1-methyl-3-isobutylxanthine has been researched along with Melanoma in 22 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Luteolin was gamma irradiated at doses of 0, 15, 30, 50, 70, and 100 kGy." | 5.46 | Gamma-Irradiated Luteolin Inhibits 3-Isobutyl-1-Methylxanthine-Induced Melanogenesis Through the Regulation of CREB/MITF, PI3K/Akt, and ERK Pathways in B16BL6 Melanoma Cells. ( Byun, EB; Byun, EH; Jang, BS; Kang, JA; Kim, HM; Mushtaq, S; Song, HY; Sung, NY; Yang, MS, 2017) |
| " In the present study, piperlonguminine from Piper longum was discovered to inhibit melanin production in melanoma B16 cells stimulated with alpha-melanocyte stimulating hormone (alpha-MSH), 3-isobutyl-1-methylxanthine or protoporphyrin IX, where the compound exhibited stronger depigmenting efficacy than kojic acid." | 3.73 | Inhibitory effect of piperlonguminine on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression. ( Eom, SY; Kim, JA; Kim, KS; Kim, Y; Lee, SH; Min, KR, 2006) |
| "Luteolin was gamma irradiated at doses of 0, 15, 30, 50, 70, and 100 kGy." | 1.46 | Gamma-Irradiated Luteolin Inhibits 3-Isobutyl-1-Methylxanthine-Induced Melanogenesis Through the Regulation of CREB/MITF, PI3K/Akt, and ERK Pathways in B16BL6 Melanoma Cells. ( Byun, EB; Byun, EH; Jang, BS; Kang, JA; Kim, HM; Mushtaq, S; Song, HY; Sung, NY; Yang, MS, 2017) |
| " alpha-MSH peptides were found to inhibit the stimulated GPx activity and had biphasic dose-response curves." | 1.31 | Alpha-melanocyte-stimulating hormone reduces impact of proinflammatory cytokine and peroxide-generated oxidative stress on keratinocyte and melanoma cell lines. ( Cartledge, S; Ghanem, G; Haycock, JW; MacNeil, S; Morandini, R; Rennie, IG; Rowe, SJ; Wyatt, A, 2000) |
| "Clin." | 1.30 | Upregulation of mRNA for the melanocortin-1 receptor but not for melanogenic proteins in macrophage x melanoma fusion hybrids exhibiting increased melanogenic and metastatic potential. ( Bhattacharya, M; Chakraborty, AK; Funasaka, Y; Ichihashi, M; Pawelek, J; Sodi, S, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (22.73) | 18.7374 |
| 1990's | 9 (40.91) | 18.2507 |
| 2000's | 5 (22.73) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Byun, EB | 1 |
| Song, HY | 1 |
| Mushtaq, S | 1 |
| Kim, HM | 1 |
| Kang, JA | 1 |
| Yang, MS | 1 |
| Sung, NY | 1 |
| Jang, BS | 1 |
| Byun, EH | 1 |
| Lee, WR | 1 |
| Shen, SC | 1 |
| Wu, PR | 1 |
| Chou, CL | 1 |
| Shih, YH | 1 |
| Yeh, CM | 1 |
| Yeh, KT | 1 |
| Jiang, MC | 1 |
| Lissitzky, JC | 1 |
| Parriaux, D | 1 |
| Ristorcelli, E | 1 |
| Vérine, A | 1 |
| Lombardo, D | 1 |
| Verrando, P | 1 |
| Hoshino, T | 1 |
| Matsuda, M | 1 |
| Yamashita, Y | 1 |
| Takehara, M | 1 |
| Fukuya, M | 1 |
| Mineda, K | 1 |
| Maji, D | 1 |
| Ihn, H | 1 |
| Adachi, H | 1 |
| Sobue, G | 1 |
| Funasaka, Y | 2 |
| Mizushima, T | 1 |
| Kim, KS | 1 |
| Kim, JA | 1 |
| Eom, SY | 1 |
| Lee, SH | 1 |
| Min, KR | 1 |
| Kim, Y | 1 |
| Lv, N | 1 |
| Koo, JH | 1 |
| Yoon, HY | 1 |
| Yu, J | 1 |
| Kim, KA | 1 |
| Choi, IW | 1 |
| Kwon, KB | 1 |
| Kwon, KS | 1 |
| Kim, HU | 1 |
| Park, JW | 1 |
| Park, BH | 1 |
| Halaban, R | 3 |
| Pomerantz, SH | 1 |
| Marshall, S | 1 |
| Lerner, AB | 2 |
| Schallreuter, KU | 1 |
| Lemke, KR | 1 |
| Hill, HZ | 2 |
| Wood, JM | 1 |
| Carsberg, CJ | 1 |
| Warenius, HM | 1 |
| Friedmann, PS | 2 |
| Smit, N | 1 |
| Tilgmann, C | 1 |
| Karhunen, T | 1 |
| Slingerland, R | 1 |
| Ulmanen, I | 1 |
| Westerhof, W | 1 |
| Pavel, S | 1 |
| Joshi-Barve, SS | 1 |
| Rangnekar, VV | 1 |
| Sells, SF | 1 |
| Rangnekar, VM | 1 |
| Li, W | 1 |
| Hedley, SJ | 1 |
| Gawkrodger, DJ | 1 |
| Weetman, AP | 1 |
| Morandini, R | 2 |
| Boeynaems, JM | 1 |
| Ghanem, G | 2 |
| Neil, SM | 1 |
| Chakraborty, AK | 1 |
| Ichihashi, M | 1 |
| Sodi, S | 1 |
| Bhattacharya, M | 1 |
| Pawelek, J | 1 |
| Haycock, JW | 1 |
| Rowe, SJ | 1 |
| Cartledge, S | 1 |
| Wyatt, A | 1 |
| Rennie, IG | 1 |
| MacNeil, S | 2 |
| Lang, R | 1 |
| Berger, A | 1 |
| Hermann, A | 1 |
| Kofler, B | 1 |
| Wren, F | 1 |
| Buffey, J | 1 |
| Naeyaert, JM | 1 |
| Eller, M | 1 |
| Gordon, PR | 1 |
| Park, HY | 1 |
| Gilchrest, BA | 1 |
| Ghosh, S | 1 |
| Duray, P | 1 |
| Kirkwood, JM | 1 |
| Abdel-Malek, ZA | 2 |
| Swope, VB | 2 |
| Amornsiripanitch, N | 1 |
| Nordlund, JJ | 2 |
| Kwon, BS | 1 |
| Kim, GS | 1 |
| Usack, L | 1 |
| Pomerantz, S | 1 |
| Haq, AK | 1 |
| Sauder, DN | 1 |
22 other studies available for 1-methyl-3-isobutylxanthine and Melanoma
| Article | Year |
|---|---|
Gamma-Irradiated Luteolin Inhibits 3-Isobutyl-1-Methylxanthine-Induced Melanogenesis Through the Regulation of CREB/MITF, PI3K/Akt, and ERK Pathways in B16BL6 Melanoma Cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line, Tumor; CREB-Binding Protein; Extracellular Signal-R | 2017 |
CSE1L Links cAMP/PKA and Ras/ERK pathways and regulates the expressions and phosphorylations of ERK1/2, CREB, and MITF in melanoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Aged; Aged, 80 and over; Animals; Cell Line, Tumor; Cellular Apoptosis | 2016 |
Cyclic AMP signaling as a mediator of vasculogenic mimicry in aggressive human melanoma cells in vitro.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Cell Line, Tumor; Colforsin; Cyclic AMP; Guanine Nucleotide | 2009 |
Suppression of melanin production by expression of HSP70.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line, Tumor; Cyclic AMP; Gene Expression Regulation; HSP7 | 2010 |
Inhibitory effect of piperlonguminine on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Animals; Cell Line, Tumor; Cell Proliferation; Cyclic AMP Re | 2006 |
Effect of Angelica gigas extract on melanogenesis in B16 melanoma cells.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Animals; Apiaceae; Cell Death; Colforsin; Gene Expression Re | 2007 |
Tyrosinase activity and abundance in Cloudman melanoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Catechol Oxidase; Cell Line; Chemical Precipitati | 1984 |
Thioredoxin reductase induction coincides with melanin biosynthesis in brown and black guinea pigs and in murine melanoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Catalase; Enzyme Induction; Female; Glutathione Reductase; Gui | 1994 |
Ultraviolet radiation-induced melanogenesis in human melanocytes. Effects of modulating protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Diglycerides; Enzyme Induction; Humans; Indoles; In | 1994 |
O-methylation of L-dopa in melanin metabolism and the presence of catechol-O-methyltransferase in melanocytes.
Topics: 1-Methyl-3-isobutylxanthine; Catechol O-Methyltransferase; Cells, Cultured; Humans; Isoenzymes; Levo | 1994 |
Interleukin-1-inducible expression of gro-beta via NF-kappa B activation is dependent upon tyrosine kinase signaling.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Cell Line; Chemokine CXCL1; Chemokines, CXC; Ch | 1993 |
Induced melanin reduces mutations and cell killing in mouse melanoma.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Animals; DNA Damage; Melanoma; Melatonin; Mice; Mutation; Tu | 1997 |
alpha-Melanocyte stimulating hormone inhibits tumour necrosis factor-alpha stimulated intercellular adhesion molecule-1 expression in normal cutaneous human melanocytes and in melanoma cell lines.
Topics: 1-Methyl-3-isobutylxanthine; Adult; alpha-MSH; Cell Culture Techniques; Colforsin; Culture Media, Co | 1998 |
Upregulation of mRNA for the melanocortin-1 receptor but not for melanogenic proteins in macrophage x melanoma fusion hybrids exhibiting increased melanogenic and metastatic potential.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Fusion; Humans; Hybridomas; Macrophages, Peritoneal; Mela | 1999 |
Alpha-melanocyte-stimulating hormone reduces impact of proinflammatory cytokine and peroxide-generated oxidative stress on keratinocyte and melanoma cell lines.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Colforsin; Cytokines; Enzyme Activation; Enzyme Inhibitors; | 2000 |
Biphasic response to human galanin of extracellular acidification in human Bowes melanoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Acids; Amiloride; Cell Line; Colforsin; Dose-Response Relationship, Dru | 2001 |
Alpha-MSH causes a small rise in cAMP but has no effect on basal or ultraviolet-stimulated melanogenesis in human melanocytes.
Topics: 1-Methyl-3-isobutylxanthine; Child; Child, Preschool; Colforsin; Cyclic AMP; Humans; Male; Melanins; | 1990 |
Pigment content of cultured human melanocytes does not correlate with tyrosinase message level.
Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cells, Cultured; Gene Expression; Humans; Melanins; Melanocy | 1991 |
Human melanocytes cultured from nevi and melanomas.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Aged; Cell Division; Cell Separation; Cells, Cultured; Child; Ch | 1986 |
In vitro modulation of proliferation and melanization of S91 melanoma cells by prostaglandins.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Bucladesine; Cell Division; Cycloheximide; Dactinomycin; D | 1987 |
A melanocyte-specific complementary DNA clone whose expression is inducible by melanotropin and isobutylmethyl xanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antibodies, Monoclonal; Catechol Oxidase; DNA; Gene Expression | 1987 |
A new role for epidermal cell-derived thymocyte activating factor/IL-1 as an antagonist for distinct epidermal cell function.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Alprostadil; Animals; Cell Line; Colony-Stimulating Factors; | 1989 |