1-methyl-3-isobutylxanthine has been researched along with Liver Cirrhosis in 1 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have combined an ex vivo model of liver fibrosis with measurement of a biochemical marker of collagen degradation in the condition medium." | 1.38 | Phosphodiesterase inhibition mediates matrix metalloproteinase activity and the level of collagen degradation fragments in a liver fibrosis ex vivo rat model. ( Karsdal, MA; Leeming, DJ; Nielsen, MJ; Veidal, SS, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Veidal, SS | 1 |
| Nielsen, MJ | 1 |
| Leeming, DJ | 1 |
| Karsdal, MA | 1 |
1 other study available for 1-methyl-3-isobutylxanthine and Liver Cirrhosis
| Article | Year |
|---|---|
Phosphodiesterase inhibition mediates matrix metalloproteinase activity and the level of collagen degradation fragments in a liver fibrosis ex vivo rat model.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Survival; Collagen Type III; Cyclic AMP; Electrophoresis, | 2012 |