1-methyl-3-isobutylxanthine has been researched along with Cardiac Failure in 12 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Rats with congestive heart failure (CHF) have increased protein level of NKCC2, which can be normalized by angiotensin II receptor type-1 (AT(1)) blockade with losartan." | 7.74 | Losartan decreases vasopressin-mediated cAMP accumulation in the thick ascending limb of the loop of Henle in rats with congestive heart failure. ( Brønd, L; Christensen, S; Hadrup, N; Jonassen, TE; Nielsen, JB; Nielsen, S; Praetorius, J; Torp, M, 2007) |
| " Rats with congestive heart failure (CHF) have increased protein level of NKCC2, which can be normalized by angiotensin II receptor type-1 (AT(1)) blockade with losartan." | 3.74 | Losartan decreases vasopressin-mediated cAMP accumulation in the thick ascending limb of the loop of Henle in rats with congestive heart failure. ( Brønd, L; Christensen, S; Hadrup, N; Jonassen, TE; Nielsen, JB; Nielsen, S; Praetorius, J; Torp, M, 2007) |
| "To corroborate alterations in the functional responses to beta-adrenergic receptor (beta-AR) stimulation with changes in beta-AR signaling in failing cardiomyocytes, contractile and L-type Ca(2+) current responses to isoproterenol along with stimulated cAMP generation were compared among cardiomyocytes isolated from canines with tachycardia-induced heart failure or healthy hearts." | 3.71 | Functional desensitization to isoproterenol without reducing cAMP production in canine failing cardiocytes. ( Armour, JA; Bouchard, C; Bouvier, M; Cardinal, R; Laurent, CE; Rousseau, G; Vermeulen, M; Wilkinson, M, 2001) |
| "Heart failure is associated with pathobiochemical changes that can reduce the responsiveness of the myocardium to positive inotropic agents." | 1.30 | The effect of positive inotropes on the failing human myocardium. ( Erdmann, E, 1997) |
| " Dose-response curves plotted as percentage change from baseline versus concentration of drug were determined for acetylstrophanthidin, isoproterenol, isobutylmethylxanthine, and milrinone." | 1.29 | Decreased inotropic but relatively preserved relaxation response to cyclic adenosine monophosphate-dependent agents in myopathic human myocardium. ( Bruce, E; Flemmal, K; Grossman, W; Gutstein, DE; Gwathmey, JK; Markis, JE; Morgan, JP; Ransil, BJ; Travers, KE, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 6 (50.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Torp, M | 1 |
| Brønd, L | 1 |
| Hadrup, N | 1 |
| Nielsen, JB | 1 |
| Praetorius, J | 1 |
| Nielsen, S | 1 |
| Christensen, S | 1 |
| Jonassen, TE | 1 |
| Wynne, DG | 1 |
| Poole-Wilson, PA | 1 |
| Harding, SE | 1 |
| De Mello, WC | 1 |
| Bethke, T | 1 |
| Klimkiewicz, A | 1 |
| Meyer, W | 1 |
| Schumacher, C | 1 |
| Schmitz, W | 2 |
| Scholz, H | 1 |
| Starbatty, J | 1 |
| Wenzlaff, H | 1 |
| Zimmermann, W | 1 |
| Gutstein, DE | 1 |
| Flemmal, K | 1 |
| Bruce, E | 1 |
| Travers, KE | 1 |
| Gwathmey, JK | 2 |
| Ransil, BJ | 1 |
| Markis, JE | 1 |
| Grossman, W | 2 |
| Morgan, JP | 2 |
| Erdmann, E | 1 |
| Gaballa, MA | 1 |
| Eckhart, A | 1 |
| Koch, WJ | 1 |
| Goldman, S | 1 |
| Laurent, CE | 1 |
| Cardinal, R | 1 |
| Rousseau, G | 1 |
| Vermeulen, M | 1 |
| Bouchard, C | 1 |
| Wilkinson, M | 1 |
| Armour, JA | 1 |
| Bouvier, M | 1 |
| Müller, FU | 1 |
| Bokník, P | 1 |
| Knapp, J | 1 |
| Linck, B | 1 |
| Lüss, H | 1 |
| Neumann, J | 1 |
| Boixel, C | 1 |
| Gonzalez, W | 1 |
| Louedec, L | 1 |
| Hatem, SN | 1 |
| Pagani, ED | 1 |
| Buchholz, RA | 1 |
| Silver, PJ | 1 |
| Feldman, MD | 1 |
| Copelas, L | 1 |
| Phillips, P | 1 |
| Warren, SE | 1 |
| Schoen, FJ | 1 |
12 other studies available for 1-methyl-3-isobutylxanthine and Cardiac Failure
| Article | Year |
|---|---|
Losartan decreases vasopressin-mediated cAMP accumulation in the thick ascending limb of the loop of Henle in rats with congestive heart failure.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Angiotensin II Type 1 Receptor Blockers; Animals; Cy | 2007 |
Incomplete reversal of beta-adrenoceptor desensitization in human and guinea-pig cardiomyocytes by cyclic nucleotide phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adrenergic beta-Antagonists | 1993 |
Impaired regulation of cell communication by beta-adrenergic receptor activation in the failing heart.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Cardiomyopathies; | 1996 |
Characterization of the phosphodiesterase inhibition by 2-(3-methoxy-5-methylsulfinyl-2-thienyl)-1H-imidazo-(4,5-c)-pyridine HCl and its sulfide- and sulfone derivatives in myocardial preparations from failing human hearts.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Chromatography, DEAE-Cellulose; Cyclic AMP; Female; Heart Failur | 1995 |
Decreased inotropic but relatively preserved relaxation response to cyclic adenosine monophosphate-dependent agents in myopathic human myocardium.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Antagonists; Adult; Analysis of Variance; Cardiotonic A | 1996 |
The effect of positive inotropes on the failing human myocardium.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Calcium; Cardiotonic Agents; Dobutamine; Hear | 1997 |
Vascular beta-adrenergic receptor system is dysfunctional after myocardial infarction.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Aorta; Aurora Kinases; Blood Pressur | 2001 |
Functional desensitization to isoproterenol without reducing cAMP production in canine failing cardiocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Calcium Channels, L-Type; Cell Membrane; Ce | 2001 |
Activation and inactivation of cAMP-response element-mediated gene transcription in cardiac myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Cantharidin; Cardiotonic Agents; Cell Cycle | 2001 |
Mechanisms of L-type Ca(2+) current downregulation in rat atrial myocytes during heart failure.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Atrial Natriuretic Factor; Calcium; | 2001 |
Cardiovascular cyclic nucleotide phosphodiesterases and their role in regulating cardiovascular function.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Cyclic GMP; Heart Failure; Humans; | 1992 |
Deficient production of cyclic AMP: pharmacologic evidence of an important cause of contractile dysfunction in patients with end-stage heart failure.
Topics: 1-Methyl-3-isobutylxanthine; Caffeine; Calcium; Cardiotonic Agents; Colforsin; Cyclic AMP; Heart Fai | 1987 |