1-methyl-3-isobutylxanthine has been researched along with Malignant Melanoma in 22 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Luteolin was gamma irradiated at doses of 0, 15, 30, 50, 70, and 100 kGy." | 5.46 | Gamma-Irradiated Luteolin Inhibits 3-Isobutyl-1-Methylxanthine-Induced Melanogenesis Through the Regulation of CREB/MITF, PI3K/Akt, and ERK Pathways in B16BL6 Melanoma Cells. ( Byun, EB; Byun, EH; Jang, BS; Kang, JA; Kim, HM; Mushtaq, S; Song, HY; Sung, NY; Yang, MS, 2017) |
| " In the present study, piperlonguminine from Piper longum was discovered to inhibit melanin production in melanoma B16 cells stimulated with alpha-melanocyte stimulating hormone (alpha-MSH), 3-isobutyl-1-methylxanthine or protoporphyrin IX, where the compound exhibited stronger depigmenting efficacy than kojic acid." | 3.73 | Inhibitory effect of piperlonguminine on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression. ( Eom, SY; Kim, JA; Kim, KS; Kim, Y; Lee, SH; Min, KR, 2006) |
| "Luteolin was gamma irradiated at doses of 0, 15, 30, 50, 70, and 100 kGy." | 1.46 | Gamma-Irradiated Luteolin Inhibits 3-Isobutyl-1-Methylxanthine-Induced Melanogenesis Through the Regulation of CREB/MITF, PI3K/Akt, and ERK Pathways in B16BL6 Melanoma Cells. ( Byun, EB; Byun, EH; Jang, BS; Kang, JA; Kim, HM; Mushtaq, S; Song, HY; Sung, NY; Yang, MS, 2017) |
| " alpha-MSH peptides were found to inhibit the stimulated GPx activity and had biphasic dose-response curves." | 1.31 | Alpha-melanocyte-stimulating hormone reduces impact of proinflammatory cytokine and peroxide-generated oxidative stress on keratinocyte and melanoma cell lines. ( Cartledge, S; Ghanem, G; Haycock, JW; MacNeil, S; Morandini, R; Rennie, IG; Rowe, SJ; Wyatt, A, 2000) |
| "Clin." | 1.30 | Upregulation of mRNA for the melanocortin-1 receptor but not for melanogenic proteins in macrophage x melanoma fusion hybrids exhibiting increased melanogenic and metastatic potential. ( Bhattacharya, M; Chakraborty, AK; Funasaka, Y; Ichihashi, M; Pawelek, J; Sodi, S, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (22.73) | 18.7374 |
| 1990's | 9 (40.91) | 18.2507 |
| 2000's | 5 (22.73) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Byun, EB | 1 |
| Song, HY | 1 |
| Mushtaq, S | 1 |
| Kim, HM | 1 |
| Kang, JA | 1 |
| Yang, MS | 1 |
| Sung, NY | 1 |
| Jang, BS | 1 |
| Byun, EH | 1 |
| Lee, WR | 1 |
| Shen, SC | 1 |
| Wu, PR | 1 |
| Chou, CL | 1 |
| Shih, YH | 1 |
| Yeh, CM | 1 |
| Yeh, KT | 1 |
| Jiang, MC | 1 |
| Lissitzky, JC | 1 |
| Parriaux, D | 1 |
| Ristorcelli, E | 1 |
| Vérine, A | 1 |
| Lombardo, D | 1 |
| Verrando, P | 1 |
| Hoshino, T | 1 |
| Matsuda, M | 1 |
| Yamashita, Y | 1 |
| Takehara, M | 1 |
| Fukuya, M | 1 |
| Mineda, K | 1 |
| Maji, D | 1 |
| Ihn, H | 1 |
| Adachi, H | 1 |
| Sobue, G | 1 |
| Funasaka, Y | 2 |
| Mizushima, T | 1 |
| Kim, KS | 1 |
| Kim, JA | 1 |
| Eom, SY | 1 |
| Lee, SH | 1 |
| Min, KR | 1 |
| Kim, Y | 1 |
| Lv, N | 1 |
| Koo, JH | 1 |
| Yoon, HY | 1 |
| Yu, J | 1 |
| Kim, KA | 1 |
| Choi, IW | 1 |
| Kwon, KB | 1 |
| Kwon, KS | 1 |
| Kim, HU | 1 |
| Park, JW | 1 |
| Park, BH | 1 |
| Halaban, R | 3 |
| Pomerantz, SH | 1 |
| Marshall, S | 1 |
| Lerner, AB | 2 |
| Schallreuter, KU | 1 |
| Lemke, KR | 1 |
| Hill, HZ | 2 |
| Wood, JM | 1 |
| Carsberg, CJ | 1 |
| Warenius, HM | 1 |
| Friedmann, PS | 2 |
| Smit, N | 1 |
| Tilgmann, C | 1 |
| Karhunen, T | 1 |
| Slingerland, R | 1 |
| Ulmanen, I | 1 |
| Westerhof, W | 1 |
| Pavel, S | 1 |
| Joshi-Barve, SS | 1 |
| Rangnekar, VV | 1 |
| Sells, SF | 1 |
| Rangnekar, VM | 1 |
| Li, W | 1 |
| Hedley, SJ | 1 |
| Gawkrodger, DJ | 1 |
| Weetman, AP | 1 |
| Morandini, R | 2 |
| Boeynaems, JM | 1 |
| Ghanem, G | 2 |
| Neil, SM | 1 |
| Chakraborty, AK | 1 |
| Ichihashi, M | 1 |
| Sodi, S | 1 |
| Bhattacharya, M | 1 |
| Pawelek, J | 1 |
| Haycock, JW | 1 |
| Rowe, SJ | 1 |
| Cartledge, S | 1 |
| Wyatt, A | 1 |
| Rennie, IG | 1 |
| MacNeil, S | 2 |
| Lang, R | 1 |
| Berger, A | 1 |
| Hermann, A | 1 |
| Kofler, B | 1 |
| Wren, F | 1 |
| Buffey, J | 1 |
| Naeyaert, JM | 1 |
| Eller, M | 1 |
| Gordon, PR | 1 |
| Park, HY | 1 |
| Gilchrest, BA | 1 |
| Ghosh, S | 1 |
| Duray, P | 1 |
| Kirkwood, JM | 1 |
| Abdel-Malek, ZA | 2 |
| Swope, VB | 2 |
| Amornsiripanitch, N | 1 |
| Nordlund, JJ | 2 |
| Kwon, BS | 1 |
| Kim, GS | 1 |
| Usack, L | 1 |
| Pomerantz, S | 1 |
| Haq, AK | 1 |
| Sauder, DN | 1 |
22 other studies available for 1-methyl-3-isobutylxanthine and Malignant Melanoma
| Article | Year |
|---|---|
Gamma-Irradiated Luteolin Inhibits 3-Isobutyl-1-Methylxanthine-Induced Melanogenesis Through the Regulation of CREB/MITF, PI3K/Akt, and ERK Pathways in B16BL6 Melanoma Cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line, Tumor; CREB-Binding Protein; Extracellular Signal-R | 2017 |
CSE1L Links cAMP/PKA and Ras/ERK pathways and regulates the expressions and phosphorylations of ERK1/2, CREB, and MITF in melanoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Aged; Aged, 80 and over; Animals; Cell Line, Tumor; Cellular Apoptosis | 2016 |
Cyclic AMP signaling as a mediator of vasculogenic mimicry in aggressive human melanoma cells in vitro.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Cell Line, Tumor; Colforsin; Cyclic AMP; Guanine Nucleotide | 2009 |
Suppression of melanin production by expression of HSP70.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line, Tumor; Cyclic AMP; Gene Expression Regulation; HSP7 | 2010 |
Inhibitory effect of piperlonguminine on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Animals; Cell Line, Tumor; Cell Proliferation; Cyclic AMP Re | 2006 |
Effect of Angelica gigas extract on melanogenesis in B16 melanoma cells.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Animals; Apiaceae; Cell Death; Colforsin; Gene Expression Re | 2007 |
Tyrosinase activity and abundance in Cloudman melanoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Catechol Oxidase; Cell Line; Chemical Precipitati | 1984 |
Thioredoxin reductase induction coincides with melanin biosynthesis in brown and black guinea pigs and in murine melanoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Catalase; Enzyme Induction; Female; Glutathione Reductase; Gui | 1994 |
Ultraviolet radiation-induced melanogenesis in human melanocytes. Effects of modulating protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Diglycerides; Enzyme Induction; Humans; Indoles; In | 1994 |
O-methylation of L-dopa in melanin metabolism and the presence of catechol-O-methyltransferase in melanocytes.
Topics: 1-Methyl-3-isobutylxanthine; Catechol O-Methyltransferase; Cells, Cultured; Humans; Isoenzymes; Levo | 1994 |
Interleukin-1-inducible expression of gro-beta via NF-kappa B activation is dependent upon tyrosine kinase signaling.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Cell Line; Chemokine CXCL1; Chemokines, CXC; Ch | 1993 |
Induced melanin reduces mutations and cell killing in mouse melanoma.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Animals; DNA Damage; Melanoma; Melatonin; Mice; Mutation; Tu | 1997 |
alpha-Melanocyte stimulating hormone inhibits tumour necrosis factor-alpha stimulated intercellular adhesion molecule-1 expression in normal cutaneous human melanocytes and in melanoma cell lines.
Topics: 1-Methyl-3-isobutylxanthine; Adult; alpha-MSH; Cell Culture Techniques; Colforsin; Culture Media, Co | 1998 |
Upregulation of mRNA for the melanocortin-1 receptor but not for melanogenic proteins in macrophage x melanoma fusion hybrids exhibiting increased melanogenic and metastatic potential.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Fusion; Humans; Hybridomas; Macrophages, Peritoneal; Mela | 1999 |
Alpha-melanocyte-stimulating hormone reduces impact of proinflammatory cytokine and peroxide-generated oxidative stress on keratinocyte and melanoma cell lines.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Colforsin; Cytokines; Enzyme Activation; Enzyme Inhibitors; | 2000 |
Biphasic response to human galanin of extracellular acidification in human Bowes melanoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Acids; Amiloride; Cell Line; Colforsin; Dose-Response Relationship, Dru | 2001 |
Alpha-MSH causes a small rise in cAMP but has no effect on basal or ultraviolet-stimulated melanogenesis in human melanocytes.
Topics: 1-Methyl-3-isobutylxanthine; Child; Child, Preschool; Colforsin; Cyclic AMP; Humans; Male; Melanins; | 1990 |
Pigment content of cultured human melanocytes does not correlate with tyrosinase message level.
Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cells, Cultured; Gene Expression; Humans; Melanins; Melanocy | 1991 |
Human melanocytes cultured from nevi and melanomas.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Aged; Cell Division; Cell Separation; Cells, Cultured; Child; Ch | 1986 |
In vitro modulation of proliferation and melanization of S91 melanoma cells by prostaglandins.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Bucladesine; Cell Division; Cycloheximide; Dactinomycin; D | 1987 |
A melanocyte-specific complementary DNA clone whose expression is inducible by melanotropin and isobutylmethyl xanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antibodies, Monoclonal; Catechol Oxidase; DNA; Gene Expression | 1987 |
A new role for epidermal cell-derived thymocyte activating factor/IL-1 as an antagonist for distinct epidermal cell function.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Alprostadil; Animals; Cell Line; Colony-Stimulating Factors; | 1989 |