1-methyl-3-isobutylxanthine has been researched along with Insulinoma in 38 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Insulinoma: A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective of the present study was to examine the effects of melatonin on transcripts of isoforms of calcium/calmodulin-dependent protein kinases in rat insulinoma beta-cells INS-1." | 7.75 | Transcripts of calcium/calmodulin-dependent kinases are changed after forskolin- or IBMX-induced insulin secretion due to melatonin treatment of rat insulinoma beta-cells (INS-1). ( Bazwinsky-Wutschke, I; Mühlbauer, E; Peschke, E; Wolgast, S, 2009) |
| "The objective of the present study was to examine the effects of melatonin on transcripts of isoforms of calcium/calmodulin-dependent protein kinases in rat insulinoma beta-cells INS-1." | 3.75 | Transcripts of calcium/calmodulin-dependent kinases are changed after forskolin- or IBMX-induced insulin secretion due to melatonin treatment of rat insulinoma beta-cells (INS-1). ( Bazwinsky-Wutschke, I; Mühlbauer, E; Peschke, E; Wolgast, S, 2009) |
| "Effects of genistein on insulin release were studied using MIN6 cells, a glucose-sensitive insulinoma cell line." | 3.68 | Genistein augments cyclic adenosine 3'5'-monophosphate(cAMP) accumulation and insulin release in MIN6 cells. ( Ishii, C; Ito, Y; Kato, N; Kawazu, S; Ohno, T; Shimizu, M; Tomono, S, 1993) |
| "The rat insulinoma RIN 5F and the mouse pituitary AtT-20 cell line, which are known to express several biologically active peptides, were found to express CCK mRNA, to correctly process, and to release immunoreactive cholecystokinin (CCK) peptides." | 3.68 | CCK mRNA expression, pro-CCK processing, and regulated secretion of immunoreactive CCK peptides by rat insulinoma (RIN 5F) and mouse pituitary tumor (AtT-20) cells in culture. ( Beinfeld, MC, 1992) |
| "A series of 3H-leucine pulse-labeling experiments was carried out with dispersed cells freshly isolated from transplanted rat insulinomas." | 3.67 | Contrasting patterns of insulin biosynthesis, compartmental storage, and secretion. Rat tumor versus islet cells. ( Chick, WL; Gishizky, ML; Gold, G; Grodsky, GM, 1984) |
| "Glucose, forskolin, IBMX and carbachol all stimulated insulin release from freshly obtained human insulinoma cells." | 3.67 | Glucose stimulates insulin release without altering cyclic AMP production or inositolphospholipid turnover in freshly obtained human insulinoma cells. ( Chiba, T; Fujita, T; Inui, T; Kadowaki, S; Saito, Y; Yamaguchi, A; Yamatani, T, 1987) |
| " Glucose dose-response studies show that both engineered and non-engineered lines respond maximally to submillimolar concentrations of glucose and that betaG 49/206 cells are the most sensitive to low concentrations of the hexose, consistent with their clearly elevated rate of [5-3H]glucose usage." | 1.30 | Regulation of insulin secretion from novel engineered insulinoma cell lines. ( BeltrandelRio, H; Clark, SA; Henkel-Rieger, R; Hohmeier, HE; Newgard, CB; Normington, K, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (13.16) | 18.7374 |
| 1990's | 16 (42.11) | 18.2507 |
| 2000's | 15 (39.47) | 29.6817 |
| 2010's | 2 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Süss, C | 1 |
| Czupalla, C | 1 |
| Winter, C | 1 |
| Pursche, T | 1 |
| Knoch, KP | 1 |
| Schroeder, M | 1 |
| Hoflack, B | 1 |
| Solimena, M | 1 |
| Sugawara, K | 1 |
| Shibasaki, T | 1 |
| Mizoguchi, A | 1 |
| Saito, T | 1 |
| Seino, S | 1 |
| Bazwinsky-Wutschke, I | 3 |
| Mühlbauer, E | 5 |
| Wolgast, S | 2 |
| Peschke, E | 5 |
| Albrecht, E | 2 |
| Musshoff, U | 1 |
| Csernus, VJ | 1 |
| Chankiewitz, E | 1 |
| Peschke, D | 1 |
| Friedrichsen, BN | 1 |
| Carlsson, C | 1 |
| Møldrup, A | 1 |
| Michelsen, B | 1 |
| Jensen, CH | 1 |
| Teisner, B | 1 |
| Nielsen, JH | 1 |
| Al-Majed, HT | 1 |
| Jones, PM | 1 |
| Persaud, SJ | 1 |
| Sugden, D | 1 |
| Huang, GC | 1 |
| Amiel, S | 1 |
| Whitehouse, BJ | 1 |
| Sekine, N | 1 |
| Takano, K | 1 |
| Kimata-Hayashi, N | 1 |
| Kadowaki, T | 1 |
| Fujita, T | 3 |
| Stumpf, I | 1 |
| Knudsen, P | 1 |
| Kofod, H | 1 |
| Lernmark, A | 1 |
| Hedeskov, CJ | 1 |
| Gold, G | 1 |
| Gishizky, ML | 1 |
| Chick, WL | 1 |
| Grodsky, GM | 1 |
| Ohno, T | 1 |
| Kato, N | 1 |
| Ishii, C | 1 |
| Shimizu, M | 1 |
| Ito, Y | 1 |
| Tomono, S | 1 |
| Kawazu, S | 1 |
| McLeod, MK | 1 |
| Kothary, PC | 1 |
| Farrell, CM | 1 |
| De Stefanis, P | 1 |
| Impagnatiello, F | 1 |
| Berkovich, A | 1 |
| Guidotti, A | 1 |
| Khan, RN | 1 |
| Hales, CN | 1 |
| Ozanne, SE | 1 |
| Adogu, AA | 1 |
| Ashford, ML | 1 |
| Ahrén, B | 1 |
| Simonsson, E | 1 |
| Karlsson, S | 1 |
| Deeg, MA | 1 |
| Verchere, CB | 1 |
| Hohmeier, HE | 1 |
| BeltrandelRio, H | 1 |
| Clark, SA | 1 |
| Henkel-Rieger, R | 1 |
| Normington, K | 1 |
| Newgard, CB | 1 |
| Chen, K | 1 |
| Stephanopoulos, GN | 1 |
| Sinskey, AJ | 1 |
| Lodish, HF | 1 |
| Mamujee, SN | 1 |
| Zhou, D | 1 |
| Wheeler, MB | 2 |
| Vacek, I | 1 |
| Sun, AM | 2 |
| Seissler, J | 1 |
| Nguyen, TB | 1 |
| Aust, G | 1 |
| Steinbrenner, H | 1 |
| Scherbaum, WA | 1 |
| Ma, Z | 2 |
| Ramanadham, S | 2 |
| Wohltmann, M | 1 |
| Bohrer, A | 1 |
| Hsu, FF | 1 |
| Turk, J | 2 |
| Su, J | 1 |
| Yu, H | 1 |
| Lenka, N | 1 |
| Hescheler, J | 1 |
| Ullrich, S | 1 |
| MacDonald, PE | 1 |
| Ha, XF | 1 |
| Wang, J | 1 |
| Smukler, SR | 1 |
| Gaisano, HY | 1 |
| Salapatek, AM | 1 |
| Backx, PH | 1 |
| Bloch, K | 1 |
| Vardi, P | 1 |
| Darville, MI | 1 |
| Eizirik, DL | 1 |
| Zhang, S | 1 |
| Asfari, M | 1 |
| Janjic, D | 1 |
| Meda, P | 1 |
| Li, G | 1 |
| Halban, PA | 1 |
| Wollheim, CB | 1 |
| Gros, L | 1 |
| Demirpence, E | 1 |
| Jarrousse, C | 1 |
| Kervran, A | 1 |
| Bataille, D | 1 |
| Matsumura, T | 1 |
| Itoh, H | 1 |
| Watanabe, N | 1 |
| Oda, Y | 1 |
| Tanaka, M | 1 |
| Namba, M | 1 |
| Kono, N | 1 |
| Matsuyama, T | 1 |
| Komatsu, R | 1 |
| Matsuzawa, Y | 1 |
| Beinfeld, MC | 1 |
| D'Ambra, R | 1 |
| Surana, M | 2 |
| Efrat, S | 2 |
| Starr, RG | 1 |
| Fleischer, N | 3 |
| Yamatani, T | 2 |
| Yamaguchi, A | 2 |
| Nakamura, A | 1 |
| Morishita, T | 1 |
| Kadowaki, S | 2 |
| Chiba, T | 2 |
| Pasmantier, R | 1 |
| Danoff, A | 1 |
| Schubart, UK | 1 |
| Inui, T | 1 |
| Saito, Y | 1 |
| Thivolet, CH | 1 |
| Demidem, A | 1 |
| Haftek, M | 1 |
| Durand, A | 1 |
| Bertrand, J | 1 |
38 other studies available for 1-methyl-3-isobutylxanthine and Insulinoma
| Article | Year |
|---|---|
Rapid changes of mRNA-binding protein levels following glucose and 3-isobutyl-1-methylxanthine stimulation of insulinoma INS-1 cells.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Motifs; Animals; Binding Sites; Blotting, Western; Computati | 2009 |
Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carrier Proteins; Cell Line, Tumor; Colforsin; Cyclic AMP; Cyc | 2009 |
Transcripts of calcium/calmodulin-dependent kinases are changed after forskolin- or IBMX-induced insulin secretion due to melatonin treatment of rat insulinoma beta-cells (INS-1).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Li | 2009 |
Melatonin influences insulin secretion primarily via MT(1) receptors in rat insulinoma cells (INS-1) and mouse pancreatic islets.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line, Tumor; Cyclic AMP; Histocytochemistry; Insulin; Ins | 2012 |
Phosphorylation of cyclic AMP-response element-binding protein (CREB) is influenced by melatonin treatment in pancreatic rat insulinoma β-cells (INS-1).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line, | 2012 |
Receptor (MT(1)) mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS-1.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Biological Transport; Colforsin; Cyclic AMP | 2002 |
Expression, biosynthesis and release of preadipocyte factor-1/ delta-like protein/fetal antigen-1 in pancreatic beta-cells: possible physiological implications.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Division; Cells, Cultured; Enzyme-Linked Immunosorbent As | 2003 |
ACTH stimulates insulin secretion from MIN6 cells and primary mouse and human islets of Langerhans.
Topics: 1-Methyl-3-isobutylxanthine; Adrenocorticotropic Hormone; Animals; Calcium Channel Blockers; Cell Li | 2004 |
Adrenomedullin inhibits insulin exocytosis via pertussis toxin-sensitive G protein-coupled mechanism.
Topics: 1-Methyl-3-isobutylxanthine; Adrenomedullin; Calcium; Cell Line, Tumor; Colforsin; Exocytosis; Forma | 2006 |
Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Cell Line, Tumor; Colforsin; Cyclic GMP; Cyclic Nucleot | 2008 |
L-leucine methyl ester stimulates insulin secretion and islet glutamate dehydrogenase.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Glucagon; Glucose; Glutamate Dehydrogenase; Glutami | 1983 |
Contrasting patterns of insulin biosynthesis, compartmental storage, and secretion. Rat tumor versus islet cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Animals; Female; Glucose; In Vitro Techniques; Ins | 1984 |
Genistein augments cyclic adenosine 3'5'-monophosphate(cAMP) accumulation and insulin release in MIN6 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cell Line; Cyclic AMP; Cytosol; Dose-Response Relatio | 1993 |
Molecular and functional studies of inhibitory G protein in RINm5F cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; DNA, Neoplasm; Drug Combinations; GTP-Binding Prot | 1994 |
Inhibitory effect of ODN, a naturally occurring processing product of diazepam binding inhibitor, on secretagogues-induced insulin secretion.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifl | 1995 |
Dissociation of KATP channel and sulphonylurea receptor in the rat clonal insulin-secreting cell line, CRI-D11.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Cel | 1993 |
Glucagon-like peptide-1(7-36)amide and cytoplasmic calcium in insulin producing cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cytoplasm; Fura-2; Glucagon; Glucagon-Like Peptide 1; | 1996 |
Regulation of glycosylphosphatidylinositol-specific phospholipase D secretion from beta TC3 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cycloheximide; Glucagon; Glucagon-Like Peptide 1; G | 1997 |
Regulation of insulin secretion from novel engineered insulinoma cell lines.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Dose-Response Relationship, Drug; Gene Expression Regulation; | 1997 |
Regulated secretion of prolactin by the mouse insulinoma cell line beta TC-3.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Glucose; Glycosylation; Insulinoma; Mice; Pancreatic | 1995 |
Evaluation of immunoisolated insulin-secreting beta TC6-F7 cells as a bioartificial pancreas.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Glucose; Capsules; Cell Division; Cell Separation; Diabe | 1997 |
Regulation of the diabetes-associated autoantigen IA-2 in INS-1 pancreatic beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Autoantigens; Colforsin; Cyclic AMP; Gene Expression Regulatio | 2000 |
Studies of insulin secretory responses and of arachidonic acid incorporation into phospholipids of stably transfected insulinoma cells that overexpress group VIA phospholipase A2 (iPLA2beta ) indicate a signaling rather than a housekeeping role for iPLA2b
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Arachidonic Acid; Colforsin; Enzyme Inhibit | 2001 |
The expression and regulation of depolarization-activated K+ channels in the insulin-secreting cell line INS-1.
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; 8-Bromo Cyclic Adenosine Monophosphate; Action Potenti | 2001 |
Members of the Kv1 and Kv2 voltage-dependent K(+) channel families regulate insulin secretion.
Topics: 1-Methyl-3-isobutylxanthine; Adenoviridae; Animals; Cell Line; Cyclic AMP-Dependent Protein Kinases; | 2001 |
Therapeutic differentiation of tumor-derived insulin-producing cells selected for resistance to diabetogenic drugs.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Differentiation; Cell Division; Cells, Cultured; Colforsi | 2000 |
Cytokine induction of Fas gene expression in insulin-producing cells requires the transcription factors NF-kappaB and C/EBP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; CCAAT-Enhancer-Binding Protein-beta; Cytokines; fas Receptor; | 2001 |
Stimulation of insulin secretion and associated nuclear accumulation of iPLA(2)beta in INS-1 insulinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Nucleus; Colforsin; Cyclic AMP-Dependent Protein Kinases; | 2002 |
Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Colforsin; Insulin; Insulin Secretion; Insulinoma; Me | 1992 |
Characterization of binding sites for oxyntomodulin on a somatostatin-secreting cell line (RIN T3).
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Bin | 1992 |
Glucagonlike peptide-1(7-36)amide suppresses glucagon secretion and decreases cyclic AMP concentration in cultured In-R1-G9 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Clone Cells; Cricetinae; Cyclic AMP; Dose-Response Relationshi | 1992 |
CCK mRNA expression, pro-CCK processing, and regulated secretion of immunoreactive CCK peptides by rat insulinoma (RIN 5F) and mouse pituitary tumor (AtT-20) cells in culture.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Cholecystokinin; Chromatography, High Pres | 1992 |
Regulation of insulin secretion from beta-cell lines derived from transgenic mice insulinomas resembles that of normal beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Animals; Carbachol; Colforsin; Cyclic AMP; Drug Sy | 1990 |
Activation of PKC inhibits NaF-induced inositol phospholipid turnover in rat insulinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Colforsin; Cyclic AMP; Enzyme Activation; Inositol | 1990 |
Glucose induces insulin gene transcription in a murine pancreatic beta-cell line.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cell Nucleus; Colforsin; Cyclic AMP; Gallopamil; Ge | 1991 |
P19, a hormonally regulated phosphoprotein of peptide hormone-producing cells: secretagogue-induced phosphorylation in AtT-20 mouse pituitary tumor cells and in rat and hamster insulinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenoma, Islet Cell; Adrenocort | 1986 |
Glucose stimulates insulin release without altering cyclic AMP production or inositolphospholipid turnover in freshly obtained human insulinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Carbachol; Colforsin; Cyclic AMP; Glucose; Humans; | 1987 |
Structure, function, and immunogenicity of human insulinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Adult; C-Peptide; Fluorescent Antibody Technique; | 1988 |