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1-methyl-3-isobutylxanthine and Cardiomegaly

1-methyl-3-isobutylxanthine has been researched along with Cardiomegaly in 13 studies

1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.

Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.

Research Excerpts

ExcerptRelevanceReference
"Indapamide-treated animals had significantly greater myocardial cAMP concentrations than control animals."5.29Effect of indapamide on cyclic adenosine 3',5'-monophosphate signal transduction system in isolated adult rat cardiomyocytes from normal myocardium and cardiac hypertrophy. ( Rabkin, SW, 1993)
"In cardiac myocytes activation of an exchange factor activated by cAMP (Epac) leads to activation of phospholipase Cε (PLCε)-dependent hydrolysis of phosphatidylinositol 4-phosphate (PI4P) in the Golgi apparatus a process critical for development of cardiac hypertrophy."3.88Compartmentalized cyclic nucleotides have opposing effects on regulation of hypertrophic phospholipase Cε signaling in cardiac myocytes. ( Brown, LM; Cheng, X; Malik, S; Nash, CA; Smrcka, AV, 2018)
"Cardiac hypertrophy was induced in rats by thoracic aortic banding over a time period of 5 weeks and was confirmed by anatomic measurements and echocardiography."1.35Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals. ( Abi-Gerges, A; Conti, M; Fischmeister, R; Heymes, C; Lefebvre, F; Lugnier, C; Mateo, P; Richter, W; Samuel, JL; Vandecasteele, G; Varin, A, 2009)
"Although norepinephrine induces cardiac hypertrophy by activating protein kinase A and C through beta- and alpha 1-adrenoceptors, respectively, protein kinase A has been reported to inhibit cell growth in many other cell types."1.30Norepinephrine induces the raf-1 kinase/mitogen-activated protein kinase cascade through both alpha 1- and beta-adrenoceptors. ( Aikawa, R; Hiroi, Y; Komuro, I; Kudoh, S; Mizuno, T; Shiojima, I; Takano, H; Yamazaki, T; Yazaki, Y; Zou, Y, 1997)
"Indapamide-treated animals had significantly greater myocardial cAMP concentrations than control animals."1.29Effect of indapamide on cyclic adenosine 3',5'-monophosphate signal transduction system in isolated adult rat cardiomyocytes from normal myocardium and cardiac hypertrophy. ( Rabkin, SW, 1993)
"Dahl S rats developed cardiac hypertrophy on a high-salt diet, whereas Dahl R rats did not."1.29Angiotensin II induced alteration of cyclic adenosine 3',5'-monophosphate generation in the hypertrophic myocardium of Dahl salt-sensitive rat on a high-salt diet. ( Rabkin, SW; Sunga, PS, 1994)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (69.23)18.2507
2000's2 (15.38)29.6817
2010's2 (15.38)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nash, CA1
Brown, LM1
Malik, S1
Cheng, X1
Smrcka, AV1
Abi-Gerges, A2
Richter, W1
Lefebvre, F1
Mateo, P1
Varin, A1
Heymes, C1
Samuel, JL1
Lugnier, C1
Conti, M1
Fischmeister, R1
Vandecasteele, G1
Sassi, Y1
Fauconnier, J1
Mougenot, N1
Reiken, S1
Haghighi, K1
Kranias, EG2
Marks, AR1
Lacampagne, A1
Engelhardt, S1
Hatem, SN1
Lompre, AM1
Hulot, JS1
Long, CS1
Hartogensis, WE1
Simpson, PC1
Rabkin, SW2
Sunga, PS1
Yamazaki, T2
Komuro, I2
Zou, Y2
Kudoh, S2
Shiojima, I2
Hiroi, Y2
Mizuno, T2
Aikawa, R1
Takano, H2
Yazaki, Y2
Osaki, J2
Haneda, T2
Sakai, H2
Kikuchi, K2
Kinugawa, Ki1
Kohmoto, O1
Takahashi, T1
Ritchie, RH1
Schiebinger, RJ1
LaPointe, MC1
Marsh, JD1
Kashiwagi, Y1
Oi, S1
Fukuzawa, J1
Sato, Y1
Kiriazis, H1
Yatani, A1
Schmidt, AG1
Hahn, H1
Ferguson, DG1
Sako, H1
Mitarai, S1
Honda, R1
Mesnard-Rouiller, L1
Frank, KF1
Beyermann, B1
Wu, G1
Fujimori, K1
Dorn, GW1
Clark, WA1
Rudnick, SJ1
LaPres, JJ1
Lesch, M1
Decker, RS1

Other Studies

13 other studies available for 1-methyl-3-isobutylxanthine and Cardiomegaly

ArticleYear
Compartmentalized cyclic nucleotides have opposing effects on regulation of hypertrophic phospholipase Cε signaling in cardiac myocytes.
    Journal of molecular and cellular cardiology, 2018, Volume: 121

    Topics: 1-Methyl-3-isobutylxanthine; A Kinase Anchor Proteins; Animals; Atrial Natriuretic Factor; Cardiomeg

2018
Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals.
    Circulation research, 2009, Oct-09, Volume: 105, Issue:8

    Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Aortic Valve S

2009
Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2012, Volume: 26, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Western; Cardiomegaly; Cell Membrane; Cells, Culture

2012
Beta-adrenergic stimulation of cardiac non-myocytes augments the growth-promoting activity of non-myocyte conditioned medium.
    Journal of molecular and cellular cardiology, 1993, Volume: 25, Issue:8

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Betaxolol; Cardiomegaly; Cell Division; Cells, Cultured; Cultu

1993
Effect of indapamide on cyclic adenosine 3',5'-monophosphate signal transduction system in isolated adult rat cardiomyocytes from normal myocardium and cardiac hypertrophy.
    Journal of cardiovascular pharmacology, 1993, Volume: 22 Suppl 6

    Topics: 1-Methyl-3-isobutylxanthine; Angiotensin II; Animals; Binding, Competitive; Carbachol; Cardiomegaly;

1993
Angiotensin II induced alteration of cyclic adenosine 3',5'-monophosphate generation in the hypertrophic myocardium of Dahl salt-sensitive rat on a high-salt diet.
    Canadian journal of physiology and pharmacology, 1994, Volume: 72, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Angiotensin II; Animals; Cardiomegaly; Cell Si

1994
Norepinephrine induces the raf-1 kinase/mitogen-activated protein kinase cascade through both alpha 1- and beta-adrenoceptors.
    Circulation, 1997, Mar-04, Volume: 95, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-1 Receptor Antagonists; Amino Acids; Animals; Animals,

1997
cAMP-mediated c-fos expression in pressure-overloaded acceleration of protein synthesis in adult rat heart.
    Cardiovascular research, 1997, Volume: 33, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Cardiomegaly; Colforsin; Cyclic AMP; Cycli

1997
Protein kinase A and protein kinase C synergistically activate the Raf-1 kinase/mitogen-activated protein kinase cascade in neonatal rat cardiomyocytes.
    Journal of molecular and cellular cardiology, 1997, Volume: 29, Issue:9

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Bucladesine; Calcium; Calcium-Calmodulin-Dep

1997
Angiotensin II-induced hypertrophy of adult rat cardiomyocytes is blocked by nitric oxide.
    The American journal of physiology, 1998, Volume: 275, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Angiotensin II; Animals; Bradyk

1998
Pressure-induced expression of heat shock protein 70 mRNA in adult rat heart is coupled both to protein kinase A-dependent and protein kinase C-dependent systems.
    Journal of hypertension, 1998, Volume: 16, Issue:8

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Pressure; Cardiomegaly; Colforsin; Cyclic AMP; Cyclic AM

1998
Rescue of contractile parameters and myocyte hypertrophy in calsequestrin overexpressing myocardium by phospholamban ablation.
    The Journal of biological chemistry, 2001, Mar-23, Volume: 276, Issue:12

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Calcium-Binding Proteins; Calseques

2001
Hypertrophy of isolated adult feline heart cells following beta-adrenergic-induced beating.
    The American journal of physiology, 1991, Volume: 261, Issue:3 Pt 1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cardiomegaly; Cats; Cells, Cultured; Colforsin; Cultu

1991