1-methyl-3-isobutylxanthine has been researched along with Breast Neoplasms in 23 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Resveratrol (RSVL) is a well-established chemopreventive agent in human breast cancer models." | 7.72 | Resveratrol activates adenylyl-cyclase in human breast cancer cells: a novel, estrogen receptor-independent cytostatic mechanism. ( Alkhalaf, M; El-Mowafy, AM, 2003) |
| "Leptin has been shown to act as a mitogen/survival factor in many types of cancer cells." | 5.35 | Leptin enhances growth inhibition by cAMP elevating agents through apoptosis of MDA-MB-231 breast cancer cells. ( Abbruzzese, A; Caraglia, M; Chiosi, E; Di Gesto, D; Illiano, F; Illiano, G; Marra, M; Naviglio, S; Romano, M; Sorrentino, A; Sorvillo, L; Spina, A, 2009) |
| "The arginine vasopressin (AVP) gene is expressed in certain cancers such as breast cancer, where it is believed to act as an autocrine growth factor." | 3.73 | Provasopressin expression by breast cancer cells: implications for growth and novel treatment strategies. ( Akerman, BL; Keegan, BP; North, WG; Péqueux, C, 2006) |
| "Resveratrol (RSVL) is a well-established chemopreventive agent in human breast cancer models." | 3.72 | Resveratrol activates adenylyl-cyclase in human breast cancer cells: a novel, estrogen receptor-independent cytostatic mechanism. ( Alkhalaf, M; El-Mowafy, AM, 2003) |
| "MCF-7 human breast cancer cells that were treated for one hour prior to X irradiation with the cyclic AMP-inducing agent 1-methyl-3-isobutylxanthine displayed a slight but significant increase in surviving fraction over untreated controls at each radiation dose level." | 3.66 | Work in progress: radioprotection of human breast cancer cells by elevation of intracellular cyclic AMP. ( Gifford, L; Griem, K; Little, JB; Umans, RS; Weichselbaum, RR, 1983) |
| "Leptin has been shown to act as a mitogen/survival factor in many types of cancer cells." | 1.35 | Leptin enhances growth inhibition by cAMP elevating agents through apoptosis of MDA-MB-231 breast cancer cells. ( Abbruzzese, A; Caraglia, M; Chiosi, E; Di Gesto, D; Illiano, F; Illiano, G; Marra, M; Naviglio, S; Romano, M; Sorrentino, A; Sorvillo, L; Spina, A, 2009) |
| "Similarly, therapeutic efficacy in breast cancer will likely depend on manipulating NIS regulation in mammary cells, which differs from that in the thyroid." | 1.33 | Hydrocortisone and purinergic signaling stimulate sodium/iodide symporter (NIS)-mediated iodide transport in breast cancer cells. ( Carrasco, N; De la Vieja, A; Dohán, O, 2006) |
| "We demonstrate here using MDA-MB-435 breast carcinoma cells that alpha6beta4 stimulates chemotactic migration, a key component of invasion, but that it has no influence on haptotaxis." | 1.30 | Release of cAMP gating by the alpha6beta4 integrin stimulates lamellae formation and the chemotactic migration of invasive carcinoma cells. ( Mercurio, AM; O'Connor, KL; Shaw, LM, 1998) |
| "In MCF-7 human breast cancer cells which contain high levels of endogenous estrogen receptor (ER), the antiestrogen trans-hydroxy-tamoxifen (TOT) fails to stimulate transcription of the estrogen-responsive promoter-reporter constructs estrogen response element (ERE)-TATA-chloramphenicol acetyl transferase (CAT), (ERE)2-TATA-CAT, and pS2-CAT." | 1.29 | Alteration in the agonist/antagonist balance of antiestrogens by activation of protein kinase A signaling pathways in breast cancer cells: antiestrogen selectivity and promoter dependence. ( Fujimoto, N; Katzenellenbogen, BS, 1994) |
| " In contrast, PR mRNA in the K3 subline, as in the parental K1 cells, is still up-regulated by E2, and ER mRAN content and the ER mRNA transcription rate are still down-regulated by E2 and show normal E2 dose-response relationships, implying that the ER in this subline is functional." | 1.28 | Differential regulation of gene expression by estrogen in estrogen growth-independent and -dependent MCF-7 human breast cancer cell sublines. ( Cho, HS; Katzenellenbogen, BS; NG, PA, 1991) |
| "The established human breast cancer cell line MCF-7 resorbs bone directly in vitro independently of viable endogenous bone cells, and this resorption of bone is closely correlated with the release of hydrolytic enzymes by the cultured tumor cells." | 1.27 | Association of increased cyclic adenosine 3':5'-monophosphate content in cultured human breast cancer cells and release of hydrolytic enzymes and bone-resorbing activity. ( Eilon, G; Mundy, GR, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (13.04) | 18.7374 |
| 1990's | 10 (43.48) | 18.2507 |
| 2000's | 10 (43.48) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Naviglio, S | 1 |
| Di Gesto, D | 1 |
| Romano, M | 1 |
| Sorrentino, A | 1 |
| Illiano, F | 1 |
| Sorvillo, L | 1 |
| Abbruzzese, A | 1 |
| Marra, M | 1 |
| Caraglia, M | 1 |
| Chiosi, E | 1 |
| Spina, A | 1 |
| Illiano, G | 1 |
| El-Mowafy, AM | 1 |
| Alkhalaf, M | 1 |
| Inadera, H | 1 |
| Keegan, BP | 1 |
| Akerman, BL | 1 |
| Péqueux, C | 1 |
| North, WG | 1 |
| Dohán, O | 1 |
| De la Vieja, A | 1 |
| Carrasco, N | 1 |
| Al-Dhaheri, MH | 1 |
| Rowan, BG | 1 |
| Chen, L | 1 |
| Zhang, JJ | 1 |
| Huang, XY | 1 |
| Ng, KW | 1 |
| Livesey, SA | 1 |
| Larkins, RG | 1 |
| Martin, TJ | 1 |
| Griem, K | 1 |
| Weichselbaum, RR | 1 |
| Umans, RS | 1 |
| Gifford, L | 1 |
| Little, JB | 1 |
| Eilon, G | 1 |
| Mundy, GR | 1 |
| Cho, H | 1 |
| Aronica, SM | 1 |
| Katzenellenbogen, BS | 3 |
| Fujimoto, N | 1 |
| Bøe, R | 1 |
| Gjertsen, BT | 1 |
| Døskeland, SO | 1 |
| Vintermyr, OK | 1 |
| Moyer, ML | 1 |
| Borror, KC | 1 |
| Bona, BJ | 1 |
| DeFranco, DB | 1 |
| Nordeen, SK | 1 |
| el-Tanani, MK | 2 |
| Green, CD | 2 |
| O'Connor, KL | 1 |
| Shaw, LM | 1 |
| Mercurio, AM | 1 |
| Rao, S | 1 |
| Gray-Bablin, J | 1 |
| Herliczek, TW | 1 |
| Keyomarsi, K | 1 |
| Slotkin, TA | 2 |
| Seidler, FJ | 2 |
| Crumpton, TL | 1 |
| Seo, HS | 1 |
| Leclercq, G | 1 |
| Vandewalle, B | 1 |
| Hornez, L | 1 |
| Révillion, F | 1 |
| Lefebvre, J | 1 |
| Cho, HS | 1 |
| NG, PA | 1 |
23 other studies available for 1-methyl-3-isobutylxanthine and Breast Neoplasms
| Article | Year |
|---|---|
Leptin enhances growth inhibition by cAMP elevating agents through apoptosis of MDA-MB-231 breast cancer cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Apoptosis; Breast Neoplasms; Ca | 2009 |
Resveratrol activates adenylyl-cyclase in human breast cancer cells: a novel, estrogen receptor-independent cytostatic mechanism.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Antineoplastic | 2003 |
Estrogen-induced genes, WISP-2 and pS2, respond divergently to protein kinase pathway.
Topics: 1-Methyl-3-isobutylxanthine; Breast Neoplasms; CCN Intercellular Signaling Proteins; Cell Division; | 2003 |
Provasopressin expression by breast cancer cells: implications for growth and novel treatment strategies.
Topics: 1-Methyl-3-isobutylxanthine; Anti-Inflammatory Agents; Antibodies, Monoclonal; Arginine Vasopressin; | 2006 |
Hydrocortisone and purinergic signaling stimulate sodium/iodide symporter (NIS)-mediated iodide transport in breast cancer cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; | 2006 |
Protein kinase A exhibits selective modulation of estradiol-dependent transcription in breast cancer cells that is associated with decreased ligand binding, altered estrogen receptor alpha promoter interaction, and changes in receptor phosphorylation.
Topics: 1-Methyl-3-isobutylxanthine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colforsin; Cycl | 2007 |
cAMP inhibits cell migration by interfering with Rac-induced lamellipodium formation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cyclic AMP; | 2008 |
Calcitonin effects on growth and on selective activation of type II isoenzyme of cyclic adenosine 3':5'-monophosphate-dependent protein kinase in T 47D human breast cancer cells.
Topics: 1-Methyl-3-isobutylxanthine; Breast Neoplasms; Calcitonin; Cell Division; Cell Line; Cyclic AMP; Din | 1983 |
Work in progress: radioprotection of human breast cancer cells by elevation of intracellular cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Breast Neoplasms; Cell Line; Cell Survival; Cyclic AMP; Female; Humans; | 1983 |
Association of increased cyclic adenosine 3':5'-monophosphate content in cultured human breast cancer cells and release of hydrolytic enzymes and bone-resorbing activity.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Alprostadil; Bone Resorption; B | 1983 |
Regulation of progesterone receptor gene expression in MCF-7 breast cancer cells: a comparison of the effects of cyclic adenosine 3',5'-monophosphate, estradiol, insulin-like growth factor-I, and serum factors.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blood Physiological Ph | 1994 |
Alteration in the agonist/antagonist balance of antiestrogens by activation of protein kinase A signaling pathways in breast cancer cells: antiestrogen selectivity and promoter dependence.
Topics: 1-Methyl-3-isobutylxanthine; Breast Neoplasms; Cholera Toxin; Cyclic AMP; Cyclic AMP-Dependent Prote | 1994 |
8-Chloro-cAMP induces apoptotic cell death in a human mammary carcinoma cell (MCF-7) line.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenocarcinoma; Adenosine Deami | 1995 |
Modulation of cell signaling pathways can enhance or impair glucocorticoid-induced gene expression without altering the state of receptor phosphorylation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Breast Neoplasms; Chloramphenic | 1993 |
Synergism between oestradiol and cAMP for specific gene transcription in breast cancer cells.
Topics: 1-Methyl-3-isobutylxanthine; Breast Neoplasms; Cholera Toxin; Cyclic AMP; Drug Synergism; Estradiol; | 1996 |
Interaction between estradiol and cAMP in the regulation of specific gene expression.
Topics: 1-Methyl-3-isobutylxanthine; Breast Neoplasms; Carcinoma; Cholera Toxin; Cyclic AMP; Cycloheximide; | 1996 |
Release of cAMP gating by the alpha6beta4 integrin stimulates lamellae formation and the chemotactic migration of invasive carcinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Antibodies; Antigens, Surface; Bre | 1998 |
The biphasic induction of p21 and p27 in breast cancer cells by modulators of cAMP is posttranscriptionally regulated and independent of the PKA pathway.
Topics: 1-Methyl-3-isobutylxanthine; Breast Neoplasms; Cell Cycle Proteins; Cholera Toxin; Colforsin; Cyclic | 1999 |
Antimitotic and cytotoxic effects of theophylline in MDA-MB-231 human breast cancer cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Antineoplastic Agents; Breast Neoplasms; Cell Adhesi | 2000 |
Generation of reactive oxygen species by xanthine derivatives in MDA-MB-231 human breast cancer cells.
Topics: 1-Methyl-3-isobutylxanthine; Breast Neoplasms; Female; Humans; Phosphodiesterase Inhibitors; Reactiv | 2001 |
Evaluation of potential implication of membrane estrogen binding sites on ERE-dependent transcriptional activity and intracellular estrogen receptor-alpha regulation in MCF-7 breast cancer cells.
Topics: 1-Methyl-3-isobutylxanthine; Breast Neoplasms; Enzyme Inhibitors; Estradiol; Estrogen Receptor alpha | 2002 |
Cyclic AMP stimulation of transferrin secretion by breast cancer cell grown on extracellular matrix or in two-compartment culture chambers.
Topics: 1-Methyl-3-isobutylxanthine; Autoradiography; Breast Neoplasms; Bucladesine; Cell Division; Cell Lin | 1991 |
Differential regulation of gene expression by estrogen in estrogen growth-independent and -dependent MCF-7 human breast cancer cell sublines.
Topics: 1-Methyl-3-isobutylxanthine; Breast Neoplasms; Cell Line, Transformed; Clone Cells; Down-Regulation; | 1991 |