1-methyl-3-isobutylxanthine has been researched along with Benign Neoplasms, Brain in 9 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bradykinin causes a concentration-dependent, transient rise in intracellular Ca2+ and a sustained inhibition of forskolin-, dopamine- and 5'-N-ethyl-carboxamidoadenosine (NECA)-stimulated cAMP accumulation in D384 astrocytoma cells." | 7.68 | Bradykinin inhibits cyclic AMP accumulation in D384-human astrocytoma cells via a calcium-dependent inhibition of adenylyl cyclase. ( Altiok, N; Fredholm, BB, 1993) |
| "The prostacyclin mimetic cicaprost increased phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) in Chinese hamster ovary cells transiently expressing human (hIP-CHO) or mouse prostacyclin (mIP-CHO) receptors, but not in human neuroblastoma SK-N-SH cells or rat/mouse neuroblastoma-glioma NG108-15 cells which endogenously express IP receptors." | 3.72 | Prostacyclin receptor-mediated activation of extracellular signal-regulated kinases 1 and 2. ( Chow, KB; Chu, KM; Wise, H; Wong, YH, 2004) |
| "Bradykinin causes a concentration-dependent, transient rise in intracellular Ca2+ and a sustained inhibition of forskolin-, dopamine- and 5'-N-ethyl-carboxamidoadenosine (NECA)-stimulated cAMP accumulation in D384 astrocytoma cells." | 3.68 | Bradykinin inhibits cyclic AMP accumulation in D384-human astrocytoma cells via a calcium-dependent inhibition of adenylyl cyclase. ( Altiok, N; Fredholm, BB, 1993) |
| "Rolipram-treated A172 or U87MG cell survival was lower in the presence of forskolin, adenylate cyclase activator, than that in its absence." | 1.38 | Phosphodiesterase inhibitors control A172 human glioblastoma cell death through cAMP-mediated activation of protein kinase A and Epac1/Rap1 pathways. ( Kim, HM; Lee, GH; Lee, JW; Lee, MS; Moon, EY, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lv, P | 1 |
| Wang, W | 1 |
| Cao, Z | 1 |
| Zhao, D | 1 |
| Zhao, G | 1 |
| Li, D | 1 |
| Qi, L | 1 |
| Xu, J | 1 |
| Moon, EY | 1 |
| Lee, GH | 1 |
| Lee, MS | 1 |
| Kim, HM | 1 |
| Lee, JW | 1 |
| Chu, KM | 1 |
| Chow, KB | 1 |
| Wong, YH | 1 |
| Wise, H | 1 |
| Freedman, SB | 1 |
| Dawson, G | 1 |
| Villereal, ML | 1 |
| Miller, RJ | 1 |
| Kuzhikandathil, EV | 1 |
| Molloy, GR | 1 |
| Altiok, N | 1 |
| Fredholm, BB | 1 |
| Pauwels, PJ | 1 |
| Wurch, T | 1 |
| Amoureux, MC | 1 |
| Palmier, C | 1 |
| Colpaert, FC | 1 |
| Boddeke, HW | 1 |
| Meigel, I | 1 |
| Boeijinga, P | 1 |
| Arbuckle, J | 1 |
| Docherty, RJ | 1 |
| Beck, H | 1 |
| Goussakov, IV | 1 |
| Lie, A | 1 |
| Helmstaedter, C | 1 |
| Elger, CE | 1 |
9 other studies available for 1-methyl-3-isobutylxanthine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Fsk and IBMX inhibit proliferation and proapoptotic of glioma stem cells via activation of cAMP signaling pathway.
Topics: 1-Methyl-3-isobutylxanthine; Apoptosis; Brain Neoplasms; Butadienes; Cell Line, Tumor; Cell Prolifer | 2019 |
Phosphodiesterase inhibitors control A172 human glioblastoma cell death through cAMP-mediated activation of protein kinase A and Epac1/Rap1 pathways.
Topics: 1-Methyl-3-isobutylxanthine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neopla | 2012 |
Prostacyclin receptor-mediated activation of extracellular signal-regulated kinases 1 and 2.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain Neoplasms; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP | 2004 |
Identification and characterization of voltage-sensitive calcium channels in neuronal clonal cell lines.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain Neoplasms; Calcium Channel Blockers; Cell Transformation | 1984 |
Transcription of the brain creatine kinase gene in glial cells is modulated by cyclic AMP-dependent protein kinase.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Brain; Brain Neoplasms; Cloning, Molecular; | 1994 |
Bradykinin inhibits cyclic AMP accumulation in D384-human astrocytoma cells via a calcium-dependent inhibition of adenylyl cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclase Inhibito | 1993 |
Stimulation of cloned human serotonin 5-HT1D beta receptor sites in stably transfected C6 glial cells promotes cell growth.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain Neoplasms; Bucladesine; Cell Division; CHO Cells; Clonin | 1996 |
Modulation by calcineurin of 5-HT3 receptor function in NG108-15 neuroblastoma x glioma cells.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Brain Neoplasms; Calcineurin; Calmodulin- | 1996 |
Synaptic plasticity in the human dentate gyrus.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Brain Neoplasms; Child; Child, Preschool; Colforsin; | 2000 |