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1-methyl-3-isobutylxanthine and Leukemia

1-methyl-3-isobutylxanthine has been researched along with Leukemia in 5 studies

1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.

Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Research Excerpts

ExcerptRelevanceReference
"Bufalin, an active principle of Chinese medicine, chan'su, induced typical apoptosis in human leukemia U937 cells."7.69The cooperative interaction of two different signaling pathways in response to bufalin induces apoptosis in human leukemia U937 cells. ( Kuroiwa, Y; Masuda, Y; Nakajo, S; Nakaya, K; Watabe, M; Yoshida, T, 1996)
"Bufalin, an active principle of Chinese medicine, chan'su, induced typical apoptosis in human leukemia U937 cells."3.69The cooperative interaction of two different signaling pathways in response to bufalin induces apoptosis in human leukemia U937 cells. ( Kuroiwa, Y; Masuda, Y; Nakajo, S; Nakaya, K; Watabe, M; Yoshida, T, 1996)
"This study demonstrates synergistic effects on Tac expression by interleukin 1 (IL-1) or tumor necrosis factor alpha (TNF alpha) in combination with the adenylate cyclase stimulator, forskolin (FK), as well as by IL-1 with TNF alpha in the human NK-like leukemic cell line YT."1.28Synergistic induction of interleukin 2 receptor (TAC) expression on YT cells by interleukin 1 or tumor necrosis factor alpha in combination with cAMP inducing agents. ( Altman, A; Scholz, W, 1989)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19902 (40.00)18.7374
1990's3 (60.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Epstein, PM1
Hachisu, R1
Watabe, M1
Masuda, Y1
Nakajo, S1
Yoshida, T1
Kuroiwa, Y1
Nakaya, K1
Hohmann, HP1
Kolbeck, R1
Remy, R1
van Loon, AP1
Wacholtz, MC1
Minakuchi, R1
Lipsky, PE1
Scholz, W1
Altman, A1

Reviews

1 review available for 1-methyl-3-isobutylxanthine and Leukemia

ArticleYear
Cyclic nucleotide phosphodiesterase in normal and leukemic human lymphocytes and lymphoblasts.
    Advances in cyclic nucleotide and protein phosphorylation research, 1984, Volume: 16

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterase

1984

Other Studies

4 other studies available for 1-methyl-3-isobutylxanthine and Leukemia

ArticleYear
The cooperative interaction of two different signaling pathways in response to bufalin induces apoptosis in human leukemia U937 cells.
    The Journal of biological chemistry, 1996, Jun-14, Volume: 271, Issue:24

    Topics: 1-Methyl-3-isobutylxanthine; Antineoplastic Agents; Apoptosis; Bufanolides; Calcium-Calmodulin-Depen

1996
Cyclic AMP-independent activation of transcription factor NF-kappa B in HL60 cells by tumor necrosis factors alpha and beta.
    Molecular and cellular biology, 1991, Volume: 11, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Colforsin; Cyclic AMP; Gene Expression Regulation; Humans; Kinetics; Le

1991
Characterization of the 3',5'-cyclic adenosine monophosphate-mediated regulation of IL2 production by T cells and Jurkat cells.
    Cellular immunology, 1991, Volume: 135, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Cell Line; Cholera Toxin; C

1991
Synergistic induction of interleukin 2 receptor (TAC) expression on YT cells by interleukin 1 or tumor necrosis factor alpha in combination with cAMP inducing agents.
    Cellular signalling, 1989, Volume: 1, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Colforsin; Cyclic AMP; Drug Synergism; Fluorescence; Humans; Interleuki

1989