1-methyl-3-isobutylxanthine has been researched along with Invasiveness, Neoplasm in 6 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We demonstrate here using MDA-MB-435 breast carcinoma cells that alpha6beta4 stimulates chemotactic migration, a key component of invasion, but that it has no influence on haptotaxis." | 1.30 | Release of cAMP gating by the alpha6beta4 integrin stimulates lamellae formation and the chemotactic migration of invasive carcinoma cells. ( Mercurio, AM; O'Connor, KL; Shaw, LM, 1998) |
| "Three human prostate cancer cell lines PC-3, DU145 and LNCaP were treated with one of the phosphodiesterase inhibitors, papaverine, 3-isobutyl-1-methylxanthine (IBMX) or theophylline, for 6 days." | 1.30 | The effect of papaverine on morphologic differentiation, proliferation and invasive potential of human prostatic cancer LNCaP cells. ( Goto, T; Hida, A; Hosaka, Y; Kasuya, Y; Kawabe, K; Kitamura, T; Matsushima, H; Ohta, Y; Simizu, T; Takeda, K, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Burdyga, A | 1 |
| Conant, A | 1 |
| Haynes, L | 1 |
| Zhang, J | 1 |
| Jalink, K | 1 |
| Sutton, R | 1 |
| Neoptolemos, J | 1 |
| Costello, E | 1 |
| Tepikin, A | 1 |
| Zimmerman, NP | 1 |
| Roy, I | 1 |
| Hauser, AD | 1 |
| Wilson, JM | 1 |
| Williams, CL | 1 |
| Dwinell, MB | 1 |
| O'Connor, KL | 1 |
| Shaw, LM | 1 |
| Mercurio, AM | 1 |
| Goto, T | 1 |
| Matsushima, H | 1 |
| Kasuya, Y | 1 |
| Hosaka, Y | 1 |
| Kitamura, T | 1 |
| Kawabe, K | 1 |
| Hida, A | 1 |
| Ohta, Y | 1 |
| Simizu, T | 1 |
| Takeda, K | 1 |
| Iwamoto, Y | 1 |
| Sugioka, Y | 1 |
| Lester, BR | 1 |
| McCarthy, JB | 1 |
| Sun, ZQ | 1 |
| Smith, RS | 1 |
| Furcht, LT | 1 |
| Spiegel, AM | 1 |
6 other studies available for 1-methyl-3-isobutylxanthine and Invasiveness, Neoplasm
| Article | Year |
|---|---|
cAMP inhibits migration, ruffling and paxillin accumulation in focal adhesions of pancreatic ductal adenocarcinoma cells: effects of PKA and EPAC.
Topics: 1-Methyl-3-isobutylxanthine; Adenocarcinoma; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Mo | 2013 |
Cyclic AMP regulates the migration and invasion potential of human pancreatic cancer cells.
Topics: 1-Methyl-3-isobutylxanthine; Amides; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell | 2015 |
Release of cAMP gating by the alpha6beta4 integrin stimulates lamellae formation and the chemotactic migration of invasive carcinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Antibodies; Antigens, Surface; Bre | 1998 |
The effect of papaverine on morphologic differentiation, proliferation and invasive potential of human prostatic cancer LNCaP cells.
Topics: 1-Methyl-3-isobutylxanthine; Cell Differentiation; Cell Division; Cell Size; Cyclic AMP; Diffusion C | 1999 |
Use of a reconstituted basement membrane to study the invasiveness of tumor cells.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Amino Acid Sequence; | 1992 |
G-protein involvement in matrix-mediated motility and invasion of high and low experimental metastatic B16 melanoma clones.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenylate Cyclase Toxin; Animals; Cell Line; Cell Membrane; Ce | 1989 |