1-methyl-3-isobutylxanthine has been researched along with Hirschsprung Disease in 3 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Hirschsprung Disease: Congenital MEGACOLON resulting from the absence of ganglion cells (aganglionosis) in a distal segment of the LARGE INTESTINE. The aganglionic segment is permanently contracted thus causing dilatation proximal to it. In most cases, the aganglionic segment is within the RECTUM and SIGMOID COLON.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bekkali, N | 1 |
| de Jonge, HR | 1 |
| van den Wijngaard, RM | 1 |
| van der Steeg, AF | 1 |
| Bijlsma, PB | 1 |
| Taminiau, JA | 1 |
| Desjeux, JF | 1 |
| Benninga, MA | 1 |
| VanderWall, KJ | 1 |
| Bealer, JF | 1 |
| Adzick, NS | 1 |
| Harrison, MR | 1 |
| Hardy, SP | 1 |
| Smith, PM | 1 |
| Bayston, R | 1 |
| Spitz, L | 1 |
3 other studies available for 1-methyl-3-isobutylxanthine and Hirschsprung Disease
| Article | Year |
|---|---|
The role of rectal chloride secretion in childhood constipation.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Biopsy; Carbachol; Child; Chlorides; Cholinergic Agonists; C | 2011 |
Cyclic GMP relaxes the internal anal sphincter in Hirschsprung's disease.
Topics: 1-Methyl-3-isobutylxanthine; Anal Canal; Colon; Cyclic AMP; Cyclic GMP; Ganglia; Hirschsprung Diseas | 1995 |
Electrogenic colonic ion transport in Hirschsprung's disease: reduced secretion to the neural secretagogues acetylcholine and iloprost.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Colon; Enterotoxins; Hirschsprung Disease; Humans; Ilopr | 1993 |