1-methyl-3-isobutylxanthine has been researched along with Muscle Contraction in 105 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment with licochalcone A enhanced the relaxant effect of forskolin, an adenylyl cyclase activator, on the contraction in a similar manner to 3-isobutyl-1-methylxanthine (IBMX), a phosphodiesterase (PDE) inhibitor." | 5.34 | Antispasmodic activity of licochalcone A, a species-specific ingredient of Glycyrrhiza inflata roots. ( Akao, T; He, JX; Nagai, H; Tani, T, 2007) |
| "Octopamine was identified in the spermathecal tissue of Locusta migratoria using HPLC and immunohistochemical techniques." | 5.32 | Octopamine modulates spermathecal muscle contractions in Locusta migratoria. ( Clark, J; Lange, AB, 2003) |
| "Glibenclamide, iberiotoxin, and apamin (blockers of ATP-sensitive, large-conductance, and small-conductance Ca(2+)-activated K+ channels, respectively) were infused into the diaphragmatic vasculature of anesthetized indomethacin-treated dogs to assess the contribution of K+ channels to active hyperemia." | 3.69 | Contribution of potassium channels to active hyperemia of the canine diaphragm. ( Chang, HY; Gatensby, AG; Hussain, SN; Vanelli, G, 1994) |
| "Rat calcitonin gene-related peptide (rat CGRP) and related peptides did not cause contraction of gastric smooth muscle cells; however, preincubation with rat CGRP or human CGRP inhibited smooth muscle contraction caused by carbachol." | 3.67 | Characterization of receptors for calcitonin gene-related peptide on gastric smooth muscle cells. ( Collins, SM; Gardner, JD; Jensen, RT; Maton, PN; Sutliff, VE; Zhou, ZC, 1988) |
| "Chlorogenic acid (CGA) is a polyphenol found in coffee and medicinal herbs such as Lonicera japonica." | 1.48 | Effects of chlorogenic acid on carbachol-induced contraction of mouse urinary bladder. ( Kaneda, T; Sasaki, N; Shimizu, K; Urakawa, N, 2018) |
| "Lactic acid treatment elevated interstitial ATP of buffer-perfused muscle and extracellular ATP of L6 myocytes: this ATP release was abolished by the non-specific CFTR inhibitor, glibenclamide, or the specific CFTR inhibitor, CFTR(inh)-172, suggesting that CFTR was involved, and by inhibition of lactic acid entry to cells, indicating that intracellular pH depression was required." | 1.38 | cAMP/protein kinase A activates cystic fibrosis transmembrane conductance regulator for ATP release from rat skeletal muscle during low pH or contractions. ( Ballard, HJ; Cai, W; Lu, L; Tu, J, 2012) |
| "Caffeine is known to inhibit cyclic nucleotide phosphodiesterases (PDEs), leading to an increase in cytosolic cAMP and stimulation of downstream cAMP-dependent mechanisms." | 1.37 | Inhibitory effect of caffeine on pacemaker activity in the oviduct is mediated by cAMP-regulated conductances. ( Britton, F; Dixon, R; Hwang, S; Sanders, K; Ward, S, 2011) |
| "Ibudilast did not inhibit 12-deoxyphorbol 13-isobutyrate (DPB)-induced contraction in the presence of verapamil." | 1.34 | Ibudilast-induced decreases in cytosolic Ca(2+) level and contraction in rat aorta. ( Kaneda, T; Konno, Y; Nakajyo, S; Shimizu, K; Urakawa, N, 2007) |
| "Pretreatment with licochalcone A enhanced the relaxant effect of forskolin, an adenylyl cyclase activator, on the contraction in a similar manner to 3-isobutyl-1-methylxanthine (IBMX), a phosphodiesterase (PDE) inhibitor." | 1.34 | Antispasmodic activity of licochalcone A, a species-specific ingredient of Glycyrrhiza inflata roots. ( Akao, T; He, JX; Nagai, H; Tani, T, 2007) |
| "Octopamine was identified in the spermathecal tissue of Locusta migratoria using HPLC and immunohistochemical techniques." | 1.32 | Octopamine modulates spermathecal muscle contractions in Locusta migratoria. ( Clark, J; Lange, AB, 2003) |
| " The dose-response curve to norepinephrine was shifted to the left in intact vessels compared with strips of vessels in the muscle bath, which suggests that whole vessels were more sensitive to norepinephrine." | 1.31 | Vascular smooth muscle mechanics in isolated perfused segments of carotid arteries. ( Bagwell, CA; Beall, A; Brophy, C; Jerius, H; Karolyi, D, 2000) |
| "Pre-treatment with motapizone, RP73401, rolipram or the methylxanthine adenosine receptor antagonist, 8-phenyltheophylline, did not significantly decrease responses to either allergen or LTC(4)." | 1.31 | The effect of selective and non-selective phosphodiesterase inhibitors on allergen- and leukotriene C(4)-induced contractions in passively sensitized human airways. ( Branscheid, D; Dent, G; Magnussen, H; Rabe, KF; Rühlmann, E; Schmidt, DT; Watson, N, 2000) |
| "The indomethacin effect was eliminated by denuding the endothelium or by inhibiting cyclic nucleotide phosphodiesterase activity." | 1.30 | Regional differentiation in the rat aorta: effects of cyclooxygenase inhibitors. ( Sang, JC; Schachter, D, 1997) |
| " This may represent a therapeutic strategy for vascular diseases characterized by decreased bioavailability of NO." | 1.30 | Adventitial gene transfer of recombinant endothelial nitric oxide synthase to rabbit carotid arteries alters vascular reactivity. ( Barber, DA; Crotty, TB; Gloviczki, P; Katusic, ZS; Kullo, IJ; Mozes, G; O'Brien, T; Schwartz, RS, 1997) |
| "125I-pindolol binding was inhibited by the three agonists, with relative potencies (IC50S) of ISO (0." | 1.28 | Characterization of beta-adrenoreceptors on smooth muscle cells from guinea pig stomach. ( Jensen, RT; Maton, PN; Zhang, L, 1990) |
| " As a whole the pharmacodynamic profile of isbufylline is promising and, in the clinical setting, this compound might exert enhanced antiasthma effects coupled to a low incidence of central and cardiovascular adverse effects." | 1.28 | Pharmacodynamic profile of isbufylline, a new antibronchospastic xanthine devoid of central excitatory actions. ( Antonelli, T; Bacciarelli, C; Ballati, L; Beani, L; Borea, PA; Giachetti, A; Manzini, S; Meini, S, 1990) |
| "Rolipram was the most potent compound in the three species." | 1.27 | Species differences in behavioural effects of rolipram and other adenosine cyclic 3H, 5H-monophosphate phosphodiesterase inhibitors. ( Wachtel, H, 1983) |
| " The dose-response curves of the strips from both strains for alpha-adrenoceptor stimulation with NA determined after pretreatment with CTX were comparable to those determined in the absence of timolol." | 1.27 | Role of stimulatory GTP-binding protein (Gs) in reduced beta-adrenoceptor coupling in the femoral artery of spontaneously hypertensive rats. ( Asano, M; Masuzawa, K; Matsuda, T, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (38.10) | 18.7374 |
| 1990's | 40 (38.10) | 18.2507 |
| 2000's | 17 (16.19) | 29.6817 |
| 2010's | 7 (6.67) | 24.3611 |
| 2020's | 1 (0.95) | 2.80 |
| Authors | Studies |
|---|---|
| Güven, C | 1 |
| Parlar, A | 1 |
| Keller, AS | 1 |
| Diederich, L | 1 |
| Panknin, C | 1 |
| DeLalio, LJ | 1 |
| Drake, JC | 1 |
| Sherman, R | 1 |
| Jackson, EK | 1 |
| Yan, Z | 1 |
| Kelm, M | 1 |
| Cortese-Krott, MM | 1 |
| Isakson, BE | 1 |
| Kaneda, T | 3 |
| Sasaki, N | 1 |
| Urakawa, N | 3 |
| Shimizu, K | 3 |
| Penna, LB | 1 |
| Bassani, RA | 1 |
| Dixon, R | 1 |
| Hwang, S | 1 |
| Britton, F | 1 |
| Sanders, K | 1 |
| Ward, S | 1 |
| Xin, W | 2 |
| Cheng, Q | 2 |
| Soder, RP | 2 |
| Petkov, GV | 2 |
| Rovner, ES | 1 |
| Tu, J | 1 |
| Lu, L | 1 |
| Cai, W | 1 |
| Ballard, HJ | 1 |
| Kovalev, IV | 2 |
| Popov, AG | 1 |
| Baskakov, MB | 2 |
| Minochenko, IL | 1 |
| Kilin, AA | 1 |
| Borodin, YL | 1 |
| Anfinogenova, YD | 1 |
| Kapilevich, LV | 2 |
| Medvedev, MA | 1 |
| Clark, J | 1 |
| Lange, AB | 2 |
| Nosarev, AV | 1 |
| D'yakova, EY | 1 |
| Oostendorp, J | 1 |
| Obels, PP | 1 |
| Terpstra, AR | 1 |
| Nelemans, SA | 1 |
| Zaagsma, J | 1 |
| Morales, S | 1 |
| Camello, PJ | 1 |
| Mawe, GM | 1 |
| Pozo, MJ | 1 |
| Bai, Y | 1 |
| Sanderson, MJ | 1 |
| Daenas, C | 1 |
| Hatziefthimiou, AA | 1 |
| Gourgoulianis, KI | 1 |
| Molyvdas, PA | 1 |
| Sakihara, T | 1 |
| Watanabe, Y | 1 |
| Mukuda, T | 1 |
| Ando, M | 1 |
| Konno, Y | 1 |
| Nakajyo, S | 2 |
| Nagai, H | 1 |
| He, JX | 1 |
| Tani, T | 1 |
| Akao, T | 1 |
| Santos-Silva, AJ | 1 |
| Cairrão, E | 1 |
| Morgado, M | 1 |
| Alvarez, E | 1 |
| Verde, I | 1 |
| Fermum, R | 1 |
| Möritz, KU | 1 |
| Schäfer, U | 1 |
| Leibelt, M | 1 |
| Ausiello, DA | 1 |
| Kreisberg, JI | 1 |
| Roy, C | 1 |
| Karnovsky, MJ | 1 |
| Napoli, SA | 1 |
| Gruetter, CA | 1 |
| Ignarro, LJ | 1 |
| Kadowitz, PJ | 1 |
| Holzmann, S | 1 |
| Kukovetz, WR | 1 |
| Schmidt, K | 1 |
| Bitar, KN | 1 |
| Makhlouf, GM | 1 |
| Jeppsson, AB | 1 |
| Johansson, U | 1 |
| Waldeck, B | 1 |
| Wachtel, H | 1 |
| Yen, YC | 1 |
| Yang, MC | 2 |
| Kenny, AD | 2 |
| Pang, PK | 2 |
| Ishikawa, Y | 1 |
| Takahashi, T | 1 |
| Yamamura, T | 1 |
| Vohra, MM | 1 |
| Matsuura, M | 1 |
| Trevethick, MA | 2 |
| Feniuk, W | 2 |
| Humphrey, PP | 2 |
| Yan, YJ | 1 |
| Blair, KL | 1 |
| Bennett, JL | 1 |
| Pax, RA | 1 |
| Yamagishi, T | 1 |
| Yanagisawa, T | 1 |
| Satoh, K | 1 |
| Taira, N | 1 |
| Rabe, KF | 2 |
| Tenor, H | 1 |
| Dent, G | 2 |
| Schudt, C | 1 |
| Nakashima, M | 1 |
| Magnussen, H | 2 |
| Vanelli, G | 1 |
| Chang, HY | 1 |
| Gatensby, AG | 1 |
| Hussain, SN | 1 |
| Grous, M | 1 |
| Barnette, M | 1 |
| Erxleben, CF | 1 |
| deSantis, A | 1 |
| Rathmayer, W | 1 |
| Linde, C | 1 |
| Quast, U | 1 |
| Takaki, M | 1 |
| Namba, T | 1 |
| Fujii, W | 1 |
| Suga, H | 1 |
| Ishikawa, M | 1 |
| Ouchi, Y | 1 |
| Orimo, H | 1 |
| Zimmermann, N | 2 |
| Bokník, P | 2 |
| Gams, E | 1 |
| Herzig, JW | 2 |
| Neumann, J | 3 |
| Schmitz, W | 3 |
| Scholz, H | 2 |
| Wenzlaff, H | 2 |
| Eschenhagen, T | 1 |
| Grupp, IL | 1 |
| Haverich, A | 1 |
| Hirt, S | 1 |
| Kalmár, P | 1 |
| Stein, B | 1 |
| Pang, IH | 1 |
| Shade, DL | 1 |
| Matsumoto, S | 1 |
| Steely, HT | 1 |
| DeSantis, L | 1 |
| Wu, CC | 1 |
| Hong, HJ | 1 |
| Chou, TC | 1 |
| Ding, YA | 1 |
| Yen, MH | 1 |
| Simon, OR | 1 |
| Powell, N | 1 |
| Davis, P | 1 |
| Gossell, M | 1 |
| Fujimoto, N | 2 |
| Zhao, C | 1 |
| Shichi, H | 1 |
| Knapp, J | 1 |
| Linck, B | 1 |
| Lüss, H | 1 |
| Müller, FU | 1 |
| Nacke, P | 1 |
| Vahlensieck, U | 1 |
| Schachter, D | 1 |
| Sang, JC | 1 |
| Kullo, IJ | 1 |
| Mozes, G | 1 |
| Schwartz, RS | 1 |
| Gloviczki, P | 1 |
| Crotty, TB | 1 |
| Barber, DA | 1 |
| Katusic, ZS | 1 |
| O'Brien, T | 1 |
| Masuda, H | 2 |
| Tamaoki, S | 1 |
| Goto, M | 1 |
| Ishida, A | 2 |
| Kamikawatoko, S | 2 |
| Tokoro, T | 2 |
| Azuma, H | 2 |
| Hamasaki, H | 1 |
| Sato, J | 1 |
| Wong, KK | 1 |
| Trim, N | 1 |
| Brooman, JE | 1 |
| Holden-Dye, L | 1 |
| Walker, RJ | 1 |
| Hanawa, T | 1 |
| Kimura, T | 1 |
| Coutts, AA | 1 |
| Pertwee, RG | 1 |
| Maréchal, G | 1 |
| Beckers-Bleukx, G | 1 |
| Taylor, MS | 1 |
| Gao, H | 1 |
| Gardner, JD | 2 |
| Benoit, JN | 1 |
| Yoshii, A | 1 |
| Iizuka, K | 1 |
| Dobashi, K | 1 |
| Horie, T | 1 |
| Harada, T | 1 |
| Nakazawa, T | 1 |
| Mori, M | 1 |
| Jerius, H | 1 |
| Bagwell, CA | 1 |
| Beall, A | 1 |
| Karolyi, D | 1 |
| Brophy, C | 1 |
| Fox, LE | 1 |
| Lloyd, PE | 1 |
| Kato, K | 1 |
| Furuya, K | 1 |
| Tsutsui, I | 1 |
| Ozaki, T | 1 |
| Yamagishi, S | 1 |
| Navegantes, LC | 1 |
| Resano, NM | 1 |
| Migliorini, RH | 1 |
| Kettelhut, IC | 1 |
| Schmidt, DT | 1 |
| Watson, N | 1 |
| Rühlmann, E | 1 |
| Branscheid, D | 1 |
| Hongo, K | 1 |
| Kusakari, Y | 1 |
| Kawai, M | 1 |
| Konishi, M | 1 |
| Kurihara, S | 1 |
| Mochizuki, S | 1 |
| Polson, JB | 1 |
| Krzanowski, JJ | 1 |
| Anderson, WH | 1 |
| Fitzpatrick, DF | 1 |
| Hwang, DP | 1 |
| Szentivanyi, A | 1 |
| Yoshino, H | 1 |
| Suzuki, R | 1 |
| Morley, GP | 1 |
| Neild, TO | 1 |
| Fujimoto, S | 1 |
| Matsuda, T | 2 |
| Reviriego, J | 1 |
| Alonso, MJ | 1 |
| Ibañez, C | 1 |
| Marín, J | 1 |
| Zhang, L | 1 |
| Jensen, RT | 2 |
| Maton, PN | 2 |
| Rinkema, LE | 1 |
| Roman, CR | 1 |
| Russell, WL | 1 |
| Spaethe, SM | 1 |
| Bemis, KG | 1 |
| Henry, DP | 1 |
| Marshall, WS | 1 |
| Fleisch, JH | 1 |
| Manzini, S | 1 |
| Meini, S | 1 |
| Giachetti, A | 1 |
| Beani, L | 1 |
| Borea, PA | 1 |
| Antonelli, T | 1 |
| Ballati, L | 1 |
| Bacciarelli, C | 1 |
| Heesen, BJ | 1 |
| De Mey, JG | 1 |
| Tsuru, H | 1 |
| Kohno, S | 1 |
| Matsubayashi, H | 1 |
| Matusak, O | 1 |
| Kuchel, O | 1 |
| Hamet, P | 1 |
| Abdel-Latif, AA | 1 |
| Zhang, YW | 1 |
| Rapoport, RM | 1 |
| Takata, Y | 1 |
| Kato, H | 1 |
| Yokoyama, K | 1 |
| Shintani, J | 1 |
| Yagasaki, O | 1 |
| Yanagiya, I | 1 |
| Orchard, I | 1 |
| Morita, T | 1 |
| Wheeler, MA | 1 |
| Miyagawa, I | 1 |
| Kondo, S | 1 |
| Weiss, RM | 1 |
| Tsujimoto, G | 2 |
| Lee, CH | 1 |
| Hoffman, BB | 2 |
| Van Inwegen, RG | 1 |
| Khandwala, A | 1 |
| Gordon, R | 1 |
| Sonnino, P | 1 |
| Coutts, S | 1 |
| Jolly, S | 1 |
| Nickols, GA | 1 |
| Cline, WH | 1 |
| Charette, L | 1 |
| Jones, TR | 1 |
| Yau, WM | 1 |
| Dorsett, JA | 1 |
| Youther, ML | 1 |
| Warbanow, W | 2 |
| Will-Shahab, L | 2 |
| Sutliff, VE | 1 |
| Zhou, ZC | 1 |
| Collins, SM | 1 |
| Evans, RL | 1 |
| McCrohan, CR | 1 |
| Butler, RD | 1 |
| Sebastião, AM | 1 |
| Ribeiro, JA | 1 |
| Iida, H | 1 |
| Page, E | 1 |
| Daugirdas, JT | 1 |
| Swanson, V | 1 |
| Islam, S | 1 |
| Nutting, C | 1 |
| Kim, DD | 1 |
| Wang, XA | 1 |
| Fiscus, RR | 1 |
| Goy, MF | 1 |
| Kravitz, EA | 1 |
| Asano, M | 1 |
| Masuzawa, K | 1 |
| Ishii, K | 1 |
| Murad, F | 1 |
| Madison, JM | 1 |
| Jones, CA | 1 |
| Sankary, RM | 1 |
| Brown, JK | 1 |
| Hughes, AD | 1 |
| Sever, PS | 1 |
| Koenig, SM | 1 |
| Mitchell, RW | 1 |
| Kelly, E | 1 |
| White, SR | 1 |
| Leff, AR | 1 |
| Popovich, KJ | 1 |
| Wanstall, JC | 1 |
| O'Donnell, SR | 1 |
| Zeng, XP | 1 |
| Mihara, S | 1 |
| Shigeri, Y | 1 |
| Fujimoto, M | 1 |
105 other studies available for 1-methyl-3-isobutylxanthine and Muscle Contraction
| Article | Year |
|---|---|
Glabridin Relaxes Vascular Smooth Muscles by Activating BK
Topics: 1-Methyl-3-isobutylxanthine; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endotheli | 2021 |
Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Triphosphate; Adenyly | 2017 |
Effects of chlorogenic acid on carbachol-induced contraction of mouse urinary bladder.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenylyl Cyclases; Anim | 2018 |
Increased spontaneous activity and reduced inotropic response to catecholamines in ventricular myocytes from footshock-stressed rats.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic Agents; Animals; Calcium; Dose-Response Relationship, Drug; | 2010 |
Inhibitory effect of caffeine on pacemaker activity in the oviduct is mediated by cAMP-regulated conductances.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; ATP-Binding Cassette Transporters; Biologic | 2011 |
Inhibition of phosphodiesterases relaxes detrusor smooth muscle via activation of the large-conductance voltage- and Ca²⁺-activated K⁺ channel.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Enzyme Inhibitors; Guinea Pigs; Large-Conductance Calcium-Acti | 2012 |
Constitutively active phosphodiesterase activity regulates urinary bladder smooth muscle function: critical role of KCa1.1 channel.
Topics: 1-Methyl-3-isobutylxanthine; Aged; Female; Humans; In Vitro Techniques; Indoles; Large-Conductance C | 2012 |
cAMP/protein kinase A activates cystic fibrosis transmembrane conductance regulator for ATP release from rat skeletal muscle during low pH or contractions.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Benzoates; Cell Line; Colforsin; Cycli | 2012 |
Effect of inhibitors of cyclic nucleotide phosphodiesterases on electrical and contractile activity of smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterase | 2002 |
Octopamine modulates spermathecal muscle contractions in Locusta migratoria.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Dose-Response Relationship, Drug; Electrophysiolog | 2003 |
Role of cyclic nucleotides in regulation of pulmonary artery tone in rabbits.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Dipyridamole; In Vitro Techniques; Iso | 2003 |
Modulation of beta2- and beta3-adrenoceptor-mediated relaxation of rat oesophagus smooth muscle by protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Dose-Response Relationship, Drug; Drug Synergism; Esophagus; E | 2004 |
Cyclic AMP-mediated inhibition of gallbladder contractility: role of K+ channel activation and Ca2+ signaling.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium Signaling; Cyclic AMP; Dose-Response Relationship, Dru | 2004 |
Modulation of the Ca2+ sensitivity of airway smooth muscle cells in murine lung slices.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arterioles; Bronchoconstrictor Agents; Caffeine; Calcium; Cent | 2006 |
Azithromycin has a direct relaxant effect on precontracted airway smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Anti-Bacterial Agents; Atropine; Azithromycin; Bronchodilator | 2006 |
Post- and pre-synaptic action of isotocin in the upper esophageal sphincter muscle of the eel: its role in water drinking.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Anesthetics, Loc | 2007 |
Ibudilast-induced decreases in cytosolic Ca(2+) level and contraction in rat aorta.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta, Thoracic; Calcium; Cyclic AMP; Cyclic GMP; Cytosol; Dos | 2007 |
Antispasmodic activity of licochalcone A, a species-specific ingredient of Glycyrrhiza inflata roots.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Chalcones; Dose-Response Relationship, Drug; Glycyrrhiza; In V | 2007 |
PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide | 2008 |
[Adenosine-3',5'-monophosphate content and muscle tension in isolated coronary arteries under the effect of lanthanum ions].
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cattle; Coronary Vessels; Cyclic AMP; In Vitro Techniques; Iso | 1984 |
Contraction of cultured rat glomerular cells of apparent mesangial origin after stimulation with angiotensin II and arginine vasopressin.
Topics: 1-Methyl-3-isobutylxanthine; Angiotensin II; Animals; Arginine Vasopressin; Cells, Cultured; Cyclic | 1980 |
Relaxation of bovine coronary arterial smooth muscle by cyclic GMP, cyclic AMP and analogs.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Cattle; Coronary Vessels; Cyclic AMP; Cyclic GM | 1980 |
Mode of action of coronary arterial relaxation by prostacyclin.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Cattle; Coronary Vessels; Cyclic AMP; Epopr | 1980 |
Relaxation of isolated gastric smooth muscle cells by vasoactive intestinal peptide.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Gastrointestinal Hormones; Guinea Pigs; In Vitro T | 1982 |
Dissociation between the effects of some xanthine derivatives on the tracheal smooth muscle and on the skeletal muscle.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Cyclic AMP; Dose-Response Relationsh | 1982 |
Species differences in behavioural effects of rolipram and other adenosine cyclic 3H, 5H-monophosphate phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Behavior, Anim | 1983 |
Parathyroid hormone (PTH) fragments relax the guinea-pig trachea in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Female; Guinea Pigs; Hydrogen Peroxide; Imidazoles; In Vitro T | 1983 |
[Action of adenosine 5'-triphosphate and effects of various purinergic receptor blocking agents on the movements of an isolated guinea pig gallbladder].
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Apamin; Atropine; Female; Gallbladder; | 1983 |
Effect of cyclic AMP, db-cyclic AMP and phosphodiesterase inhibitors on histamine inhibition of the contractile response of the mouse vas deferens.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cyclic AMP; Histamine; In Vitro Techniques; Male; | 1984 |
Relaxation of Mytilus catch muscle by 8-bromo-cyclic GMP and related compounds.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Bivalvia; Cyclic GMP; Egtazic Acid; Electric St | 1984 |
5-hydroxytryptamine-induced relaxation of neonatal porcine vena cava in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Cyclic AMP; Dinoprost; Histamine; Kinetics; | 1984 |
[Parathyroid hormone fragments relax guinea pig trachea in vitro].
Topics: 1-Methyl-3-isobutylxanthine; Animals; Female; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; | 1984 |
Serotonin and acetylcholine: further analysis of praziquantel-induced contraction of magnesium-paralysed Schistosoma mansoni.
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; Amifampridine; Animals; Arecoline; Carbachol; Colforsi | 1993 |
Relaxant mechanisms of cyclic AMP-increasing agents in porcine coronary artery.
Topics: 1-Methyl-3-isobutylxanthine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adr | 1994 |
Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Aged; Antihypertensive Agents; Carbachol; Colforsin; Cytosol; Di | 1994 |
Contribution of potassium channels to active hyperemia of the canine diaphragm.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Apamin; Blood Gas Analysis; Diaphragm; Dogs; Electric Stimulat | 1994 |
Prevention by phosphodiesterase inhibitors of antigen-induced contraction of guinea-pig colonic smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterase | 1994 |
Effects of proctolin on contractions, membrane resistance, and non-voltage-dependent sarcolemmal ion channels in crustacean muscle fibers.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cell Membrane; Crustacea; Cyclic AMP; Cyclic AMP- | 1995 |
Potentiation of P1075-induced K+ channel opening by stimulation of adenylate cyclase in rat isolated aorta.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Aorta; Binding, Competitive; Bucladesine; C | 1995 |
Adenosine inhibits efferent function of extrinsic capsaicin-sensitive sensory nerves in the enteric nervous system.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Adenosine; Animals; Capsaicin; Electric Stimulation; Ele | 1993 |
Effect of calcitonin gene-related peptide on cytosolic free Ca2+ level in vascular smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta, Thoracic; Bucladesine; Calcitonin Gene-Related Peptide; | 1993 |
Positive inotropic effects of the calcium sensitizer CGP 48506 in guinea pig myocardium.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Azocines; Cardiotonic Agents; Dose-Response Relationship, Drug | 1996 |
Positive inotropic effects of the calcium sensitizer CGP 48506 in failing human myocardium.
Topics: 1-Methyl-3-isobutylxanthine; Azocines; Calcium; Carbachol; Cardiotonic Agents; Dose-Response Relatio | 1996 |
Presence of functional type B natriuretic peptide receptor in human ocular cells.
Topics: 1-Methyl-3-isobutylxanthine; Atrial Natriuretic Factor; Calcium; Carbachol; Cell Line, Transformed; | 1996 |
Evidence for inducible nitric oxide synthase in spontaneously hypertensive rats.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Aorta, Thoracic; Arginine; Blood Pressure; Cycl | 1996 |
Evidence that guanylate cyclase is involved in modulating the resting tension and neurally-induced contraction of the guinea pig tracheal muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic GMP; Electric Stimulation; Guanylate Cyclase; Guinea Pi | 1996 |
The effects of prostaglandins E2 and F2 alpha on porcine ciliary muscle cells in culture.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Bucladesine; Cells, Cultured; Ciliary Body; | 1995 |
The effect of the protein phosphatases inhibitor cantharidin on beta-adrenoceptor-mediated vasorelaxation.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Cantharidin; Cattle; Cells, Cultured | 1997 |
Regional differentiation in the rat aorta: effects of cyclooxygenase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Animals; Aorta, Abdominal; Aorta, Thoracic; Aspir | 1997 |
Effects of various selective phosphodiesterase inhibitors on muscle contractility in guinea pig ileal longitudinal smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Carbachol; Cell Membrane Permeability; Cyclic AMP; Cy | 1997 |
Adventitial gene transfer of recombinant endothelial nitric oxide synthase to rabbit carotid arteries alters vascular reactivity.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Animals; beta-Galactosidase; Calcimycin; Calcium; | 1997 |
Nitric oxide-induced ciliary muscle relaxation during contraction with endothelin-1 is mediated through elevation of cyclic GMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cattle; Ciliary Body; Cyclic GMP; Drug Combinations; Endotheli | 1997 |
Nitric oxide relaxes bovine ciliary muscle contracted by carbachol through elevation of cyclic GMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Carbachol; Cattle; Cil | 1998 |
Drug induced contraction and relaxation in mouse isolated aorta.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta | 1997 |
The role of cAMP in the actions of the peptide AF3 in the parasitic nematodes Ascaris suum and Ascaridia galli.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Ascaridia; Ascaris suum; Colforsin; Cyclic AMP; | 1998 |
Effect of cAMP- and cGMP-related drugs on porcine cultured ciliary muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antihypertensive Agents; Bucladesine; Carbachol; Cells, Cultur | 1998 |
Evidence that cannabinoid-induced inhibition of electrically evoked contractions of the myenteric plexus--longitudinal muscle preparation of guinea-pig small intestine can be modulated by Ca2+ and cAMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylate Cyclase Toxin; Animal | 1998 |
Effect of nitric oxide on the maximal velocity of shortening of a mouse skeletal muscle.
Topics: 1-Methyl-3-isobutylxanthine; Aminoquinolines; Animals; Biomechanical Phenomena; Cyclic GMP; Enzyme I | 1998 |
Effects of IBMX on norepinephrine-induced vasoconstriction in small mesenteric arteries.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifl | 1999 |
Relaxation of contracted rabbit tracheal and human bronchial smooth muscle by Y-27632 through inhibition of Ca2+ sensitization.
Topics: 1-Methyl-3-isobutylxanthine; Amides; Animals; Bronchi; Calcium; Carbachol; Cholinergic Agents; Deter | 1999 |
Vascular smooth muscle mechanics in isolated perfused segments of carotid arteries.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Biomechanical Phenomena; Carotid Arteries; Catt | 2000 |
Role of cAMP in the short-term modulation of a neuromuscular system in aplysia.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Animals; Aplysia; Colforsin; Cyclic AMP; C | 2000 |
Cyclic AMP-mediated inhibition of noradrenaline-induced contraction and Ca2+ influx in guinea-pig vas deferens.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Calcium; Calcium Channel Blockers; Colforsin; Cyclic | 2000 |
Role of adrenoceptors and cAMP on the catecholamine-induced inhibition of proteolysis in rat skeletal muscle.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic alpha-Ant | 2000 |
The effect of selective and non-selective phosphodiesterase inhibitors on allergen- and leukotriene C(4)-induced contractions in passively sensitized human airways.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Antigens, Dermatophagoides; Benzam | 2000 |
Use of tetanus to investigate myofibrillar responsiveness to Ca(2+) in isolated mouse ventricular myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Calcium; Calcium-Transporting ATPase | 2002 |
Analysis of the relationship between pharmacological inhibition of cyclic nucleotide phosphodiesterase and relaxation of canine tracheal smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterase | 1979 |
Effect of phosphodiesterase inhibitors on bovine ciliary muscle and outflow facility.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Aqueous Humor; Caffeine; Cattle; Cil | 1992 |
Response of the rat tail artery to prolonged exposure to noradrenaline.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arteries; Colforsin; Female; In Vitro Techniques; Male; Muscle | 1990 |
Effects of pimobendan, a cardiotonic and vasodilating agent with phosphodiesterase inhibiting properties, on isolated arteries and veins of rats.
Topics: 1-Methyl-3-isobutylxanthine; Aminophylline; Animals; Arteries; Cardiotonic Agents; Colforsin; Drug I | 1990 |
Action of adenosine and characterization of adenosine receptors in human placental vasculature.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Blood Vessels; Bucladesin | 1990 |
Characterization of beta-adrenoreceptors on smooth muscle cells from guinea pig stomach.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Binding, Competitive; Carbachol; Cyclic AMP; Epinephrine; Guin | 1990 |
Leukotriene receptor antagonism and augmentation of beta-receptor-mediated events by LY171883.
Topics: 1-Methyl-3-isobutylxanthine; Acetophenones; Adrenergic beta-Agonists; Animals; Bronchodilator Agents | 1990 |
Pharmacodynamic profile of isbufylline, a new antibronchospastic xanthine devoid of central excitatory actions.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Anticonvulsants; Blood Pressure; Brain Chemistry; Bronchial Sp | 1990 |
Effects of cyclic AMP-affecting agents on contractile reactivity of isolated mesenteric and renal resistance arteries of the rat.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Arteries; Buclades | 1990 |
Relaxation response of isolated canine veins to agents that act on the adenylate cyclase-cyclic AMP system: further investigation.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenergic alpha-Agonists; Animals; Colforsin; Cycli | 1990 |
Effect of atrial natriuretic factor and 8-bromo cyclic guanosine 3':5'-monophosphate on [3H]acetylcholine outflow from myenteric-plexus longitudinal muscle of the guinea pig.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Atrial Natriuretic Factor; Cyclic GMP; Guinea P | 1991 |
Effects of surgical sympathetic denervation on myo-inositol trisphosphate production and contraction in the dilator and sphincter smooth muscles of the rabbit iris: evidence for interaction between the cyclic AMP and calcium signaling systems.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Carbachol; Cyclic AMP; Female; Inositol 1,4,5-Trispho | 1991 |
Inhibitory effects of cyclic AMP-elevating agents on norepinephrine-induced phosphatidylinositide hydrolysis and contraction in rat aorta.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Buclades | 1991 |
Effects of Ca antagonists on the norepinephrine release and contractile responses of isolated canine saphenous veins to high KCl.
Topics: 1-Methyl-3-isobutylxanthine; Anesthetics, Local; Animals; Calcium Channel Blockers; Diltiazem; Dogs; | 1985 |
Effects of adenylate cyclase inhibitors, phosphodiesterase inhibitors, and dibutyryl cyclic AMP on spontaneous and various stimuli-induced acetylcholine release from guinea pig ileum myenteric plexus.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Adenylyl Cyclase Inhibitors; Animals; Bucladesine; Guine | 1985 |
Identified octopaminergic neurons modulate contractions of locust visceral muscle via adenosine 3',5'-monophosphate (cyclic AMP).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biogenic Amines; Colforsin; Cyclic AMP; Female; Grasshoppers; | 1986 |
5-Carboxamidotryptamine: a potent agonist mediating relaxation and elevation of cyclic AMP in the isolated neonatal porcine vena cava.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Atropine; Cimetidine; Cocaine; Cyclic AMP; D | 1986 |
Effects of forskolin on contractility and cyclic AMP levels in rabbit detrusor muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; In Vitro Techniques; Muscle Contraction | 1986 |
Age-related decrease in beta adrenergic receptor-mediated vascular smooth muscle relaxation.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcholine; Aging; B | 1986 |
REV 5901: an orally effective peptidoleukotriene antagonist, detailed biochemical/pharmacological profile.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Chromones; Coronary Circulation; Dose-Response Relationship, D | 1987 |
Parathyroid hormone-induced changes in cyclic nucleotide levels during relaxation of the rabbit [correction of rat] aorta.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta, Thoracic; Colforsin; Cyclic AMP; Cyclic GMP; In Vitro T | 1987 |
Effects of L-serine borate on antagonism of leukotriene C4-induced contractions of guinea-pig trachea.
Topics: 1-Methyl-3-isobutylxanthine; Albuterol; Animals; Borates; Bucladesine; Guinea Pigs; In Vitro Techniq | 1987 |
Stimulation of acetylcholine release from myenteric neurons of guinea pig small intestine by forskolin and cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Animals; Buclade | 1987 |
Decreased contractile response after exposure of the rat aorta to Db cAMP or IBMX.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifl | 1987 |
Characterization of receptors for calcitonin gene-related peptide on gastric smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcitonin; Calcitonin Gene-Related Peptide; Carbachol; Cells, | 1988 |
Altered effect of BAY K 8644 after exposure of the rat aorta to IBMX or Db cAMP.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifl | 1988 |
Tentacle contraction in Heliophrya erhardi (Suctoria): the role of inositol phospholipid metabolites and cyclic nucleotides in stimulus-response coupling.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Chlorides; Ciliophora; Cyclic AMP; Cyclic GMP; Di | 1988 |
On the adenosine receptor and adenosine inactivation at the rat diaphragm neuromuscular junction.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Animals; Diaphragm; Evoked Potentials; Fe | 1988 |
Inhibition of atrial natriuretic peptide secretion by forskolin in noncontracting cultured atrial myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Atrial Natriuretic Factor; Bucladesine; Calcium; Cel | 1988 |
Acetate causes endothelium-independent increases in cyclic AMP in rat caudal artery.
Topics: 1-Methyl-3-isobutylxanthine; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisot | 1988 |
Cyclic AMP only partially mediates the actions of serotonin at lobster neuromuscular junctions.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Cyclic AMP; | 1989 |
Role of stimulatory GTP-binding protein (Gs) in reduced beta-adrenoceptor coupling in the femoral artery of spontaneously hypertensive rats.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Antagonists; Animals; Bucladesine; Cholera Toxin; Colf | 1988 |
ANP relaxes bovine tracheal smooth muscle and increases cGMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Carbachol; Cattle; Cyclic AMP; Cycl | 1989 |
Differential effects of prostaglandin E2 on contractions of airway smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Atropine; Carbachol; Dimethylphenylpiperazinium | 1989 |
Action of fenoldopam, a selective dopamine (DA1) receptor agonist, on isolated human arteries.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Aged; Aged, 80 and over; Arteries; Benzazepines; But | 1989 |
Beta-adrenergic relaxation of dog trachealis: contractile agonist-specific interaction.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Adrenergic beta-Agonists; Animals; Bucladesine; Colforsi | 1989 |
Age-dependence of the effects of pinacidil on rat aorta.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Aorta, Thoracic; Guanidines; In Vitro Techniques; Male; | 1989 |
Neuropeptide Y-induced intracellular Ca2+ increases in vascular smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Angiotensin II; Animals; Bradykinin; Calcium; Cells, Cultured; Colforsi | 1989 |
Desensitization of beta-adrenergic receptor-mediated vascular smooth muscle relaxation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Catecholamines; Cyclic AMP; Epinephrine; In Vitro Techniques; | 1985 |