1-methyl-3-isobutylxanthine has been researched along with Cystic Fibrosis in 39 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thirteen cystic fibrosis and 12 normal strains of skin fibroblasts obtained from the Institute for Medical Research were compared for their degree of production of cyclic adenosine 3':5'-monophosphate in response to isoproterenol and prostaglandin E1." | 7.66 | Cystic fibrosis fibroblasts respond normally to isoproterenol. ( Kurz, JB; Perkins, JP, 1981) |
| "Cystic fibrosis jejunum had a significantly lower Na+ content, higher K+ and Cl- content, and higher potassium/phosphorus ratio in both villus and crypt regions." | 3.69 | X-ray microanalysis of cell elements in normal and cystic fibrosis jejunum: evidence for chloride secretion in villi. ( Bostrom, TE; Cockayne, DJ; Gaskin, KJ; Gyory, A; Hunt, DM; Hunter, D; O'Loughlin, EV, 1996) |
| "The in-vitro investigation of secretory responses of submandibular tissues from three cystic fibrosis (CF) patients and four control subjects showed that responses to a beta-adrenergic stimulus (isoproterenol) were much poorer in CF cells than in control cells." | 3.67 | Defective beta-adrenergic secretory responses in submandibular acinar cells from cystic fibrosis patients. ( Bradbury, NA; Dodge, JA; Dormer, RL; Goodchild, MC; McPherson, MA, 1986) |
| "Thirteen cystic fibrosis and 12 normal strains of skin fibroblasts obtained from the Institute for Medical Research were compared for their degree of production of cyclic adenosine 3':5'-monophosphate in response to isoproterenol and prostaglandin E1." | 3.66 | Cystic fibrosis fibroblasts respond normally to isoproterenol. ( Kurz, JB; Perkins, JP, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (12.82) | 18.7374 |
| 1990's | 22 (56.41) | 18.2507 |
| 2000's | 8 (20.51) | 29.6817 |
| 2010's | 2 (5.13) | 24.3611 |
| 2020's | 2 (5.13) | 2.80 |
| Authors | Studies |
|---|---|
| Luan, X | 1 |
| Le, Y | 1 |
| Jagadeeshan, S | 1 |
| Murray, B | 1 |
| Carmalt, JL | 1 |
| Duke, T | 1 |
| Beazley, S | 1 |
| Fujiyama, M | 1 |
| Swekla, K | 1 |
| Gray, B | 1 |
| Burmester, M | 1 |
| Campanucci, VA | 1 |
| Shipley, A | 1 |
| Machen, TE | 1 |
| Tam, JS | 1 |
| Ianowski, JP | 1 |
| Lu, B | 1 |
| Corey, DA | 1 |
| Kelley, TJ | 2 |
| Nilsson, HE | 1 |
| Dragomir, A | 2 |
| Lazorova, L | 1 |
| Johannesson, M | 1 |
| Roomans, GM | 2 |
| Sousa, M | 1 |
| Servidoni, MF | 1 |
| Vinagre, AM | 1 |
| Ramalho, AS | 1 |
| Bonadia, LC | 1 |
| Felício, V | 1 |
| Ribeiro, MA | 1 |
| Uliyakina, I | 1 |
| Marson, FA | 1 |
| Kmit, A | 1 |
| Cardoso, SR | 1 |
| Ribeiro, JD | 1 |
| Bertuzzo, CS | 1 |
| Sousa, L | 1 |
| Kunzelmann, K | 5 |
| Ribeiro, AF | 1 |
| Amaral, MD | 1 |
| Cho, WK | 1 |
| Siegrist, VJ | 1 |
| Zinzow, W | 1 |
| Kurz, JB | 1 |
| Perkins, JP | 1 |
| Mills, CL | 2 |
| Dorin, JR | 2 |
| Davidson, DJ | 1 |
| Porteus, DJ | 1 |
| Alton, EW | 3 |
| Dormer, RL | 5 |
| McPherson, MA | 5 |
| Levesque, PC | 1 |
| Hume, JR | 1 |
| Grubb, B | 1 |
| Lazarowski, E | 1 |
| Knowles, M | 1 |
| Boucher, R | 1 |
| Dechecchi, MC | 1 |
| Tamanini, A | 1 |
| Berton, G | 1 |
| Cabrini, G | 1 |
| Becq, F | 1 |
| Fanjul, M | 1 |
| Merten, M | 1 |
| Figarella, C | 1 |
| Hollande, E | 1 |
| Gola, M | 1 |
| O'Loughlin, EV | 2 |
| Hunt, DM | 2 |
| Bostrom, TE | 1 |
| Hunter, D | 1 |
| Gaskin, KJ | 2 |
| Gyory, A | 1 |
| Cockayne, DJ | 1 |
| Al-Nakkash, L | 2 |
| Cotton, CU | 1 |
| Drumm, ML | 2 |
| Rückes, C | 1 |
| Blank, U | 1 |
| Möller, K | 1 |
| Rieboldt, J | 1 |
| Lindemann, H | 1 |
| Münker, G | 1 |
| Clauss, W | 1 |
| Weber, WM | 2 |
| Smith, SN | 2 |
| Delaney, SJ | 1 |
| Farley, R | 1 |
| Geddes, DM | 1 |
| Porteous, DJ | 1 |
| Wainwright, BJ | 2 |
| Quesnel, LB | 1 |
| Jaran, AS | 1 |
| Braganza, JM | 1 |
| Yoshimura, K | 1 |
| Tada, H | 1 |
| Anzai, C | 1 |
| Mall, M | 3 |
| Bleich, M | 1 |
| Greger, R | 3 |
| Schreiber, R | 3 |
| Jiang, Q | 1 |
| Mak, D | 1 |
| Devidas, S | 1 |
| Schwiebert, EM | 1 |
| Bragin, A | 1 |
| Zhang, Y | 1 |
| Skach, WR | 1 |
| Guggino, WB | 1 |
| Foskett, JK | 1 |
| Engelhardt, JF | 1 |
| Hwang, TC | 1 |
| Haardt, M | 1 |
| Benharouga, M | 1 |
| Lechardeur, D | 1 |
| Kartner, N | 1 |
| Lukacs, GL | 1 |
| Wissner, A | 2 |
| Seydewitz, HH | 2 |
| Hübner, M | 1 |
| Kuehr, J | 2 |
| Brandis, M | 2 |
| Segal, A | 1 |
| Simaels, J | 1 |
| Vankeerberghen, A | 1 |
| Cassiman, JJ | 1 |
| Van Driessche, W | 1 |
| Cuppoletti, J | 1 |
| Tewari, KP | 1 |
| Sherry, AM | 1 |
| Kupert, EY | 1 |
| Malinowska, DH | 1 |
| Wagner, CA | 1 |
| Ott, M | 1 |
| Klingel, K | 1 |
| Beck, S | 1 |
| Melzig, J | 1 |
| Friedrich, B | 1 |
| Wild, KN | 1 |
| Bröer , S | 1 |
| Moschen, I | 1 |
| Albers, A | 1 |
| Waldegger, S | 1 |
| Tümmler , B | 1 |
| Egan, ME | 1 |
| Geibel, JP | 1 |
| Kandolf, R | 1 |
| Lang, F | 1 |
| Andersson, C | 1 |
| Aslund, M | 1 |
| Hjelte, L | 1 |
| Oceandy, D | 1 |
| McMorran, BJ | 1 |
| Hume, DA | 1 |
| Pereira, MM | 1 |
| Pedersen, PS | 1 |
| Allan, BJ | 2 |
| Izutsu, KT | 2 |
| Ramsey, BW | 2 |
| Schubert, MM | 2 |
| Ensign, WY | 2 |
| Truelove, EL | 2 |
| Stiel, D | 1 |
| Bruzuszcak, IM | 1 |
| Martin, HC | 1 |
| Bambach, C | 1 |
| Smith, R | 1 |
| Sato, K | 1 |
| Ohtsuyama, M | 1 |
| Suzuki, Y | 1 |
| Samman, G | 1 |
| Sato, KT | 1 |
| Sato, F | 1 |
| Wilkinson, DJ | 1 |
| Smit, LS | 1 |
| Worrell, RT | 1 |
| Strong, TV | 1 |
| Frizzell, RA | 1 |
| Dawson, DC | 1 |
| Collins, FS | 1 |
| Dodge, JA | 2 |
| Goodchild, MC | 2 |
| Bradbury, NA | 1 |
| Boucher, RC | 1 |
| Cheng, EH | 1 |
| Paradiso, AM | 1 |
| Stutts, MJ | 1 |
| Knowles, MR | 1 |
| Earp, HS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Characterization of β-cell Function and Insulin Sensitivity in Pre-transplant Patients With Cystic Fibrosis[NCT04379726] | 150 participants (Anticipated) | Observational | 2020-07-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for 1-methyl-3-isobutylxanthine and Cystic Fibrosis
| Article | Year |
|---|---|
[Cystic fibrosis].
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Amiloride; Aminoglycosides; Anti-Bacterial Agen | 1998 |
38 other studies available for 1-methyl-3-isobutylxanthine and Cystic Fibrosis
| Article | Year |
|---|---|
cAMP triggers Na
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Animals; Animals, Genetically Modified; Colforsin; Cyclic AM | 2021 |
Resveratrol restores intracellular transport in cystic fibrosis epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Acetylation; Biological Transport; Carbazoles; Cells, Cultured; Cholest | 2020 |
CFTR and tight junctions in cultured bronchial epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Actins; Bronchi; Cell Line; Cell Membrane Permeability; Colforsin; Cyst | 2010 |
Measurements of CFTR-mediated Cl- secretion in human rectal biopsies constitute a robust biomarker for Cystic Fibrosis diagnosis and prognosis.
Topics: 1-Methyl-3-isobutylxanthine; Biomarkers; Biopsy; Carbachol; Chlorides; Colforsin; Cystic Fibrosis; C | 2012 |
Impaired regulatory volume decrease in freshly isolated cholangiocytes from cystic fibrosis mice: implications for cystic fibrosis transmembrane conductance regulator effect on potassium conductance.
Topics: 1-Methyl-3-isobutylxanthine; Angiogenesis Inhibitors; Animals; Bile Ducts; Buffers; Colforsin; Cycli | 2004 |
Cystic fibrosis fibroblasts respond normally to isoproterenol.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adolescent; Adult; Cell | 1981 |
Decreased beta-adrenergic stimulation of glycoprotein secretion in CF mice submandibular glands: reversal by the methylxanthine, IBMX.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Amylases; Animals; Carbachol; Cyclic AMP; Cys | 1995 |
ATPo but not cAMPi activates a chloride conductance in mouse ventricular myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Triphosphate; Animals; Cells, Cultured; Chloride C | 1995 |
Isobutylmethylxanthine fails to stimulate chloride secretion in cystic fibrosis airway epithelia.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adult; Amiloride; Bronchi; Cells, Cultured; Chloride | 1993 |
Protein kinase C activates chloride conductance in C127 cells stably expressing the cystic fibrosis gene.
Topics: 1-Methyl-3-isobutylxanthine; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisot | 1993 |
Possible regulation of CFTR-chloride channels by membrane-bound phosphatases in pancreatic duct cells.
Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Base Sequence; Chloride Channels; Chlorides; Cyst | 1993 |
X-ray microanalysis of cell elements in normal and cystic fibrosis jejunum: evidence for chloride secretion in villi.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Cond | 1996 |
Activation of endogenous deltaF508 cystic fibrosis transmembrane conductance regulator by phosphodiesterase inhibition.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Albuterol; Base Sequence; Calcium; Cell Line; | 1996 |
Amiloride-sensitive Na+ channels in human nasal epithelium are different from classical epithelial Na+ channels.
Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Anti-Infla | 1997 |
Effect of IBMX and alkaline phosphatase inhibitors on Cl- secretion in G551D cystic fibrosis mutant mice.
Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Animals; Chlorides; Colforsin; Cystic Fibrosis; C | 1998 |
Antibiotic accumulation and membrane trafficking in cystic fibrosis cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; | 1998 |
The amiloride-inhibitable Na+ conductance is reduced by the cystic fibrosis transmembrane conductance regulator in normal but not in cystic fibrosis airways.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Chlorides; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Tran | 1998 |
Cystic fibrosis transmembrane conductance regulator-associated ATP release is controlled by a chloride sensor.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Chlorides; Colforsin; Cystic Fibrosis; | 1998 |
Activation of wild-type and deltaF508-CFTR by phosphodiesterase inhibitors through cAMP-dependent and -independent mechanisms.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Cell Line; Colforsin; Cyclic AMP; Cystic Fibrosis; | 1999 |
C-terminal truncations destabilize the cystic fibrosis transmembrane conductance regulator without impairing its biogenesis. A novel class of mutation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cell Membrane; Codon, Terminator; COS Cells; Cricet | 1999 |
Effect of genistein on native epithelial tissue from normal individuals and CF patients and on ion channels expressed in Xenopus oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Aged; Amiloride; Animals; Child; Child, Preschool; C | 2000 |
Role of K(V)LQT1 in cyclic adenosine monophosphate-mediated Cl(-) secretion in human airway epithelia.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Biological Transport; Bronchi; Cell Line, Transformed; Chlor | 2000 |
Functional integrity of the vesicle transporting machinery is required for complete activation of cFTR expressed in xenopus laevis oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antimalarials; Antineoplastic Agents; Brefeldin A; Calcium; Ch | 2001 |
ClC-2 Cl- channels in human lung epithelia: activation by arachidonic acid, amidation, and acid-activated omeprazole.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Amides; Arachidonic Acids; Cell Line; Cells, Cu | 2001 |
Effects of the serine/threonine kinase SGK1 on the epithelial Na(+) channel (ENaC) and CFTR: implications for cystic fibrosis.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Substitution; Animals; Bronchi; Cell Line; Cystic Fibrosis; | 2001 |
Assessment of chloride secretion in human nasal epithelial cells by X-ray microanalysis.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Chlorides; Colforsin; Cystic Fibrosis; Electron | 2001 |
Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bronchoalveolar Lavage; Cells, Cultured; Chemokine CXCL2; Colf | 2002 |
An antibody against a CFTR-derived synthetic peptide, incorporated into living submandibular cells, inhibits beta-adrenergic stimulation of mucin secretion.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Antibodies; | 1992 |
CFTR mechanism.
Topics: 1-Methyl-3-isobutylxanthine; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; M | 1992 |
Chloride permeability regulation via a cyclic AMP pathway in cultured human sweat duct cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic Agonists; Cell Membr | 1990 |
Cyclic nucleotide responses in control and cystic fibrosis labial glands.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Cyclic AMP; Cyclic GMP; Cystic Fibrosis; Female; Hum | 1990 |
Abnormal epithelial transport in cystic fibrosis jejunum.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Aged; Biological Transport; Bucladesine; Calcimycin; | 1991 |
Roles of Ca and cAMP on C1 channel activity in cystic fibrosis sweat clear cells as studied by microsuperfusion and cell volume analysis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Chloride Channels; Chlorides; Cyclic AMP; Cystic Fibr | 1991 |
Chloride conductance expressed by delta F508 and other mutant CFTRs in Xenopus oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Chloride Channels; Chlorides; Cystic Fibrosis; Cystic Fibrosis | 1991 |
Adrenergic secretory responses of submandibular tissues from control subjects and cystic fibrosis patients.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Amylases; Child; Cyclic AMP; Cystic Fibrosis; Dose-Response Rela | 1985 |
Defective beta-adrenergic secretory responses in submandibular acinar cells from cystic fibrosis patients.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Amylases; Cells, Cultured; Child; Cystic Fibrosis; Humans; Infan | 1986 |
Potassium release in labial glands from controls and patients with cystic fibrosis.
Topics: 1-Methyl-3-isobutylxanthine; Carbachol; Cystic Fibrosis; Humans; Potassium; Salivary Glands; Salivar | 1989 |
Chloride secretory response of cystic fibrosis human airway epithelia. Preservation of calcium but not protein kinase C- and A-dependent mechanisms.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Amiloride; Bradykinin; Calcimycin; Calcium; Child; C | 1989 |