Page last updated: 2024-10-29

1-methyl-3-isobutylxanthine and Cystic Fibrosis

1-methyl-3-isobutylxanthine has been researched along with Cystic Fibrosis in 39 studies

1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.

Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.

Research Excerpts

ExcerptRelevanceReference
"Thirteen cystic fibrosis and 12 normal strains of skin fibroblasts obtained from the Institute for Medical Research were compared for their degree of production of cyclic adenosine 3':5'-monophosphate in response to isoproterenol and prostaglandin E1."7.66Cystic fibrosis fibroblasts respond normally to isoproterenol. ( Kurz, JB; Perkins, JP, 1981)
"Cystic fibrosis jejunum had a significantly lower Na+ content, higher K+ and Cl- content, and higher potassium/phosphorus ratio in both villus and crypt regions."3.69X-ray microanalysis of cell elements in normal and cystic fibrosis jejunum: evidence for chloride secretion in villi. ( Bostrom, TE; Cockayne, DJ; Gaskin, KJ; Gyory, A; Hunt, DM; Hunter, D; O'Loughlin, EV, 1996)
"The in-vitro investigation of secretory responses of submandibular tissues from three cystic fibrosis (CF) patients and four control subjects showed that responses to a beta-adrenergic stimulus (isoproterenol) were much poorer in CF cells than in control cells."3.67Defective beta-adrenergic secretory responses in submandibular acinar cells from cystic fibrosis patients. ( Bradbury, NA; Dodge, JA; Dormer, RL; Goodchild, MC; McPherson, MA, 1986)
"Thirteen cystic fibrosis and 12 normal strains of skin fibroblasts obtained from the Institute for Medical Research were compared for their degree of production of cyclic adenosine 3':5'-monophosphate in response to isoproterenol and prostaglandin E1."3.66Cystic fibrosis fibroblasts respond normally to isoproterenol. ( Kurz, JB; Perkins, JP, 1981)

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19905 (12.82)18.7374
1990's22 (56.41)18.2507
2000's8 (20.51)29.6817
2010's2 (5.13)24.3611
2020's2 (5.13)2.80

Authors

AuthorsStudies
Luan, X1
Le, Y1
Jagadeeshan, S1
Murray, B1
Carmalt, JL1
Duke, T1
Beazley, S1
Fujiyama, M1
Swekla, K1
Gray, B1
Burmester, M1
Campanucci, VA1
Shipley, A1
Machen, TE1
Tam, JS1
Ianowski, JP1
Lu, B1
Corey, DA1
Kelley, TJ2
Nilsson, HE1
Dragomir, A2
Lazorova, L1
Johannesson, M1
Roomans, GM2
Sousa, M1
Servidoni, MF1
Vinagre, AM1
Ramalho, AS1
Bonadia, LC1
Felício, V1
Ribeiro, MA1
Uliyakina, I1
Marson, FA1
Kmit, A1
Cardoso, SR1
Ribeiro, JD1
Bertuzzo, CS1
Sousa, L1
Kunzelmann, K5
Ribeiro, AF1
Amaral, MD1
Cho, WK1
Siegrist, VJ1
Zinzow, W1
Kurz, JB1
Perkins, JP1
Mills, CL2
Dorin, JR2
Davidson, DJ1
Porteus, DJ1
Alton, EW3
Dormer, RL5
McPherson, MA5
Levesque, PC1
Hume, JR1
Grubb, B1
Lazarowski, E1
Knowles, M1
Boucher, R1
Dechecchi, MC1
Tamanini, A1
Berton, G1
Cabrini, G1
Becq, F1
Fanjul, M1
Merten, M1
Figarella, C1
Hollande, E1
Gola, M1
O'Loughlin, EV2
Hunt, DM2
Bostrom, TE1
Hunter, D1
Gaskin, KJ2
Gyory, A1
Cockayne, DJ1
Al-Nakkash, L2
Cotton, CU1
Drumm, ML2
Rückes, C1
Blank, U1
Möller, K1
Rieboldt, J1
Lindemann, H1
Münker, G1
Clauss, W1
Weber, WM2
Smith, SN2
Delaney, SJ1
Farley, R1
Geddes, DM1
Porteous, DJ1
Wainwright, BJ2
Quesnel, LB1
Jaran, AS1
Braganza, JM1
Yoshimura, K1
Tada, H1
Anzai, C1
Mall, M3
Bleich, M1
Greger, R3
Schreiber, R3
Jiang, Q1
Mak, D1
Devidas, S1
Schwiebert, EM1
Bragin, A1
Zhang, Y1
Skach, WR1
Guggino, WB1
Foskett, JK1
Engelhardt, JF1
Hwang, TC1
Haardt, M1
Benharouga, M1
Lechardeur, D1
Kartner, N1
Lukacs, GL1
Wissner, A2
Seydewitz, HH2
Hübner, M1
Kuehr, J2
Brandis, M2
Segal, A1
Simaels, J1
Vankeerberghen, A1
Cassiman, JJ1
Van Driessche, W1
Cuppoletti, J1
Tewari, KP1
Sherry, AM1
Kupert, EY1
Malinowska, DH1
Wagner, CA1
Ott, M1
Klingel, K1
Beck, S1
Melzig, J1
Friedrich, B1
Wild, KN1
Bröer , S1
Moschen, I1
Albers, A1
Waldegger, S1
Tümmler , B1
Egan, ME1
Geibel, JP1
Kandolf, R1
Lang, F1
Andersson, C1
Aslund, M1
Hjelte, L1
Oceandy, D1
McMorran, BJ1
Hume, DA1
Pereira, MM1
Pedersen, PS1
Allan, BJ2
Izutsu, KT2
Ramsey, BW2
Schubert, MM2
Ensign, WY2
Truelove, EL2
Stiel, D1
Bruzuszcak, IM1
Martin, HC1
Bambach, C1
Smith, R1
Sato, K1
Ohtsuyama, M1
Suzuki, Y1
Samman, G1
Sato, KT1
Sato, F1
Wilkinson, DJ1
Smit, LS1
Worrell, RT1
Strong, TV1
Frizzell, RA1
Dawson, DC1
Collins, FS1
Dodge, JA2
Goodchild, MC2
Bradbury, NA1
Boucher, RC1
Cheng, EH1
Paradiso, AM1
Stutts, MJ1
Knowles, MR1
Earp, HS1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Characterization of β-cell Function and Insulin Sensitivity in Pre-transplant Patients With Cystic Fibrosis[NCT04379726]150 participants (Anticipated)Observational2020-07-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for 1-methyl-3-isobutylxanthine and Cystic Fibrosis

ArticleYear
[Cystic fibrosis].
    Ryoikibetsu shokogun shirizu, 1998, Issue:19 Pt 2

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Amiloride; Aminoglycosides; Anti-Bacterial Agen

1998

Other Studies

38 other studies available for 1-methyl-3-isobutylxanthine and Cystic Fibrosis

ArticleYear
cAMP triggers Na
    Cell reports, 2021, 10-05, Volume: 37, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Animals; Animals, Genetically Modified; Colforsin; Cyclic AM

2021
Resveratrol restores intracellular transport in cystic fibrosis epithelial cells.
    American journal of physiology. Lung cellular and molecular physiology, 2020, 06-01, Volume: 318, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; Acetylation; Biological Transport; Carbazoles; Cells, Cultured; Cholest

2020
CFTR and tight junctions in cultured bronchial epithelial cells.
    Experimental and molecular pathology, 2010, Volume: 88, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Actins; Bronchi; Cell Line; Cell Membrane Permeability; Colforsin; Cyst

2010
Measurements of CFTR-mediated Cl- secretion in human rectal biopsies constitute a robust biomarker for Cystic Fibrosis diagnosis and prognosis.
    PloS one, 2012, Volume: 7, Issue:10

    Topics: 1-Methyl-3-isobutylxanthine; Biomarkers; Biopsy; Carbachol; Chlorides; Colforsin; Cystic Fibrosis; C

2012
Impaired regulatory volume decrease in freshly isolated cholangiocytes from cystic fibrosis mice: implications for cystic fibrosis transmembrane conductance regulator effect on potassium conductance.
    The Journal of biological chemistry, 2004, Apr-09, Volume: 279, Issue:15

    Topics: 1-Methyl-3-isobutylxanthine; Angiogenesis Inhibitors; Animals; Bile Ducts; Buffers; Colforsin; Cycli

2004
Cystic fibrosis fibroblasts respond normally to isoproterenol.
    Pediatric research, 1981, Volume: 15, Issue:10

    Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adolescent; Adult; Cell

1981
Decreased beta-adrenergic stimulation of glycoprotein secretion in CF mice submandibular glands: reversal by the methylxanthine, IBMX.
    Biochemical and biophysical research communications, 1995, Oct-13, Volume: 215, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Amylases; Animals; Carbachol; Cyclic AMP; Cys

1995
ATPo but not cAMPi activates a chloride conductance in mouse ventricular myocytes.
    Cardiovascular research, 1995, Volume: 29, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Triphosphate; Animals; Cells, Cultured; Chloride C

1995
Isobutylmethylxanthine fails to stimulate chloride secretion in cystic fibrosis airway epithelia.
    American journal of respiratory cell and molecular biology, 1993, Volume: 8, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adult; Amiloride; Bronchi; Cells, Cultured; Chloride

1993
Protein kinase C activates chloride conductance in C127 cells stably expressing the cystic fibrosis gene.
    The Journal of biological chemistry, 1993, May-25, Volume: 268, Issue:15

    Topics: 1-Methyl-3-isobutylxanthine; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisot

1993
Possible regulation of CFTR-chloride channels by membrane-bound phosphatases in pancreatic duct cells.
    FEBS letters, 1993, Aug-02, Volume: 327, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Base Sequence; Chloride Channels; Chlorides; Cyst

1993
X-ray microanalysis of cell elements in normal and cystic fibrosis jejunum: evidence for chloride secretion in villi.
    Gastroenterology, 1996, Volume: 110, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Cond

1996
Activation of endogenous deltaF508 cystic fibrosis transmembrane conductance regulator by phosphodiesterase inhibition.
    The Journal of clinical investigation, 1996, Jul-15, Volume: 98, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Albuterol; Base Sequence; Calcium; Cell Line;

1996
Amiloride-sensitive Na+ channels in human nasal epithelium are different from classical epithelial Na+ channels.
    Biochemical and biophysical research communications, 1997, Aug-28, Volume: 237, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Anti-Infla

1997
Effect of IBMX and alkaline phosphatase inhibitors on Cl- secretion in G551D cystic fibrosis mutant mice.
    The American journal of physiology, 1998, Volume: 274, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Animals; Chlorides; Colforsin; Cystic Fibrosis; C

1998
Antibiotic accumulation and membrane trafficking in cystic fibrosis cells.
    The Journal of antimicrobial chemotherapy, 1998, Volume: 41, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate;

1998
The amiloride-inhibitable Na+ conductance is reduced by the cystic fibrosis transmembrane conductance regulator in normal but not in cystic fibrosis airways.
    The Journal of clinical investigation, 1998, Jul-01, Volume: 102, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Chlorides; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Tran

1998
Cystic fibrosis transmembrane conductance regulator-associated ATP release is controlled by a chloride sensor.
    The Journal of cell biology, 1998, Nov-02, Volume: 143, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Chlorides; Colforsin; Cystic Fibrosis;

1998
Activation of wild-type and deltaF508-CFTR by phosphodiesterase inhibitors through cAMP-dependent and -independent mechanisms.
    Pflugers Archiv : European journal of physiology, 1999, Volume: 437, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Cell Line; Colforsin; Cyclic AMP; Cystic Fibrosis;

1999
C-terminal truncations destabilize the cystic fibrosis transmembrane conductance regulator without impairing its biogenesis. A novel class of mutation.
    The Journal of biological chemistry, 1999, Jul-30, Volume: 274, Issue:31

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cell Membrane; Codon, Terminator; COS Cells; Cricet

1999
Effect of genistein on native epithelial tissue from normal individuals and CF patients and on ion channels expressed in Xenopus oocytes.
    British journal of pharmacology, 2000, Volume: 130, Issue:8

    Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Aged; Amiloride; Animals; Child; Child, Preschool; C

2000
Role of K(V)LQT1 in cyclic adenosine monophosphate-mediated Cl(-) secretion in human airway epithelia.
    American journal of respiratory cell and molecular biology, 2000, Volume: 23, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Biological Transport; Bronchi; Cell Line, Transformed; Chlor

2000
Functional integrity of the vesicle transporting machinery is required for complete activation of cFTR expressed in xenopus laevis oocytes.
    Pflugers Archiv : European journal of physiology, 2001, Volume: 441, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Antimalarials; Antineoplastic Agents; Brefeldin A; Calcium; Ch

2001
ClC-2 Cl- channels in human lung epithelia: activation by arachidonic acid, amidation, and acid-activated omeprazole.
    American journal of physiology. Cell physiology, 2001, Volume: 281, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Amides; Arachidonic Acids; Cell Line; Cells, Cu

2001
Effects of the serine/threonine kinase SGK1 on the epithelial Na(+) channel (ENaC) and CFTR: implications for cystic fibrosis.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2001, Volume: 11, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Substitution; Animals; Bronchi; Cell Line; Cystic Fibrosis;

2001
Assessment of chloride secretion in human nasal epithelial cells by X-ray microanalysis.
    Journal of microscopy, 2001, Volume: 203, Issue:Pt 3

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Chlorides; Colforsin; Cystic Fibrosis; Electron

2001
Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities.
    Human molecular genetics, 2002, May-01, Volume: 11, Issue:9

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Bronchoalveolar Lavage; Cells, Cultured; Chemokine CXCL2; Colf

2002
An antibody against a CFTR-derived synthetic peptide, incorporated into living submandibular cells, inhibits beta-adrenergic stimulation of mucin secretion.
    Biochemical and biophysical research communications, 1992, Nov-16, Volume: 188, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Antibodies;

1992
CFTR mechanism.
    Nature, 1992, Mar-12, Volume: 356, Issue:6365

    Topics: 1-Methyl-3-isobutylxanthine; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; M

1992
Chloride permeability regulation via a cyclic AMP pathway in cultured human sweat duct cells.
    The Journal of physiology, 1990, Volume: 421

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic Agonists; Cell Membr

1990
Cyclic nucleotide responses in control and cystic fibrosis labial glands.
    The American journal of physiology, 1990, Volume: 258, Issue:6 Pt 2

    Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Cyclic AMP; Cyclic GMP; Cystic Fibrosis; Female; Hum

1990
Abnormal epithelial transport in cystic fibrosis jejunum.
    The American journal of physiology, 1991, Volume: 260, Issue:5 Pt 1

    Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Aged; Biological Transport; Bucladesine; Calcimycin;

1991
Roles of Ca and cAMP on C1 channel activity in cystic fibrosis sweat clear cells as studied by microsuperfusion and cell volume analysis.
    Advances in experimental medicine and biology, 1991, Volume: 290

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Chloride Channels; Chlorides; Cyclic AMP; Cystic Fibr

1991
Chloride conductance expressed by delta F508 and other mutant CFTRs in Xenopus oocytes.
    Science (New York, N.Y.), 1991, Dec-20, Volume: 254, Issue:5039

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Chloride Channels; Chlorides; Cystic Fibrosis; Cystic Fibrosis

1991
Adrenergic secretory responses of submandibular tissues from control subjects and cystic fibrosis patients.
    Clinica chimica acta; international journal of clinical chemistry, 1985, Jun-14, Volume: 148, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Adult; Amylases; Child; Cyclic AMP; Cystic Fibrosis; Dose-Response Rela

1985
Defective beta-adrenergic secretory responses in submandibular acinar cells from cystic fibrosis patients.
    Lancet (London, England), 1986, Nov-01, Volume: 2, Issue:8514

    Topics: 1-Methyl-3-isobutylxanthine; Adult; Amylases; Cells, Cultured; Child; Cystic Fibrosis; Humans; Infan

1986
Potassium release in labial glands from controls and patients with cystic fibrosis.
    Laboratory investigation; a journal of technical methods and pathology, 1989, Volume: 60, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Carbachol; Cystic Fibrosis; Humans; Potassium; Salivary Glands; Salivar

1989
Chloride secretory response of cystic fibrosis human airway epithelia. Preservation of calcium but not protein kinase C- and A-dependent mechanisms.
    The Journal of clinical investigation, 1989, Volume: 84, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Amiloride; Bradykinin; Calcimycin; Calcium; Child; C

1989