1-methyl-3-isobutylxanthine has been researched along with Cardiac Hypertrophy in 13 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Cardiac Hypertrophy: Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Indapamide-treated animals had significantly greater myocardial cAMP concentrations than control animals." | 5.29 | Effect of indapamide on cyclic adenosine 3',5'-monophosphate signal transduction system in isolated adult rat cardiomyocytes from normal myocardium and cardiac hypertrophy. ( Rabkin, SW, 1993) |
| "In cardiac myocytes activation of an exchange factor activated by cAMP (Epac) leads to activation of phospholipase Cε (PLCε)-dependent hydrolysis of phosphatidylinositol 4-phosphate (PI4P) in the Golgi apparatus a process critical for development of cardiac hypertrophy." | 3.88 | Compartmentalized cyclic nucleotides have opposing effects on regulation of hypertrophic phospholipase Cε signaling in cardiac myocytes. ( Brown, LM; Cheng, X; Malik, S; Nash, CA; Smrcka, AV, 2018) |
| "Cardiac hypertrophy was induced in rats by thoracic aortic banding over a time period of 5 weeks and was confirmed by anatomic measurements and echocardiography." | 1.35 | Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals. ( Abi-Gerges, A; Conti, M; Fischmeister, R; Heymes, C; Lefebvre, F; Lugnier, C; Mateo, P; Richter, W; Samuel, JL; Vandecasteele, G; Varin, A, 2009) |
| "Although norepinephrine induces cardiac hypertrophy by activating protein kinase A and C through beta- and alpha 1-adrenoceptors, respectively, protein kinase A has been reported to inhibit cell growth in many other cell types." | 1.30 | Norepinephrine induces the raf-1 kinase/mitogen-activated protein kinase cascade through both alpha 1- and beta-adrenoceptors. ( Aikawa, R; Hiroi, Y; Komuro, I; Kudoh, S; Mizuno, T; Shiojima, I; Takano, H; Yamazaki, T; Yazaki, Y; Zou, Y, 1997) |
| "Indapamide-treated animals had significantly greater myocardial cAMP concentrations than control animals." | 1.29 | Effect of indapamide on cyclic adenosine 3',5'-monophosphate signal transduction system in isolated adult rat cardiomyocytes from normal myocardium and cardiac hypertrophy. ( Rabkin, SW, 1993) |
| "Dahl S rats developed cardiac hypertrophy on a high-salt diet, whereas Dahl R rats did not." | 1.29 | Angiotensin II induced alteration of cyclic adenosine 3',5'-monophosphate generation in the hypertrophic myocardium of Dahl salt-sensitive rat on a high-salt diet. ( Rabkin, SW; Sunga, PS, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (69.23) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nash, CA | 1 |
| Brown, LM | 1 |
| Malik, S | 1 |
| Cheng, X | 1 |
| Smrcka, AV | 1 |
| Abi-Gerges, A | 2 |
| Richter, W | 1 |
| Lefebvre, F | 1 |
| Mateo, P | 1 |
| Varin, A | 1 |
| Heymes, C | 1 |
| Samuel, JL | 1 |
| Lugnier, C | 1 |
| Conti, M | 1 |
| Fischmeister, R | 1 |
| Vandecasteele, G | 1 |
| Sassi, Y | 1 |
| Fauconnier, J | 1 |
| Mougenot, N | 1 |
| Reiken, S | 1 |
| Haghighi, K | 1 |
| Kranias, EG | 2 |
| Marks, AR | 1 |
| Lacampagne, A | 1 |
| Engelhardt, S | 1 |
| Hatem, SN | 1 |
| Lompre, AM | 1 |
| Hulot, JS | 1 |
| Long, CS | 1 |
| Hartogensis, WE | 1 |
| Simpson, PC | 1 |
| Rabkin, SW | 2 |
| Sunga, PS | 1 |
| Yamazaki, T | 2 |
| Komuro, I | 2 |
| Zou, Y | 2 |
| Kudoh, S | 2 |
| Shiojima, I | 2 |
| Hiroi, Y | 2 |
| Mizuno, T | 2 |
| Aikawa, R | 1 |
| Takano, H | 2 |
| Yazaki, Y | 2 |
| Osaki, J | 2 |
| Haneda, T | 2 |
| Sakai, H | 2 |
| Kikuchi, K | 2 |
| Kinugawa, Ki | 1 |
| Kohmoto, O | 1 |
| Takahashi, T | 1 |
| Ritchie, RH | 1 |
| Schiebinger, RJ | 1 |
| LaPointe, MC | 1 |
| Marsh, JD | 1 |
| Kashiwagi, Y | 1 |
| Oi, S | 1 |
| Fukuzawa, J | 1 |
| Sato, Y | 1 |
| Kiriazis, H | 1 |
| Yatani, A | 1 |
| Schmidt, AG | 1 |
| Hahn, H | 1 |
| Ferguson, DG | 1 |
| Sako, H | 1 |
| Mitarai, S | 1 |
| Honda, R | 1 |
| Mesnard-Rouiller, L | 1 |
| Frank, KF | 1 |
| Beyermann, B | 1 |
| Wu, G | 1 |
| Fujimori, K | 1 |
| Dorn, GW | 1 |
| Clark, WA | 1 |
| Rudnick, SJ | 1 |
| LaPres, JJ | 1 |
| Lesch, M | 1 |
| Decker, RS | 1 |
13 other studies available for 1-methyl-3-isobutylxanthine and Cardiac Hypertrophy
| Article | Year |
|---|---|
Compartmentalized cyclic nucleotides have opposing effects on regulation of hypertrophic phospholipase Cε signaling in cardiac myocytes.
Topics: 1-Methyl-3-isobutylxanthine; A Kinase Anchor Proteins; Animals; Atrial Natriuretic Factor; Cardiomeg | 2018 |
Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Aortic Valve S | 2009 |
Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Western; Cardiomegaly; Cell Membrane; Cells, Culture | 2012 |
Beta-adrenergic stimulation of cardiac non-myocytes augments the growth-promoting activity of non-myocyte conditioned medium.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Betaxolol; Cardiomegaly; Cell Division; Cells, Cultured; Cultu | 1993 |
Effect of indapamide on cyclic adenosine 3',5'-monophosphate signal transduction system in isolated adult rat cardiomyocytes from normal myocardium and cardiac hypertrophy.
Topics: 1-Methyl-3-isobutylxanthine; Angiotensin II; Animals; Binding, Competitive; Carbachol; Cardiomegaly; | 1993 |
Angiotensin II induced alteration of cyclic adenosine 3',5'-monophosphate generation in the hypertrophic myocardium of Dahl salt-sensitive rat on a high-salt diet.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Angiotensin II; Animals; Cardiomegaly; Cell Si | 1994 |
Norepinephrine induces the raf-1 kinase/mitogen-activated protein kinase cascade through both alpha 1- and beta-adrenoceptors.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-1 Receptor Antagonists; Amino Acids; Animals; Animals, | 1997 |
cAMP-mediated c-fos expression in pressure-overloaded acceleration of protein synthesis in adult rat heart.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Cardiomegaly; Colforsin; Cyclic AMP; Cycli | 1997 |
Protein kinase A and protein kinase C synergistically activate the Raf-1 kinase/mitogen-activated protein kinase cascade in neonatal rat cardiomyocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Bucladesine; Calcium; Calcium-Calmodulin-Dep | 1997 |
Angiotensin II-induced hypertrophy of adult rat cardiomyocytes is blocked by nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Angiotensin II; Animals; Bradyk | 1998 |
Pressure-induced expression of heat shock protein 70 mRNA in adult rat heart is coupled both to protein kinase A-dependent and protein kinase C-dependent systems.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Pressure; Cardiomegaly; Colforsin; Cyclic AMP; Cyclic AM | 1998 |
Rescue of contractile parameters and myocyte hypertrophy in calsequestrin overexpressing myocardium by phospholamban ablation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Calcium-Binding Proteins; Calseques | 2001 |
Hypertrophy of isolated adult feline heart cells following beta-adrenergic-induced beating.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cardiomegaly; Cats; Cells, Cultured; Colforsin; Cultu | 1991 |