1-methyl-3-isobutylxanthine has been researched along with Coronary Disease in 4 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aims of this study were to determine whether a relationship exists between the occurrence of coronary artery occlusion-induced arrhythmias in the anaesthetized rat and the levels of cyclic AMP and cyclic GMP in both normal and ischaemic myocardium, and to assess whether such arrhythmias were modified by pretreatment with the phosphodiesterase inhibitors, quazodine and isobutyl methylxanthine (IBMX), or with the butyryl derivatives of cyclic AMP and cyclic GMP." | 3.67 | The relationship between coronary artery occlusion-induced arrhythmias and myocardial cyclic nucleotide levels in the anaesthetized rat. ( Kane, KA; Morcillo-Sanchez, EJ; Parratt, JR; Rodger, IW; Shahid, M, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ross-Ascuitto, NT | 1 |
| Ascuitto, RJ | 1 |
| Ramage, D | 1 |
| McDonough, KH | 1 |
| Näbauer, M | 1 |
| Böhm, M | 1 |
| Brown, L | 1 |
| Diet, F | 1 |
| Eichhorn, M | 1 |
| Kemkes, B | 1 |
| Pieske, B | 1 |
| Erdmann, E | 1 |
| Holbrook, M | 1 |
| Coker, SJ | 1 |
| Kane, KA | 1 |
| Morcillo-Sanchez, EJ | 1 |
| Parratt, JR | 1 |
| Rodger, IW | 1 |
| Shahid, M | 1 |
4 other studies available for 1-methyl-3-isobutylxanthine and Coronary Disease
| Article | Year |
|---|---|
The effects of milrinone in the neonatal pig heart.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Cells, Cultured; Coronary Circulation; Coron | 1991 |
Positive inotropic effects in isolated ventricular myocardium from non-failing and terminally failing human hearts.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Bucladesine; Calcium; Cardiomyopathy, Dilated; Cardiotonic Agent | 1988 |
Comparison of the effects of isobutylmethylxanthine and milrinone on ischaemia-induced arrhythmias and platelet aggregation in anaesthetized rabbits.
Topics: 1-Methyl-3-isobutylxanthine; Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bloo | 1989 |
The relationship between coronary artery occlusion-induced arrhythmias and myocardial cyclic nucleotide levels in the anaesthetized rat.
Topics: 1-Methyl-3-isobutylxanthine; Anesthesia; Animals; Arrhythmias, Cardiac; Bucladesine; Coronary Diseas | 1985 |