1-methyl-3-isobutylxanthine has been researched along with Glioma in 39 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To clarify the functional significance of type IV phosphodiesterase (PDEIV) in neurons and glia cells [3H]rolipram binding and phosphodiesterase (PDE) activity were examined in cytosol and membrane fractions of neuroblastoma N18TG-2 and glioma C6Bu-1 cells." | 7.69 | [3H]Rolipram binding and phosphodiesterase activity in neuroblastoma N18TG-2 and glioma C6Bu-1. ( Hasegawa, H; Murayama, T; Nogiri, S; Nomura, Y; Tohda, M, 1994) |
| "Atrial natriuretic factors (ANFs) were tested for their effects on cyclic GMP production in two neurally derived cell lines, the C6-2B rat glioma cells and the PC12 rat pheochromocytoma cells." | 7.67 | Atrial natriuretic factors stimulate accumulation and efflux of cyclic GMP in C6-2B rat glioma and PC12 rat pheochromocytoma cell cultures. ( Fiscus, RR; Murad, F; Robles, BT; Waldman, SA, 1987) |
| "Acute incubation of NMDA with neuroblastoma x glioma hybrid (NG108-15) cells or neuroblastoma SK-N-SH cells produced significant attenuation of nociceptin/orphanin FQ (N/OFQ)-induced activation of G protein and inhibition of adenylyl cyclase." | 3.70 | Attenuation of nociceptin/orphanin FQ-induced signaling by N-methyl-D-aspartate in neuronal cells. ( Ma, L; Pei, G; Xin, SM; Zhang, Y; Zhao, J, 1998) |
| "To clarify the functional significance of type IV phosphodiesterase (PDEIV) in neurons and glia cells [3H]rolipram binding and phosphodiesterase (PDE) activity were examined in cytosol and membrane fractions of neuroblastoma N18TG-2 and glioma C6Bu-1 cells." | 3.69 | [3H]Rolipram binding and phosphodiesterase activity in neuroblastoma N18TG-2 and glioma C6Bu-1. ( Hasegawa, H; Murayama, T; Nogiri, S; Nomura, Y; Tohda, M, 1994) |
| "Exposure of C62B rat glioma cells to fresh medium containing fetal bovine serum induced a sensitization of the subsequent ability of isoproterenol and forskolin to stimulate cyclic AMP accumulation, compared to cells exposed to fresh medium without serum." | 3.68 | Serum-induced sensitization of cyclic AMP accumulation in C62B rat glioma cells. ( Arneson-Rotert, LJ; Hoffman, JM; Liewer, SA; Toews, ML, 1992) |
| "When exposed to the beta-agonist (-)-isoproterenol, rat glioma C6 cells exhibited a time-and concentration-dependent reduction in isoproterenol responsiveness (desensitization) and a loss of beta-adrenergic receptors (down-regulation)." | 3.67 | Desensitization of catecholamine-stimulated adenylate cyclase and down-regulation of beta-adrenergic receptors in rat glioma C6 cells. Role of cyclic AMP and protein synthesis. ( Fishman, PH; Zaremba, TG, 1984) |
| "The activity of transglutaminase (TGase) was measured in cultured C6 glioma cells after their stimulation by either isoproterenol and isobutyl-methylxanthine or by a serum-containing medium." | 3.67 | Activation and de novo synthesis of transglutaminase in cultured glioma cells. ( Bachrach, U; Korner, G, 1985) |
| "Atrial natriuretic factors (ANFs) were tested for their effects on cyclic GMP production in two neurally derived cell lines, the C6-2B rat glioma cells and the PC12 rat pheochromocytoma cells." | 3.67 | Atrial natriuretic factors stimulate accumulation and efflux of cyclic GMP in C6-2B rat glioma and PC12 rat pheochromocytoma cell cultures. ( Fiscus, RR; Murad, F; Robles, BT; Waldman, SA, 1987) |
| "Chronic pertussis toxin treatment (5 days) of NG108-15 neuroblastoma X glioma hybrid cells had no significant effect on basal cyclic AMP levels whereas it effectively blocked the inhibitory action of acute (10 min) exposure of carbachol (10(-4)M) on intracellular cyclic AMP accumulation, stimulated by prostaglandin E1." | 3.67 | Chronic exposure to pertussis toxin alters muscarinic receptor-mediated regulation of cyclic AMP metabolism in neuroblastoma x glioma NG108-15 hybrid cells. ( Askelöf, P; Bartfai, T; Gillenius, P; Westlind-Danielsson, A, 1988) |
| "Pre-treatment with isoproterenol or the cyclic AMP analogue, dibutyryl cyclic AMP, induced refractoriness to forskolin." | 1.27 | Forskolin-stimulated cyclic AMP accumulation mediates protein synthesis-dependent refractoriness in C6-2B rat glioma cells. ( Barovsky, K; Brooker, G; Pedone, C, 1983) |
| " At peptide concentrations of 1 microM clear-cut plateaus of the dose-response curves are not yet reached." | 1.27 | Atrial natriuretic hormones raise the level of cyclic GMP in neural cell lines. ( Friedl, A; Hamprecht, B; Harmening, C, 1986) |
| "Carbachol treatment of cells resulted in down-regulation of muscarinic cholinergic receptors to 45." | 1.27 | Agonist-induced down-regulation of muscarinic cholinergic and alpha 2-adrenergic receptors after inactivation of Ni by pertussis toxin. ( Hoffman, BB; Thomas, JM, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (38.46) | 18.7374 |
| 1990's | 19 (48.72) | 18.2507 |
| 2000's | 4 (10.26) | 29.6817 |
| 2010's | 1 (2.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lv, P | 1 |
| Wang, W | 1 |
| Cao, Z | 1 |
| Zhao, D | 1 |
| Zhao, G | 1 |
| Li, D | 1 |
| Qi, L | 1 |
| Xu, J | 1 |
| Clark, MJ | 1 |
| Traynor, JR | 1 |
| Koschel, K | 1 |
| Derda, DF | 1 |
| Miles, MF | 1 |
| Schweppe, JS | 1 |
| Jungmann, RA | 1 |
| Norman, JA | 1 |
| Staehelin, M | 1 |
| Barovsky, K | 1 |
| Pedone, C | 1 |
| Brooker, G | 2 |
| Freedman, SB | 1 |
| Dawson, G | 2 |
| Villereal, ML | 1 |
| Miller, RJ | 1 |
| Zaremba, TG | 1 |
| Fishman, PH | 1 |
| Sernia, C | 1 |
| Thomas, WG | 1 |
| Tohda, M | 1 |
| Murayama, T | 1 |
| Hasegawa, H | 1 |
| Nogiri, S | 1 |
| Nomura, Y | 1 |
| Kuzhikandathil, EV | 1 |
| Molloy, GR | 1 |
| Fukumoto, H | 1 |
| Kakihana, M | 1 |
| Suno, M | 1 |
| Bergsbaken, CL | 1 |
| Sommers, SL | 1 |
| Law, PY | 1 |
| Zhang, X | 1 |
| Miskimins, R | 1 |
| Pauwels, PJ | 1 |
| Wurch, T | 1 |
| Amoureux, MC | 1 |
| Palmier, C | 1 |
| Colpaert, FC | 1 |
| Cai, Y | 1 |
| Zhang, Y | 2 |
| Wu, Y | 1 |
| Pei, G | 2 |
| Boddeke, HW | 1 |
| Meigel, I | 1 |
| Boeijinga, P | 1 |
| Arbuckle, J | 1 |
| Docherty, RJ | 1 |
| Chen, G | 1 |
| Pan, B | 1 |
| Hawver, DB | 1 |
| Wright, CB | 1 |
| Potter, WZ | 1 |
| Manji, HK | 1 |
| Zhao, J | 1 |
| Xin, SM | 1 |
| Ma, L | 1 |
| Allen, ML | 1 |
| Koh, DS | 1 |
| Tempel, BL | 1 |
| Wöltje, M | 1 |
| Kraus, J | 1 |
| Höllt, V | 1 |
| Slamon, ND | 2 |
| Pentreath, VW | 2 |
| Ward, TH | 1 |
| Butler, J | 1 |
| Propst, F | 1 |
| Moroder, L | 1 |
| Wünsch, E | 1 |
| Hamprecht, B | 2 |
| Bouillon, M | 1 |
| Fortier, MA | 1 |
| Boulianne, R | 1 |
| Audette, M | 1 |
| Langeveld, CH | 1 |
| Jongenelen, CA | 1 |
| Heimans, JJ | 1 |
| Stoof, JC | 1 |
| Toews, ML | 1 |
| Hoffman, JM | 1 |
| Liewer, SA | 1 |
| Arneson-Rotert, LJ | 1 |
| Tao-Cheng, JH | 1 |
| Bressler, JP | 1 |
| Brightman, MW | 1 |
| Thomas, JM | 2 |
| Vagelos, R | 1 |
| Hoffman, BB | 2 |
| DeBernardi, MA | 1 |
| Seki, T | 1 |
| Kobierski, LA | 1 |
| Chu, HM | 1 |
| Tan, Y | 1 |
| Comb, MJ | 1 |
| Korner, G | 1 |
| Bachrach, U | 1 |
| Friedl, A | 1 |
| Harmening, C | 1 |
| Scheideler, MA | 1 |
| Fiscus, RR | 1 |
| Robles, BT | 1 |
| Waldman, SA | 1 |
| Murad, F | 1 |
| Westlind-Danielsson, A | 1 |
| Gillenius, P | 1 |
| Askelöf, P | 1 |
| Bartfai, T | 1 |
| Collins, S | 1 |
| Bouvier, M | 1 |
| Bolanowski, MA | 1 |
| Caron, MG | 1 |
| Lefkowitz, RJ | 1 |
| Kim, UH | 1 |
| Kim, JW | 1 |
| Rhee, SG | 1 |
39 other studies available for 1-methyl-3-isobutylxanthine and Glioma
| Article | Year |
|---|---|
Fsk and IBMX inhibit proliferation and proapoptotic of glioma stem cells via activation of cAMP signaling pathway.
Topics: 1-Methyl-3-isobutylxanthine; Apoptosis; Brain Neoplasms; Butadienes; Cell Line, Tumor; Cell Prolifer | 2019 |
Mediation of adenylyl cyclase sensitization by PTX-insensitive GalphaoA, Galphai1, Galphai2 or Galphai3.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Analgesics, Opioid; Blotting, Western; Cell Line; Co | 2006 |
A hormone-independent rise of adenosine 3',5'-monophosphate desensitizes coupling of beta-adrenergic receptors to adenylate cyclase in rat glioma C6-cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Carrier Proteins; Cholera Toxin; Cyclic AMP | 1980 |
Cyclic AMP regulation of lactate dehydrogenase. Isoproterenol and N6,O2'-dibutyryl cyclic AMP increase the levels of lactate dehydrogenase-5 isozyme and its messenger RNA in rat C6 glioma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cell Line; Cyclic AMP; Dactinomycin; Glioma; Half | 1980 |
Calmodulin inhibitors activate glycogen phosphorylase B to A conversion in C6 glioma cells.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Antipsychotic | 1982 |
Forskolin-stimulated cyclic AMP accumulation mediates protein synthesis-dependent refractoriness in C6-2B rat glioma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Cyclohexi | 1983 |
Identification and characterization of voltage-sensitive calcium channels in neuronal clonal cell lines.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain Neoplasms; Calcium Channel Blockers; Cell Transformation | 1984 |
Desensitization of catecholamine-stimulated adenylate cyclase and down-regulation of beta-adrenergic receptors in rat glioma C6 cells. Role of cyclic AMP and protein synthesis.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Bucladesine; Cell Line; Cell Membrane; Chol | 1984 |
A novel inhibitory role for glucocorticoids in the secretion of angiotensinogen by C6 glioma cells.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Angiotensinogen; Animals; Bucladesine; Cyclic AMP; Dexamet | 1994 |
[3H]Rolipram binding and phosphodiesterase activity in neuroblastoma N18TG-2 and glioma C6Bu-1.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imi | 1994 |
Transcription of the brain creatine kinase gene in glial cells is modulated by cyclic AMP-dependent protein kinase.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Brain; Brain Neoplasms; Cloning, Molecular; | 1994 |
Characterization of C6-10A glioma cells highly responsive to beta-adrenergic receptor agonist-induced NGF synthesis/secretion.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blo | 1994 |
Effect of forskolin and isobutylmethylxanthine on delta-opioid receptor activity in neuroblastoma x glioma NG108-15 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Differentiation; Colforsin; Cyclic AMP; Enkephalin, Leuci | 1993 |
Binding at an NFI site is modulated by cyclic AMP-dependent activation of myelin basic protein gene expression.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Binding Sites; Bucladesine; CCAAT-Enhancer-Bind | 1993 |
Stimulation of cloned human serotonin 5-HT1D beta receptor sites in stably transfected C6 glial cells promotes cell growth.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain Neoplasms; Bucladesine; Cell Division; CHO Cells; Clonin | 1996 |
delta Opioid receptor in neuronal cells undergoes acute and homologous desensitization.
Topics: 1-Methyl-3-isobutylxanthine; Analgesics; Animals; Cerebral Cortex; Cyclic AMP; Dose-Response Relatio | 1996 |
Modulation by calcineurin of 5-HT3 receptor function in NG108-15 neuroblastoma x glioma cells.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Brain Neoplasms; Calcineurin; Calmodulin- | 1996 |
Attenuation of cyclic AMP production by carbamazepine.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylate Cyclase Toxin; Adenylyl | 1996 |
Attenuation of nociceptin/orphanin FQ-induced signaling by N-methyl-D-aspartate in neuronal cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Gliom | 1998 |
Cyclic AMP regulates potassium channel expression in C6 glioma by destabilizing Kv1.1 mRNA.
Topics: 1-Methyl-3-isobutylxanthine; Animals; CHO Cells; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protei | 1998 |
Regulation of mouse delta-opioid receptor gene transcription: involvement of the transcription factors AP-1 and AP-2.
Topics: 1-Methyl-3-isobutylxanthine; Aged; Animals; Carcinogens; Colforsin; Cyclic AMP-Dependent Protein Kin | 2000 |
Antioxidant defense against antidepressants in C6 and 1321N1 cells.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Antidepressive Agents; Antimetabolit | 2000 |
Assessment of DNA damage in C6 glioma cells after antidepressant treatment using an alkaline comet assay.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agent | 2001 |
The influence of secretin, glucagon and other peptides, of amino acids, prostaglandin endoperoxide analogues and diazepam on the level of adenosine 3',5'-cyclic monophosphate in neuroblastoma x glioma hybrid cells.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amino Acids; Cyclic AMP | 1979 |
Biphasic effect of cAMP-elevating agents on ICAM-1 expression stimulated by retinoic acid and interferon gamma.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Cell Adhesion Molecules; Ch | 1992 |
8-Chloro-cyclic adenosine monophosphate, a novel cyclic AMP analog that inhibits human glioma cell growth in concentrations that do not induce differentiation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; | 1992 |
Serum-induced sensitization of cyclic AMP accumulation in C62B rat glioma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Physiological Phenomena; Cyclic AMP; Glioma; Isoproteren | 1992 |
Astroglial membrane structure is affected by agents that raise cyclic AMP and by phosphatidylcholine phospholipase C.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Astrocytes; Cattle; Ce | 1992 |
Decreased cyclic AMP degradation in NG 108-15 neuroblastoma X glioma hybrid cells and S49 lymphoma cells chronically treated with drugs that inhibit adenylate cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Alprostadil; Animals; Cyclic AMP; Glioma; | 1990 |
Inhibition of cAMP accumulation by intracellular calcium mobilization in C6-2B cells stably transfected with substance K receptor cDNA.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenylyl Cyclases; Anim | 1991 |
cAMP-dependent regulation of proenkephalin by JunD and JunB: positive and negative effects of AP-1 proteins.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Cell Line; Colforsin; Cyclic AMP; Enhancer Elem | 1991 |
Activation and de novo synthesis of transglutaminase in cultured glioma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cells, Cultured; Cycloheximide; Dactinomycin; Fluor | 1985 |
Atrial natriuretic hormones raise the level of cyclic GMP in neural cell lines.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Calcimycin; Calcium; Cell Line; Cyc | 1986 |
Direct demonstration of the activation of UDP-N-acetylgalactosamine: [GM3]N-acetylgalactosaminyltransferase by cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Cell Line; Cyclic AMP; Enkephalin, Leucine; Enkephalin, | 1986 |
Agonist-induced down-regulation of muscarinic cholinergic and alpha 2-adrenergic receptors after inactivation of Ni by pertussis toxin.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase | 1986 |
Atrial natriuretic factors stimulate accumulation and efflux of cyclic GMP in C6-2B rat glioma and PC12 rat pheochromocytoma cell cultures.
Topics: 1-Methyl-3-isobutylxanthine; Adrenal Gland Neoplasms; Animals; Atrial Natriuretic Factor; Cell Line; | 1987 |
Chronic exposure to pertussis toxin alters muscarinic receptor-mediated regulation of cyclic AMP metabolism in neuroblastoma x glioma NG108-15 hybrid cells.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Atropine; Carbachol; Cyclic AMP; Glioma; Hybrid Cells; Neu | 1988 |
cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Cell Line; Cell Membrane; Colforsin; Cricetinae | 1989 |
Phosphorylation of phospholipase C-gamma by cAMP-dependent protein kinase.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Amino Acids; Animals; Cell Line | 1989 |