1-methyl-3-isobutylxanthine has been researched along with Hypoxia in 11 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Milrinone and 6-bromo-8(methylamino)imidazo[1,2a]pyrazine-2-carbonitrile [SCA40; phosphodiesterase (PDE) III inhibitors], zaprinast (PDE V inhibitor), and 3-isobutyl-1-methyl xanthine (IBMX; nonselective PDE inhibitor) were examined on main pulmonary arteries from control rats and rats exposed to hypoxia (10% O2; 1 or 4 weeks) to induce pulmonary hypertension." | 3.70 | Phosphodiesterase III and V inhibitors on pulmonary artery from pulmonary hypertensive rats: differences between early and established pulmonary hypertension. ( Jeffery, TK; Wanstall, JC, 1998) |
| " Moreover, ACh and Ca(2+) dose-response studies showed that accumulation of cAMP shifted the dose-response curves to the low concentration side, suggesting that it increases Ca(2+) sensitivity in the fusion of the exocytotic cycle." | 1.31 | cAMP modulation of Ca(2+)-regulated exocytosis in ACh-stimulated antral mucous cells of guinea pig. ( Fujiwara, S; Imai, Y; Katsu, K; Kojima, K; Nakahari, T; Shimamoto, C, 2002) |
| "roughly 47% rods after 30 min of anoxia)." | 1.31 | 3-isobutyl-1-methylxanthine (IBMX) sensitizes cardiac myocytes to anoxia. ( Ervin, HD; Geisbuhler, TP; Schwager, TL, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (45.45) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Itoigawa, Y | 1 |
| Kishimoto, KN | 1 |
| Okuno, H | 1 |
| Sano, H | 1 |
| Kaneko, K | 1 |
| Itoi, E | 1 |
| Jackson-Weaver, O | 1 |
| Paredes, DA | 1 |
| Gonzalez Bosc, LV | 1 |
| Walker, BR | 1 |
| Kanagy, NL | 1 |
| Hashimoto, T | 1 |
| Sugiyama, A | 1 |
| Taguchi, S | 1 |
| Williams, JM | 1 |
| White, CR | 1 |
| Chang, MM | 1 |
| Injeti, ER | 1 |
| Zhang, L | 1 |
| Pearce, WJ | 1 |
| Shaul, PW | 1 |
| Wells, LB | 1 |
| Jeffery, TK | 1 |
| Wanstall, JC | 1 |
| Huang, CC | 1 |
| Hsu, KS | 1 |
| Nakahari, T | 1 |
| Fujiwara, S | 1 |
| Shimamoto, C | 1 |
| Kojima, K | 1 |
| Katsu, K | 1 |
| Imai, Y | 1 |
| Geisbuhler, TP | 1 |
| Schwager, TL | 1 |
| Ervin, HD | 1 |
| Delpiano, MA | 1 |
| Acker, H | 1 |
| Pérez-García, MT | 1 |
| Almaraz, L | 1 |
| González, C | 1 |
11 other studies available for 1-methyl-3-isobutylxanthine and Hypoxia
| Article | Year |
|---|---|
Hypoxia induces adipogenic differentitation of myoblastic cell lines.
Topics: 1-Methyl-3-isobutylxanthine; Adipocytes; Adipogenesis; Animals; CCAAT-Enhancer-Binding Protein-alpha | 2010 |
Intermittent hypoxia in rats increases myogenic tone through loss of hydrogen sulfide activation of large-conductance Ca(2+)-activated potassium channels.
Topics: 1-Methyl-3-isobutylxanthine; Air Pollutants; Animals; Blood Pressure; Endothelium, Vascular; Glyburi | 2011 |
Myosin heavy chain isoforms expression and cyclic AMP concentrations in hypoxia-induced hypertrophied right ventricle in rats.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Altitude; Animals; Cell Membrane; Colforsin; Cyclic | 2004 |
Chronic hypoxic decreases in soluble guanylate cyclase protein and enzyme activity are age dependent in fetal and adult ovine carotid arteries.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Carotid Arteries; Cyclic GMP; Cyclic GMP-Dependent Prot | 2006 |
Oxygen modulates nitric oxide production selectively in fetal pulmonary endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Oxidoreductases; Animals; Bradykinin; Calcimycin; Cells, Cul | 1994 |
Phosphodiesterase III and V inhibitors on pulmonary artery from pulmonary hypertensive rats: differences between early and established pulmonary hypertension.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterase | 1998 |
Protein tyrosine kinase is required for the induction of long-term potentiation in the rat hippocampus.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Electric Stimulation; Enzyme Inhibitors; Excitatory | 1999 |
cAMP modulation of Ca(2+)-regulated exocytosis in ACh-stimulated antral mucous cells of guinea pig.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Adenosine Tripho | 2002 |
3-isobutyl-1-methylxanthine (IBMX) sensitizes cardiac myocytes to anoxia.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Hypoxia; Heart; Hypoxia; Myocardium; Phosphodiesterase In | 2002 |
Hypoxia increases the cyclic AMP content of the cat carotid body in vitro.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclase Inhibitors; Anima | 1991 |
Cyclic AMP modulates differentially the release of dopamine induced by hypoxia and other stimuli and increases dopamine synthesis in the rabbit carotid body.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Carotid Body; Colforsin; Cyclic AMP; Dop | 1991 |