, H | 1 |
| Knapp, J | 1 |
| Bokník, P | 1 |
| Linck, B | 1 |
| Lüss, H | 1 |
| Müller, FU | 1 |
| Nacke, P | 1 |
| Neumann, J | 1 |
| Vahlensieck, U | 1 |
| Schmitz, W | 1 |
| Shenberger, JS | 1 |
| Shew, RL | 1 |
| Johnson, DE | 1 |
| Kannan, MS | 1 |
| Gladis-Villanueva, MM | 1 |
| Usera, F | 1 |
| Toro, MJ | 1 |
| Masuda, H | 2 |
| Tamaoki, S | 1 |
| Goto, M | 1 |
| Ishida, A | 2 |
| Kamikawatoko, S | 2 |
| Tokoro, T | 2 |
| Azuma, H | 2 |
| Yousufzai, SY | 1 |
| Abdel-Latif, AA | 1 |
| Onoue, H | 1 |
| Katusic, ZS | 2 |
| Hamasaki, H | 1 |
| Sato, J | 1 |
| Wong, KK | 1 |
| Eckman, DM | 1 |
| Hopkins, N | 1 |
| McBride, C | 1 |
| Keef, KD | 1 |
| Weisbrod, RM | 1 |
| Griswold, MC | 1 |
| Yaghoubi, M | 1 |
| Komalavilas, P | 1 |
| Lincoln, TM | 1 |
| Cohen, RA | 1 |
| O'Kane, K | 1 |
| Gibson, A | 1 |
| Jerius, H | 1 |
| Bagwell, CA | 1 |
| Beall, A | 1 |
| Karolyi, D | 1 |
| Brophy, C | 1 |
| Nakahara, T | 1 |
| Yunoki, M | 1 |
| Moriuchi, H | 1 |
| Sakamato, K | 1 |
| Ishii, K | 2 |
| Chow, JM | 1 |
| Moffatt, JD | 1 |
| Cocks, TM | 1 |
| Taylor, HJ | 1 |
| Chaytor, AT | 1 |
| Edwards, DH | 1 |
| Griffith, TM | 1 |
| Tolsa, JF | 1 |
| Gao, Y | 1 |
| Sander, FC | 1 |
| Souici, AC | 1 |
| Moessinger, A | 1 |
| Raj, JU | 1 |
| Polson, JB | 1 |
| Krzanowski, JJ | 1 |
| Anderson, WH | 1 |
| Fitzpatrick, DF | 1 |
| Hwang, DP | 1 |
| Szentivanyi, A | 1 |
| Cosentino, F | 1 |
| Schirger, A | 1 |
| Fujimoto, S | 1 |
| Matsuda, T | 2 |
| Sheng, H | 1 |
| Rinkema, LE | 1 |
| Roman, CR | 1 |
| Russell, WL | 1 |
| Spaethe, SM | 1 |
| Bemis, KG | 1 |
| Henry, DP | 1 |
| Marshall, WS | 1 |
| Fleisch, JH | 1 |
| Heesen, BJ | 1 |
| De Mey, JG | 1 |
| Tsuru, H | 1 |
| Kohno, S | 1 |
| Matsubayashi, H | 1 |
| Villanueva, MM | 1 |
| Nunes, JP | 1 |
| Soares-da-Silva, P | 1 |
| Kazanietz, MG | 1 |
| Enero, MA | 1 |
| Shikada, K | 1 |
| Yamamoto, A | 1 |
| Tanaka, S | 1 |
| Wang, X | 1 |
| Han, C | 1 |
| Fiscus, RR | 1 |
| Nickols, GA | 3 |
| Metz, MA | 1 |
| Cline, WH | 2 |
| Tsujimoto, G | 2 |
| Lee, CH | 1 |
| Hoffman, BB | 2 |
| Asano, M | 1 |
| Masuzawa, K | 1 |
| Murad, F | 1 |
| Hughes, AD | 1 |
| Sever, PS | 1 |
1 review available for 1-methyl-3-isobutylxanthine and Muscle Relaxation
| Article | Year |
|---|---|
Phosphodiesterase inhibition and theophylline.
Topics: 1-Methyl-3-isobutylxanthine; Cromolyn Sodium; Histamine Release; Humans; Kinetics; Lung; Muscle Rela | 1980 |
74 other studies available for 1-methyl-3-isobutylxanthine and Muscle Relaxation
| Article | Year |
|---|---|
Novel compounds possessing potent cAMP and cGMP phosphodiesterase inhibitory activity. Synthesis and cardiovascular effects of a series of imidazo[1,2-a]quinoxalinones and imidazo[1,5-a]quinoxalinones and their aza analogues.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aza Compounds; Ca | 1991 |
Glabridin Relaxes Vascular Smooth Muscles by Activating BK
Topics: 1-Methyl-3-isobutylxanthine; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endotheli | 2021 |
Effects of chlorogenic acid on carbachol-induced contraction of mouse urinary bladder.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenylyl Cyclases; Anim | 2018 |
Selective inhibition of phosphodiesterase 1 relaxes urinary bladder smooth muscle: role for ryanodine receptor-mediated BK channel activation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Cyclic AMP; Cyclic Nucleotide Phosphodiestera | 2012 |
Comparative analysis of nitric oxide and SALMFamide neuropeptides as general muscle relaxants in starfish.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Muscle Relaxation; Neuropeptides; Nitr | 2003 |
Modulation of beta2- and beta3-adrenoceptor-mediated relaxation of rat oesophagus smooth muscle by protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Dose-Response Relationship, Drug; Drug Synergism; Esophagus; E | 2004 |
Azithromycin has a direct relaxant effect on precontracted airway smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Anti-Bacterial Agents; Atropine; Azithromycin; Bronchodilator | 2006 |
PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide | 2008 |
Relaxation of bovine coronary arterial smooth muscle by cyclic GMP, cyclic AMP and analogs.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Cattle; Coronary Vessels; Cyclic AMP; Cyclic GM | 1980 |
Mode of action of coronary arterial relaxation by prostacyclin.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Cattle; Coronary Vessels; Cyclic AMP; Epopr | 1980 |
Relaxation of isolated gastric smooth muscle cells by vasoactive intestinal peptide.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Gastrointestinal Hormones; Guinea Pigs; In Vitro T | 1982 |
Block of some non-adrenergic inhibitory responses of smooth muscle by a substance from haemolysed erythrocytes.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Apamin; Cattle; Dose-Response Relationship, Drug; | 1982 |
Effects of vasoactive intestinal polypeptide (VIP) and cyclic-AMP on the isolated sphincter pupillae muscles of the albino rabbit.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Gastrointestinal Hormones; Iris; Muscle Relaxation | 1982 |
Cyclic AMP-dependent and -independent effects of beta-adrenergic stimulation on the contraction-relaxation cycle of spontaneously beating rat atria.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Calcium; Cyclic AMP; Heart Atria; Io | 1982 |
Parathyroid hormone (PTH) fragments relax the guinea-pig trachea in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Female; Guinea Pigs; Hydrogen Peroxide; Imidazoles; In Vitro T | 1983 |
[Action of adenosine 5'-triphosphate and effects of various purinergic receptor blocking agents on the movements of an isolated guinea pig gallbladder].
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Apamin; Atropine; Female; Gallbladder; | 1983 |
Relaxation of Mytilus catch muscle by 8-bromo-cyclic GMP and related compounds.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Bivalvia; Cyclic GMP; Egtazic Acid; Electric St | 1984 |
5-hydroxytryptamine-induced relaxation of neonatal porcine vena cava in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Cyclic AMP; Dinoprost; Histamine; Kinetics; | 1984 |
[Parathyroid hormone fragments relax guinea pig trachea in vitro].
Topics: 1-Methyl-3-isobutylxanthine; Animals; Female; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; | 1984 |
Cyclic GMP relaxes the internal anal sphincter in Hirschsprung's disease.
Topics: 1-Methyl-3-isobutylxanthine; Anal Canal; Colon; Cyclic AMP; Cyclic GMP; Ganglia; Hirschsprung Diseas | 1995 |
Isolation and characterization of ovokinin, a bradykinin B1 agonist peptide derived from ovalbumin.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Bradykinin; Dinoprost; Dogs; Dose-Respons | 1995 |
A selective agonist of endothelin type B receptor, IRL 1620, stimulates cyclic GMP increase via nitric oxide formation in rat aorta.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta, Thoracic; Arginine; Binding Sites; Calcium; Cyclic GMP; | 1993 |
Relaxant mechanisms of cyclic AMP-increasing agents in porcine coronary artery.
Topics: 1-Methyl-3-isobutylxanthine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adr | 1994 |
Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Aged; Antihypertensive Agents; Carbachol; Colforsin; Cytosol; Di | 1994 |
Impaired cyclic nucleotide-dependent vasorelaxation in human umbilical artery smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carotid Arteries; Cattle; Colforsin; Cyclic AMP; Cyclic AMP-De | 1995 |
Influence of age on the signal transduction pathway of non-adrenergic non-cholinergic neurotransmitters in the rat gastric fundus.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Analysis of Variance; Animals; Colforsin; Cyclic AMP; Cyclic GMP | 1995 |
Relaxant influence of phosphodiesterase inhibitors in the cat gastric fundus.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cats; Cyclic GMP; Dose-Response Relationship, Drug; Female; Ga | 1995 |
Effects of calcitonin gene-related peptide on cyclic AMP production and relaxation of longitudinal muscle of guinea pig ileum.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcitonin Gene-Related Peptide; Cyclic AMP; Dose-Response Rel | 1995 |
Potentiation of P1075-induced K+ channel opening by stimulation of adenylate cyclase in rat isolated aorta.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Aorta; Binding, Competitive; Bucladesine; C | 1995 |
Calcitonin gene-related peptide relaxes porcine coronary arteries via cyclic AMP-dependent mechanisms, but not activation of ATP-sensitive potassium channels.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Benzopyrans; Calcitonin Gene-Related P | 1993 |
Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adult; Aged; Bucladesine; C | 1993 |
Comparison of relaxation responses of detrusor strips from neuropathic and control patients.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Aged; Arginine; Electric Stimulation; Female; Humans; Male; Midd | 1995 |
Calcitonin gene-related peptide induced relaxation of the rabbit iris dilator muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcitonin Gene-Related Peptide; Cyclic AMP; Electric Stimulat | 1996 |
The involvement of the release of nitric oxide in the pharmacological activity of the new furoxan derivative CHF 2363.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta; Cyclic GMP; Dose-Response Relationship, Drug; Humans; M | 1996 |
Further investigation into the signal transduction mechanism of the 5-HT4-like receptor in the circular smooth muscle of human colon.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Benzimidazoles; Bridged Bicyclo Compounds, Hetero | 1996 |
Evidence that guanylate cyclase is involved in modulating the resting tension and neurally-induced contraction of the guinea pig tracheal muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic GMP; Electric Stimulation; Guanylate Cyclase; Guinea Pi | 1996 |
Impairment of endothelium-dependent relaxation of the isolated basilar artery from streptozotocin-induced diabetic rats.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Basilar Artery; Diabetes Mellitus, Experimental | 1996 |
The effect of the protein phosphatases inhibitor cantharidin on beta-adrenoceptor-mediated vasorelaxation.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Cantharidin; Cattle; Cells, Cultured | 1997 |
Relaxation of porcine tracheal smooth muscle by parathyroid hormone-related protein.
Topics: 1-Methyl-3-isobutylxanthine; Aminoquinolines; Animals; Carbachol; Cyclic AMP; Dose-Response Relation | 1997 |
Denervation-induced supersensitivity to forskolin and pinacidil is not related to changes in the adenylate cyclase transduction pathway in the rabbit femoral artery.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylate Cyclase Toxin; Adenylyl | 1997 |
Nitric oxide-induced ciliary muscle relaxation during contraction with endothelin-1 is mediated through elevation of cyclic GMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cattle; Ciliary Body; Cyclic GMP; Drug Combinations; Endotheli | 1997 |
Calcitonin gene-related peptide relaxes rabbit iris dilator smooth muscle via cyclic AMP-dependent mechanisms: cross-talk between the sensory and sympathetic nervous systems.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Agonists; Animals; Calcitonin Gene-Related Peptide; Cy | 1998 |
The effect of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) and charybdotoxin (CTX) on relaxations of isolated cerebral arteries to nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bradykinin; Cerebral Arteries; Charybdotoxin; Colforsin; Cycli | 1998 |
Nitric oxide relaxes bovine ciliary muscle contracted by carbachol through elevation of cyclic GMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Carbachol; Cattle; Cil | 1998 |
Drug induced contraction and relaxation in mouse isolated aorta.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta | 1997 |
Endothelium-dependent relaxation and hyperpolarization in guinea-pig coronary artery: role of epoxyeicosatrienoic acid.
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; 8,11,14-Eicosatrienoic Acid; Acetylcholine; Animals; A | 1998 |
Evidence that additional mechanisms to cyclic GMP mediate the decrease in intracellular calcium and relaxation of rabbit aortic smooth muscle to nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Angiotensin II; Animals; Aorta; Ca | 1998 |
Characterisation of nitrergic transmission in the isolated anococcygeus muscle of the female mouse.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Catechols; Dose-Response Relationship, Drug; Electric Stimulat | 1999 |
Vascular smooth muscle mechanics in isolated perfused segments of carotid arteries.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Biomechanical Phenomena; Carotid Arteries; Catt | 2000 |
Lidocaine potentiates the relaxant effects of cAMP-elevating agents in bovine tracheal smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Albuterol; Anesthetics, Local; Animals; Bupivacaine; Cattle; Colforsin; | 2000 |
Effect of protease-activated receptor (PAR)-1, -2 and -4-activating peptides, thrombin and trypsin in rat isolated airways.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bronchi; Bronchodilator Agents; Cyclooxygenase Inhibitors; Dos | 2000 |
Gap junction-dependent increases in smooth muscle cAMP underpin the EDHF phenomenon in rabbit arteries.
Topics: 1-Methyl-3-isobutylxanthine; 8,11,14-Eicosatrienoic Acid; Acetylcholine; Animals; Arteries; Biologic | 2001 |
Differential responses of newborn pulmonary arteries and veins to atrial and C-type natriuretic peptides.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cyclic GMP; Gene | 2002 |
Analysis of the relationship between pharmacological inhibition of cyclic nucleotide phosphodiesterase and relaxation of canine tracheal smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterase | 1979 |
Effect of 3-isobutyl-1-methylxanthine and zaprinast on non-adrenergic non-cholinergic relaxation in the rat gastric fundus.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterase | 1992 |
HN-10200 causes endothelium-independent relaxations in isolated canine arteries.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Basilar Artery; Dogs; Endothelium, Vascular; Femoral Artery; I | 1992 |
Effects of pimobendan, a cardiotonic and vasodilating agent with phosphodiesterase inhibiting properties, on isolated arteries and veins of rats.
Topics: 1-Methyl-3-isobutylxanthine; Aminophylline; Animals; Arteries; Cardiotonic Agents; Colforsin; Drug I | 1990 |
The effects of pyrogallol and hydroquinone on the response to NANC nerve stimulation in the rat anococcygeus and the bovine retractor penis muscles.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Autonomic Nervous System; Cattle; Electric Stimulati | 1990 |
Leukotriene receptor antagonism and augmentation of beta-receptor-mediated events by LY171883.
Topics: 1-Methyl-3-isobutylxanthine; Acetophenones; Adrenergic beta-Agonists; Animals; Bronchodilator Agents | 1990 |
Effects of cyclic AMP-affecting agents on contractile reactivity of isolated mesenteric and renal resistance arteries of the rat.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Arteries; Buclades | 1990 |
Relaxation response of isolated canine veins to agents that act on the adenylate cyclase-cyclic AMP system: further investigation.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenergic alpha-Agonists; Animals; Colforsin; Cycli | 1990 |
Relaxant effects of alpha-human atrial natriuretic peptide on venous smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Carbachol; Colforsin; Cyclic AMP; C | 1991 |
Decreased beta-adrenoceptor-mediated vasodilation in aorta from aged rats: possible involvement of a stimulatory GTP-binding protein.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Aging; Animals; Aorta; Clenbuterol; Colforsin; Cycli | 1991 |
Effects of phosphodiesterase inhibitors on vasoactive intestinal peptide-induced relaxation of isolated guinea-pig trachea.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Dinoprostone; Guinea Pigs; In Vitro Tec | 1991 |
Calcitonin gene-related peptide (CGRP) causes endothelium-dependent cyclic AMP, cyclic GMP and vasorelaxant responses in rat abdominal aorta.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta, Abdominal; Calcitonin Gene-Related Peptide; Cyclic AMP; | 1991 |
Increased cyclic AMP in cultured vascular smooth muscle cells and relaxation of aortic strips by parathyroid hormone.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Aorta, Thoracic; Cattle; Colforsin; Cyclic | 1985 |
5-Carboxamidotryptamine: a potent agonist mediating relaxation and elevation of cyclic AMP in the isolated neonatal porcine vena cava.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Atropine; Cimetidine; Cocaine; Cyclic AMP; D | 1986 |
Endothelium-independent linkage of parathyroid hormone receptors of rat vascular tissue with increased adenosine 3',5'-monophosphate and relaxation of vascular smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Aorta, Thoracic; Cells, Cultured; Colforsin | 1986 |
Age-related decrease in beta adrenergic receptor-mediated vascular smooth muscle relaxation.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcholine; Aging; B | 1986 |
Parathyroid hormone-induced changes in cyclic nucleotide levels during relaxation of the rabbit [correction of rat] aorta.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta, Thoracic; Colforsin; Cyclic AMP; Cyclic GMP; In Vitro T | 1987 |
Evidence for reduced beta-adrenoceptor coupling to adenylate cyclase in femoral arteries from spontaneously hypertensive rats.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Bucladesine; Colforsin; Femoral Artery; Hyp | 1988 |
ANP relaxes bovine tracheal smooth muscle and increases cGMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Carbachol; Cattle; Cyclic AMP; Cycl | 1989 |
Action of fenoldopam, a selective dopamine (DA1) receptor agonist, on isolated human arteries.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Aged; Aged, 80 and over; Arteries; Benzazepines; But | 1989 |
Desensitization of beta-adrenergic receptor-mediated vascular smooth muscle relaxation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Catecholamines; Cyclic AMP; Epinephrine; In Vitro Techniques; | 1985 |