1-methyl-3-isobutylxanthine has been researched along with Cystic Fibrosis of Pancreas in 39 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thirteen cystic fibrosis and 12 normal strains of skin fibroblasts obtained from the Institute for Medical Research were compared for their degree of production of cyclic adenosine 3':5'-monophosphate in response to isoproterenol and prostaglandin E1." | 7.66 | Cystic fibrosis fibroblasts respond normally to isoproterenol. ( Kurz, JB; Perkins, JP, 1981) |
| "Cystic fibrosis jejunum had a significantly lower Na+ content, higher K+ and Cl- content, and higher potassium/phosphorus ratio in both villus and crypt regions." | 3.69 | X-ray microanalysis of cell elements in normal and cystic fibrosis jejunum: evidence for chloride secretion in villi. ( Bostrom, TE; Cockayne, DJ; Gaskin, KJ; Gyory, A; Hunt, DM; Hunter, D; O'Loughlin, EV, 1996) |
| "The in-vitro investigation of secretory responses of submandibular tissues from three cystic fibrosis (CF) patients and four control subjects showed that responses to a beta-adrenergic stimulus (isoproterenol) were much poorer in CF cells than in control cells." | 3.67 | Defective beta-adrenergic secretory responses in submandibular acinar cells from cystic fibrosis patients. ( Bradbury, NA; Dodge, JA; Dormer, RL; Goodchild, MC; McPherson, MA, 1986) |
| "Thirteen cystic fibrosis and 12 normal strains of skin fibroblasts obtained from the Institute for Medical Research were compared for their degree of production of cyclic adenosine 3':5'-monophosphate in response to isoproterenol and prostaglandin E1." | 3.66 | Cystic fibrosis fibroblasts respond normally to isoproterenol. ( Kurz, JB; Perkins, JP, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (12.82) | 18.7374 |
| 1990's | 22 (56.41) | 18.2507 |
| 2000's | 8 (20.51) | 29.6817 |
| 2010's | 2 (5.13) | 24.3611 |
| 2020's | 2 (5.13) | 2.80 |
| Authors | Studies |
|---|---|
| Luan, X | 1 |
| Le, Y | 1 |
| Jagadeeshan, S | 1 |
| Murray, B | 1 |
| Carmalt, JL | 1 |
| Duke, T | 1 |
| Beazley, S | 1 |
| Fujiyama, M | 1 |
| Swekla, K | 1 |
| Gray, B | 1 |
| Burmester, M | 1 |
| Campanucci, VA | 1 |
| Shipley, A | 1 |
| Machen, TE | 1 |
| Tam, JS | 1 |
| Ianowski, JP | 1 |
| Lu, B | 1 |
| Corey, DA | 1 |
| Kelley, TJ | 2 |
| Nilsson, HE | 1 |
| Dragomir, A | 2 |
| Lazorova, L | 1 |
| Johannesson, M | 1 |
| Roomans, GM | 2 |
| Sousa, M | 1 |
| Servidoni, MF | 1 |
| Vinagre, AM | 1 |
| Ramalho, AS | 1 |
| Bonadia, LC | 1 |
| Felício, V | 1 |
| Ribeiro, MA | 1 |
| Uliyakina, I | 1 |
| Marson, FA | 1 |
| Kmit, A | 1 |
| Cardoso, SR | 1 |
| Ribeiro, JD | 1 |
| Bertuzzo, CS | 1 |
| Sousa, L | 1 |
| Kunzelmann, K | 5 |
| Ribeiro, AF | 1 |
| Amaral, MD | 1 |
| Cho, WK | 1 |
| Siegrist, VJ | 1 |
| Zinzow, W | 1 |
| Kurz, JB | 1 |
| Perkins, JP | 1 |
| Mills, CL | 2 |
| Dorin, JR | 2 |
| Davidson, DJ | 1 |
| Porteus, DJ | 1 |
| Alton, EW | 3 |
| Dormer, RL | 5 |
| McPherson, MA | 5 |
| Levesque, PC | 1 |
| Hume, JR | 1 |
| Grubb, B | 1 |
| Lazarowski, E | 1 |
| Knowles, M | 1 |
| Boucher, R | 1 |
| Dechecchi, MC | 1 |
| Tamanini, A | 1 |
| Berton, G | 1 |
| Cabrini, G | 1 |
| Becq, F | 1 |
| Fanjul, M | 1 |
| Merten, M | 1 |
| Figarella, C | 1 |
| Hollande, E | 1 |
| Gola, M | 1 |
| O'Loughlin, EV | 2 |
| Hunt, DM | 2 |
| Bostrom, TE | 1 |
| Hunter, D | 1 |
| Gaskin, KJ | 2 |
| Gyory, A | 1 |
| Cockayne, DJ | 1 |
| Al-Nakkash, L | 2 |
| Cotton, CU | 1 |
| Drumm, ML | 2 |
| Rückes, C | 1 |
| Blank, U | 1 |
| Möller, K | 1 |
| Rieboldt, J | 1 |
| Lindemann, H | 1 |
| Münker, G | 1 |
| Clauss, W | 1 |
| Weber, WM | 2 |
| Smith, SN | 2 |
| Delaney, SJ | 1 |
| Farley, R | 1 |
| Geddes, DM | 1 |
| Porteous, DJ | 1 |
| Wainwright, BJ | 2 |
| Quesnel, LB | 1 |
| Jaran, AS | 1 |
| Braganza, JM | 1 |
| Yoshimura, K | 1 |
| Tada, H | 1 |
| Anzai, C | 1 |
| Mall, M | 3 |
| Bleich, M | 1 |
| Greger, R | 3 |
| Schreiber, R | 3 |
| Jiang, Q | 1 |
| Mak, D | 1 |
| Devidas, S | 1 |
| Schwiebert, EM | 1 |
| Bragin, A | 1 |
| Zhang, Y | 1 |
| Skach, WR | 1 |
| Guggino, WB | 1 |
| Foskett, JK | 1 |
| Engelhardt, JF | 1 |
| Hwang, TC | 1 |
| Haardt, M | 1 |
| Benharouga, M | 1 |
| Lechardeur, D | 1 |
| Kartner, N | 1 |
| Lukacs, GL | 1 |
| Wissner, A | 2 |
| Seydewitz, HH | 2 |
| Hübner, M | 1 |
| Kuehr, J | 2 |
| Brandis, M | 2 |
| Segal, A | 1 |
| Simaels, J | 1 |
| Vankeerberghen, A | 1 |
| Cassiman, JJ | 1 |
| Van Driessche, W | 1 |
| Cuppoletti, J | 1 |
| Tewari, KP | 1 |
| Sherry, AM | 1 |
| Kupert, EY | 1 |
| Malinowska, DH | 1 |
| Wagner, CA | 1 |
| Ott, M | 1 |
| Klingel, K | 1 |
| Beck, S | 1 |
| Melzig, J | 1 |
| Friedrich, B | 1 |
| Wild, KN | 1 |
| Bröer , S | 1 |
| Moschen, I | 1 |
| Albers, A | 1 |
| Waldegger, S | 1 |
| Tümmler , B | 1 |
| Egan, ME | 1 |
| Geibel, JP | 1 |
| Kandolf, R | 1 |
| Lang, F | 1 |
| Andersson, C | 1 |
| Aslund, M | 1 |
| Hjelte, L | 1 |
| Oceandy, D | 1 |
| McMorran, BJ | 1 |
| Hume, DA | 1 |
| Pereira, MM | 1 |
| Pedersen, PS | 1 |
| Allan, BJ | 2 |
| Izutsu, KT | 2 |
| Ramsey, BW | 2 |
| Schubert, MM | 2 |
| Ensign, WY | 2 |
| Truelove, EL | 2 |
| Stiel, D | 1 |
| Bruzuszcak, IM | 1 |
| Martin, HC | 1 |
| Bambach, C | 1 |
| Smith, R | 1 |
| Sato, K | 1 |
| Ohtsuyama, M | 1 |
| Suzuki, Y | 1 |
| Samman, G | 1 |
| Sato, KT | 1 |
| Sato, F | 1 |
| Wilkinson, DJ | 1 |
| Smit, LS | 1 |
| Worrell, RT | 1 |
| Strong, TV | 1 |
| Frizzell, RA | 1 |
| Dawson, DC | 1 |
| Collins, FS | 1 |
| Dodge, JA | 2 |
| Goodchild, MC | 2 |
| Bradbury, NA | 1 |
| Boucher, RC | 1 |
| Cheng, EH | 1 |
| Paradiso, AM | 1 |
| Stutts, MJ | 1 |
| Knowles, MR | 1 |
| Earp, HS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Characterization of β-cell Function and Insulin Sensitivity in Pre-transplant Patients With Cystic Fibrosis[NCT04379726] | 150 participants (Anticipated) | Observational | 2020-07-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for 1-methyl-3-isobutylxanthine and Cystic Fibrosis of Pancreas
| Article | Year |
|---|---|
[Cystic fibrosis].
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Amiloride; Aminoglycosides; Anti-Bacterial Agen | 1998 |
38 other studies available for 1-methyl-3-isobutylxanthine and Cystic Fibrosis of Pancreas
| Article | Year |
|---|---|
cAMP triggers Na
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Animals; Animals, Genetically Modified; Colforsin; Cyclic AM | 2021 |
Resveratrol restores intracellular transport in cystic fibrosis epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Acetylation; Biological Transport; Carbazoles; Cells, Cultured; Cholest | 2020 |
CFTR and tight junctions in cultured bronchial epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Actins; Bronchi; Cell Line; Cell Membrane Permeability; Colforsin; Cyst | 2010 |
Measurements of CFTR-mediated Cl- secretion in human rectal biopsies constitute a robust biomarker for Cystic Fibrosis diagnosis and prognosis.
Topics: 1-Methyl-3-isobutylxanthine; Biomarkers; Biopsy; Carbachol; Chlorides; Colforsin; Cystic Fibrosis; C | 2012 |
Impaired regulatory volume decrease in freshly isolated cholangiocytes from cystic fibrosis mice: implications for cystic fibrosis transmembrane conductance regulator effect on potassium conductance.
Topics: 1-Methyl-3-isobutylxanthine; Angiogenesis Inhibitors; Animals; Bile Ducts; Buffers; Colforsin; Cycli | 2004 |
Cystic fibrosis fibroblasts respond normally to isoproterenol.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adolescent; Adult; Cell | 1981 |
Decreased beta-adrenergic stimulation of glycoprotein secretion in CF mice submandibular glands: reversal by the methylxanthine, IBMX.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Amylases; Animals; Carbachol; Cyclic AMP; Cys | 1995 |
ATPo but not cAMPi activates a chloride conductance in mouse ventricular myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Triphosphate; Animals; Cells, Cultured; Chloride C | 1995 |
Isobutylmethylxanthine fails to stimulate chloride secretion in cystic fibrosis airway epithelia.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adult; Amiloride; Bronchi; Cells, Cultured; Chloride | 1993 |
Protein kinase C activates chloride conductance in C127 cells stably expressing the cystic fibrosis gene.
Topics: 1-Methyl-3-isobutylxanthine; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisot | 1993 |
Possible regulation of CFTR-chloride channels by membrane-bound phosphatases in pancreatic duct cells.
Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Base Sequence; Chloride Channels; Chlorides; Cyst | 1993 |
X-ray microanalysis of cell elements in normal and cystic fibrosis jejunum: evidence for chloride secretion in villi.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Cond | 1996 |
Activation of endogenous deltaF508 cystic fibrosis transmembrane conductance regulator by phosphodiesterase inhibition.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Albuterol; Base Sequence; Calcium; Cell Line; | 1996 |
Amiloride-sensitive Na+ channels in human nasal epithelium are different from classical epithelial Na+ channels.
Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Anti-Infla | 1997 |
Effect of IBMX and alkaline phosphatase inhibitors on Cl- secretion in G551D cystic fibrosis mutant mice.
Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Animals; Chlorides; Colforsin; Cystic Fibrosis; C | 1998 |
Antibiotic accumulation and membrane trafficking in cystic fibrosis cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; | 1998 |
The amiloride-inhibitable Na+ conductance is reduced by the cystic fibrosis transmembrane conductance regulator in normal but not in cystic fibrosis airways.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Chlorides; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Tran | 1998 |
Cystic fibrosis transmembrane conductance regulator-associated ATP release is controlled by a chloride sensor.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Chlorides; Colforsin; Cystic Fibrosis; | 1998 |
Activation of wild-type and deltaF508-CFTR by phosphodiesterase inhibitors through cAMP-dependent and -independent mechanisms.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Cell Line; Colforsin; Cyclic AMP; Cystic Fibrosis; | 1999 |
C-terminal truncations destabilize the cystic fibrosis transmembrane conductance regulator without impairing its biogenesis. A novel class of mutation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cell Membrane; Codon, Terminator; COS Cells; Cricet | 1999 |
Effect of genistein on native epithelial tissue from normal individuals and CF patients and on ion channels expressed in Xenopus oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Aged; Amiloride; Animals; Child; Child, Preschool; C | 2000 |
Role of K(V)LQT1 in cyclic adenosine monophosphate-mediated Cl(-) secretion in human airway epithelia.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Biological Transport; Bronchi; Cell Line, Transformed; Chlor | 2000 |
Functional integrity of the vesicle transporting machinery is required for complete activation of cFTR expressed in xenopus laevis oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antimalarials; Antineoplastic Agents; Brefeldin A; Calcium; Ch | 2001 |
ClC-2 Cl- channels in human lung epithelia: activation by arachidonic acid, amidation, and acid-activated omeprazole.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Amides; Arachidonic Acids; Cell Line; Cells, Cu | 2001 |
Effects of the serine/threonine kinase SGK1 on the epithelial Na(+) channel (ENaC) and CFTR: implications for cystic fibrosis.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Substitution; Animals; Bronchi; Cell Line; Cystic Fibrosis; | 2001 |
Assessment of chloride secretion in human nasal epithelial cells by X-ray microanalysis.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Chlorides; Colforsin; Cystic Fibrosis; Electron | 2001 |
Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bronchoalveolar Lavage; Cells, Cultured; Chemokine CXCL2; Colf | 2002 |
An antibody against a CFTR-derived synthetic peptide, incorporated into living submandibular cells, inhibits beta-adrenergic stimulation of mucin secretion.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Antibodies; | 1992 |
CFTR mechanism.
Topics: 1-Methyl-3-isobutylxanthine; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; M | 1992 |
Chloride permeability regulation via a cyclic AMP pathway in cultured human sweat duct cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic Agonists; Cell Membr | 1990 |
Cyclic nucleotide responses in control and cystic fibrosis labial glands.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Cyclic AMP; Cyclic GMP; Cystic Fibrosis; Female; Hum | 1990 |
Abnormal epithelial transport in cystic fibrosis jejunum.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Aged; Biological Transport; Bucladesine; Calcimycin; | 1991 |
Roles of Ca and cAMP on C1 channel activity in cystic fibrosis sweat clear cells as studied by microsuperfusion and cell volume analysis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Chloride Channels; Chlorides; Cyclic AMP; Cystic Fibr | 1991 |
Chloride conductance expressed by delta F508 and other mutant CFTRs in Xenopus oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Chloride Channels; Chlorides; Cystic Fibrosis; Cystic Fibrosis | 1991 |
Adrenergic secretory responses of submandibular tissues from control subjects and cystic fibrosis patients.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Amylases; Child; Cyclic AMP; Cystic Fibrosis; Dose-Response Rela | 1985 |
Defective beta-adrenergic secretory responses in submandibular acinar cells from cystic fibrosis patients.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Amylases; Cells, Cultured; Child; Cystic Fibrosis; Humans; Infan | 1986 |
Potassium release in labial glands from controls and patients with cystic fibrosis.
Topics: 1-Methyl-3-isobutylxanthine; Carbachol; Cystic Fibrosis; Humans; Potassium; Salivary Glands; Salivar | 1989 |
Chloride secretory response of cystic fibrosis human airway epithelia. Preservation of calcium but not protein kinase C- and A-dependent mechanisms.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Amiloride; Bradykinin; Calcimycin; Calcium; Child; C | 1989 |