1-methyl-3-isobutylxanthine has been researched along with Bone Loss, Osteoclastic in 19 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Induction of osteoclastic bone resorption by various endocrine or paracrine factors is mediated via the osteoblasts." | 1.29 | Interleukin-1 beta induces cyclic AMP formation in isolated human osteoblasts: a signalling mechanism that is not related to enhanced prostaglandin formation. ( Bornefalk, E; Johansson, AG; Ljunggren, O; Ljunghall, S; Nilsson, K, 1994) |
| "To elucidate the role of cGMP in bone resorption, the nucleotide was measured in bone and bone cells in response to several agents including stimulators of bone resorption." | 1.28 | Sodium nitroprusside increases cyclic GMP in fetal rat bone cells and inhibits resorption of fetal rat limb bones. ( Diamond, J; Stern, PH, 1992) |
| "The established human breast cancer cell line MCF-7 resorbs bone directly in vitro independently of viable endogenous bone cells, and this resorption of bone is closely correlated with the release of hydrolytic enzymes by the cultured tumor cells." | 1.27 | Association of increased cyclic adenosine 3':5'-monophosphate content in cultured human breast cancer cells and release of hydrolytic enzymes and bone-resorbing activity. ( Eilon, G; Mundy, GR, 1983) |
| " Thus, palytoxin exhibited a biphasic dose-response curve for enhanced bone resorption, with stimulation at low concentrations (0." | 1.27 | Palytoxin: an extraordinarily potent stimulator of prostaglandin production and bone resorption in cultured mouse calvariae. ( Fujiki, H; Lazzaro, M; Levine, L; Tashjian, AH, 1987) |
| "The effect on cyclic AMP levels and bone resorption by two methylxanthine cyclic AMP phosphodiesterase (PDE) inhibitors, isobutyl-methylxanthine (IBMX) and theophylline, and two non-xanthine PDE inhibitors, Ro 20-1724 and rolipram, was studied in cultured mouse calvarial bones." | 1.27 | Delayed stimulation of bone resorption in vitro by phosphodiesterase inhibitors requires the presence of adenylate cyclase stimulation. ( Fredholm, BB; Lerner, UH; Ransjö, M, 1988) |
| "The action of PDGF on bone resorption occurred at low concentrations of the protein (ED50 = 10 ng/ml)." | 1.26 | Platelet-derived growth factor stimulates bone resorption via a prostaglandin-mediated mechanism. ( Antoniades, HN; Hohmann, EL; Levine, L; Tashjian, AH, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (63.16) | 18.7374 |
| 1990's | 7 (36.84) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lerner, U | 3 |
| Gustafson, GT | 1 |
| Tashjian, AH | 4 |
| Ivey, JL | 1 |
| Hohmann, EL | 2 |
| Antoniades, HN | 1 |
| Levine, L | 3 |
| Eilon, G | 1 |
| Mundy, GR | 1 |
| Kozawa, O | 1 |
| Tokuda, H | 1 |
| Kotoyori, J | 1 |
| Oiso, Y | 1 |
| Bornefalk, E | 1 |
| Ljunghall, S | 1 |
| Johansson, AG | 1 |
| Nilsson, K | 1 |
| Ljunggren, O | 2 |
| Miyamoto, K | 1 |
| Waki, Y | 1 |
| Horita, T | 1 |
| Kasugai, S | 1 |
| Ohya, K | 1 |
| Stern, PH | 2 |
| Diamond, J | 1 |
| Reid, IR | 1 |
| Lowe, C | 1 |
| Cornish, J | 1 |
| Gray, DH | 1 |
| Skinner, SJ | 1 |
| Dewhirst, FE | 1 |
| Ago, JM | 1 |
| Stashenko, P | 1 |
| Murrills, RJ | 1 |
| Dempster, DW | 1 |
| Ransjö, M | 3 |
| Fredholm, BB | 2 |
| Lazzaro, M | 1 |
| Fujiki, H | 1 |
| Lerner, UH | 2 |
| Lorenzo, JA | 1 |
| Sousa, S | 1 |
| Quinton, J | 1 |
19 other studies available for 1-methyl-3-isobutylxanthine and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Inhibition of bone resorption and lysosomal enzyme release from calvarial bones cultured for 24 hours: synergism between cyclic AMP analogues and phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bone and Bones; Bone Resorption; Bucladesine; Calcium; Cyclic | 1980 |
Delayed stimulatory effect of cyclic AMP on bone resorption in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bone Resorption; Bucladesine; Cells, Cultured; Mice; Parathyro | 1981 |
Stimulation of bone resorption in organ culture by cholera toxin.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Bone and Bones; Bone Resorption; Calcitonin; | 1981 |
Platelet-derived growth factor stimulates bone resorption via a prostaglandin-mediated mechanism.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bone Resorption; Calcium; Cyclic AMP; Dinoprostone; Dose-Respo | 1982 |
Vasoactive intestinal peptide stimulates bone resorption via a cyclic adenosine 3',5'-monophosphate-dependent mechanism.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bone Resorption; Cyclic AMP; Dinoprostone; Dose-Response Relat | 1983 |
Association of increased cyclic adenosine 3':5'-monophosphate content in cultured human breast cancer cells and release of hydrolytic enzymes and bone-resorbing activity.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Alprostadil; Bone Resorption; B | 1983 |
Effects of glucocorticoid on signalling by prostaglandin E2 in osteoblast-like cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Bone Resorption; Cell Line; Colforsin; Cycl | 1993 |
Interleukin-1 beta induces cyclic AMP formation in isolated human osteoblasts: a signalling mechanism that is not related to enhanced prostaglandin formation.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Bone Resorption; Calcimycin; Calcium; Cells, Cult | 1994 |
Reduction of bone loss by denbufylline, an inhibitor of phosphodiesterase 4.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imi | 1997 |
Sodium nitroprusside increases cyclic GMP in fetal rat bone cells and inhibits resorption of fetal rat limb bones.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Animals; Bone and Bones; Bone Resorption; Calcitr | 1992 |
Adenylate cyclase blockers dissociate PTH-stimulated bone resorption from cAMP production.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenylyl Cyclase Inhibitors; Animals; Bone and Bones; Bone Res | 1990 |
Interleukin 1 interacts synergistically with forskolin and isobutylmethylxanthine in stimulating bone resorption in organ culture.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bone and Bones; Bone Resorption; Colforsin; Drug Synergism; In | 1990 |
The effects of stimulators of intracellular cyclic AMP on rat and chick osteoclasts in vitro: validation of a simplified light microscope assay of bone resorption.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bone Resorption; Bucladesine; Cell Movement; Chick Embryo; Col | 1990 |
Biphasic effects of manganese on hormone-stimulated bone resorption.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bone and Bones; Bone Resorption; Calcimycin; Calcitonin; Calci | 1985 |
Comparative study of the effects of cyclic nucleotide phosphodiesterase inhibitors on bone resorption and cyclic AMP formation in vitro.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl | 1986 |
Palytoxin: an extraordinarily potent stimulator of prostaglandin production and bone resorption in cultured mouse calvariae.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Acrylamides; Animals; Bone and | 1987 |
Prostaglandin E2 causes a transient inhibition of mineral mobilization, matrix degradation, and lysosomal enzyme release from mouse calvarial bones in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bone and Bones; Bone Matrix; Bone Resorption; Calcitonin; Calc | 1987 |
Forskolin has both stimulatory and inhibitory effects on bone resorption in fetal rat long bone cultures.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bone and Bones; Bone Development; Bone Resorption; Calcium; Co | 1986 |
Delayed stimulation of bone resorption in vitro by phosphodiesterase inhibitors requires the presence of adenylate cyclase stimulation.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenylyl Cyclases; Anim | 1988 |