1-methyl-3-isobutylxanthine has been researched along with Hypertension in 16 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The dose-response curves of the strips from both strains for alpha-adrenoceptor stimulation with NA determined after pretreatment with CTX were comparable to those determined in the absence of timolol." | 1.27 | Role of stimulatory GTP-binding protein (Gs) in reduced beta-adrenoceptor coupling in the femoral artery of spontaneously hypertensive rats. ( Asano, M; Masuzawa, K; Matsuda, T, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (25.00) | 18.7374 |
| 1990's | 8 (50.00) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cheng, D | 1 |
| Ren, J | 1 |
| Gillespie, DG | 1 |
| Mi, Z | 2 |
| Jackson, EK | 2 |
| Dubey, RK | 1 |
| Lu, C | 1 |
| Pribanic, S | 1 |
| Debonneville, A | 1 |
| Jiang, C | 1 |
| Rotin, D | 1 |
| Dusseau, JW | 1 |
| Hutchins, PM | 1 |
| Dean, T | 1 |
| Kornhauser, R | 1 |
| Papapetropoulos, A | 1 |
| Marczin, N | 1 |
| Snead, MD | 1 |
| Cheng, C | 1 |
| Milici, A | 1 |
| Catravas, JD | 1 |
| Bogoyevitch, MA | 1 |
| Fuller, SJ | 1 |
| Sugden, PH | 1 |
| Grove, KL | 1 |
| Gonçalves, J | 1 |
| Picard, S | 1 |
| Thibault, G | 1 |
| Deschepper, CF | 1 |
| McConnell, BK | 1 |
| Moravec, CS | 1 |
| Morano, I | 1 |
| Bond, M | 1 |
| Osaki, J | 1 |
| Haneda, T | 1 |
| Kashiwagi, Y | 1 |
| Oi, S | 1 |
| Fukuzawa, J | 1 |
| Sakai, H | 1 |
| Kikuchi, K | 1 |
| Hopf, A | 1 |
| Schreiber, R | 1 |
| Mall, M | 1 |
| Greger, R | 1 |
| Kunzelmann, K | 1 |
| Snyder, PM | 1 |
| Nishimura, Y | 1 |
| Usui, H | 1 |
| Suzuki, A | 1 |
| Kajimoto, N | 1 |
| Yamanishi, Y | 1 |
| Asano, M | 3 |
| Masuzawa, K | 3 |
| Matsuda, T | 3 |
| Asano, T | 1 |
16 other studies available for 1-methyl-3-isobutylxanthine and Hypertension
| Article | Year |
|---|---|
Regulation of 3',5'-cAMP in preglomerular smooth muscle and endothelial cells from genetically hypertensive rats.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adrenergic beta-Agonist | 2010 |
The extracellular cAMP-adenosine pathway significantly contributes to the in vivo production of adenosine.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Cyclic AMP; Hypertension; Male; Rats; Rats, Inbred | 2007 |
The PY motif of ENaC, mutated in Liddle syndrome, regulates channel internalization, sorting and mobilization from subapical pool.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Motifs; Animals; Cell Line; Cell Membrane; Cyclic AMP; Endoc | 2007 |
Elevated arteriolar adenosine 3',5'-cyclic monophosphate production by SHR.
Topics: 1-Methyl-3-isobutylxanthine; Albuterol; Animals; Arterioles; Blood Pressure; Body Weight; Cyclic AMP | 1982 |
Increased platelet reactivity to prostaglandin E1 in hypertension is linked with altered signal transduction.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Blood Platelets; Colforsin; Cyclic AMP; GTP Phosp | 1993 |
Smooth muscle cell responsiveness to nitrovasodilators in hypertensive and normotensive rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Base Sequence; Blotting, Northern; Cells, Cultured; | 1994 |
cAMP and protein synthesis in isolated adult rat heart preparations.
Topics: 1-Methyl-3-isobutylxanthine; Adenine Nucleotides; Animals; Colforsin; Cyclic AMP; Cyclic AMP-Depende | 1993 |
Comparison of ANP binding and sensitivity in brains from hypertensive and normotensive rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Brain; Cyclic GMP; Guanylate Cyclas | 1997 |
Troponin I phosphorylation in spontaneously hypertensive rat heart: effect of beta-adrenergic stimulation.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifl | 1997 |
Pressure-induced expression of heat shock protein 70 mRNA in adult rat heart is coupled both to protein kinase A-dependent and protein kinase C-dependent systems.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Pressure; Cardiomegaly; Colforsin; Cyclic AMP; Cyclic AM | 1998 |
Cystic fibrosis transmembrane conductance regulator inhibits epithelial Na+ channels carrying Liddle's syndrome mutations.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antibodies; Calcium-Binding Proteins; Cyclic AMP-Dependent Pro | 1999 |
Liddle's syndrome mutations disrupt cAMP-mediated translocation of the epithelial Na(+) channel to the cell surface.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biological Transport; Cells, Cultured; Cyclic AMP; Cystic Fibr | 2000 |
Relaxant response of isolated basilar arteries to calcitonin gene-related peptide in stroke-prone spontaneously hypertensive rats.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Basilar Artery; Bucladesine; Calcitonin Gene-Re | 1992 |
Evidence for reduced beta-adrenoceptor coupling to adenylate cyclase in femoral arteries from spontaneously hypertensive rats.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Bucladesine; Colforsin; Femoral Artery; Hyp | 1988 |
Reduced function of the stimulatory GTP-binding protein in beta adrenoceptor-adenylate cyclase system of femoral arteries isolated from spontaneously hypertensive rats.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Bucladesine; Cholera Toxin; Colforsin; Cycl | 1988 |
Role of stimulatory GTP-binding protein (Gs) in reduced beta-adrenoceptor coupling in the femoral artery of spontaneously hypertensive rats.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Antagonists; Animals; Bucladesine; Cholera Toxin; Colf | 1988 |