1-methyl-3-isobutylxanthine has been researched along with Cardiomegaly in 13 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Indapamide-treated animals had significantly greater myocardial cAMP concentrations than control animals." | 5.29 | Effect of indapamide on cyclic adenosine 3',5'-monophosphate signal transduction system in isolated adult rat cardiomyocytes from normal myocardium and cardiac hypertrophy. ( Rabkin, SW, 1993) |
| "In cardiac myocytes activation of an exchange factor activated by cAMP (Epac) leads to activation of phospholipase Cε (PLCε)-dependent hydrolysis of phosphatidylinositol 4-phosphate (PI4P) in the Golgi apparatus a process critical for development of cardiac hypertrophy." | 3.88 | Compartmentalized cyclic nucleotides have opposing effects on regulation of hypertrophic phospholipase Cε signaling in cardiac myocytes. ( Brown, LM; Cheng, X; Malik, S; Nash, CA; Smrcka, AV, 2018) |
| "Cardiac hypertrophy was induced in rats by thoracic aortic banding over a time period of 5 weeks and was confirmed by anatomic measurements and echocardiography." | 1.35 | Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals. ( Abi-Gerges, A; Conti, M; Fischmeister, R; Heymes, C; Lefebvre, F; Lugnier, C; Mateo, P; Richter, W; Samuel, JL; Vandecasteele, G; Varin, A, 2009) |
| "Although norepinephrine induces cardiac hypertrophy by activating protein kinase A and C through beta- and alpha 1-adrenoceptors, respectively, protein kinase A has been reported to inhibit cell growth in many other cell types." | 1.30 | Norepinephrine induces the raf-1 kinase/mitogen-activated protein kinase cascade through both alpha 1- and beta-adrenoceptors. ( Aikawa, R; Hiroi, Y; Komuro, I; Kudoh, S; Mizuno, T; Shiojima, I; Takano, H; Yamazaki, T; Yazaki, Y; Zou, Y, 1997) |
| "Indapamide-treated animals had significantly greater myocardial cAMP concentrations than control animals." | 1.29 | Effect of indapamide on cyclic adenosine 3',5'-monophosphate signal transduction system in isolated adult rat cardiomyocytes from normal myocardium and cardiac hypertrophy. ( Rabkin, SW, 1993) |
| "Dahl S rats developed cardiac hypertrophy on a high-salt diet, whereas Dahl R rats did not." | 1.29 | Angiotensin II induced alteration of cyclic adenosine 3',5'-monophosphate generation in the hypertrophic myocardium of Dahl salt-sensitive rat on a high-salt diet. ( Rabkin, SW; Sunga, PS, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (69.23) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nash, CA | 1 |
| Brown, LM | 1 |
| Malik, S | 1 |
| Cheng, X | 1 |
| Smrcka, AV | 1 |
| Abi-Gerges, A | 2 |
| Richter, W | 1 |
| Lefebvre, F | 1 |
| Mateo, P | 1 |
| Varin, A | 1 |
| Heymes, C | 1 |
| Samuel, JL | 1 |
| Lugnier, C | 1 |
| Conti, M | 1 |
| Fischmeister, R | 1 |
| Vandecasteele, G | 1 |
| Sassi, Y | 1 |
| Fauconnier, J | 1 |
| Mougenot, N | 1 |
| Reiken, S | 1 |
| Haghighi, K | 1 |
| Kranias, EG | 2 |
| Marks, AR | 1 |
| Lacampagne, A | 1 |
| Engelhardt, S | 1 |
| Hatem, SN | 1 |
| Lompre, AM | 1 |
| Hulot, JS | 1 |
| Long, CS | 1 |
| Hartogensis, WE | 1 |
| Simpson, PC | 1 |
| Rabkin, SW | 2 |
| Sunga, PS | 1 |
| Yamazaki, T | 2 |
| Komuro, I | 2 |
| Zou, Y | 2 |
| Kudoh, S | 2 |
| Shiojima, I | 2 |
| Hiroi, Y | 2 |
| Mizuno, T | 2 |
| Aikawa, R | 1 |
| Takano, H | 2 |
| Yazaki, Y | 2 |
| Osaki, J | 2 |
| Haneda, T | 2 |
| Sakai, H | 2 |
| Kikuchi, K | 2 |
| Kinugawa, Ki | 1 |
| Kohmoto, O | 1 |
| Takahashi, T | 1 |
| Ritchie, RH | 1 |
| Schiebinger, RJ | 1 |
| LaPointe, MC | 1 |
| Marsh, JD | 1 |
| Kashiwagi, Y | 1 |
| Oi, S | 1 |
| Fukuzawa, J | 1 |
| Sato, Y | 1 |
| Kiriazis, H | 1 |
| Yatani, A | 1 |
| Schmidt, AG | 1 |
| Hahn, H | 1 |
| Ferguson, DG | 1 |
| Sako, H | 1 |
| Mitarai, S | 1 |
| Honda, R | 1 |
| Mesnard-Rouiller, L | 1 |
| Frank, KF | 1 |
| Beyermann, B | 1 |
| Wu, G | 1 |
| Fujimori, K | 1 |
| Dorn, GW | 1 |
| Clark, WA | 1 |
| Rudnick, SJ | 1 |
| LaPres, JJ | 1 |
| Lesch, M | 1 |
| Decker, RS | 1 |
13 other studies available for 1-methyl-3-isobutylxanthine and Cardiomegaly
| Article | Year |
|---|---|
Compartmentalized cyclic nucleotides have opposing effects on regulation of hypertrophic phospholipase Cε signaling in cardiac myocytes.
Topics: 1-Methyl-3-isobutylxanthine; A Kinase Anchor Proteins; Animals; Atrial Natriuretic Factor; Cardiomeg | 2018 |
Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Aortic Valve S | 2009 |
Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Western; Cardiomegaly; Cell Membrane; Cells, Culture | 2012 |
Beta-adrenergic stimulation of cardiac non-myocytes augments the growth-promoting activity of non-myocyte conditioned medium.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Betaxolol; Cardiomegaly; Cell Division; Cells, Cultured; Cultu | 1993 |
Effect of indapamide on cyclic adenosine 3',5'-monophosphate signal transduction system in isolated adult rat cardiomyocytes from normal myocardium and cardiac hypertrophy.
Topics: 1-Methyl-3-isobutylxanthine; Angiotensin II; Animals; Binding, Competitive; Carbachol; Cardiomegaly; | 1993 |
Angiotensin II induced alteration of cyclic adenosine 3',5'-monophosphate generation in the hypertrophic myocardium of Dahl salt-sensitive rat on a high-salt diet.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Angiotensin II; Animals; Cardiomegaly; Cell Si | 1994 |
Norepinephrine induces the raf-1 kinase/mitogen-activated protein kinase cascade through both alpha 1- and beta-adrenoceptors.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-1 Receptor Antagonists; Amino Acids; Animals; Animals, | 1997 |
cAMP-mediated c-fos expression in pressure-overloaded acceleration of protein synthesis in adult rat heart.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Cardiomegaly; Colforsin; Cyclic AMP; Cycli | 1997 |
Protein kinase A and protein kinase C synergistically activate the Raf-1 kinase/mitogen-activated protein kinase cascade in neonatal rat cardiomyocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Bucladesine; Calcium; Calcium-Calmodulin-Dep | 1997 |
Angiotensin II-induced hypertrophy of adult rat cardiomyocytes is blocked by nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Angiotensin II; Animals; Bradyk | 1998 |
Pressure-induced expression of heat shock protein 70 mRNA in adult rat heart is coupled both to protein kinase A-dependent and protein kinase C-dependent systems.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Pressure; Cardiomegaly; Colforsin; Cyclic AMP; Cyclic AM | 1998 |
Rescue of contractile parameters and myocyte hypertrophy in calsequestrin overexpressing myocardium by phospholamban ablation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Calcium-Binding Proteins; Calseques | 2001 |
Hypertrophy of isolated adult feline heart cells following beta-adrenergic-induced beating.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cardiomegaly; Cats; Cells, Cultured; Colforsin; Cultu | 1991 |