1-methyl-3-isobutylxanthine has been researched along with Inflammation in 12 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aims of this study were to determine which phosphodiesterase (PDE) isoenzymes are involved in the control of eosinophil accumulation in the airways of ovalbumin (OVA)-immunized guinea-pigs by the use of isoenzyme selective inhibitors and to compare the effects of acute versus chronic administration of PDE isozyme inhibitors on pulmonary cell influx in ovalbumin-immunized guinea-pigs." | 1.29 | Acute versus chronic administration of phosphodiesterase inhibitors on allergen-induced pulmonary cell influx in sensitized guinea-pigs. ( Banner, KH; Page, CP, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Nightingale, TD | 1 |
| McCormack, JJ | 1 |
| Grimes, W | 1 |
| Robinson, C | 1 |
| Lopes da Silva, M | 1 |
| White, IJ | 1 |
| Vaughan, A | 1 |
| Cramer, LP | 1 |
| Cutler, DF | 1 |
| Kim Chung, le T | 1 |
| Hosaka, T | 1 |
| Yoshida, M | 1 |
| Harada, N | 1 |
| Sakaue, H | 1 |
| Sakai, T | 1 |
| Nakaya, Y | 1 |
| Grisouard, J | 1 |
| Timper, K | 1 |
| Bouillet, E | 1 |
| Radimerski, T | 1 |
| Dembinski, K | 1 |
| Frey, DM | 1 |
| Peterli, R | 1 |
| Zulewski, H | 1 |
| Keller, U | 1 |
| Müller, B | 1 |
| Christ-Crain, M | 1 |
| Radu, CG | 1 |
| Nijagal, A | 1 |
| McLaughlin, J | 1 |
| Wang, L | 1 |
| Witte, ON | 1 |
| Pérez-Navarro, R | 1 |
| Martínez-Augustin, O | 1 |
| Ballester, I | 1 |
| Zarzuelo, A | 1 |
| Sánchez de Medina, F | 1 |
| Dong, H | 1 |
| Osmanova, V | 1 |
| Epstein, PM | 1 |
| Brocke, S | 1 |
| Erdogan, S | 1 |
| Aslantas, O | 1 |
| Celik, S | 1 |
| Atik, E | 1 |
| Banner, KH | 1 |
| Page, CP | 1 |
| Nystedt, S | 1 |
| Ramakrishnan, V | 1 |
| Sundelin, J | 1 |
| Bonta, IL | 1 |
| Parnham, MJ | 1 |
| Adolfs, MJ | 1 |
| Arita, H | 1 |
| Nakano, T | 1 |
| Ohara, O | 1 |
| Teraoka, H | 1 |
12 other studies available for 1-methyl-3-isobutylxanthine and Inflammation
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Tuning the endothelial response: differential release of exocytic cargos from Weibel-Palade bodies.
Topics: 1-Methyl-3-isobutylxanthine; Actomyosin; Cytochalasins; Endothelial Cells; Epinephrine; Exocytosis; | 2018 |
Exendin-4, a GLP-1 receptor agonist, directly induces adiponectin expression through protein kinase A pathway and prevents inflammatory adipokine expression.
Topics: 1-Methyl-3-isobutylxanthine; 3T3-L1 Cells; Adipocytes; Adipokines; Adiponectin; Animals; Colforsin; | 2009 |
Metformin counters both lipolytic/inflammatory agents-decreased hormone sensitive lipase phosphorylation at Ser-554 and -induced lipolysis in human adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adipocytes; Adult; Aged; Colforsin; Female; Humans; Hypoglycemic Agents | 2011 |
Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Cell Cycle Proteins; Cell Death; Cell Lin | 2005 |
Experimental inflammation of the rat distal colon inhibits ion secretion in the proximal colon by affecting the enteric nervous system.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cholinergic Agonists; Colon; Colonic Diseases; Fema | 2005 |
Phosphodiesterase 8 (PDE8) regulates chemotaxis of activated lymphocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Chemotaxis; Colforsin; Co | 2006 |
The effects of increased cAMP content on inflammation, oxidative stress and PDE4 transcripts during Brucella melitensis infection.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Brucella melitensis; Bruc | 2008 |
Acute versus chronic administration of phosphodiesterase inhibitors on allergen-induced pulmonary cell influx in sensitized guinea-pigs.
Topics: 1-Methyl-3-isobutylxanthine; Allergens; Animals; Guinea Pigs; Inflammation; Male; Ovalbumin; Phospho | 1995 |
The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Cell Adhesion Molecules; Cell Line; Cells, | 1996 |
Mimickry of anti-granuloma effect of prostaglandin E by dibutyryl cyclic-AMP and some phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Anti-Inflammatory Agents; Bucladesine; Disease Models, Animal; | 1979 |
Activation of group II phospholipase A2 gene via two distinct mechanisms in rat vascular smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Annexins; Aorta, Thoracic; Bucladesine; Calcium-Binding Protei | 1991 |