1-methyl-3-isobutylxanthine has been researched along with Cell Transformation, Neoplastic in 17 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cell hybrids (BIM) were produced between human neuroblastoma cells (IMR-32) and thymidine auxotrophs (B3T) of rat nerve-like cells (B103) in order to obtain cell lines undergoing stable neuronal differentiation." | 7.68 | Spontaneous and cAMP-dependent induction of a resting phase and neurite formation in cell hybrids between human neuroblastoma cells and thymidine auxotrophs of rat nerve-like cells. ( Adachi, Y; Furuyama, J; Hatanaka, M; Ishii, K; Sakamoto, H, 1990) |
| "Cell hybrids (BIM) were produced between human neuroblastoma cells (IMR-32) and thymidine auxotrophs (B3T) of rat nerve-like cells (B103) in order to obtain cell lines undergoing stable neuronal differentiation." | 3.68 | Spontaneous and cAMP-dependent induction of a resting phase and neurite formation in cell hybrids between human neuroblastoma cells and thymidine auxotrophs of rat nerve-like cells. ( Adachi, Y; Furuyama, J; Hatanaka, M; Ishii, K; Sakamoto, H, 1990) |
| "These retinoid-treated choriocarcinoma cells remained responsive to 8BrcAMP or compounds that increase intracellular cAMP concentrations and to BrdUrd; the production to PS beta G and hCG was greatly stimulated by 8BrcAMP, cholera toxin, or MIX, and the production of hCG and hCG alpha was greatly inhibited by BrdUrd." | 1.26 | Effects of retinoic acid on differentiation of choriocarcinoma cells in vitro. ( Chou, JY, 1982) |
| " The dose-response effects of IBX on growth inhibition of malignant cells in mixed cultures appear to correlate well with its ability to elevate cAMP levels." | 1.26 | Modulation of cellular interactions between C3H/10T1/2 cells and their transformed counterparts by phosphodiesterase inhibitors. ( Bertram, JS, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (52.94) | 18.7374 |
| 1990's | 8 (47.06) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hahn, GL | 1 |
| Haynes, L | 1 |
| Chlapowski, FJ | 1 |
| Chou, JY | 2 |
| Freedman, SB | 1 |
| Dawson, G | 1 |
| Villereal, ML | 1 |
| Miller, RJ | 1 |
| Martin, JL | 1 |
| Coverley, JA | 1 |
| Baxter, RC | 1 |
| Hurta, RA | 1 |
| Wright, JA | 1 |
| Iwamoto, Y | 1 |
| Reich, R | 1 |
| Nemeth, G | 1 |
| Yamada, Y | 1 |
| Martin, GR | 1 |
| Bertram, JS | 1 |
| Roseng, LE | 1 |
| Rivedal, E | 1 |
| Sanner, T | 1 |
| Ishii, K | 1 |
| Adachi, Y | 1 |
| Hatanaka, M | 1 |
| Sakamoto, H | 1 |
| Furuyama, J | 1 |
| Krystosek, A | 2 |
| Puck, TT | 2 |
| Orlow, SJ | 1 |
| Chakraborty, AK | 1 |
| Boissy, RE | 1 |
| Pawelek, JM | 1 |
| Bartholdi, M | 1 |
| Johnson, R | 1 |
| Haag, M | 1 |
| Blenis, J | 1 |
| Kuo, CJ | 1 |
| Alcorta, DA | 1 |
| Erikson, RL | 1 |
| Felder, CC | 1 |
| Ma, AL | 1 |
| Conklin, BR | 1 |
| Buchou, T | 1 |
| Charollais, RH | 1 |
| Fagot, D | 1 |
| Mester, J | 1 |
| Majmudar, G | 1 |
| Peterkofsky, B | 1 |
17 other studies available for 1-methyl-3-isobutylxanthine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Variations of adenosine 3',5'-cyclic monophosphate levels in four chemically transformed rat transitional epithelial cell lines.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Monophosphate; Animals; Cell Line; Cell Transformation, Neopl | 1980 |
Effects of retinoic acid on differentiation of choriocarcinoma cells in vitro.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Cell Line; Cell Transformation, | 1982 |
Role of cyclic adenosine 3',5'-monophosphate in differentiation of fetal liver cells in vitro.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Albumins; alpha-Fetoproteins; A | 1983 |
Identification and characterization of voltage-sensitive calcium channels in neuronal clonal cell lines.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain Neoplasms; Calcium Channel Blockers; Cell Transformation | 1984 |
Regulation of immunoreactive insulin-like growth factor binding protein-6 in normal and transformed human fibroblasts.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Carrier Proteins; Cell Line; Cell Line, Transformed; Cell | 1994 |
Ornithine decarboxylase gene expression is aberrantly regulated via the cAMP signal transduction pathway in malignant H-ras transformed cell lines.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Transformation, Neoplastic; Colforsin; Cyclic AMP; Fibrob | 1994 |
Cyclic AMP decreases chemotaxis, invasiveness and lung colonization of H-ras transformed mouse fibroblasts.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Cell Tran | 1993 |
Modulation of cellular interactions between C3H/10T1/2 cells and their transformed counterparts by phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cell Communication; Cell Division; Cell Line; Cel | 1979 |
Effect of cAMP elevating compounds on inhibition of gap junctional communication and induction of morphological transformation in Syrian hamster embryo cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Communication; Cell Transformation, Neoplastic; Cells, Cu | 1992 |
Spontaneous and cAMP-dependent induction of a resting phase and neurite formation in cell hybrids between human neuroblastoma cells and thymidine auxotrophs of rat nerve-like cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Axons; Bucladesine; Calcimycin; Cell Cycle; Cell Transformatio | 1990 |
The spatial distribution of exposed nuclear DNA in normal, cancer, and reverse-transformed cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Line; Cell Nucleu | 1990 |
Inhibition of induced melanogenesis in Cloudman melanoma cells by four phenotypic modifiers.
Topics: 1-Methyl-3-isobutylxanthine; Acetamides; Animals; Butyrates; Butyric Acid; Cell Transformation, Neop | 1990 |
Confocal microscopy of genome exposure in normal, cancer, and reverse-transformed cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Cell Nucl | 1991 |
Role of second messengers in regulating the growth-associated S6 protein kinase activity.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Avian Sarcoma Viruses; Bucladesine; Calcimycin; Cell Transform | 1987 |
Carbachol-induced reverse transformation of Chinese hamster ovary cells transfected with and expressing the m5 muscarinic acetylcholine receptor.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Carbachol; Cell Line; Cell Transformation, Neopla | 1989 |
Mitogenic activity of phorbol esters and insulin-like growth factor 1 in chemically transformed mouse fibroblasts BP-A31: independent effects and differential sensitivity to inhibition by 3-isobutyl-1-methyl xanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Cell Division; Cell Transformation, Neopla | 1989 |
Cyclic AMP-independent processes mediate Kirsten sarcoma virus-induced changes in collagen production and other properties of cultured cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cell Line; Cell Transformation, Neoplastic; Cells | 1985 |