1-methyl-3-isobutylxanthine has been researched along with Heart Failure in 12 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Rats with congestive heart failure (CHF) have increased protein level of NKCC2, which can be normalized by angiotensin II receptor type-1 (AT(1)) blockade with losartan." | 7.74 | Losartan decreases vasopressin-mediated cAMP accumulation in the thick ascending limb of the loop of Henle in rats with congestive heart failure. ( Brønd, L; Christensen, S; Hadrup, N; Jonassen, TE; Nielsen, JB; Nielsen, S; Praetorius, J; Torp, M, 2007) |
| " Rats with congestive heart failure (CHF) have increased protein level of NKCC2, which can be normalized by angiotensin II receptor type-1 (AT(1)) blockade with losartan." | 3.74 | Losartan decreases vasopressin-mediated cAMP accumulation in the thick ascending limb of the loop of Henle in rats with congestive heart failure. ( Brønd, L; Christensen, S; Hadrup, N; Jonassen, TE; Nielsen, JB; Nielsen, S; Praetorius, J; Torp, M, 2007) |
| "To corroborate alterations in the functional responses to beta-adrenergic receptor (beta-AR) stimulation with changes in beta-AR signaling in failing cardiomyocytes, contractile and L-type Ca(2+) current responses to isoproterenol along with stimulated cAMP generation were compared among cardiomyocytes isolated from canines with tachycardia-induced heart failure or healthy hearts." | 3.71 | Functional desensitization to isoproterenol without reducing cAMP production in canine failing cardiocytes. ( Armour, JA; Bouchard, C; Bouvier, M; Cardinal, R; Laurent, CE; Rousseau, G; Vermeulen, M; Wilkinson, M, 2001) |
| "Heart failure is associated with pathobiochemical changes that can reduce the responsiveness of the myocardium to positive inotropic agents." | 1.30 | The effect of positive inotropes on the failing human myocardium. ( Erdmann, E, 1997) |
| " Dose-response curves plotted as percentage change from baseline versus concentration of drug were determined for acetylstrophanthidin, isoproterenol, isobutylmethylxanthine, and milrinone." | 1.29 | Decreased inotropic but relatively preserved relaxation response to cyclic adenosine monophosphate-dependent agents in myopathic human myocardium. ( Bruce, E; Flemmal, K; Grossman, W; Gutstein, DE; Gwathmey, JK; Markis, JE; Morgan, JP; Ransil, BJ; Travers, KE, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 6 (50.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Torp, M | 1 |
| Brønd, L | 1 |
| Hadrup, N | 1 |
| Nielsen, JB | 1 |
| Praetorius, J | 1 |
| Nielsen, S | 1 |
| Christensen, S | 1 |
| Jonassen, TE | 1 |
| Wynne, DG | 1 |
| Poole-Wilson, PA | 1 |
| Harding, SE | 1 |
| De Mello, WC | 1 |
| Bethke, T | 1 |
| Klimkiewicz, A | 1 |
| Meyer, W | 1 |
| Schumacher, C | 1 |
| Schmitz, W | 2 |
| Scholz, H | 1 |
| Starbatty, J | 1 |
| Wenzlaff, H | 1 |
| Zimmermann, W | 1 |
| Gutstein, DE | 1 |
| Flemmal, K | 1 |
| Bruce, E | 1 |
| Travers, KE | 1 |
| Gwathmey, JK | 2 |
| Ransil, BJ | 1 |
| Markis, JE | 1 |
| Grossman, W | 2 |
| Morgan, JP | 2 |
| Erdmann, E | 1 |
| Gaballa, MA | 1 |
| Eckhart, A | 1 |
| Koch, WJ | 1 |
| Goldman, S | 1 |
| Laurent, CE | 1 |
| Cardinal, R | 1 |
| Rousseau, G | 1 |
| Vermeulen, M | 1 |
| Bouchard, C | 1 |
| Wilkinson, M | 1 |
| Armour, JA | 1 |
| Bouvier, M | 1 |
| Müller, FU | 1 |
| Bokník, P | 1 |
| Knapp, J | 1 |
| Linck, B | 1 |
| Lüss, H | 1 |
| Neumann, J | 1 |
| Boixel, C | 1 |
| Gonzalez, W | 1 |
| Louedec, L | 1 |
| Hatem, SN | 1 |
| Pagani, ED | 1 |
| Buchholz, RA | 1 |
| Silver, PJ | 1 |
| Feldman, MD | 1 |
| Copelas, L | 1 |
| Phillips, P | 1 |
| Warren, SE | 1 |
| Schoen, FJ | 1 |
12 other studies available for 1-methyl-3-isobutylxanthine and Heart Failure
| Article | Year |
|---|---|
Losartan decreases vasopressin-mediated cAMP accumulation in the thick ascending limb of the loop of Henle in rats with congestive heart failure.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Angiotensin II Type 1 Receptor Blockers; Animals; Cy | 2007 |
Incomplete reversal of beta-adrenoceptor desensitization in human and guinea-pig cardiomyocytes by cyclic nucleotide phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adrenergic beta-Antagonists | 1993 |
Impaired regulation of cell communication by beta-adrenergic receptor activation in the failing heart.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Cardiomyopathies; | 1996 |
Characterization of the phosphodiesterase inhibition by 2-(3-methoxy-5-methylsulfinyl-2-thienyl)-1H-imidazo-(4,5-c)-pyridine HCl and its sulfide- and sulfone derivatives in myocardial preparations from failing human hearts.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Chromatography, DEAE-Cellulose; Cyclic AMP; Female; Heart Failur | 1995 |
Decreased inotropic but relatively preserved relaxation response to cyclic adenosine monophosphate-dependent agents in myopathic human myocardium.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Antagonists; Adult; Analysis of Variance; Cardiotonic A | 1996 |
The effect of positive inotropes on the failing human myocardium.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Calcium; Cardiotonic Agents; Dobutamine; Hear | 1997 |
Vascular beta-adrenergic receptor system is dysfunctional after myocardial infarction.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Aorta; Aurora Kinases; Blood Pressur | 2001 |
Functional desensitization to isoproterenol without reducing cAMP production in canine failing cardiocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Calcium Channels, L-Type; Cell Membrane; Ce | 2001 |
Activation and inactivation of cAMP-response element-mediated gene transcription in cardiac myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Cantharidin; Cardiotonic Agents; Cell Cycle | 2001 |
Mechanisms of L-type Ca(2+) current downregulation in rat atrial myocytes during heart failure.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Atrial Natriuretic Factor; Calcium; | 2001 |
Cardiovascular cyclic nucleotide phosphodiesterases and their role in regulating cardiovascular function.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Cyclic GMP; Heart Failure; Humans; | 1992 |
Deficient production of cyclic AMP: pharmacologic evidence of an important cause of contractile dysfunction in patients with end-stage heart failure.
Topics: 1-Methyl-3-isobutylxanthine; Caffeine; Calcium; Cardiotonic Agents; Colforsin; Cyclic AMP; Heart Fai | 1987 |