1-methyl-3-isobutylxanthine has been researched along with Cancer of Prostate in 7 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, we used prostate cancer PC3 cells, which express neurotensin receptors and 12-adrenergic receptors, to demonstrate that neurotensin can potentiate the effects of isoproterenol on 3',5'-cyclic adenosine monophosphate (cAMP) formation and on inhibition of DNA synthesis." | 1.30 | Synergistic effects of neurotensin and beta-adrenergic agonist on 3,5-cyclic adenosine monophosphate accumulation and DNA synthesis in prostate cancer PC3 cells. ( Carraway, RE; Mitra, SP, 1999) |
| "Three human prostate cancer cell lines PC-3, DU145 and LNCaP were treated with one of the phosphodiesterase inhibitors, papaverine, 3-isobutyl-1-methylxanthine (IBMX) or theophylline, for 6 days." | 1.30 | The effect of papaverine on morphologic differentiation, proliferation and invasive potential of human prostatic cancer LNCaP cells. ( Goto, T; Hida, A; Hosaka, Y; Kasuya, Y; Kawabe, K; Kitamura, T; Matsushima, H; Ohta, Y; Simizu, T; Takeda, K, 1999) |
| "The standard therapy for advanced prostate cancer is androgen ablation." | 1.28 | Cyclic AMP induces transforming growth factor beta 2 gene expression and growth arrest in the human androgen-independent prostate carcinoma cell line PC-3. ( Bang, YJ; Danielpour, D; Kim, KY; Kim, SJ; Myers, CE; O'Reilly, MA; Trepel, JB, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fukami, K | 1 |
| Asano, E | 1 |
| Ueda, M | 1 |
| Sekiguchi, F | 1 |
| Yoshida, S | 1 |
| Kawabata, A | 1 |
| Mitra, SP | 1 |
| Carraway, RE | 1 |
| Goto, T | 1 |
| Matsushima, H | 1 |
| Kasuya, Y | 1 |
| Hosaka, Y | 1 |
| Kitamura, T | 1 |
| Kawabe, K | 1 |
| Hida, A | 1 |
| Ohta, Y | 1 |
| Simizu, T | 1 |
| Takeda, K | 1 |
| Cox, ME | 1 |
| Deeble, PD | 1 |
| Lakhani, S | 1 |
| Parsons, SJ | 1 |
| Macchia, V | 1 |
| Di Carlo, A | 1 |
| De Luca, C | 1 |
| Mariano, A | 1 |
| Niles, RM | 1 |
| Ludwig, KW | 1 |
| Makarski, JS | 1 |
| Bang, YJ | 1 |
| Kim, SJ | 1 |
| Danielpour, D | 1 |
| O'Reilly, MA | 1 |
| Kim, KY | 1 |
| Myers, CE | 1 |
| Trepel, JB | 1 |
7 other studies available for 1-methyl-3-isobutylxanthine and Cancer of Prostate
| Article | Year |
|---|---|
High glucose induces N-linked glycosylation-mediated functional upregulation and overexpression of Ca
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Calcium Channels, T-Type; Cell Differentiation; Cell Line, | 2017 |
Synergistic effects of neurotensin and beta-adrenergic agonist on 3,5-cyclic adenosine monophosphate accumulation and DNA synthesis in prostate cancer PC3 cells.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Bucladesine; Cell Division; Cyclic AMP; DNA; | 1999 |
The effect of papaverine on morphologic differentiation, proliferation and invasive potential of human prostatic cancer LNCaP cells.
Topics: 1-Methyl-3-isobutylxanthine; Cell Differentiation; Cell Division; Cell Size; Cyclic AMP; Diffusion C | 1999 |
Acquisition of neuroendocrine characteristics by prostate tumor cells is reversible: implications for prostate cancer progression.
Topics: 1-Methyl-3-isobutylxanthine; Adenocarcinoma; Androgens; Biomarkers; Bombesin; Bucladesine; Calcium-C | 1999 |
Effects of cyclic adenosine-monophosphate on growth and PSA secretion of human prostate cancer cell line.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Cell Division; Colforsin; Cyclic AMP; Dihydrotestosterone; | 2001 |
Differential growth inhibition in two human carcinoma cell lines by cyclic adenosine 5'-monophosphate analogs.
Topics: 1-Methyl-3-isobutylxanthine; Adenocarcinoma, Bronchiolo-Alveolar; Cell Division; Cell Line; Cyclic A | 1979 |
Cyclic AMP induces transforming growth factor beta 2 gene expression and growth arrest in the human androgen-independent prostate carcinoma cell line PC-3.
Topics: 1-Methyl-3-isobutylxanthine; Aprotinin; Blotting, Northern; Bucladesine; Cell Division; Cell Line; C | 1992 |