1-methyl-3-isobutylxanthine has been researched along with Disease Models, Animal in 28 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Rats with congestive heart failure (CHF) have increased protein level of NKCC2, which can be normalized by angiotensin II receptor type-1 (AT(1)) blockade with losartan." | 7.74 | Losartan decreases vasopressin-mediated cAMP accumulation in the thick ascending limb of the loop of Henle in rats with congestive heart failure. ( Brønd, L; Christensen, S; Hadrup, N; Jonassen, TE; Nielsen, JB; Nielsen, S; Praetorius, J; Torp, M, 2007) |
| " Rats with congestive heart failure (CHF) have increased protein level of NKCC2, which can be normalized by angiotensin II receptor type-1 (AT(1)) blockade with losartan." | 3.74 | Losartan decreases vasopressin-mediated cAMP accumulation in the thick ascending limb of the loop of Henle in rats with congestive heart failure. ( Brønd, L; Christensen, S; Hadrup, N; Jonassen, TE; Nielsen, JB; Nielsen, S; Praetorius, J; Torp, M, 2007) |
| "Tachyarrhythmia was evoked in isolated rat right atria by trains of electric stimuli." | 1.32 | Cholinergic-adrenergic antagonism in the induction of tachyarrhythmia by electrical stimulation in isolated rat atria. ( Bassani, JW; Bassani, RA; Zafalon, N, 2004) |
| "When mannoheptulose was introduced 15 min after starting perfusion with 27 mM glucose, inhibition was apparent in non-diabetic rats, but not in STZ." | 1.27 | B cell insensitivity in a rat model of non-insulin-dependent diabetes. Evidence for a rapidly reversible effect of previous hyperglycemia. ( Grill, V; Ostenson, CG; Westberg, M, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (14.29) | 18.7374 |
| 1990's | 3 (10.71) | 18.2507 |
| 2000's | 12 (42.86) | 29.6817 |
| 2010's | 5 (17.86) | 24.3611 |
| 2020's | 4 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Luan, X | 1 |
| Le, Y | 1 |
| Jagadeeshan, S | 1 |
| Murray, B | 1 |
| Carmalt, JL | 1 |
| Duke, T | 1 |
| Beazley, S | 1 |
| Fujiyama, M | 1 |
| Swekla, K | 1 |
| Gray, B | 1 |
| Burmester, M | 1 |
| Campanucci, VA | 1 |
| Shipley, A | 1 |
| Machen, TE | 1 |
| Tam, JS | 1 |
| Ianowski, JP | 1 |
| Lee, CD | 1 |
| Choi, WS | 2 |
| Choi, YG | 1 |
| Kang, HS | 2 |
| Lee, WT | 2 |
| Kim, HJ | 2 |
| Lee, JY | 2 |
| Sohn, UD | 1 |
| Peng, LH | 1 |
| Li, Q | 1 |
| Balbo, SL | 1 |
| Ribeiro, RA | 1 |
| Mendes, MC | 1 |
| Lubaczeuski, C | 1 |
| Maller, AC | 1 |
| Carneiro, EM | 1 |
| Bonfleur, ML | 1 |
| Wei, D | 1 |
| Hurd, C | 1 |
| Galleguillos, D | 1 |
| Singh, J | 1 |
| Fenrich, KK | 1 |
| Webber, CA | 1 |
| Sipione, S | 1 |
| Fouad, K | 1 |
| Hansen, NU | 1 |
| Karsdal, MA | 1 |
| Brockbank, S | 1 |
| Cruwys, S | 1 |
| Rønnow, S | 1 |
| Leeming, DJ | 1 |
| Rangel-Barajas, C | 1 |
| Silva, I | 1 |
| García-Ramírez, M | 1 |
| Sánchez-Lemus, E | 1 |
| Floran, L | 1 |
| Aceves, J | 1 |
| Erlij, D | 1 |
| Florán, B | 1 |
| Schmidt, EP | 1 |
| Damarla, M | 1 |
| Rentsendorj, O | 1 |
| Servinsky, LE | 1 |
| Zhu, B | 1 |
| Moldobaeva, A | 1 |
| Gonzalez, A | 1 |
| Hassoun, PM | 1 |
| Pearse, DB | 1 |
| Zhu, S | 1 |
| White, RE | 1 |
| Barman, SA | 1 |
| Schrott, LM | 1 |
| Baumgart, MI | 1 |
| Zhang, X | 1 |
| Sparber, SB | 1 |
| Herrerías, JM | 2 |
| Esteban, JM | 1 |
| Caballero-Plasencia, AM | 1 |
| Valenzuela-Barranco, M | 1 |
| Motilva, V | 1 |
| Alarcón, C | 1 |
| Martín, J | 1 |
| Esteban, P | 1 |
| Zafalon, N | 1 |
| Bassani, JW | 1 |
| Bassani, RA | 1 |
| Garthwaite, G | 1 |
| Batchelor, AM | 1 |
| Goodwin, DA | 1 |
| Hewson, AK | 1 |
| Leeming, K | 1 |
| Ahmed, Z | 1 |
| Cuzner, ML | 1 |
| Garthwaite, J | 1 |
| Vallazza-Deschamps, G | 1 |
| Cia, D | 1 |
| Gong, J | 1 |
| Jellali, A | 1 |
| Duboc, A | 1 |
| Forster, V | 1 |
| Sahel, JA | 1 |
| Tessier, LH | 1 |
| Picaud, S | 1 |
| Budde, T | 1 |
| Caputi, L | 1 |
| Kanyshkova, T | 1 |
| Staak, R | 1 |
| Abrahamczik, C | 1 |
| Munsch, T | 1 |
| Pape, HC | 1 |
| Schermuly, RT | 1 |
| Pullamsetti, SS | 1 |
| Kwapiszewska, G | 1 |
| Dumitrascu, R | 1 |
| Tian, X | 1 |
| Weissmann, N | 1 |
| Ghofrani, HA | 1 |
| Kaulen, C | 1 |
| Dunkern, T | 1 |
| Schudt, C | 1 |
| Voswinckel, R | 1 |
| Zhou, J | 1 |
| Samidurai, A | 1 |
| Klepetko, W | 1 |
| Paddenberg, R | 1 |
| Kummer, W | 1 |
| Seeger, W | 1 |
| Grimminger, F | 1 |
| Torp, M | 1 |
| Brønd, L | 1 |
| Hadrup, N | 1 |
| Nielsen, JB | 1 |
| Praetorius, J | 1 |
| Nielsen, S | 1 |
| Christensen, S | 1 |
| Jonassen, TE | 1 |
| Dousa, TP | 1 |
| Shah, SV | 1 |
| Abboud, HE | 1 |
| Shaul, PW | 1 |
| Wells, LB | 1 |
| Smith, SN | 1 |
| Delaney, SJ | 1 |
| Dorin, JR | 1 |
| Farley, R | 1 |
| Geddes, DM | 1 |
| Porteous, DJ | 1 |
| Wainwright, BJ | 1 |
| Alton, EW | 1 |
| Bertuccio, C | 1 |
| Ibarra, FR | 1 |
| Pignataro, O | 1 |
| Toledo, J | 1 |
| Paz, L | 1 |
| Arrizurieta, E | 1 |
| Martin, RS | 1 |
| Boixel, C | 1 |
| Gonzalez, W | 1 |
| Louedec, L | 1 |
| Hatem, SN | 1 |
| Bonta, IL | 1 |
| Parnham, MJ | 1 |
| Adolfs, MJ | 1 |
| Olgaard, K | 1 |
| Schwartz, J | 1 |
| Arbelaez, M | 1 |
| Slatopolsky, E | 1 |
| Grill, V | 1 |
| Westberg, M | 1 |
| Ostenson, CG | 1 |
1 review available for 1-methyl-3-isobutylxanthine and Disease Models, Animal
| Article | Year |
|---|---|
Potential role of cyclic nucleotides in glomerular pathophysiology.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cholera Toxin; Cyclic AMP; Cyclic GMP; Disease Models, Animal; | 1980 |
27 other studies available for 1-methyl-3-isobutylxanthine and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
cAMP triggers Na
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Animals; Animals, Genetically Modified; Colforsin; Cyclic AM | 2021 |
Inhibition of phosphodiesterase suppresses allergic lung inflammation by regulating MCP-1 in an OVA-induced asthma murine model with co-exposure to lipopolysaccharide.
Topics: 1-Methyl-3-isobutylxanthine; Administration, Inhalation; Airway Resistance; Animals; Asthma; Broncho | 2020 |
Vinpocetine alleviates lung inflammation via macrophage inflammatory protein-1β inhibition in an ovalbumin-induced allergic asthma model.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Anti-Inflammatory Agents; Asthma; Chemokine CCL4; Dexamethason | 2021 |
Effect of the Stromal Vascular Fraction on Changes in Melanin Formation in B16 Cells Treated by IBMX.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biopsy, Needle; Cells, Cultured; Coculture Techniques; Disease | 2019 |
Vagotomy diminishes obesity in cafeteria rats by decreasing cholinergic potentiation of insulin release.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Body Weight; Carbachol; Colforsin; Cyclic AMP; | 2016 |
Inhibiting cortical protein kinase A in spinal cord injured rats enhances efficacy of rehabilitative training.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Animals; Cell Line, Transformed; Cells, Cultured; | 2016 |
Tissue turnover of collagen type I, III and elastin is elevated in the PCLS model of IPF and can be restored back to vehicle levels using a phosphodiesterase inhibitor.
Topics: 1-Methyl-3-isobutylxanthine; Airway Remodeling; Animals; Bleomycin; Collagen Type I; Collagen Type I | 2016 |
6-OHDA-induced hemiparkinsonism and chronic L-DOPA treatment increase dopamine D1-stimulated [(3)H]-GABA release and [(3)H]-cAMP production in substantia nigra pars reticulata of the rat.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Animals; Antiparkinson Agents; Behavior, Animal; | 2008 |
Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood-Air Barrier; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide P | 2008 |
Role of phosphodiesterases in modulation of BKCa channels in hypertensive pulmonary arterial smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Disease Models, Animal; Hypertension, P | 2008 |
Prenatal opiate withdrawal activates the chick embryo hypothalamic pituitary-adrenal axis and dilates vitelline blood vessels via serotonin(2) receptors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Chick Embryo; Corticosterone; Disease Models, Animal; Hypothal | 2002 |
Preventive effect of zaprinast and 3-isobutyl, 1-methylxanthine (phosphodiesterase inhibitors) on gastric injury induced by nonsteroidal antiinflammatory drugs in rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclic GMP; Disease M | 2003 |
Cholinergic-adrenergic antagonism in the induction of tachyarrhythmia by electrical stimulation in isolated rat atria.
Topics: 1-Methyl-3-isobutylxanthine; Amiodarone; Animals; Anti-Arrhythmia Agents; Carbachol; Cholinergic Ago | 2004 |
Pathological implications of iNOS expression in central white matter: an ex vivo study of optic nerves from rats with experimental allergic encephalomyelitis.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Arginine; Biomarkers; CD11b Antigen; CD2 An | 2005 |
Excessive activation of cyclic nucleotide-gated channels contributes to neuronal degeneration of photoreceptors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Blotting, Western; Cadmium Chloride; Calcium | 2005 |
Impaired regulation of thalamic pacemaker channels through an imbalance of subunit expression in absence epilepsy.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Adenine; Ani | 2005 |
Phosphodiesterase 1 upregulation in pulmonary arterial hypertension: target for reverse-remodeling therapy.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cell Division; Chronic Di | 2007 |
Losartan decreases vasopressin-mediated cAMP accumulation in the thick ascending limb of the loop of Henle in rats with congestive heart failure.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Angiotensin II Type 1 Receptor Blockers; Animals; Cy | 2007 |
Oxygen modulates nitric oxide production selectively in fetal pulmonary endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Oxidoreductases; Animals; Bradykinin; Calcimycin; Cells, Cul | 1994 |
Effect of IBMX and alkaline phosphatase inhibitors on Cl- secretion in G551D cystic fibrosis mutant mice.
Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Animals; Chlorides; Colforsin; Cystic Fibrosis; C | 1998 |
Regulation of cell cyclic AMP in medullary thick ascending limb of Henle in a rat model of chronic renal failure.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Agonists; Animals; Calcitonin; Cell Separation; Clonid | 1998 |
Mechanisms of L-type Ca(2+) current downregulation in rat atrial myocytes during heart failure.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Atrial Natriuretic Factor; Calcium; | 2001 |
Mimickry of anti-granuloma effect of prostaglandin E by dibutyryl cyclic-AMP and some phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Anti-Inflammatory Agents; Bucladesine; Disease Models, Animal; | 1979 |
Impaired skeletal response to parathyroid hormone in uremia: the role of phosphorus.
Topics: 1-Methyl-3-isobutylxanthine; Acute Kidney Injury; Animals; Bone and Bones; Cyclic AMP; Disease Model | 1985 |
B cell insensitivity in a rat model of non-insulin-dependent diabetes. Evidence for a rapidly reversible effect of previous hyperglycemia.
Topics: 1-Methyl-3-isobutylxanthine; Animals; B-Lymphocytes; Diabetes Mellitus, Experimental; Diabetes Melli | 1987 |