1-methyl-3-isobutylxanthine has been researched along with B16 Melanoma in 35 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sesamolin is a lignan compound isolated from sesame seeds with several beneficial properties, including potential for melanin inhibition." | 1.56 | Inhibitory Effect of Sesamolin on Melanogenesis in B16F10 Cells Determined by In Vitro and Molecular Docking Analyses. ( Baek, SH; Kang, MG; Park, D, 2020) |
| "Chaetocin is a natural product isolated from Chaetomium species that has anti-bacterial and anti-myeloma activities." | 1.43 | Chaetocin inhibits IBMX-induced melanogenesis in B16F10 mouse melanoma cells through activation of ERK. ( Bae, JS; Chung, JH; Han, M; Yao, C, 2016) |
| "We assessed melanin production of PQQ-treated B16 melanoma cells." | 1.35 | Effect of pyrroloquinoline quinone (PQQ) on melanogenic protein expression in murine B16 melanoma. ( Sato, K; Toriyama, M, 2009) |
| "In cultured B16 melanoma cells, 1-3 markedly inhibited (>50%) melanin synthesis at 50 microM." | 1.35 | Inhibitory effects of kurarinol, kuraridinol, and trifolirhizin from Sophora flavescens on tyrosinase and melanin synthesis. ( Choi, JS; Hyun, SK; Jeong, DM; Kim, Y; Lee, WH, 2008) |
| "Fusion of Cloudman S91 melanoma cells with macrophages results in hybrids with increased metastatic potential." | 1.30 | Acquired melanocyte stimulating hormone-inducible chemotaxis following macrophage fusion with Cloudman S91 melanoma cells. ( Pawelek, J; Rachkovsky, M, 1999) |
| "In this study, using B16 melanoma cells, we showed that cAMP-elevating agents stimulated mitogen-activated protein (MAP) kinase, p44mapk." | 1.29 | Mitogen-activated protein kinase pathway and AP-1 are activated during cAMP-induced melanogenesis in B-16 melanoma cells. ( Ballotti, R; Durand-Clément, M; Englaro, W; Lallemand, D; Ortonne, JP; Rezzonico, R, 1995) |
| "4 clonal sublines of Cloudman S91 melanoma cells, S91/mel, S91/I3, S91/6 and S91/amel, were evaluated for changes in growth, pigment content and plating efficiency during and after treatment with a cyclic-AMP phosphodiesterase inhibitor-melanin-stimulating agent, 3-isobutyl-1-methyl-xanthine (IBMX) plus beta-melanocyte stimulating hormone (beta-MSH) or IBMX alone." | 1.29 | Growth and pigmentation in genetically related Cloudman S91 melanoma cell lines treated with 3-isobutyl-1-methyl-xanthine and beta-melanocyte-stimulating hormone. ( Cieszka, KA; Hill, GJ; Hill, HZ; Plonka, PM, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (11.43) | 18.7374 |
| 1990's | 17 (48.57) | 18.2507 |
| 2000's | 6 (17.14) | 29.6817 |
| 2010's | 6 (17.14) | 24.3611 |
| 2020's | 2 (5.71) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, S | 1 |
| Na, GH | 1 |
| Jung, HM | 1 |
| Han, SH | 1 |
| Han, J | 1 |
| Koo, YK | 1 |
| Baek, SH | 1 |
| Kang, MG | 1 |
| Park, D | 1 |
| Peng, LH | 1 |
| Li, Q | 1 |
| Yan, G | 1 |
| Zhu, J | 1 |
| Zhang, L | 1 |
| Xu, Z | 1 |
| Wang, G | 1 |
| Zhu, W | 1 |
| Hou, A | 1 |
| Wang, H | 1 |
| Bae, JS | 1 |
| Han, M | 1 |
| Yao, C | 1 |
| Chung, JH | 1 |
| Be Tu, PT | 1 |
| Nguyen, BC | 1 |
| Tawata, S | 1 |
| Yun, CY | 1 |
| Kim, EG | 1 |
| Maruta, H | 1 |
| Koo, JH | 1 |
| Kim, HT | 1 |
| Yoon, HY | 1 |
| Kwon, KB | 1 |
| Choi, IW | 1 |
| Jung, SH | 1 |
| Kim, HU | 1 |
| Park, BH | 1 |
| Park, JW | 1 |
| Sato, K | 1 |
| Toriyama, M | 1 |
| Kim, A | 1 |
| Yang, Y | 1 |
| Lee, MS | 1 |
| Yoo, YD | 1 |
| Lee, HG | 1 |
| Lim, JS | 1 |
| Ohguchi, K | 1 |
| Ito, M | 1 |
| Yokoyama, K | 1 |
| Iinuma, M | 1 |
| Itoh, T | 1 |
| Nozawa, Y | 1 |
| Akao, Y | 1 |
| Park, SY | 1 |
| Jin, ML | 1 |
| Kim, YH | 1 |
| Kim, Y | 3 |
| Lee, SJ | 1 |
| Cha, JY | 1 |
| Yang, HJ | 1 |
| Moon, HI | 1 |
| Cho, YS | 1 |
| Hyun, SK | 1 |
| Lee, WH | 2 |
| Jeong, DM | 1 |
| Choi, JS | 1 |
| Choi, JY | 1 |
| Choi, EH | 1 |
| Jung, HW | 1 |
| Oh, JS | 1 |
| Lee, JG | 1 |
| Son, JK | 1 |
| Lee, SH | 1 |
| Schallreuter, KU | 1 |
| Lemke, KR | 1 |
| Hill, HZ | 4 |
| Wood, JM | 1 |
| Carsberg, CJ | 1 |
| Warenius, HM | 1 |
| Friedmann, PS | 1 |
| Blanchard, SG | 1 |
| Harris, CO | 1 |
| Ittoop, OR | 1 |
| Nichols, JS | 1 |
| Parks, DJ | 1 |
| Truesdale, AT | 1 |
| Wilkison, WO | 1 |
| Englaro, W | 1 |
| Rezzonico, R | 1 |
| Durand-Clément, M | 1 |
| Lallemand, D | 1 |
| Ortonne, JP | 1 |
| Ballotti, R | 1 |
| Degani, H | 2 |
| DeJordy, JO | 2 |
| Salomon, Y | 2 |
| Cieszka, KA | 1 |
| Hill, GJ | 1 |
| Plonka, PM | 1 |
| Xiao, Y | 1 |
| Desai, D | 1 |
| Quick, TC | 1 |
| Niles, RM | 1 |
| Goodman, RM | 1 |
| Li, W | 1 |
| Xin, P | 1 |
| Mitchell, DL | 1 |
| Juranić, Z | 1 |
| Radulović, S | 1 |
| Joksimović, J | 1 |
| Juranić, I | 1 |
| Rachkovsky, M | 1 |
| Pawelek, J | 1 |
| Pawelek, JM | 3 |
| Chakraborty, AK | 3 |
| Rachkovsky, ML | 1 |
| Orlow, SJ | 3 |
| Bolognia, JL | 1 |
| Sodi, SA | 1 |
| Djordevic, B | 1 |
| Lange, CS | 1 |
| Rotman, M | 1 |
| Boissy, RE | 1 |
| Fuller, BB | 1 |
| Niekrasz, I | 1 |
| Hoganson, GE | 1 |
| de Graan, PN | 1 |
| Brussaard, AB | 1 |
| Gamboni, G | 1 |
| Girard, J | 1 |
| Eberle, AN | 1 |
| Kwon, BS | 1 |
| Halaban, R | 1 |
| Kim, GS | 1 |
| Usack, L | 1 |
| Pomerantz, S | 1 |
| Haq, AK | 1 |
| Abdel-Malek, ZA | 1 |
| Swope, VB | 1 |
| Trinkle, LS | 1 |
| Nordlund, JJ | 1 |
| Lester, BR | 1 |
| McCarthy, JB | 1 |
| Sun, ZQ | 1 |
| Smith, RS | 1 |
| Furcht, LT | 1 |
| Spiegel, AM | 1 |
1 review available for 1-methyl-3-isobutylxanthine and B16 Melanoma
| Article | Year |
|---|---|
Melanin: a two edged sword?
Topics: 1-Methyl-3-isobutylxanthine; Animals; Disease Susceptibility; DNA Damage; Humans; Melanins; Melanocy | 1997 |
34 other studies available for 1-methyl-3-isobutylxanthine and B16 Melanoma
| Article | Year |
|---|---|
Enzyme-treated caviar extract ameliorates melanogenesis in UVB-induced SKH-1 hairless mice.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line, Tumor; Melanins; Melanoma, Experimental; Mice; Mice | 2023 |
Inhibitory Effect of Sesamolin on Melanogenesis in B16F10 Cells Determined by In Vitro and Molecular Docking Analyses.
Topics: 1-Methyl-3-isobutylxanthine; Agaricales; Animals; Antineoplastic Agents; Cell Line, Tumor; Dioxoles; | 2020 |
Effect of the Stromal Vascular Fraction on Changes in Melanin Formation in B16 Cells Treated by IBMX.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biopsy, Needle; Cells, Cultured; Coculture Techniques; Disease | 2019 |
Dodoviscin a inhibits melanogenesis in mouse b16-f10 melanoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line, Tumor; Cell Survival; Cyclic AMP Response Element-B | 2013 |
Chaetocin inhibits IBMX-induced melanogenesis in B16F10 mouse melanoma cells through activation of ERK.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Cell Line, Tumor | 2016 |
The serum/PDGF-dependent "melanogenic" role of the minute level of the oncogenic kinase PAK1 in melanoma cells proven by the highly sensitive kinase assay.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line, Tumor; Down-Regulation; Gene Expression Regulation, | 2017 |
Effect of xanthohumol on melanogenesis in B16 melanoma cells.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Animals; Cell Line; Cell Survival; Colforsin; Dose-Response | 2008 |
Effect of pyrroloquinoline quinone (PQQ) on melanogenic protein expression in murine B16 melanoma.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Animals; Cell Line, Tumor; Cell Proliferation; Dose-Response | 2009 |
NDRG2 gene expression in B16F10 melanoma cells restrains melanogenesis via inhibition of Mitf expression.
Topics: 1-Methyl-3-isobutylxanthine; Adaptor Proteins, Signal Transducing; alpha-MSH; Animals; beta Catenin; | 2008 |
Effects of sesquiterpene lactones on melanogenesis in mouse B16 melanoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Asteraceae; Blotting, Western; Cell Line, Tumor; Cell Survival | 2009 |
Aromatic-turmerone inhibits α-MSH and IBMX-induced melanogenesis by inactivating CREB and MITF signaling pathways.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Animals; Cosmetics; Curcuma; Curcumin; Cyclic AMP; Enzyme Ac | 2011 |
Branched-chain amino acids complex inhibits melanogenesis in B16F0 melanoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Agaricales; Amino Acids; Animals; Arbutin; Biocatalysis; Biosynthetic P | 2012 |
Inhibitory effects of kurarinol, kuraridinol, and trifolirhizin from Sophora flavescens on tyrosinase and melanin synthesis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Benzopyrans; Enzyme Inhibitors; Flavonoids; Glucosides; Hetero | 2008 |
Melanogenesis inhibitory compounds from Saussureae Radix.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arbutin; Cell Line, Tumor; Dermatologic Agents; Dose-Response | 2008 |
Thioredoxin reductase induction coincides with melanin biosynthesis in brown and black guinea pigs and in murine melanoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Catalase; Enzyme Induction; Female; Glutathione Reductase; Gui | 1994 |
Ultraviolet radiation-induced melanogenesis in human melanocytes. Effects of modulating protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Diglycerides; Enzyme Induction; Humans; Indoles; In | 1994 |
Agouti antagonism of melanocortin binding and action in the B16F10 murine melanoma cell line.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Agouti Signaling Protein; alpha-MSH; Animals; Bindin | 1995 |
Mitogen-activated protein kinase pathway and AP-1 are activated during cAMP-induced melanogenesis in B-16 melanoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Affinity Labels; alpha-MSH; Animals; Calcium-Calmodulin-Dependent Prote | 1995 |
Determination of the response of melanoma cells to melanocyte stimulating hormone by 31P nuclear magnetic resonance spectroscopy.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Ethanolamines; Magnetic Resonance Spect | 1993 |
Growth and pigmentation in genetically related Cloudman S91 melanoma cell lines treated with 3-isobutyl-1-methyl-xanthine and beta-melanocyte-stimulating hormone.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Division; Electron Spin Resonance Spectroscopy; Melanins; | 1995 |
Control of retinoic acid receptor expression in mouse melanoma cells by cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blotting, Northern; Cy | 1996 |
Interference by cellular melanin with assay of DNA-protein crosslinks by the potassium dodecyl sulfate precipitation method.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Chemical Phenomena; Chemistry, Physical; Cross-Linking Reagent | 1996 |
The mechanism of 8-Cl-cAMP action.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; | 1998 |
Acquired melanocyte stimulating hormone-inducible chemotaxis following macrophage fusion with Cloudman S91 melanoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Fusion; Chemotactic Factors; Chemotaxis; Culture Media, C | 1999 |
Altered N-glycosylation in macrophage x melanoma fusion hybrids.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Animals; Antigens, CD; Glucosamine; Glycosylation; Humans; H | 1999 |
Potentiation of radiation lethality in mouse melanoma cells by mild hyperthermia and chloroquine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Survival; Chloroquine; Dose-Response Relationship, Drug; | 1992 |
Membrane glycoproteins common to vesicles and melanosomes in mouse melanoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Acetamides; Animals; Female; Gene Expression Regulation, Neoplastic; Im | 1992 |
Inhibition of induced melanogenesis in Cloudman melanoma cells by four phenotypic modifiers.
Topics: 1-Methyl-3-isobutylxanthine; Acetamides; Animals; Butyrates; Butyric Acid; Cell Transformation, Neop | 1990 |
Down-regulation of tyrosinase mRNA levels in melanoma cells by tumor promoters and by insulin.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Enzyme Induction; Gene Expression Regulation, Neo | 1990 |
Stimulation of cAMP and phosphomonoester production by melanotropin in melanoma cells: 31P NMR studies.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Cell Line; Colforsin; Cyclic AMP; Kine | 1991 |
alpha-MSH-induced changes in protein phosphorylation of Cloudman S91 mouse melanoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Colforsin; Melanocyte-Stimulating Hormones; Melan | 1987 |
A melanocyte-specific complementary DNA clone whose expression is inducible by melanotropin and isobutylmethyl xanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antibodies, Monoclonal; Catechol Oxidase; DNA; Gene Expression | 1987 |
Stimulation of Cloudman melanoma tyrosinase activity occurs predominantly in G2 phase of the cell cycle.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Bucladesine; Catechol Oxidase; Cyclic AMP; Dideox | 1989 |
G-protein involvement in matrix-mediated motility and invasion of high and low experimental metastatic B16 melanoma clones.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenylate Cyclase Toxin; Animals; Cell Line; Cell Membrane; Ce | 1989 |