1-methyl-3-isobutylxanthine has been researched along with Cardiomegaly in 13 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
Excerpt | Relevance | Reference |
---|---|---|
"Indapamide-treated animals had significantly greater myocardial cAMP concentrations than control animals." | 5.29 | Effect of indapamide on cyclic adenosine 3',5'-monophosphate signal transduction system in isolated adult rat cardiomyocytes from normal myocardium and cardiac hypertrophy. ( Rabkin, SW, 1993) |
"In cardiac myocytes activation of an exchange factor activated by cAMP (Epac) leads to activation of phospholipase Cε (PLCε)-dependent hydrolysis of phosphatidylinositol 4-phosphate (PI4P) in the Golgi apparatus a process critical for development of cardiac hypertrophy." | 3.88 | Compartmentalized cyclic nucleotides have opposing effects on regulation of hypertrophic phospholipase Cε signaling in cardiac myocytes. ( Brown, LM; Cheng, X; Malik, S; Nash, CA; Smrcka, AV, 2018) |
"Cardiac hypertrophy was induced in rats by thoracic aortic banding over a time period of 5 weeks and was confirmed by anatomic measurements and echocardiography." | 1.35 | Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals. ( Abi-Gerges, A; Conti, M; Fischmeister, R; Heymes, C; Lefebvre, F; Lugnier, C; Mateo, P; Richter, W; Samuel, JL; Vandecasteele, G; Varin, A, 2009) |
"Although norepinephrine induces cardiac hypertrophy by activating protein kinase A and C through beta- and alpha 1-adrenoceptors, respectively, protein kinase A has been reported to inhibit cell growth in many other cell types." | 1.30 | Norepinephrine induces the raf-1 kinase/mitogen-activated protein kinase cascade through both alpha 1- and beta-adrenoceptors. ( Aikawa, R; Hiroi, Y; Komuro, I; Kudoh, S; Mizuno, T; Shiojima, I; Takano, H; Yamazaki, T; Yazaki, Y; Zou, Y, 1997) |
"Indapamide-treated animals had significantly greater myocardial cAMP concentrations than control animals." | 1.29 | Effect of indapamide on cyclic adenosine 3',5'-monophosphate signal transduction system in isolated adult rat cardiomyocytes from normal myocardium and cardiac hypertrophy. ( Rabkin, SW, 1993) |
"Dahl S rats developed cardiac hypertrophy on a high-salt diet, whereas Dahl R rats did not." | 1.29 | Angiotensin II induced alteration of cyclic adenosine 3',5'-monophosphate generation in the hypertrophic myocardium of Dahl salt-sensitive rat on a high-salt diet. ( Rabkin, SW; Sunga, PS, 1994) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 9 (69.23) | 18.2507 |
2000's | 2 (15.38) | 29.6817 |
2010's | 2 (15.38) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Nash, CA | 1 |
Brown, LM | 1 |
Malik, S | 1 |
Cheng, X | 1 |
Smrcka, AV | 1 |
Abi-Gerges, A | 2 |
Richter, W | 1 |
Lefebvre, F | 1 |
Mateo, P | 1 |
Varin, A | 1 |
Heymes, C | 1 |
Samuel, JL | 1 |
Lugnier, C | 1 |
Conti, M | 1 |
Fischmeister, R | 1 |
Vandecasteele, G | 1 |
Sassi, Y | 1 |
Fauconnier, J | 1 |
Mougenot, N | 1 |
Reiken, S | 1 |
Haghighi, K | 1 |
Kranias, EG | 2 |
Marks, AR | 1 |
Lacampagne, A | 1 |
Engelhardt, S | 1 |
Hatem, SN | 1 |
Lompre, AM | 1 |
Hulot, JS | 1 |
Long, CS | 1 |
Hartogensis, WE | 1 |
Simpson, PC | 1 |
Rabkin, SW | 2 |
Sunga, PS | 1 |
Yamazaki, T | 2 |
Komuro, I | 2 |
Zou, Y | 2 |
Kudoh, S | 2 |
Shiojima, I | 2 |
Hiroi, Y | 2 |
Mizuno, T | 2 |
Aikawa, R | 1 |
Takano, H | 2 |
Yazaki, Y | 2 |
Osaki, J | 2 |
Haneda, T | 2 |
Sakai, H | 2 |
Kikuchi, K | 2 |
Kinugawa, Ki | 1 |
Kohmoto, O | 1 |
Takahashi, T | 1 |
Ritchie, RH | 1 |
Schiebinger, RJ | 1 |
LaPointe, MC | 1 |
Marsh, JD | 1 |
Kashiwagi, Y | 1 |
Oi, S | 1 |
Fukuzawa, J | 1 |
Sato, Y | 1 |
Kiriazis, H | 1 |
Yatani, A | 1 |
Schmidt, AG | 1 |
Hahn, H | 1 |
Ferguson, DG | 1 |
Sako, H | 1 |
Mitarai, S | 1 |
Honda, R | 1 |
Mesnard-Rouiller, L | 1 |
Frank, KF | 1 |
Beyermann, B | 1 |
Wu, G | 1 |
Fujimori, K | 1 |
Dorn, GW | 1 |
Clark, WA | 1 |
Rudnick, SJ | 1 |
LaPres, JJ | 1 |
Lesch, M | 1 |
Decker, RS | 1 |
13 other studies available for 1-methyl-3-isobutylxanthine and Cardiomegaly
Article | Year |
---|---|
Compartmentalized cyclic nucleotides have opposing effects on regulation of hypertrophic phospholipase Cε signaling in cardiac myocytes.
Topics: 1-Methyl-3-isobutylxanthine; A Kinase Anchor Proteins; Animals; Atrial Natriuretic Factor; Cardiomeg | 2018 |
Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Aortic Valve S | 2009 |
Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Western; Cardiomegaly; Cell Membrane; Cells, Culture | 2012 |
Beta-adrenergic stimulation of cardiac non-myocytes augments the growth-promoting activity of non-myocyte conditioned medium.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Betaxolol; Cardiomegaly; Cell Division; Cells, Cultured; Cultu | 1993 |
Effect of indapamide on cyclic adenosine 3',5'-monophosphate signal transduction system in isolated adult rat cardiomyocytes from normal myocardium and cardiac hypertrophy.
Topics: 1-Methyl-3-isobutylxanthine; Angiotensin II; Animals; Binding, Competitive; Carbachol; Cardiomegaly; | 1993 |
Angiotensin II induced alteration of cyclic adenosine 3',5'-monophosphate generation in the hypertrophic myocardium of Dahl salt-sensitive rat on a high-salt diet.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Angiotensin II; Animals; Cardiomegaly; Cell Si | 1994 |
Norepinephrine induces the raf-1 kinase/mitogen-activated protein kinase cascade through both alpha 1- and beta-adrenoceptors.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-1 Receptor Antagonists; Amino Acids; Animals; Animals, | 1997 |
cAMP-mediated c-fos expression in pressure-overloaded acceleration of protein synthesis in adult rat heart.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Cardiomegaly; Colforsin; Cyclic AMP; Cycli | 1997 |
Protein kinase A and protein kinase C synergistically activate the Raf-1 kinase/mitogen-activated protein kinase cascade in neonatal rat cardiomyocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Bucladesine; Calcium; Calcium-Calmodulin-Dep | 1997 |
Angiotensin II-induced hypertrophy of adult rat cardiomyocytes is blocked by nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Angiotensin II; Animals; Bradyk | 1998 |
Pressure-induced expression of heat shock protein 70 mRNA in adult rat heart is coupled both to protein kinase A-dependent and protein kinase C-dependent systems.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Pressure; Cardiomegaly; Colforsin; Cyclic AMP; Cyclic AM | 1998 |
Rescue of contractile parameters and myocyte hypertrophy in calsequestrin overexpressing myocardium by phospholamban ablation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Calcium-Binding Proteins; Calseques | 2001 |
Hypertrophy of isolated adult feline heart cells following beta-adrenergic-induced beating.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cardiomegaly; Cats; Cells, Cultured; Colforsin; Cultu | 1991 |