1-methyl-3-isobutylxanthine has been researched along with Carcinoma, Hepatocellular in 8 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We developed a human hepatoma cell model that faithfully reproduces the responsiveness of the CYP2E1 gene to IL-4 at least in part through transcriptional activation, upon treatment with 150 U/ml of IL-4." | 1.31 | The induction of the human hepatic CYP2E1 gene by interleukin 4 is transcriptional and regulated by protein kinase C. ( Corcos, L; Galisteo, M; Guillouzo, A; Joannard, F; Lagadic-Gossmann, D; Lerche, C; Rissel, M, 2000) |
| "Herein, the Epo-synthesizing human hepatoma cell line HepG2 was used to investigate whether protein kinase C (PKC) is involved in the inhibitory action of the cytokines." | 1.29 | Distinct signaling pathways mediate phorbol-ester-induced and cytokine-induced inhibition of erythropoietin gene expression. ( Fandrey, J; Frede, S; Huwiler, A; Jelkmann, W; Pfeilschifter, J, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nguyen, GH | 1 |
| French, R | 1 |
| Radhakrishna, H | 1 |
| Singh, R | 1 |
| Czaja, MJ | 1 |
| Fandrey, J | 1 |
| Huwiler, A | 1 |
| Frede, S | 1 |
| Pfeilschifter, J | 1 |
| Jelkmann, W | 1 |
| Rashed, HM | 1 |
| Sun, H | 1 |
| Patel, TB | 1 |
| Lagadic-Gossmann, D | 1 |
| Lerche, C | 1 |
| Rissel, M | 1 |
| Joannard, F | 1 |
| Galisteo, M | 1 |
| Guillouzo, A | 1 |
| Corcos, L | 1 |
| Mahadev, K | 1 |
| Zilbering, A | 1 |
| Zhu, L | 1 |
| Goldstein, BJ | 1 |
| Tanner, JW | 1 |
| Leingang, KA | 1 |
| Mueckler, MM | 1 |
| Glenn, KC | 1 |
| Lindvall, L | 1 |
| Lantz, M | 1 |
| Gullberg, U | 1 |
| Olsson, I | 1 |
8 other studies available for 1-methyl-3-isobutylxanthine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Protein kinase A inhibits lysophosphatidic acid induction of serum response factor via alterations in the actin cytoskeleton.
Topics: 1-Methyl-3-isobutylxanthine; Actin Cytoskeleton; Actins; Animals; Carcinoma, Hepatocellular; Cell Ad | 2004 |
Capitalizing on AKT signaling to inhibit hepatocellular carcinoma cell proliferation.
Topics: 1-Methyl-3-isobutylxanthine; 3-Phosphoinositide-Dependent Protein Kinases; 8-Bromo Cyclic Adenosine | 2005 |
Distinct signaling pathways mediate phorbol-ester-induced and cytokine-induced inhibition of erythropoietin gene expression.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Carcinoma, Hepatocellular; Cell Hypoxia; Cyclic AMP; Cytok | 1994 |
Atrial natriuretic peptide inhibits growth of hepatoblastoma (HEP G2) cells by means of activation of clearance receptors.
Topics: 1-Methyl-3-isobutylxanthine; Atrial Natriuretic Factor; Carcinoma, Hepatocellular; Cell Division; Cy | 1993 |
The induction of the human hepatic CYP2E1 gene by interleukin 4 is transcriptional and regulated by protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Carcinoma, Hepatocellular; Cytochrome P-450 CYP2E1; Gene E | 2000 |
Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Adipocytes; Animals; Carcinoma, Hepatocellular; Cell Differe | 2001 |
Cellular mechanism of the insulin-like effect of growth hormone in adipocytes. Rapid translocation of the HepG2-type and adipocyte/muscle glucose transporters.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Blotting, Western; Carcinoma, Hepatocellular; | 1992 |
Modulation of the constitutive gene expression of the 55 kD tumor necrosis factor receptor in hematopoietic cells.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Carcinoma, Hepatocellular; Colforsin; Gene Expression Regu | 1990 |