1-methyl-3-isobutylxanthine has been researched along with Hypertension, Pulmonary in 4 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Milrinone and 6-bromo-8(methylamino)imidazo[1,2a]pyrazine-2-carbonitrile [SCA40; phosphodiesterase (PDE) III inhibitors], zaprinast (PDE V inhibitor), and 3-isobutyl-1-methyl xanthine (IBMX; nonselective PDE inhibitor) were examined on main pulmonary arteries from control rats and rats exposed to hypoxia (10% O2; 1 or 4 weeks) to induce pulmonary hypertension." | 3.70 | Phosphodiesterase III and V inhibitors on pulmonary artery from pulmonary hypertensive rats: differences between early and established pulmonary hypertension. ( Jeffery, TK; Wanstall, JC, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, S | 1 |
| White, RE | 1 |
| Barman, SA | 1 |
| Crosswhite, P | 1 |
| Sun, Z | 1 |
| Schermuly, RT | 1 |
| Pullamsetti, SS | 1 |
| Kwapiszewska, G | 1 |
| Dumitrascu, R | 1 |
| Tian, X | 1 |
| Weissmann, N | 1 |
| Ghofrani, HA | 1 |
| Kaulen, C | 1 |
| Dunkern, T | 1 |
| Schudt, C | 1 |
| Voswinckel, R | 1 |
| Zhou, J | 1 |
| Samidurai, A | 1 |
| Klepetko, W | 1 |
| Paddenberg, R | 1 |
| Kummer, W | 1 |
| Seeger, W | 1 |
| Grimminger, F | 1 |
| Jeffery, TK | 1 |
| Wanstall, JC | 1 |
4 other studies available for 1-methyl-3-isobutylxanthine and Hypertension, Pulmonary
| Article | Year |
|---|---|
Role of phosphodiesterases in modulation of BKCa channels in hypertensive pulmonary arterial smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Disease Models, Animal; Hypertension, P | 2008 |
Inhibition of phosphodiesterase-1 attenuates cold-induced pulmonary hypertension.
Topics: 1-Methyl-3-isobutylxanthine; Acetophenones; Animals; Cold Temperature; Cyclic Nucleotide Phosphodies | 2013 |
Phosphodiesterase 1 upregulation in pulmonary arterial hypertension: target for reverse-remodeling therapy.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cell Division; Chronic Di | 2007 |
Phosphodiesterase III and V inhibitors on pulmonary artery from pulmonary hypertensive rats: differences between early and established pulmonary hypertension.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterase | 1998 |