1-methyl-3-isobutylxanthine has been researched along with Keratoconjunctivitis Sicca in 2 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Keratoconjunctivitis Sicca: Drying and inflammation of the conjunctiva as a result of insufficient lacrimal secretion. When found in association with XEROSTOMIA and polyarthritis, it is called SJOGREN'S SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine the effects of topical 3-isobutyl-1-methylxanthine treatment on tear-film osmolarity, conjunctival goblet-cell densities, and corneal epithelial glycogen levels in a rabbit model for keratoconjunctivitis sicca." | 3.69 | Treatment of keratoconjunctivitis sicca in rabbits with 3-isobutyl-1-methylxanthine. ( Gilbard, JP, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gilbard, JP | 2 |
1 review available for 1-methyl-3-isobutylxanthine and Keratoconjunctivitis Sicca
| Article | Year |
|---|---|
The tear film: pharmacological approaches and effects.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Count; Conjunctiva; Cornea; Epithelium; Glycogen; Humans; | 1994 |
1 other study available for 1-methyl-3-isobutylxanthine and Keratoconjunctivitis Sicca
| Article | Year |
|---|---|
Treatment of keratoconjunctivitis sicca in rabbits with 3-isobutyl-1-methylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Count; Conjunctiva; Cornea; Glycogen; Keratoconjunctiviti | 1994 |