1-methyl-3-isobutylxanthine has been researched along with Glial Cell Tumors in 39 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To clarify the functional significance of type IV phosphodiesterase (PDEIV) in neurons and glia cells [3H]rolipram binding and phosphodiesterase (PDE) activity were examined in cytosol and membrane fractions of neuroblastoma N18TG-2 and glioma C6Bu-1 cells." | 7.69 | [3H]Rolipram binding and phosphodiesterase activity in neuroblastoma N18TG-2 and glioma C6Bu-1. ( Hasegawa, H; Murayama, T; Nogiri, S; Nomura, Y; Tohda, M, 1994) |
| "Atrial natriuretic factors (ANFs) were tested for their effects on cyclic GMP production in two neurally derived cell lines, the C6-2B rat glioma cells and the PC12 rat pheochromocytoma cells." | 7.67 | Atrial natriuretic factors stimulate accumulation and efflux of cyclic GMP in C6-2B rat glioma and PC12 rat pheochromocytoma cell cultures. ( Fiscus, RR; Murad, F; Robles, BT; Waldman, SA, 1987) |
| "Acute incubation of NMDA with neuroblastoma x glioma hybrid (NG108-15) cells or neuroblastoma SK-N-SH cells produced significant attenuation of nociceptin/orphanin FQ (N/OFQ)-induced activation of G protein and inhibition of adenylyl cyclase." | 3.70 | Attenuation of nociceptin/orphanin FQ-induced signaling by N-methyl-D-aspartate in neuronal cells. ( Ma, L; Pei, G; Xin, SM; Zhang, Y; Zhao, J, 1998) |
| "To clarify the functional significance of type IV phosphodiesterase (PDEIV) in neurons and glia cells [3H]rolipram binding and phosphodiesterase (PDE) activity were examined in cytosol and membrane fractions of neuroblastoma N18TG-2 and glioma C6Bu-1 cells." | 3.69 | [3H]Rolipram binding and phosphodiesterase activity in neuroblastoma N18TG-2 and glioma C6Bu-1. ( Hasegawa, H; Murayama, T; Nogiri, S; Nomura, Y; Tohda, M, 1994) |
| "Exposure of C62B rat glioma cells to fresh medium containing fetal bovine serum induced a sensitization of the subsequent ability of isoproterenol and forskolin to stimulate cyclic AMP accumulation, compared to cells exposed to fresh medium without serum." | 3.68 | Serum-induced sensitization of cyclic AMP accumulation in C62B rat glioma cells. ( Arneson-Rotert, LJ; Hoffman, JM; Liewer, SA; Toews, ML, 1992) |
| "When exposed to the beta-agonist (-)-isoproterenol, rat glioma C6 cells exhibited a time-and concentration-dependent reduction in isoproterenol responsiveness (desensitization) and a loss of beta-adrenergic receptors (down-regulation)." | 3.67 | Desensitization of catecholamine-stimulated adenylate cyclase and down-regulation of beta-adrenergic receptors in rat glioma C6 cells. Role of cyclic AMP and protein synthesis. ( Fishman, PH; Zaremba, TG, 1984) |
| "The activity of transglutaminase (TGase) was measured in cultured C6 glioma cells after their stimulation by either isoproterenol and isobutyl-methylxanthine or by a serum-containing medium." | 3.67 | Activation and de novo synthesis of transglutaminase in cultured glioma cells. ( Bachrach, U; Korner, G, 1985) |
| "Atrial natriuretic factors (ANFs) were tested for their effects on cyclic GMP production in two neurally derived cell lines, the C6-2B rat glioma cells and the PC12 rat pheochromocytoma cells." | 3.67 | Atrial natriuretic factors stimulate accumulation and efflux of cyclic GMP in C6-2B rat glioma and PC12 rat pheochromocytoma cell cultures. ( Fiscus, RR; Murad, F; Robles, BT; Waldman, SA, 1987) |
| "Chronic pertussis toxin treatment (5 days) of NG108-15 neuroblastoma X glioma hybrid cells had no significant effect on basal cyclic AMP levels whereas it effectively blocked the inhibitory action of acute (10 min) exposure of carbachol (10(-4)M) on intracellular cyclic AMP accumulation, stimulated by prostaglandin E1." | 3.67 | Chronic exposure to pertussis toxin alters muscarinic receptor-mediated regulation of cyclic AMP metabolism in neuroblastoma x glioma NG108-15 hybrid cells. ( Askelöf, P; Bartfai, T; Gillenius, P; Westlind-Danielsson, A, 1988) |
| "Pre-treatment with isoproterenol or the cyclic AMP analogue, dibutyryl cyclic AMP, induced refractoriness to forskolin." | 1.27 | Forskolin-stimulated cyclic AMP accumulation mediates protein synthesis-dependent refractoriness in C6-2B rat glioma cells. ( Barovsky, K; Brooker, G; Pedone, C, 1983) |
| " At peptide concentrations of 1 microM clear-cut plateaus of the dose-response curves are not yet reached." | 1.27 | Atrial natriuretic hormones raise the level of cyclic GMP in neural cell lines. ( Friedl, A; Hamprecht, B; Harmening, C, 1986) |
| "Carbachol treatment of cells resulted in down-regulation of muscarinic cholinergic receptors to 45." | 1.27 | Agonist-induced down-regulation of muscarinic cholinergic and alpha 2-adrenergic receptors after inactivation of Ni by pertussis toxin. ( Hoffman, BB; Thomas, JM, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (38.46) | 18.7374 |
| 1990's | 19 (48.72) | 18.2507 |
| 2000's | 4 (10.26) | 29.6817 |
| 2010's | 1 (2.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lv, P | 1 |
| Wang, W | 1 |
| Cao, Z | 1 |
| Zhao, D | 1 |
| Zhao, G | 1 |
| Li, D | 1 |
| Qi, L | 1 |
| Xu, J | 1 |
| Clark, MJ | 1 |
| Traynor, JR | 1 |
| Koschel, K | 1 |
| Derda, DF | 1 |
| Miles, MF | 1 |
| Schweppe, JS | 1 |
| Jungmann, RA | 1 |
| Norman, JA | 1 |
| Staehelin, M | 1 |
| Barovsky, K | 1 |
| Pedone, C | 1 |
| Brooker, G | 2 |
| Freedman, SB | 1 |
| Dawson, G | 2 |
| Villereal, ML | 1 |
| Miller, RJ | 1 |
| Zaremba, TG | 1 |
| Fishman, PH | 1 |
| Sernia, C | 1 |
| Thomas, WG | 1 |
| Tohda, M | 1 |
| Murayama, T | 1 |
| Hasegawa, H | 1 |
| Nogiri, S | 1 |
| Nomura, Y | 1 |
| Kuzhikandathil, EV | 1 |
| Molloy, GR | 1 |
| Fukumoto, H | 1 |
| Kakihana, M | 1 |
| Suno, M | 1 |
| Bergsbaken, CL | 1 |
| Sommers, SL | 1 |
| Law, PY | 1 |
| Zhang, X | 1 |
| Miskimins, R | 1 |
| Pauwels, PJ | 1 |
| Wurch, T | 1 |
| Amoureux, MC | 1 |
| Palmier, C | 1 |
| Colpaert, FC | 1 |
| Cai, Y | 1 |
| Zhang, Y | 2 |
| Wu, Y | 1 |
| Pei, G | 2 |
| Boddeke, HW | 1 |
| Meigel, I | 1 |
| Boeijinga, P | 1 |
| Arbuckle, J | 1 |
| Docherty, RJ | 1 |
| Chen, G | 1 |
| Pan, B | 1 |
| Hawver, DB | 1 |
| Wright, CB | 1 |
| Potter, WZ | 1 |
| Manji, HK | 1 |
| Zhao, J | 1 |
| Xin, SM | 1 |
| Ma, L | 1 |
| Allen, ML | 1 |
| Koh, DS | 1 |
| Tempel, BL | 1 |
| Wöltje, M | 1 |
| Kraus, J | 1 |
| Höllt, V | 1 |
| Slamon, ND | 2 |
| Pentreath, VW | 2 |
| Ward, TH | 1 |
| Butler, J | 1 |
| Propst, F | 1 |
| Moroder, L | 1 |
| Wünsch, E | 1 |
| Hamprecht, B | 2 |
| Bouillon, M | 1 |
| Fortier, MA | 1 |
| Boulianne, R | 1 |
| Audette, M | 1 |
| Langeveld, CH | 1 |
| Jongenelen, CA | 1 |
| Heimans, JJ | 1 |
| Stoof, JC | 1 |
| Toews, ML | 1 |
| Hoffman, JM | 1 |
| Liewer, SA | 1 |
| Arneson-Rotert, LJ | 1 |
| Tao-Cheng, JH | 1 |
| Bressler, JP | 1 |
| Brightman, MW | 1 |
| Thomas, JM | 2 |
| Vagelos, R | 1 |
| Hoffman, BB | 2 |
| DeBernardi, MA | 1 |
| Seki, T | 1 |
| Kobierski, LA | 1 |
| Chu, HM | 1 |
| Tan, Y | 1 |
| Comb, MJ | 1 |
| Korner, G | 1 |
| Bachrach, U | 1 |
| Friedl, A | 1 |
| Harmening, C | 1 |
| Scheideler, MA | 1 |
| Fiscus, RR | 1 |
| Robles, BT | 1 |
| Waldman, SA | 1 |
| Murad, F | 1 |
| Westlind-Danielsson, A | 1 |
| Gillenius, P | 1 |
| Askelöf, P | 1 |
| Bartfai, T | 1 |
| Collins, S | 1 |
| Bouvier, M | 1 |
| Bolanowski, MA | 1 |
| Caron, MG | 1 |
| Lefkowitz, RJ | 1 |
| Kim, UH | 1 |
| Kim, JW | 1 |
| Rhee, SG | 1 |
39 other studies available for 1-methyl-3-isobutylxanthine and Glial Cell Tumors
| Article | Year |
|---|---|
Fsk and IBMX inhibit proliferation and proapoptotic of glioma stem cells via activation of cAMP signaling pathway.
Topics: 1-Methyl-3-isobutylxanthine; Apoptosis; Brain Neoplasms; Butadienes; Cell Line, Tumor; Cell Prolifer | 2019 |
Mediation of adenylyl cyclase sensitization by PTX-insensitive GalphaoA, Galphai1, Galphai2 or Galphai3.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Analgesics, Opioid; Blotting, Western; Cell Line; Co | 2006 |
A hormone-independent rise of adenosine 3',5'-monophosphate desensitizes coupling of beta-adrenergic receptors to adenylate cyclase in rat glioma C6-cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Carrier Proteins; Cholera Toxin; Cyclic AMP | 1980 |
Cyclic AMP regulation of lactate dehydrogenase. Isoproterenol and N6,O2'-dibutyryl cyclic AMP increase the levels of lactate dehydrogenase-5 isozyme and its messenger RNA in rat C6 glioma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cell Line; Cyclic AMP; Dactinomycin; Glioma; Half | 1980 |
Calmodulin inhibitors activate glycogen phosphorylase B to A conversion in C6 glioma cells.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Antipsychotic | 1982 |
Forskolin-stimulated cyclic AMP accumulation mediates protein synthesis-dependent refractoriness in C6-2B rat glioma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Cyclohexi | 1983 |
Identification and characterization of voltage-sensitive calcium channels in neuronal clonal cell lines.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain Neoplasms; Calcium Channel Blockers; Cell Transformation | 1984 |
Desensitization of catecholamine-stimulated adenylate cyclase and down-regulation of beta-adrenergic receptors in rat glioma C6 cells. Role of cyclic AMP and protein synthesis.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Bucladesine; Cell Line; Cell Membrane; Chol | 1984 |
A novel inhibitory role for glucocorticoids in the secretion of angiotensinogen by C6 glioma cells.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Angiotensinogen; Animals; Bucladesine; Cyclic AMP; Dexamet | 1994 |
[3H]Rolipram binding and phosphodiesterase activity in neuroblastoma N18TG-2 and glioma C6Bu-1.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imi | 1994 |
Transcription of the brain creatine kinase gene in glial cells is modulated by cyclic AMP-dependent protein kinase.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Brain; Brain Neoplasms; Cloning, Molecular; | 1994 |
Characterization of C6-10A glioma cells highly responsive to beta-adrenergic receptor agonist-induced NGF synthesis/secretion.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blo | 1994 |
Effect of forskolin and isobutylmethylxanthine on delta-opioid receptor activity in neuroblastoma x glioma NG108-15 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Differentiation; Colforsin; Cyclic AMP; Enkephalin, Leuci | 1993 |
Binding at an NFI site is modulated by cyclic AMP-dependent activation of myelin basic protein gene expression.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Binding Sites; Bucladesine; CCAAT-Enhancer-Bind | 1993 |
Stimulation of cloned human serotonin 5-HT1D beta receptor sites in stably transfected C6 glial cells promotes cell growth.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain Neoplasms; Bucladesine; Cell Division; CHO Cells; Clonin | 1996 |
delta Opioid receptor in neuronal cells undergoes acute and homologous desensitization.
Topics: 1-Methyl-3-isobutylxanthine; Analgesics; Animals; Cerebral Cortex; Cyclic AMP; Dose-Response Relatio | 1996 |
Modulation by calcineurin of 5-HT3 receptor function in NG108-15 neuroblastoma x glioma cells.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Brain Neoplasms; Calcineurin; Calmodulin- | 1996 |
Attenuation of cyclic AMP production by carbamazepine.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylate Cyclase Toxin; Adenylyl | 1996 |
Attenuation of nociceptin/orphanin FQ-induced signaling by N-methyl-D-aspartate in neuronal cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Gliom | 1998 |
Cyclic AMP regulates potassium channel expression in C6 glioma by destabilizing Kv1.1 mRNA.
Topics: 1-Methyl-3-isobutylxanthine; Animals; CHO Cells; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protei | 1998 |
Regulation of mouse delta-opioid receptor gene transcription: involvement of the transcription factors AP-1 and AP-2.
Topics: 1-Methyl-3-isobutylxanthine; Aged; Animals; Carcinogens; Colforsin; Cyclic AMP-Dependent Protein Kin | 2000 |
Antioxidant defense against antidepressants in C6 and 1321N1 cells.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Antidepressive Agents; Antimetabolit | 2000 |
Assessment of DNA damage in C6 glioma cells after antidepressant treatment using an alkaline comet assay.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agent | 2001 |
The influence of secretin, glucagon and other peptides, of amino acids, prostaglandin endoperoxide analogues and diazepam on the level of adenosine 3',5'-cyclic monophosphate in neuroblastoma x glioma hybrid cells.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amino Acids; Cyclic AMP | 1979 |
Biphasic effect of cAMP-elevating agents on ICAM-1 expression stimulated by retinoic acid and interferon gamma.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Cell Adhesion Molecules; Ch | 1992 |
8-Chloro-cyclic adenosine monophosphate, a novel cyclic AMP analog that inhibits human glioma cell growth in concentrations that do not induce differentiation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; | 1992 |
Serum-induced sensitization of cyclic AMP accumulation in C62B rat glioma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Physiological Phenomena; Cyclic AMP; Glioma; Isoproteren | 1992 |
Astroglial membrane structure is affected by agents that raise cyclic AMP and by phosphatidylcholine phospholipase C.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Astrocytes; Cattle; Ce | 1992 |
Decreased cyclic AMP degradation in NG 108-15 neuroblastoma X glioma hybrid cells and S49 lymphoma cells chronically treated with drugs that inhibit adenylate cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Alprostadil; Animals; Cyclic AMP; Glioma; | 1990 |
Inhibition of cAMP accumulation by intracellular calcium mobilization in C6-2B cells stably transfected with substance K receptor cDNA.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenylyl Cyclases; Anim | 1991 |
cAMP-dependent regulation of proenkephalin by JunD and JunB: positive and negative effects of AP-1 proteins.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Cell Line; Colforsin; Cyclic AMP; Enhancer Elem | 1991 |
Activation and de novo synthesis of transglutaminase in cultured glioma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cells, Cultured; Cycloheximide; Dactinomycin; Fluor | 1985 |
Atrial natriuretic hormones raise the level of cyclic GMP in neural cell lines.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Calcimycin; Calcium; Cell Line; Cyc | 1986 |
Direct demonstration of the activation of UDP-N-acetylgalactosamine: [GM3]N-acetylgalactosaminyltransferase by cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Cell Line; Cyclic AMP; Enkephalin, Leucine; Enkephalin, | 1986 |
Agonist-induced down-regulation of muscarinic cholinergic and alpha 2-adrenergic receptors after inactivation of Ni by pertussis toxin.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase | 1986 |
Atrial natriuretic factors stimulate accumulation and efflux of cyclic GMP in C6-2B rat glioma and PC12 rat pheochromocytoma cell cultures.
Topics: 1-Methyl-3-isobutylxanthine; Adrenal Gland Neoplasms; Animals; Atrial Natriuretic Factor; Cell Line; | 1987 |
Chronic exposure to pertussis toxin alters muscarinic receptor-mediated regulation of cyclic AMP metabolism in neuroblastoma x glioma NG108-15 hybrid cells.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Atropine; Carbachol; Cyclic AMP; Glioma; Hybrid Cells; Neu | 1988 |
cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Cell Line; Cell Membrane; Colforsin; Cricetinae | 1989 |
Phosphorylation of phospholipase C-gamma by cAMP-dependent protein kinase.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Amino Acids; Animals; Cell Line | 1989 |