Compounds > 1-methyl-3-isobutylxanthine
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1-methyl-3-isobutylxanthine and Lung Neoplasms

1-methyl-3-isobutylxanthine has been researched along with Lung Neoplasms in 16 studies

1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.

Lung Neoplasms: Tumors or cancer of the LUNG.

Research Excerpts

ExcerptRelevanceReference
"Pre-treatment with motapizone, RP73401, rolipram or the methylxanthine adenosine receptor antagonist, 8-phenyltheophylline, did not significantly decrease responses to either allergen or LTC(4)."1.31The effect of selective and non-selective phosphodiesterase inhibitors on allergen- and leukotriene C(4)-induced contractions in passively sensitized human airways. ( Branscheid, D; Dent, G; Magnussen, H; Rabe, KF; Rühlmann, E; Schmidt, DT; Watson, N, 2000)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19903 (18.75)18.7374
1990's10 (62.50)18.2507
2000's2 (12.50)29.6817
2010's1 (6.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lange, A1
Gustke, H1
Glassmeier, G1
Heine, M1
Zangemeister-Wittke, U1
Schwarz, JR1
Schumacher, U1
Lange, T1
Janik, P1
Assaf, A1
Bertram, JS1
Laburthe, M1
Boissard, C1
Chevalier, G1
Zweibaum, A1
Rosselin, G1
Rizzoli, R1
Aubert, ML1
Sappino, AP1
Bonjour, JP1
Rabe, KF3
Tenor, H2
Dent, G3
Schudt, C2
Nakashima, M1
Magnussen, H3
Friedmann, AS1
Fay, MJ1
Memoli, VA1
North, WG1
Liebig, S1
Chilco, PJ1
Gerardi, JM1
Kaczmarczyk, SJ1
Chu, S1
Leopold, V1
Zajac, JD1
Iwamoto, Y1
Reich, R1
Nemeth, G1
Yamada, Y1
Martin, GR1
Allam, M1
Bertrand, R1
Zhang-Sun, G1
Pappas, J1
Viallet, J2
Maruno, K1
Absood, A1
Said, SI1
Wittau, N1
Grosse, R1
Kalkbrenner, F1
Gohla, A1
Schultz, G1
Gudermann, T1
Schmidt, DT1
Watson, N1
Rühlmann, E1
Branscheid, D1
Niles, RM1
Ludwig, KW1
Makarski, JS1
Kaur, G1
Laborda, J1
Blair, O1
Gazdar, AF1
Minna, JD1
Sausville, EA1
Verbeeck, MA1
Sutanto, W1
Burbach, JP1

Other Studies

16 other studies available for 1-methyl-3-isobutylxanthine and Lung Neoplasms

ArticleYear
Neuronal differentiation by indomethacin and IBMX inhibits proliferation of small cell lung cancer cells in vitro.
    Lung cancer (Amsterdam, Netherlands), 2011, Volume: 74, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; CD56 Antigen; Cell Differentiation; Cell Growth Processes; Cell Line, T

2011
Inhibition of growth of primary and metastatic Lewis lung carcinoma cells by the phosphodiesterase inhibitor isobutylmethylxanthine.
    Cancer research, 1980, Volume: 40, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Division; Female; Lung Neoplasms; Male; Mice; Neoplasm Me

1980
Peptide receptors in human lung tumor cells in culture: vasoactive intestinal peptide (VIP) and secretin interaction with the Calu-1 and SW-900 cell lines.
    Regulatory peptides, 1981, Volume: 2, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Carcinoma, Squamous Cell; Cell Line; Cyclic AMP; Gastrointestinal Hormo

1981
Cyclic AMP increases the release of parathyroid hormone-related protein from a lung-cancer cell line.
    International journal of cancer, 1994, Feb-01, Volume: 56, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Bucladesine; Calcitonin; Carcinoma, Squamous Cell; C

1994
Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors.
    The American journal of physiology, 1994, Volume: 266, Issue:5 Pt 1

    Topics: 1-Methyl-3-isobutylxanthine; Adult; Aged; Antihypertensive Agents; Carbachol; Colforsin; Cytosol; Di

1994
Factors regulating the production of vasopressin-associated human neurophysin by small-cell carcinoma of the lung: evaluation by computer-enhanced quantitative immunocytochemistry.
    Neuropeptides, 1995, Volume: 28, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Carcinoma, Small Cell; Colforsi

1995
Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization.
    The American journal of physiology, 1993, Volume: 264, Issue:5 Pt 1

    Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adult; Aged; Bucladesine; C

1993
Calcitonin increases transcription of parathyroid hormone-related protein via cAMP.
    Molecular and cellular endocrinology, 1993, Volume: 94, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Base Sequence; Bucladesine; Calcitonin; Colforsin; Cyclic AMP; Gene Exp

1993
Cyclic AMP decreases chemotaxis, invasiveness and lung colonization of H-ras transformed mouse fibroblasts.
    Clinical & experimental metastasis, 1993, Volume: 11, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Cell Tran

1993
Cholera toxin triggers apoptosis in human lung cancer cell lines.
    Cancer research, 1997, Jul-01, Volume: 57, Issue:13

    Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Apoptosis; bcl-2-Associated X Protein; Benzophenanthridines;

1997
Vasoactive intestinal peptide inhibits human small-cell lung cancer proliferation in vitro and in vivo.
    Proceedings of the National Academy of Sciences of the United States of America, 1998, Nov-24, Volume: 95, Issue:24

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Carcinoma, Small Cell; Cell Division; Colfo

1998
The galanin receptor type 2 initiates multiple signaling pathways in small cell lung cancer cells by coupling to G(q), G(i) and G(12) proteins.
    Oncogene, 2000, Aug-31, Volume: 19, Issue:37

    Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Actin Cytoskeleton; Actins; Animals; Calcium Signaling; Carc

2000
The effect of selective and non-selective phosphodiesterase inhibitors on allergen- and leukotriene C(4)-induced contractions in passively sensitized human airways.
    British journal of pharmacology, 2000, Volume: 131, Issue:8

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Antigens, Dermatophagoides; Benzam

2000
Differential growth inhibition in two human carcinoma cell lines by cyclic adenosine 5'-monophosphate analogs.
    Journal of the National Cancer Institute, 1979, Volume: 63, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Adenocarcinoma, Bronchiolo-Alveolar; Cell Division; Cell Line; Cyclic A

1979
Growth inhibition by cholera toxin of human lung carcinoma cell lines: correlation with GM1 ganglioside expression.
    Cancer research, 1992, Jun-15, Volume: 52, Issue:12

    Topics: 1-Methyl-3-isobutylxanthine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Division; C

1992
Regulation of vasopressin messenger RNA levels in the small cell lung carcinoma cell line GLC-8: interactions between glucocorticoids and second messengers.
    Molecular endocrinology (Baltimore, Md.), 1991, Volume: 5, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Aldosterone; Carcinoma, Small C

1991