1-methyl-3-isobutylxanthine has been researched along with Leukemia in 5 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bufalin, an active principle of Chinese medicine, chan'su, induced typical apoptosis in human leukemia U937 cells." | 7.69 | The cooperative interaction of two different signaling pathways in response to bufalin induces apoptosis in human leukemia U937 cells. ( Kuroiwa, Y; Masuda, Y; Nakajo, S; Nakaya, K; Watabe, M; Yoshida, T, 1996) |
| "Bufalin, an active principle of Chinese medicine, chan'su, induced typical apoptosis in human leukemia U937 cells." | 3.69 | The cooperative interaction of two different signaling pathways in response to bufalin induces apoptosis in human leukemia U937 cells. ( Kuroiwa, Y; Masuda, Y; Nakajo, S; Nakaya, K; Watabe, M; Yoshida, T, 1996) |
| "This study demonstrates synergistic effects on Tac expression by interleukin 1 (IL-1) or tumor necrosis factor alpha (TNF alpha) in combination with the adenylate cyclase stimulator, forskolin (FK), as well as by IL-1 with TNF alpha in the human NK-like leukemic cell line YT." | 1.28 | Synergistic induction of interleukin 2 receptor (TAC) expression on YT cells by interleukin 1 or tumor necrosis factor alpha in combination with cAMP inducing agents. ( Altman, A; Scholz, W, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Epstein, PM | 1 |
| Hachisu, R | 1 |
| Watabe, M | 1 |
| Masuda, Y | 1 |
| Nakajo, S | 1 |
| Yoshida, T | 1 |
| Kuroiwa, Y | 1 |
| Nakaya, K | 1 |
| Hohmann, HP | 1 |
| Kolbeck, R | 1 |
| Remy, R | 1 |
| van Loon, AP | 1 |
| Wacholtz, MC | 1 |
| Minakuchi, R | 1 |
| Lipsky, PE | 1 |
| Scholz, W | 1 |
| Altman, A | 1 |
1 review available for 1-methyl-3-isobutylxanthine and Leukemia
| Article | Year |
|---|---|
Cyclic nucleotide phosphodiesterase in normal and leukemic human lymphocytes and lymphoblasts.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterase | 1984 |
4 other studies available for 1-methyl-3-isobutylxanthine and Leukemia
| Article | Year |
|---|---|
The cooperative interaction of two different signaling pathways in response to bufalin induces apoptosis in human leukemia U937 cells.
Topics: 1-Methyl-3-isobutylxanthine; Antineoplastic Agents; Apoptosis; Bufanolides; Calcium-Calmodulin-Depen | 1996 |
Cyclic AMP-independent activation of transcription factor NF-kappa B in HL60 cells by tumor necrosis factors alpha and beta.
Topics: 1-Methyl-3-isobutylxanthine; Colforsin; Cyclic AMP; Gene Expression Regulation; Humans; Kinetics; Le | 1991 |
Characterization of the 3',5'-cyclic adenosine monophosphate-mediated regulation of IL2 production by T cells and Jurkat cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Cell Line; Cholera Toxin; C | 1991 |
Synergistic induction of interleukin 2 receptor (TAC) expression on YT cells by interleukin 1 or tumor necrosis factor alpha in combination with cAMP inducing agents.
Topics: 1-Methyl-3-isobutylxanthine; Colforsin; Cyclic AMP; Drug Synergism; Fluorescence; Humans; Interleuki | 1989 |