1-methyl-3-isobutylxanthine has been researched along with Intraocular Pressure in 12 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Intraocular Pressure: The pressure of the fluids in the eye.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have studied the effects of terbutaline, timolol, forskolin and 8-bromo cyclic AMP on aqueous humour formation, intraocular pressure and on ciliary epithelial cyclic AMP levels, either in presence or in absence of IBMX, using the bovine isolated arterially perfused eye, excised ciliary processes and cultured ciliary epithelium." | 3.69 | Effects of timolol, terbutaline and forskolin on IOP, aqueous humour formation and ciliary cyclic AMP levels in the bovine eye. ( Millar, C; Shahidullah, M; Wilson, WS, 1995) |
| "Isobutylmethylxanthine (IBMX), a phosphodiesterase/adenosine receptor inhibitor, was combined with norepinephrine (nE), epinephrine (Epi) and isoproterenol, respectively, to evaluate their effect on intraocular pressure (IOP)." | 3.68 | Isobutylmethylxanthine enhances adrenergic-induced ocular hypotension in rabbits and beagles. ( Busch, MJ; Groeneboer, MC; Hoyng, PF, 1991) |
| "Intraocular pressure was measured at specific times after exposure." | 1.29 | Enhanced prostaglandin synthesis after ultraviolet-B exposure modulates DNA synthesis of lens epithelial cells and lowers intraocular pressure in vivo. ( Andley, UP; Becker, B; Hebert, JS; Morrison, AR; Pentland, AP; Reddan, JR, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (83.33) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alarma-Estrany, P | 1 |
| Crooke, A | 1 |
| Mediero, A | 1 |
| Peláez, T | 1 |
| Pintor, J | 1 |
| Busch, MJ | 4 |
| Hoyng, PF | 4 |
| Shahidullah, M | 1 |
| Wilson, WS | 1 |
| Millar, C | 1 |
| Andley, UP | 1 |
| Becker, B | 1 |
| Hebert, JS | 1 |
| Reddan, JR | 1 |
| Morrison, AR | 1 |
| Pentland, AP | 1 |
| Pang, IH | 1 |
| Shade, DL | 1 |
| Matsumoto, S | 1 |
| Steely, HT | 1 |
| DeSantis, L | 1 |
| Fujimoto, N | 1 |
| Hanawa, T | 1 |
| Kimura, T | 1 |
| Nii, H | 1 |
| Ikeda, H | 1 |
| Okada, K | 1 |
| Yoshitomi, T | 1 |
| Gregory, DS | 2 |
| Kiuchi, Y | 2 |
| Yamazaki, M | 1 |
| Yasumoto, T | 1 |
| Iijima, Y | 1 |
| Yokoyama, T | 1 |
| Fukami, S | 1 |
| Kaneko, M | 1 |
| Mishima, H | 1 |
| Stjernschantz, J | 1 |
| Groeneboer, MC | 1 |
12 other studies available for 1-methyl-3-isobutylxanthine and Intraocular Pressure
| Article | Year |
|---|---|
Sympathetic nervous system modulates the ocular hypotensive action of MT2-melatonin receptors in normotensive rabbits.
Topics: 1-Methyl-3-isobutylxanthine; Administration, Topical; Adrenergic beta-Agonists; Albuterol; Animals; | 2008 |
Evaluation of IBMX-enhanced ocular hypotension after adrenergic agonists in the rabbit eye.
Topics: 1-Methyl-3-isobutylxanthine; Administration, Topical; Adrenergic alpha-Agonists; Adrenergic beta-Ago | 1995 |
Effects of timolol, terbutaline and forskolin on IOP, aqueous humour formation and ciliary cyclic AMP levels in the bovine eye.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic beta-Agonists; Adren | 1995 |
Enhanced prostaglandin synthesis after ultraviolet-B exposure modulates DNA synthesis of lens epithelial cells and lowers intraocular pressure in vivo.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Autoradiography; Cell Division; Cell Line; Cells, Cultured; Cy | 1996 |
Presence of functional type B natriuretic peptide receptor in human ocular cells.
Topics: 1-Methyl-3-isobutylxanthine; Atrial Natriuretic Factor; Calcium; Carbachol; Cell Line, Transformed; | 1996 |
Effect of cAMP- and cGMP-related drugs on porcine cultured ciliary muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antihypertensive Agents; Bucladesine; Carbachol; Cells, Cultur | 1998 |
Circadian change of adenylate cyclase activity in rabbit ciliary processes.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenergic alpha-Agonists; Adrenergic beta-Antagonis | 2001 |
Rabbits have a circadian rhythm of aqueous humor cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aqueous Humor; Circadian Rhythm; Cyclic AMP; Dark Adaptation; | 1992 |
Griseolic acid, a cAMP phosphodiesterase inhibitor, and its ester: increase in cellular cAMP levels and reduction of intraocular pressure.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Animals; Cattle; Cell L | 1990 |
Increase in ocular blood flow induced by isobutylmethylxanthine and epinephrine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Choroid; Ciliary Body; Drug Synergism; Epinephrine; Eye; Femal | 1991 |
Isobutylmethylxanthine enhances adrenergic-induced ocular hypotension in rabbits and beagles.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Agonists; Animals; Aqueous Humor; Cyclic AMP; Dogs; Do | 1991 |
Soluble forms of isobutylmethylxanthine enhance the ocular hypotension induced by catecholamines.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Catecholamines; Cyclodextrins; Dose-Response Relationship, Dru | 1991 |