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1-methyl-3-isobutylxanthine and Insulinoma

1-methyl-3-isobutylxanthine has been researched along with Insulinoma in 38 studies

1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.

Insulinoma: A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.

Research Excerpts

ExcerptRelevanceReference
"The objective of the present study was to examine the effects of melatonin on transcripts of isoforms of calcium/calmodulin-dependent protein kinases in rat insulinoma beta-cells INS-1."7.75Transcripts of calcium/calmodulin-dependent kinases are changed after forskolin- or IBMX-induced insulin secretion due to melatonin treatment of rat insulinoma beta-cells (INS-1). ( Bazwinsky-Wutschke, I; Mühlbauer, E; Peschke, E; Wolgast, S, 2009)
"The objective of the present study was to examine the effects of melatonin on transcripts of isoforms of calcium/calmodulin-dependent protein kinases in rat insulinoma beta-cells INS-1."3.75Transcripts of calcium/calmodulin-dependent kinases are changed after forskolin- or IBMX-induced insulin secretion due to melatonin treatment of rat insulinoma beta-cells (INS-1). ( Bazwinsky-Wutschke, I; Mühlbauer, E; Peschke, E; Wolgast, S, 2009)
"Effects of genistein on insulin release were studied using MIN6 cells, a glucose-sensitive insulinoma cell line."3.68Genistein augments cyclic adenosine 3'5'-monophosphate(cAMP) accumulation and insulin release in MIN6 cells. ( Ishii, C; Ito, Y; Kato, N; Kawazu, S; Ohno, T; Shimizu, M; Tomono, S, 1993)
"The rat insulinoma RIN 5F and the mouse pituitary AtT-20 cell line, which are known to express several biologically active peptides, were found to express CCK mRNA, to correctly process, and to release immunoreactive cholecystokinin (CCK) peptides."3.68CCK mRNA expression, pro-CCK processing, and regulated secretion of immunoreactive CCK peptides by rat insulinoma (RIN 5F) and mouse pituitary tumor (AtT-20) cells in culture. ( Beinfeld, MC, 1992)
"A series of 3H-leucine pulse-labeling experiments was carried out with dispersed cells freshly isolated from transplanted rat insulinomas."3.67Contrasting patterns of insulin biosynthesis, compartmental storage, and secretion. Rat tumor versus islet cells. ( Chick, WL; Gishizky, ML; Gold, G; Grodsky, GM, 1984)
"Glucose, forskolin, IBMX and carbachol all stimulated insulin release from freshly obtained human insulinoma cells."3.67Glucose stimulates insulin release without altering cyclic AMP production or inositolphospholipid turnover in freshly obtained human insulinoma cells. ( Chiba, T; Fujita, T; Inui, T; Kadowaki, S; Saito, Y; Yamaguchi, A; Yamatani, T, 1987)
" Glucose dose-response studies show that both engineered and non-engineered lines respond maximally to submillimolar concentrations of glucose and that betaG 49/206 cells are the most sensitive to low concentrations of the hexose, consistent with their clearly elevated rate of [5-3H]glucose usage."1.30Regulation of insulin secretion from novel engineered insulinoma cell lines. ( BeltrandelRio, H; Clark, SA; Henkel-Rieger, R; Hohmeier, HE; Newgard, CB; Normington, K, 1997)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19905 (13.16)18.7374
1990's16 (42.11)18.2507
2000's15 (39.47)29.6817
2010's2 (5.26)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Süss, C1
Czupalla, C1
Winter, C1
Pursche, T1
Knoch, KP1
Schroeder, M1
Hoflack, B1
Solimena, M1
Sugawara, K1
Shibasaki, T1
Mizoguchi, A1
Saito, T1
Seino, S1
Bazwinsky-Wutschke, I3
Mühlbauer, E5
Wolgast, S2
Peschke, E5
Albrecht, E2
Musshoff, U1
Csernus, VJ1
Chankiewitz, E1
Peschke, D1
Friedrichsen, BN1
Carlsson, C1
Møldrup, A1
Michelsen, B1
Jensen, CH1
Teisner, B1
Nielsen, JH1
Al-Majed, HT1
Jones, PM1
Persaud, SJ1
Sugden, D1
Huang, GC1
Amiel, S1
Whitehouse, BJ1
Sekine, N1
Takano, K1
Kimata-Hayashi, N1
Kadowaki, T1
Fujita, T3
Stumpf, I1
Knudsen, P1
Kofod, H1
Lernmark, A1
Hedeskov, CJ1
Gold, G1
Gishizky, ML1
Chick, WL1
Grodsky, GM1
Ohno, T1
Kato, N1
Ishii, C1
Shimizu, M1
Ito, Y1
Tomono, S1
Kawazu, S1
McLeod, MK1
Kothary, PC1
Farrell, CM1
De Stefanis, P1
Impagnatiello, F1
Berkovich, A1
Guidotti, A1
Khan, RN1
Hales, CN1
Ozanne, SE1
Adogu, AA1
Ashford, ML1
Ahrén, B1
Simonsson, E1
Karlsson, S1
Deeg, MA1
Verchere, CB1
Hohmeier, HE1
BeltrandelRio, H1
Clark, SA1
Henkel-Rieger, R1
Normington, K1
Newgard, CB1
Chen, K1
Stephanopoulos, GN1
Sinskey, AJ1
Lodish, HF1
Mamujee, SN1
Zhou, D1
Wheeler, MB2
Vacek, I1
Sun, AM2
Seissler, J1
Nguyen, TB1
Aust, G1
Steinbrenner, H1
Scherbaum, WA1
Ma, Z2
Ramanadham, S2
Wohltmann, M1
Bohrer, A1
Hsu, FF1
Turk, J2
Su, J1
Yu, H1
Lenka, N1
Hescheler, J1
Ullrich, S1
MacDonald, PE1
Ha, XF1
Wang, J1
Smukler, SR1
Gaisano, HY1
Salapatek, AM1
Backx, PH1
Bloch, K1
Vardi, P1
Darville, MI1
Eizirik, DL1
Zhang, S1
Asfari, M1
Janjic, D1
Meda, P1
Li, G1
Halban, PA1
Wollheim, CB1
Gros, L1
Demirpence, E1
Jarrousse, C1
Kervran, A1
Bataille, D1
Matsumura, T1
Itoh, H1
Watanabe, N1
Oda, Y1
Tanaka, M1
Namba, M1
Kono, N1
Matsuyama, T1
Komatsu, R1
Matsuzawa, Y1
Beinfeld, MC1
D'Ambra, R1
Surana, M2
Efrat, S2
Starr, RG1
Fleischer, N3
Yamatani, T2
Yamaguchi, A2
Nakamura, A1
Morishita, T1
Kadowaki, S2
Chiba, T2
Pasmantier, R1
Danoff, A1
Schubart, UK1
Inui, T1
Saito, Y1
Thivolet, CH1
Demidem, A1
Haftek, M1
Durand, A1
Bertrand, J1

Other Studies

38 other studies available for 1-methyl-3-isobutylxanthine and Insulinoma

ArticleYear
Rapid changes of mRNA-binding protein levels following glucose and 3-isobutyl-1-methylxanthine stimulation of insulinoma INS-1 cells.
    Molecular & cellular proteomics : MCP, 2009, Volume: 8, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Motifs; Animals; Binding Sites; Blotting, Western; Computati

2009
Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis.
    Genes to cells : devoted to molecular & cellular mechanisms, 2009, Volume: 14, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Carrier Proteins; Cell Line, Tumor; Colforsin; Cyclic AMP; Cyc

2009
Transcripts of calcium/calmodulin-dependent kinases are changed after forskolin- or IBMX-induced insulin secretion due to melatonin treatment of rat insulinoma beta-cells (INS-1).
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2009, Volume: 41, Issue:11

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Li

2009
Melatonin influences insulin secretion primarily via MT(1) receptors in rat insulinoma cells (INS-1) and mouse pancreatic islets.
    Journal of pineal research, 2012, Volume: 52, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line, Tumor; Cyclic AMP; Histocytochemistry; Insulin; Ins

2012
Phosphorylation of cyclic AMP-response element-binding protein (CREB) is influenced by melatonin treatment in pancreatic rat insulinoma β-cells (INS-1).
    Journal of pineal research, 2012, Volume: 53, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line,

2012
Receptor (MT(1)) mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS-1.
    Journal of pineal research, 2002, Volume: 33, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Biological Transport; Colforsin; Cyclic AMP

2002
Expression, biosynthesis and release of preadipocyte factor-1/ delta-like protein/fetal antigen-1 in pancreatic beta-cells: possible physiological implications.
    The Journal of endocrinology, 2003, Volume: 176, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Division; Cells, Cultured; Enzyme-Linked Immunosorbent As

2003
ACTH stimulates insulin secretion from MIN6 cells and primary mouse and human islets of Langerhans.
    The Journal of endocrinology, 2004, Volume: 180, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adrenocorticotropic Hormone; Animals; Calcium Channel Blockers; Cell Li

2004
Adrenomedullin inhibits insulin exocytosis via pertussis toxin-sensitive G protein-coupled mechanism.
    American journal of physiology. Endocrinology and metabolism, 2006, Volume: 291, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adrenomedullin; Calcium; Cell Line, Tumor; Colforsin; Exocytosis; Forma

2006
Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells.
    Journal of pineal research, 2008, Volume: 45, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Cell Line, Tumor; Colforsin; Cyclic GMP; Cyclic Nucleot

2008
L-leucine methyl ester stimulates insulin secretion and islet glutamate dehydrogenase.
    The American journal of physiology, 1983, Volume: 245, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Glucagon; Glucose; Glutamate Dehydrogenase; Glutami

1983
Contrasting patterns of insulin biosynthesis, compartmental storage, and secretion. Rat tumor versus islet cells.
    Diabetes, 1984, Volume: 33, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Animals; Female; Glucose; In Vitro Techniques; Ins

1984
Genistein augments cyclic adenosine 3'5'-monophosphate(cAMP) accumulation and insulin release in MIN6 cells.
    Endocrine research, 1993, Volume: 19, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cell Line; Cyclic AMP; Cytosol; Dose-Response Relatio

1993
Molecular and functional studies of inhibitory G protein in RINm5F cells.
    The Journal of surgical research, 1994, Volume: 57, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; DNA, Neoplasm; Drug Combinations; GTP-Binding Prot

1994
Inhibitory effect of ODN, a naturally occurring processing product of diazepam binding inhibitor, on secretagogues-induced insulin secretion.
    Regulatory peptides, 1995, Apr-14, Volume: 56, Issue:2-3

    Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifl

1995
Dissociation of KATP channel and sulphonylurea receptor in the rat clonal insulin-secreting cell line, CRI-D11.
    Proceedings. Biological sciences, 1993, Sep-22, Volume: 253, Issue:1338

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Cel

1993
Glucagon-like peptide-1(7-36)amide and cytoplasmic calcium in insulin producing cells.
    Acta physiologica Scandinavica, 1996, Volume: 157, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cytoplasm; Fura-2; Glucagon; Glucagon-Like Peptide 1;

1996
Regulation of glycosylphosphatidylinositol-specific phospholipase D secretion from beta TC3 cells.
    Endocrinology, 1997, Volume: 138, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cycloheximide; Glucagon; Glucagon-Like Peptide 1; G

1997
Regulation of insulin secretion from novel engineered insulinoma cell lines.
    Diabetes, 1997, Volume: 46, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Dose-Response Relationship, Drug; Gene Expression Regulation;

1997
Regulated secretion of prolactin by the mouse insulinoma cell line beta TC-3.
    Bio/technology (Nature Publishing Company), 1995, Volume: 13, Issue:11

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Glucose; Glycosylation; Insulinoma; Mice; Pancreatic

1995
Evaluation of immunoisolated insulin-secreting beta TC6-F7 cells as a bioartificial pancreas.
    Annals of transplantation, 1997, Volume: 2, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Glucose; Capsules; Cell Division; Cell Separation; Diabe

1997
Regulation of the diabetes-associated autoantigen IA-2 in INS-1 pancreatic beta-cells.
    Diabetes, 2000, Volume: 49, Issue:7

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Autoantigens; Colforsin; Cyclic AMP; Gene Expression Regulatio

2000
Studies of insulin secretory responses and of arachidonic acid incorporation into phospholipids of stably transfected insulinoma cells that overexpress group VIA phospholipase A2 (iPLA2beta ) indicate a signaling rather than a housekeeping role for iPLA2b
    The Journal of biological chemistry, 2001, Apr-20, Volume: 276, Issue:16

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Arachidonic Acid; Colforsin; Enzyme Inhibit

2001
The expression and regulation of depolarization-activated K+ channels in the insulin-secreting cell line INS-1.
    Pflugers Archiv : European journal of physiology, 2001, Volume: 442, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; 8-Bromo Cyclic Adenosine Monophosphate; Action Potenti

2001
Members of the Kv1 and Kv2 voltage-dependent K(+) channel families regulate insulin secretion.
    Molecular endocrinology (Baltimore, Md.), 2001, Volume: 15, Issue:8

    Topics: 1-Methyl-3-isobutylxanthine; Adenoviridae; Animals; Cell Line; Cyclic AMP-Dependent Protein Kinases;

2001
Therapeutic differentiation of tumor-derived insulin-producing cells selected for resistance to diabetogenic drugs.
    International journal of experimental diabetes research, 2000, Volume: 1, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Differentiation; Cell Division; Cells, Cultured; Colforsi

2000
Cytokine induction of Fas gene expression in insulin-producing cells requires the transcription factors NF-kappaB and C/EBP.
    Diabetes, 2001, Volume: 50, Issue:8

    Topics: 1-Methyl-3-isobutylxanthine; Animals; CCAAT-Enhancer-Binding Protein-beta; Cytokines; fas Receptor;

2001
Stimulation of insulin secretion and associated nuclear accumulation of iPLA(2)beta in INS-1 insulinoma cells.
    American journal of physiology. Endocrinology and metabolism, 2002, Volume: 282, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Nucleus; Colforsin; Cyclic AMP-Dependent Protein Kinases;

2002
Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.
    Endocrinology, 1992, Volume: 130, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Colforsin; Insulin; Insulin Secretion; Insulinoma; Me

1992
Characterization of binding sites for oxyntomodulin on a somatostatin-secreting cell line (RIN T3).
    Endocrinology, 1992, Volume: 130, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Bin

1992
Glucagonlike peptide-1(7-36)amide suppresses glucagon secretion and decreases cyclic AMP concentration in cultured In-R1-G9 cells.
    Biochemical and biophysical research communications, 1992, Jul-15, Volume: 186, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Clone Cells; Cricetinae; Cyclic AMP; Dose-Response Relationshi

1992
CCK mRNA expression, pro-CCK processing, and regulated secretion of immunoreactive CCK peptides by rat insulinoma (RIN 5F) and mouse pituitary tumor (AtT-20) cells in culture.
    Neuropeptides, 1992, Volume: 22, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Cholecystokinin; Chromatography, High Pres

1992
Regulation of insulin secretion from beta-cell lines derived from transgenic mice insulinomas resembles that of normal beta-cells.
    Endocrinology, 1990, Volume: 126, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Animals; Carbachol; Colforsin; Cyclic AMP; Drug Sy

1990
Activation of PKC inhibits NaF-induced inositol phospholipid turnover in rat insulinoma cells.
    The American journal of physiology, 1990, Volume: 259, Issue:1 Pt 1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Colforsin; Cyclic AMP; Enzyme Activation; Inositol

1990
Glucose induces insulin gene transcription in a murine pancreatic beta-cell line.
    The Journal of biological chemistry, 1991, Jun-15, Volume: 266, Issue:17

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cell Nucleus; Colforsin; Cyclic AMP; Gallopamil; Ge

1991
P19, a hormonally regulated phosphoprotein of peptide hormone-producing cells: secretagogue-induced phosphorylation in AtT-20 mouse pituitary tumor cells and in rat and hamster insulinoma cells.
    Endocrinology, 1986, Volume: 119, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenoma, Islet Cell; Adrenocort

1986
Glucose stimulates insulin release without altering cyclic AMP production or inositolphospholipid turnover in freshly obtained human insulinoma cells.
    Biochemical and biophysical research communications, 1987, May-29, Volume: 145, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Carbachol; Colforsin; Cyclic AMP; Glucose; Humans;

1987
Structure, function, and immunogenicity of human insulinoma cells.
    Diabetes, 1988, Volume: 37, Issue:9

    Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Adult; C-Peptide; Fluorescent Antibody Technique;

1988