1-methyl-3-isobutylxanthine has been researched along with Cardiac Output, Low in 3 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Cardiac Output, Low: A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zimmermann, W | 1 |
| Scholz, H | 2 |
| Schumacher, C | 1 |
| Wenzlaff, H | 2 |
| Haverich, A | 1 |
| von der Leyen, H | 1 |
| Mende, U | 1 |
| Meyer, W | 1 |
| Neumann, J | 1 |
| Nose, M | 1 |
| Schmitz, W | 1 |
| Starbatty, J | 1 |
| Stein, B | 1 |
| Böhm, M | 1 |
| Beuckelmann, D | 1 |
| Brown, L | 1 |
| Feiler, G | 1 |
| Lorenz, B | 1 |
| Näbauer, M | 1 |
| Kemkes, B | 1 |
| Erdmann, E | 1 |
3 other studies available for 1-methyl-3-isobutylxanthine and Cardiac Output, Low
| Article | Year |
|---|---|
Effects of saterinone and its enantiomers R(+)-saterinone and S(-)-saterinone on the phosphodiesterase isoenzymes from ventricular tissue of failing human hearts and porcine hearts.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Animals; Cardiac Output, Low; Cardiomyopathy, Dilated; Cardioton | 1994 |
Mechanism underlying the reduced positive inotropic effects of the phosphodiesterase III inhibitors pimobendan, adibendan and saterinone in failing as compared to nonfailing human cardiac muscle preparations.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Aged; Benzimidazoles; Calci | 1991 |
Reduction of beta-adrenoceptor density and evaluation of positive inotropic responses in isolated, diseased human myocardium.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Bucladesine; Calcium; Cardiac Output, Low; Cardiotonic Agents; C | 1988 |